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Adverse Reaction: Dizziness, drowsiness, headache, and weakness.<br />
Interactions: Androgens, chloramphenicol, clofibrate, guanethidine, etc.<br />
Glucophage(Metformin)<br />
Pronunciation: Met-for-min<br />
Classification: Biguanide<br />
IFU: Type 2 diabetes mellitus<br />
Route: Orally<br />
Dosage: 500 mg, and 1,000mg.<br />
Action: Increase insulin sensitivity by decreasing glucose production and absorption in liver and<br />
intestine and enhancing glucose uptake and utilization<br />
Adverse Reaction: Diarrhea, nausea, vomiting, and abdominal bloating.<br />
Interactions: Amiloride, calcium channel blockers, digoxin, morphine, procainamide, etc.<br />
Glucotrol(Glipizide)<br />
Pronunciation: Glip-i-zid<br />
Classification: Sulfonylurea<br />
IFU: Type 2 diabetes mellitus<br />
Route: Orally<br />
Dosage: 5mg, 10mg.<br />
Action: Lowers blood glucose level by stimulating insulin release from pancreas, increasing<br />
insulin sensitivity at receptor sites, and decrease hepatic glucose production.<br />
Adverse Reaction: Dizziness, drowsiness, headache, and weakness.<br />
Interactions: Androgens, chloramphenicol, clofibrate, guanethidine, etc.<br />
HumaLog(Insulin lispro)<br />
Pronunciation: lis-pro<br />
Classification: insulin<br />
IFU: Type 1 diabetes mellitus<br />
Route: by injection<br />
Dosage: 75% insulin lispro protamine suspension/25% insulin lispro injection subcut.<br />
Action: lower blood glucose by stimulating glucose uptake in skeletal muscle and fat, and<br />
inhibiting hepatic glucose production.<br />
Adverse Reaction: hypoglycemia, lipodystrophy, pruritus, erythema, swelling.<br />
Interactions: beta blockers, clonidine, and reserpine.<br />
HumuLin(Insulin NPH)<br />
Pronunciation: neutral protamine hagedorn<br />
Classification: insulin
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