Coyne Healthcare - Bio-Curcumin

Bio-Curcumin
Enhanced Absorption. ®
Proven Efficacy.
Naturally Better Curcumin

Curcumin
Turmeric is an ancient spice, a native of South East Asia with India being the principal supplier of turmeric
to the world market. Its use dates back nearly 4000 years to the Vedic culture in India where it was used
as a culinary spice and had some religious significance. Turmeric has always been considered an auspicious
material in the Indian sub-continent. Turmeric has been, and still is, used in traditional Indian, Chinese and
Unani medicines for a range of conditions such as biliary disorders, diabetic wounds, hepatic disorders,
rheumatic disorders, sprains and swellings caused by injury, and sinusitis.
Modern medicine has substantiated many of these traditional uses and has identified the true potential
for turmeric. The major active ingredients in turmeric are curcuminoids which normally vary from 1-6%
in the dried rhizome. Curcuminoids comprise curcumin, demethoxy and bisdemethoxy curcumin. The
second most active ingredient is the essential oil of turmeric which varies from 3-7% and is comprised of
turmerones and aromatic turmerones.
Produces
Produces
100 kg of fresh
turmeric rhizome
10 kg of dry turmeric 400 g curcumin
(95%) extract
Curcumin and its effects in the body
Curcumin has been shown to modulate complex networks of both extracellular and intracellular signals
that orchestrate cell-to-cell communication in diverse physiological processes that drive our bodily
functions. Typically, extracellular signals are composed of growth factors, cytokines, chemokines,
hormones and neurotransmitters that bind to specific cell surface receptors. These receptor-ligand
interactions then generate various types of intracellular signals that ultimately lead to the activation
of transcription factors that regulate the expression of specific sets of genes essential for diverse
cellular functions. Thus, curcumin has shown therapeutic potential against metabolic, cardiovascular,
neurodegenerative, pulmonary, autoimmune and neoplastic diseases.
The exceptional activity of curcumin may arise, partly, from it being simultaneously an antioxidant and an
anti-inflammatory agent. This is very important because oxidative stress and inflammation are intimately
connected, one inducing the other. It is not a coincidence that these two conditions coexist in all chronic
disease conditions. Unless both can be tackled simultaneously, no clinical benefit can accrue.

The challenge with curcumin supplementation
Despite the remarkable benefits of curcumin, the major challenge of supplementation is poor oral
bioavailability. The major reasons contributing to low plasma and tissue levels of curcumin appear to be
due to poor absorption, rapid metabolism and rapid systemic elimination. Earlier clinical trials investigating
the benefits of curcumin required large doses of up to 12 grams per day in order to supply sufficient
levels into the blood stream. The improvement of curcumin bioavailability has become a major focus of
researchers with many enhanced curcumin extracts now available which claim to solve the challenge of
poor absorption.
Key points to consider when selecting a curcumin
supplement
Only bioactive or free curcumin is active within the human body and
provides the benefits we want. Many companies measure not only
free curcumin but include in-actives such as curcumin metabolites
when measuring bioavailability. Ensure you understand the claimed
improvement in bioactive or free curcumin bioavailability. It is
easy to be misled by simply choosing a product with the highest
supposed bioavailability. Ensure that you understand the difference
between bioactive/free curcumin and curcumin metabolites to make
an informed decision. This information should be transparent and
available to you from a manufacturer.
95%
Standard curcumin 95% extracts offer a short active life of
approximately 4-5 hours, resulting in users needing multiple doses per
day. Ensure that you understand the active life of your supplement
in order to compare and plan the required dosing schedule. Different
products offer different active lives.
Additional additives. In an attempt to improve bioavailability
companies have combined curcumin with various substances, many
of which may be questionable in a natural supplement or have
potential consequences when used long term. Substances such as
polysorbate 80 and Polyvinylpyrrolidone (PVP) are not uncommon.
Piperine has also been used in curcumin supplements, however
there is a concern related to their long term use, with various studies
indicating potential risk. Piperine has been noted to be a potent
inhibitor of drug metabolism and may be contraindicated for those
using various medications.
Clinical evidence. A body of reputable evidence exists which can be
used to substantiate or validate claims being made about a product or
its benefits.

