The Most Effective Weight Loss Supplement - Rimonabant Powder (AASraw)

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Whatsapp:+8618928439036 

The most effective weight loss supplement-- 

Rimonabant powder 

1. History of Rimonabant.................................................................................................................... 1 

2. Rimonabant..................................................................................................................................... 2 

3. Brand Name of Rimonabant Variations.......................................................................................... 3 

4. Rimonabant powder........................................................................................................................3 

5. Mechanism of action-- Rimonabant powder..................................................................................3 

6. How does Rimonabant powder work?........................................................................................... 3 

7. What is Rimonabant powder used for?.......................................................................................... 4 

8. Rimonabant for overweight or obesity...........................................................................................4 

9. Rimonabant powder dosage........................................................................................................... 5 

10. Advantages of Rimonabant & the Rimonabant benefits..........................................................6 

11. The warning on Rimonabant.........................................................................................................8 

12. Side effects of Rimonabant powder..............................................................................................8 

13. Rimonabant Review.......................................................................................................................9 

(1) Safety– “Serious Health Concerns”....................................................................................... 9 

(2) Availability– “Not Approved in Most Countries”.................................................................10 

(3) The Science – “Strong Clinical Support?”............................................................................10 

14. Rimonabant tablet Recipe...........................................................................................................11 

15. Does Rimonabant powder also aid smoking cessation?............................................................ 12 

16. What were the results of Rimonabant powder clinical trial studies?........................................ 12 

17. Rimonabant for prevention of cardiovascular events................................................................ 13 

(1) Background.......................................................................................................................... 13 

(2) Methods...............................................................................................................................13 

(3) Findings................................................................................................................................ 14 

(4) Interpretation.......................................................................................................................14 

18. Buy Rimonabant Powder online................................................................................................. 14 

(1) Buy Rimonabant Powder Questions & Answers................................................................. 15 

(2) Rimonabant powder for sale............................................................................................... 17 

1. History of Rimonabant 

Rimonabant became available in UK in the beginning of July 2006 and by 

2008, there were 56 countries where it was available. It was meant for people 

1

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with a BMI greater than 30 or people whose BMI was greater than 27 but who 

had other risk factors like dyslipidemia and type 2-diabetes. 

In June 2006, European Commission approved its sale and it was submitted 

to FDA for US approval. However, FDA’s EMDAC voted against the drug, 

concluding that Sanofi-Aventis, the manufacturers of Rimonabant, had not 

demonstrated its safety effectively. In 2009, EMEA withdrew Acomplia, after 

suspending it in 2008, because of severe psychological side effects of the drug, 

such as suicidal tendencies. FDA never approved Rimonabant and therefore, it 

has never been marketed in the US. 

2. Rimonabant 

Rimonabant is an anorectic anti-obesity drug produced and marketed by 

Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its 

main avenue of effect is reduction in appetite. Rimonabant is the first selective 

CB1 receptor blocker to be approved for use anywhere in the world. 

Rimonabant is approved in 38 countries including the E.U., Mexico, and 

Brazil. It was rejected for approval for use in the United States. This decision 

was made after a U.S. advisory panel recommended the medicine not be 

approved because it may increase suicidal thinking and depression. 

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3. Brand Name of Rimonabant Variations 

Other names for Rimonabant are Zimulti, Acomplia, Monaslim, Bethin, 

Riobant, Remonabent, Rimoslim and Riomont. 

4. Rimonabant powder 

Product Name 

Rimonabant powder 

CAS 168273-06-1 

Molecular Formula 

C22H21Cl3N4O 

Molecular Weight 463.79 

Melt Point 

230-240ºC 

Storage Temp 

Refrigerator 

Color 

White or off white Crystalline powder 

5. Mechanism of action-- Rimonabant powder 

Rimonabant is a specific CB1 cannabinoid receptor antagonist. There is 

considerable evidence that the endocannabinoid (endogenous cannabinoid) 

system plays a significant role in appetitive drive and associated behaviours. It 

is therefore reasonable to hypothesize that the attenuation of the activity of 

this system would have therapeutic benefit in treating disorders that might 

have a component of excess appetitive drive or over-activity of the 

endocannabinoid system, such as obesity, ethanol and other drug abuse, and a 

variety of central nervous system and other disorders. 

6. How does Rimonabant powder work? 

• Rimonabant powder acts by selectively blocking CB1 receptors found in the 

brain and in peripheral organs important in glucose and lipid (or fat) 

3


metabolism, including adipose tissue, the liver, gastrointestinal tract and 

muscle2. 

