Coyne Healthcare - Bio-Curcumin
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The challenge with curcumin supplementation<br />
Despite the remarkable benefits of curcumin, the major challenge of supplementation is poor oral<br />
bioavailability. The major reasons contributing to low plasma and tissue levels of curcumin appear to be<br />
due to poor absorption, rapid metabolism and rapid systemic elimination. Earlier clinical trials investigating<br />
the benefits of curcumin required large doses of up to 12 grams per day in order to supply sufficient<br />
levels into the blood stream. The improvement of curcumin bioavailability has become a major focus of<br />
researchers with many enhanced curcumin extracts now available which claim to solve the challenge of<br />
poor absorption.<br />
Key points to consider when selecting a curcumin<br />
supplement<br />
Only bioactive or free curcumin is active within the human body and<br />
provides the benefits we want. Many companies measure not only<br />
free curcumin but include in-actives such as curcumin metabolites<br />
when measuring bioavailability. Ensure you understand the claimed<br />
improvement in bioactive or free curcumin bioavailability. It is<br />
easy to be misled by simply choosing a product with the highest<br />
supposed bioavailability. Ensure that you understand the difference<br />
between bioactive/free curcumin and curcumin metabolites to make<br />
an informed decision. This information should be transparent and<br />
available to you from a manufacturer.<br />
95%<br />
Standard curcumin 95% extracts offer a short active life of<br />
approximately 4-5 hours, resulting in users needing multiple doses per<br />
day. Ensure that you understand the active life of your supplement<br />
in order to compare and plan the required dosing schedule. Different<br />
products offer different active lives.<br />
Additional additives. In an attempt to improve bioavailability<br />
companies have combined curcumin with various substances, many<br />
of which may be questionable in a natural supplement or have<br />
potential consequences when used long term. Substances such as<br />
polysorbate 80 and Polyvinylpyrrolidone (PVP) are not uncommon.<br />
Piperine has also been used in curcumin supplements, however<br />
there is a concern related to their long term use, with various studies<br />
indicating potential risk. Piperine has been noted to be a potent<br />
inhibitor of drug metabolism and may be contraindicated for those<br />
using various medications.<br />
Clinical evidence. A body of reputable evidence exists which can be<br />
used to substantiate or validate claims being made about a product or<br />
its benefits.