The BCM-95 solution
BCM-95, regarded as the world’s preferred and leading bioavailable curcumin extract, has been, and
continues to be, extensively researched and developed by Arjuna Natural Extracts. BCM-95 was developed
to overcome the various challenges faced by clinicians and users when wanting to use curcumin
supplementation for its health benefits.
700%
Delivers 700% more bioactive/free curcumin into the blood stream
than standard curcumin extracts.
8 hrs
Is active for over 8 hours in the blood stream. Convenient once or
twice per day dosing.
Uses a patented combination of curcumin 95% extract with
A-turmerone, an essential oil of turmeric. This combination has been
proven not only to increase bioavailability but also to offer additional
benefits over and above curcumin alone.
Uses no artificial additives and is 100% derived from the turmeric
plant.
Is the most extensively researched curcumin extract on the market,
with over 33 human clinical studies and counting, validating and
verifying its benefit and superiority.
Is produced using green energy in an eco-friendly facility. Solar is the
exclusive source of energy for the production of BCM-95.
Fast acting. Users with inflammatory pain and discomfort are in most
cases able to feel benefits within the first 3 days of use.
Offers long term safety and is free from any major side effects.

Bio-Curcumin
95% Curcumin
400 mg = 2 700 mg
Pilot Cross-Over Study to Compare Human Oral
Bioavailability of 95% Curcumin Formulations
SINGLE ORAL DOSES OF 2 000 MG EACH
CURCUMIN IN BLOOD (ng/ml)
700
500
300
100
BIO-CURCUMIN
Curcumin w Piperine and Lecithin
0 2 4 5 6 7 8
Cross-Over Study to Compare Human Oral
Bioavailability of 95% Curcumin Formulations
SINGLE ORAL DOSES OF 4 000 MG EACH
CURCUMIN IN BLOOD (ng/ml)
1 500
1 200
900
600
300
BIO-CURCUMIN
Other Curcumin 95%
0 2 4 6 8 10 12

Boswellia serrata
Boswellia (also commonly known as Frankincense) is a plant native to India and Pakistan, used extensively
in traditional Ayurveda medicine and to a lesser degree Chinese traditional medicine. The gum resin is
extracted from which one obtains the active boswellic acids. The major anti-inflammatory benefit arises
from its novel inhibition of a pro-inflammatory enzyme called 5-Lipoxygenase (LOX) as well as it’s positive
effect on NF-kB. Over and above the anti-inflammatory benefit, Boswellia has also been proven to have
an effective analgesic effect and is well tolerated with a strong long term safety profile. This makes it an
excellent consideration for those challenged with chronic conditions resulting in pain and inflammation.
There are two major points of consideration when wanting to utilise boswellic acids therapeutically.
3-Acetyl-11-keto-beta-boswellic acid = 3-Acetyl-11-keto-beta-boswellic acid - referred to as AKBA - has
been clinically shown to be the most potent anti-inflammatory acid of boswellia, whereas β-boswellic acid
has been shown to stimulate the platelet-induced generation of thrombin, liberate arachidonic acid, and
induce platelet aggregation. It therefore makes sense to consider supplementation rich in AKBA which is
free from β-boswellic acid for the purpose of reducing pain and inflammation.
AKBA 3% - 10% - 30%
Comparison of efficacy across concentrations
5-LOX activity
15-LOX activity
4
5
3
4
IC50 values in µM
2
1
IC50 values in µM
3
2
1
3% AKBA 10% AKBA 30% AKBA
0
0
3% AKBA 10% AKBA 30% AKBA
Study of lipoxygenase inhibitory effect - In vitro study in human monocytes
• 5-LOX and 15-LOX inhibited in a dose dependant manner
• 3% vs 10%: significent inhibiton
• 10% vs 30%: no further significant inhibition

AKBAMAX
A high quality standardised extract of Boswellia serrata containing a rich supply of AKBA and no β-boswellic
acid in a therapeutic and safe concentration.
• Standardized with 10% AKBA
• Enriched with acetyl group of boswellic acids
• Does not contain β-boswellic acids
• Total boswellic acids minimum 40% (HPLC)
• Does not use strong acids for acetylation
• Natural inhibitor of leukotrienes (LOX)
• Clinically proven and produced under GMP
BCM-95 & AKBAMAX
Synergistic Effect of BCM- 95 & AKBAMAX
Linoleic acid 18:2
present in most of
vegetable oils
gamma-linolenic acid
https://en.wikipedia.org/wi
ki/Gamma-Linolenic_acid
Dihomo-gamma-lin
olenic acid
20:3 28
Delta 5
desaturase
Arachidonic acid
20:4 w6
Good PGE 1
Cycloxygenase 2
(COX 2)
BCM-95 (INHIBITS)
5 Lipoxygease
(AKBA INHIBITS)
Most of the anti-arthritic
drugs are COX 2 inhibitors
COX 2 inhibitors do not block
5 Lipoxygenase pathway
Prostaglandin E2
(PGE 2)
Leukotriene B(4)
Inflammation, pain
and joint destruction