• Rimonabant powder switches off the same brain circuits that make people 

hungry when they smoke cannabis. 

• CB1 receptor blockade with rimonabant powder acts to decrease the 

overactivity of the endocannabinoid system (EC system).3,4 The EC system is 

a recently characterised physiological system that includes receptors such as 

the CB1 receptor and it has been shown to play an important role in regulating 

body weight and in controlling energy balance, as well as glucose and lipid (or 

fat) metabolism. 

7. What is Rimonabant powder used for? 

• Rimonabant powder was studied to be used complementary to diet and 

exercise to treat obese or overweight patients who suffer from type 2 diabetes 

and abnormal levels of fat in the blood. 

• Sanofi argued that rimonabant powder could also prevent the risk of 

cardiovascular disease. 

• Patients with large waist circumference (102 cm in men and 88 cm in women) 

were said to most benefit from taking the drug. 

8. Rimonabant for overweight or obesity 

Rimonabant is the first drug of a new class of medications that seems to 

reduce body weight and improve risk factors for diseases of the blood vessels 

and heart in people who are overweight or obese. We found four studies which 

evaluated weight loss, occurrence of disorders and adverse effects of treatment. 

The four studies involved 6625 people comparing rimonabant 20 mg with 

rimonabant 5 mg and placebo, in combination with a hypocaloric diet after 

one or two years of treatment. Greater weight loss and improvement in risk 

factors were seen after 20 mg of rimonabant. These results have to be 

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interpreted with caution though, due to high discontinuation rates of study 

participants and the overall low quality of the included studies. 

We conclude that: average weight loss with rimonabant appears modest and 

more rigorous studies examining the efficacy and safety of rimonabant are 

required to fully evaluate the benefit risk ratio of this new drug. 

In Europe, rimonabant is contraindicated for patients with severe depression 

and/or patients who are treated with antidepressive medications. Rimonabant 

is furthermore not recommended for patients with other untreated psychiatric 

conditions. 

9. Rimonabant powder dosage 

Rimonabant powder are taken by mouth. The recommended frequency of 

using Rimonabant powder is once daily. The maximum single dose of 

Rimonabant is 20mg. 

Rimonabant powder should be taken in the morning before breakfast. 

Regardless of obesity severity, Rimonabant powder should be taken every day. 

5


The maximum recommended duration of using Rimonabant powder is 24 

months. 

• An adjustment of Rimonabant dosing regimen is not required in elderly 

patients under 75 years old. Patients over 75 years old should take 

Rimonabant powder with caution. 

• Reduction of Rimonabant daily dose is not required in patients with mild 

hepatic insufficiency. The reduction of Rimonabant single dose may be 

required in patients with moderate hepatic insufficiency. Patients with severe 

hepatic insufficiency should not take Rimonabant powder. 

• Change of Rimonabant powder dosage is not required in patients with mild 

and moderate renal diseases. If severe renal disease is diagnosed in a patient, 

he should refrain from the use of Rimonabant powder. 

• Adolescents under 18 years old were not involved in clinical and 

post-marketing studies of Rimonabant. Therefore, Rimonabant 

powder should not be used as a long-term therapy of adolescent obesity. 

If you want to buy Rimonabant powder online but have never taken these 

weight loss tablets, get to know the side effects and potential risks of 

Rimonabant powder. Before buying Rimonabant powder online no 

prescription, you can get the information about this weight loss drug by email. 

10. Advantages of Rimonabant & the 

Rimonabant benefits 

This supplement has the following benefits: 

• It helps obese and overweight people to lose* weight in the safest and easiest 

way possible. Normally obesity and diabetes go hand in hand and the 

supplement also helps decrease* the symptoms of diabetes so that the user 

does not only cut weight but also gets relief from diabetes. 

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• The supplement can be purchased online meaning that finding it is easier 

and it also comes with a 30 day money back guarantee. Therefore, if there is a 

problem with the product or if it does not work for you are assured of getting 

your money. 

• It also comes at an affordable price with small pills that can be easily 

swallowed. Only pill is recommended daily to achieve weight loss* so you do 

not have to worry about taking several pills a day and sometimes forgetting 

some doses. 

• The supplement comes packaged well and labeled clearly with all ingredients 

and their amounts. This enables the user to know exactly that what they are 

taking is clinically proven and to determine if they have any sensitivity to the 

ingredients in advance. 

• While using Rimonabant you do not need to starve yourself all go through 

painful and intense workouts. Normal house chores and walks are enough to 

give you effective results. 

