Coyne Healthcare - Bio-Curcumin

Boswellia serrata
Boswellia (also commonly known as Frankincense) is a plant native to India and Pakistan, used extensively
in traditional Ayurveda medicine and to a lesser degree Chinese traditional medicine. The gum resin is
extracted from which one obtains the active boswellic acids. The major anti-inflammatory benefit arises
from its novel inhibition of a pro-inflammatory enzyme called 5-Lipoxygenase (LOX) as well as it’s positive
effect on NF-kB. Over and above the anti-inflammatory benefit, Boswellia has also been proven to have
an effective analgesic effect and is well tolerated with a strong long term safety profile. This makes it an
excellent consideration for those challenged with chronic conditions resulting in pain and inflammation.
There are two major points of consideration when wanting to utilise boswellic acids therapeutically.
3-Acetyl-11-keto-beta-boswellic acid = 3-Acetyl-11-keto-beta-boswellic acid - referred to as AKBA - has
been clinically shown to be the most potent anti-inflammatory acid of boswellia, whereas β-boswellic acid
has been shown to stimulate the platelet-induced generation of thrombin, liberate arachidonic acid, and
induce platelet aggregation. It therefore makes sense to consider supplementation rich in AKBA which is
free from β-boswellic acid for the purpose of reducing pain and inflammation.
AKBA 3% - 10% - 30%
Comparison of efficacy across concentrations
5-LOX activity
15-LOX activity
4
5
3
4
IC50 values in µM
2
1
IC50 values in µM
3
2
1
3% AKBA 10% AKBA 30% AKBA
0
0
3% AKBA 10% AKBA 30% AKBA
Study of lipoxygenase inhibitory effect - In vitro study in human monocytes
• 5-LOX and 15-LOX inhibited in a dose dependant manner
• 3% vs 10%: significent inhibiton
• 10% vs 30%: no further significant inhibition