Bio-Curcumin
Bio-curcumin exclusively utilises BCM-95 offering a standardised supplement of the highest quality.
• 400 mg of BCM-95 per capsule
• Recommended 1-2 capsules taken once or twice daily
• Available in 30s and 60s
• Clear vegetable capsules used, vegetarian friendly
• Produced under GMP
Safety: Turmeric has long been consumed as a part
of the human diet. BCM-95 as an extract has had
no adverse reactions reported in any of the clinical
trials. It has been used as a supplement for over a
decade around the world by millions of people.
It is therefore assumed to be safe when consumed
as recommended.
Special precautions: Any person with a preexisting
medical condition should consult with a
medical professional before introducing any new
supplement. Bio-Curcumin should not be used by
pregnant or breast feeding woman. It should be
discontinued 2 weeks before any surgery. Those
using anti-platelet medication such as Warfarin
should consult with and be monitored by the
prescriber. Due to curcumin stimulating the
gallbladder, those with gallstones may experience
discomfort due to contractions of the gallbladder.
Dosing: It is generally recommended that an initial
loading dose be used when starting Bio-Curcumin
for best results and then establish a long term daily
dose. During this period users should consume 2
capsules morning and night for the first 3 days.
Thereafter a dose of 1-2 capsules can be used once
or twice per day as needed. Dose is dependent
on the individual, some requiring more or less to
receive the desired benefit. Positively Bio-Curcumin
is known to produce a rapid result and generally
most users will feel the benefit within the first 3
days of use. Bio-Curcumin can be used for 8-12
weeks at a time followed by a 1-2 discontinuation
before resuming once again.

Bio-Curcumin Advanced
Bio-Curcumin Advanced utilises both BCM-95 and AKBAMAX for an advanced anti-inflammatory and
analgesic effect.
• 300 mg BCM-95 + 300 mg AKBAMAX per capsule
• Recommended 1-3 capsules taken once to thrice daily
• Available in 30s
• Clear vegetable capsule used, vegetarian friendly
• Produced under GMP
Safety: BCM-95 as well as AKBAMAX as an
extract have had no adverse reactions reported in
any of the clinical trials. Both have been used as
a supplement for over a decade around the world
by millions of people. It is therefore assumed to be
safe to be consumed as recommended.
Special precautions: Any person with a preexisting
medical condition should consult with a
medical professional before introducing any new
supplement. Bio-Curcumin Advanced should not
be used by pregnant or breast feeding woman.
It should be discontinued 2 weeks before any
surgery. Those using anti-platelet medication such
as Warfarin should consult with and be monitored
by the prescriber. Due to curcumin stimulating the
gallbladder, those will gallstones may experience
discomfort due to contractions of the gallbladder.
Dosing: It is generally recommended that an initial
loading dose be used when starting Bio-Curcumin
Advanced for best results and then establish a long
term daily dose. During this period users should
consume 1 capsule morning, midday and night for
the first 3 days. Thereafter a dose of 1 capsule can
be used once to thrice daily as needed. Dose is
dependent on the individual, some requiring more
or less to receive the desired benefit. Positively
Bio-Curcumin Advanced is known to produce a
rapid result and generally most users will feel the
benefit within the first 3 days of use. Bio-Curcumin
Advanced can be used for 8-12 weeks at a time
followed by a 1-2 discontinuation before resuming
once again.

