Evidence-based medicine in the treatment of ... - Alfredo Garofalo
Evidence-based medicine in the treatment of ... - Alfredo Garofalo
Evidence-based medicine in the treatment of ... - Alfredo Garofalo
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Figure 2: Study design <strong>of</strong> <strong>the</strong> PSOG-USMCI cl<strong>in</strong>ical trial.<br />
Limited<br />
Peritoneal Surface<br />
Malignancy <strong>of</strong><br />
Colonic<br />
Orig<strong>in</strong><br />
with<br />
No prior<br />
Cytoreduction<br />
S<br />
T<br />
R<br />
A<br />
T<br />
I<br />
F<br />
Y<br />
Sync<br />
Vs<br />
Met<br />
Measurable<br />
Vs<br />
Not meas.<br />
R<br />
A<br />
N<br />
D<br />
O<br />
M<br />
I<br />
Z<br />
E<br />
Best Systemic<br />
Therapy<br />
N=155<br />
Cytoreduction<br />
+ HIPEC (MMC)<br />
+ Best Systemic<br />
Rx<br />
N=155<br />
Primary Outcome<br />
1.Overall Survival<br />
Cross<br />
Over Secondary Outcomes<br />
At 1. PFS<br />
Progression<br />
2. Toxicity burden<br />
3. QOL appraisal<br />
4. CTC dur<strong>in</strong>g Rx
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