Bacterial Meningitis
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Diagnosis (cont.)<br />
• Quellung procedure (Quellung capsular reaction)<br />
• Used to confirm presence of S.pneumoniae,<br />
N.meningitidis, or H.influenzae<br />
• Antisera specific for the capsular polysaccharides of each<br />
of these 3 bacteria are mixed with separate portions of<br />
clinical specimens.<br />
• Formation of Ag/Ab complexes on the surfaces of these<br />
bacteria induces changes in the refractive indices of their<br />
capsules.<br />
• The capsules appear clear & swollen.
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