Notable Published Studies Completed on BCM-95 and
AKBAMAX as of January 2018
A randomized, pilot study to assess the efficacy and safety of Curcumin in patients with active rheumatoid
arthritis, Chandran B et al., Phytother Res, 2012;26(11):1719-25.
A pilot clinical trial of radioprotective effects of Curcumin supplementation in patients with prostate cancer,
Hejazi J et al., J Cancer Sci Ther, 2013;5:320-324.
Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the
management of knee osteoarthritis, Kizhakkedath R, Mol Med Rep, 2013;8(5):1542-8.
Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial, Sanmukhani J
et al., Phytother Res, 2014:28(4):579-85.
Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study.
Lopresti AL et al., J Affect Disord, 2014;167:368-75.
Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor
microenvironment: potential role of EMT, Buhrmann C et al., PLoS ONE 9(9): e107514.
Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density
cultures, Shakibaei M et al., PLoS ONE 9(1): e85397.
Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of
colorectal cancer, Shakibaei M et al., BMC Cancer, 2015;15:250.
Novel evidence for Curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a
and miR-27a in colorectal cancer, Toden S et al., Cancer Prev Res (Phila), 2015;8(5):431-43.
Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the
potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of
change. Lopresti AL et al., Eu Neuropsychopharmacol, 2015;25(1):38-50.
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of
epithelial-to-mesenchymal transition in chemoresistant colorectal cancer, Toden S et al., Carcinogenesis,
2015;36(3):355-67.
BCM-95 and (2-hydroxypropyl)-ß-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in
Sap C-deficient fibroblasts, Tatti M et al., Hum Mol Genet, 2015;24(15):4198-211.
Evaluation of antidepressant like activity of Curcumin and its combination with Fluoxetine and Imipramine:
an acute and chronic study, Sanmukhani J et al., Acta Pol Pharm, 2011;68(5):769-75.
Comparative study of the efficacy of Curcumin and Turmeric oil as chemopreventive agents in oral
submucous fibrosis: a clinical and histopathological evaluation, J Deepa Das A et al., Indian Acad Oral Med
Radiol, 2010;22(2):88-92.
A pilot cross-over study to evaluate human oral bioavailability of BCM-95 ® CG, a novel bioenhanced
preparation of Curcumin, Antony B et al., Indian J Pharm Sci 2008;70(4):445-449.
Six-month double-blind, placebo-controlled, pilot clinical trial of curcumin in patients with Alzheimer’s
disease, Baum L et al., J Clin Psychopharmacol, 2008:28:110-113.
Curcumin effects on blood lipid profile in a 6-month human study, Baum L et al., Pharmaco Res, 56 (2007)
2007;56(6):509-514.

Bioavailability of Biocurcumax TM (BCM-095TM), Benny M et al., Spice India, 2006 (Sept);11-15.
Enhancing the absorption of curcuminoids, Benny M et al., Spice India, 2005(July); 23-26.
Evaluation of antiepileptic and memory retention activity of Curcumin per se and in combination with
antiepileptic drugs, Anovadiya AP et al., Asian J Pharm Clin Res, 2014;6(2):145-148.
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of
epithelial-to-mesenchymal transition in chemoresistant colorectal cancer, Toden S et al., Carcinogenesis,
2015:36(3):355-367.
Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty)
compared to Curcumin in Wistar rats, Vinaykumar S et al., Pharmacognosy Journal, 2016;8(4):380-384.
Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: a
bioavailable turmeric formulation, Aggarwal ML et al., Mol Med Rep, 2016;13:592-604.
Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling
older adults, Rainey-Smith SR et al., 2016;115(12):2106-2113.
Effect of Curcumin supplementation during radiotherapy on oxidative status of patients with prostate
cancer: a double blinded, randomized, placebo-controlled study; Hejazi J et al., Cancer, 2016;68(1):77-85.
A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia, Kuriakose MA
et al., Cancer Prev Res (Phila), 2016;9(8):683-691.
The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and biocurcumin
with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebocontrolled
study, Sterzi S et al., Eur J Phys Rehabil Med, 2016:52(3):321-330.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a
randomised, double-blind, placebo-controlled study, Lopresti AL et al., J Affect Disord, 2017; 207:188-196.
Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer
stem cells. Siddappa G et al., Molecular Carcinog, 2017;56:2446–2460.
Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral
mononuclear cells and on C-reactive protein in blood, Journal of Translational Medicine 201715:213
Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced
colitis,Toden S et al., Sci Rep, 2017;7(1):814.
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative,
randomized, double-blind, placebo-controlled study, Haroyan A et al., BMC Complement Altern Med,
2018;18(1):7

www.biocurcumin.co.za
info@coynehealthcare.co.za
Phone: 021 4219144
Moorings 2 Portswood Road
V&A Waterfront Cape Town