Avanafil Compared to Viagra and Cialis for ED Treatment

Email: aas12@aasraw.com WhatsApp: +86 18928411063
experience erectile dysfunction and you want to take one of the erectile dysfunction drugs,
the recent approval of Avanafil by the Food and Drug Administration (FDA) means you
now have five drugs from which to choose. Is Avanafil your best choice because it is the
newest drug? How does Avanafil compare with other drugs for erectile dysfunction? And
most important, how effective is Avanafil compared to Viagra and Cialis?
The Five Erectile Dysfunction Drugs
The five FDA-approved erectile dysfunction drugs on the market are avanafil (Stendra),
sildenafil (Viagra), tadalafil (Cialis), and vardenafil (both Levitra and Staxyn, an orally
dissolving form of Levitra). All of these drugs belong to the same drug class known as
phosphodiesterase (PDE) inhibitors because they all work by blocking the enzyme
phosphodiesterase type 5 (PDE-5).
When PDE-5 is blocked, this increases blood flow to the penis, which in turn will, in most
cases, result in an erection. We say “most cases” because the efficacy of all five drugs are
similar, depending on the dose taken, and average about 77% to 84%.
Avanafil for Erectile Dysfunction
Because Avanafil is the newest addition to the arsenal of erectile dysfunction drugs, let’s
take a closer look at it before we do a comparison with the other ED drugs. In clinical trials,
overall 77% of men with general erectile dysfunction who took Avanafil achieved an
erection compared with 54% of men who took placebo. Among men with erectile
dysfunction related to diabetes, 63% achieved an erection after taking Avanafil compared
with 42% who took placebo.
Let’s look at the results of one 12-week Phase III trial in particular. A total of 646 men were
randomly assigned to take either 50, 100, or 200 mg of avanafil 30 minutes before
initiating sexual activity. There were no restrictions on food or alcohol use. Of the 300
sexual attempts made during the study, 64% to 71% were successful among men who
took avanafil compared with 27% among men who took placebo. Other good news: 59%
to 83% of the 80 attempts at sexual intercourse made more than 6 hours after taking
Avanafil were successful compared with only 25% successful attempts in men who took
placebo. In some men, Avanafil worked in as little as 15 minutes. (Goldstein 2012)
In fact, one thing that may separate Avanafil from the other four ED drugs is how fast it
works. Dr. Wayne Hellstrom, professor of urology at Tulane University School of Medicine
in New Orleans, stated in a Reuters article that Avanafil “is potentially the fastest acting of