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11. The warning on Rimonabant 

Rimonabant is not recommended in pregnancy and is contraindicated in 

breast-feeding women.15 The SPC advises “caution” if the drug is used to treat 

patients with “moderate hepatic impairment”. Rimonabant is not 

recommended in patients with “severe hepatic impairment” and should not be 

used in patients with “severe renal impairment”.15 The SPC states that 

rimonabant should not be started in patients with uncontrolled serious 

psychiatric illness such as major depression, and that appropriate treament 

for the psychiatric condition should be started first and rimonabant therapy 

considered once the condition is controlled. However, it also states that the 

use of rimonabant in combination with antidepressant medication is not 

recommended, because of limited data. 

12. Side effects of Rimonabant powder 

The side effects of Rimonabant powder are so many that they effectively 

counteract any positive effects that it may present. Even during the trials, it 

was reported that 1 patient out of every 8 dropped out of the said trials since 

the side effects became intolerable for them. 

The biggest and the most adverse effects, however, were psychological. 

Depression has come to get associated as a severe side effect of 

Rimonabant powder. This depression was so serious that it required medical 

treatment to be managed. Because of Rimonabant powder’s effectiveness 

against smoking, many people used it for smoking cessation and suffered from 

suicidal depression. 

Many patients experienced and reported extreme anxiety levels after taking 

Rimonabant powder. Nausea is another side effect which was so severe that it 

started interfering with the patients’ daily life. 

To summarize, the adverse side effects of Rimonabant powder are many – 

• Gastrointestinal Problems – One of the noted side effects are diarrhea, dry 

mouth, loss of appetite, nausea, vomiting and other gastrointestinal disorders. 

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• Skin Problems – Excessive sweating and itching has been reported. 

• Musculoskeletal Problems – Joint sprains, back pain, inflammation and pain 

in the tendons, and spasms and cramps in muscles are common side effects. 

• Central Nervous System – Depression, memory loss, anxiety, mood changes, 

dizziness, diarrhea and sleep disorder. 

While experts speculate that if the dosage is lowered, some side effects may be 

managed but that still does not change the fact that the drug was never 

approved in the US because of the severity of its side effects. Also, the side 

effects that have been reported are rather serious which nullifies the drug’s 

positive effects against weight gain and smoking cessation. 

13. Rimonabant Review 

You may be surprised by what I say in this Rimonabant review. We took the 

time to focus closely on the scientific studies, ingredients, side effects, and 

customer-service quality. Then we looked at user reviews from all over the 

internet. At last, we summarized the data we collected to give you the facts. 

(1) Safety– “Serious Health Concerns” 

Our first issue is the safety of the product. According to our Research Editor, 

“Post market analysis indicated a higher prevalence of suicidal thoughts and 

major depressions in patients treated with Rimonabant. The results were 

concerning enough to have approval revoked in a number of countries.” 

One dieter said, “I was in France when this was released and it worked great 

but I became severely depressed. How can you be that sad and losing 

weight?” Another claimed, “I was willing to try anything when I was at my 

heaviest. The side effects were brutal, nothing is worth feeling like that.” 

Others did not experience the debilitating depression as a side effect and had a 

more positive experience. One explained, “It worked great for me and I lost 

the weight I needed. I didn’t have a problem.” Another said, “I wasn’t as happy 

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as I normally am while I was taking it but it worked so well I would totally use 

it again.” 

(2) Availability– “Not Approved in Most Countries” 

It is very difficult to find Rimonabant now because it has been banned in the 

countries where it was once available. One disappointed dieter said, “I loved it 

when I used it before but now I can’t find it anywhere!” 

Another complained, “I don’t understand why when something works that 

can’t be enough for everyone. They take away all the useful options.” Some 

were appreciative of the safety measures. One consumer said, “I liked that it 

worked so well but it was dangerous. I’m hoping the company tweaks the 

formula so I can get it again.” 

Another claimed, “I still have access to it so it isn’t as big of a deal to me. It 

isn’t easy but I can get it.” According to our research, safety and availability 

are two of the major concerns for dieters. If a product isn’t safe, it is difficult to 

trust that Rimonabant will lead to improved health overall and that ruins your 

chance of lasting results. 

(3) The Science – “Strong Clinical Support?” 

At DietSpotlight, we are primarily concerned with how effectively a product 

works. In the case of Rimonabant, the studies indicated it worked quite well 

for the majority of dieters. However, the science also shows that a greater 

number of participants had side effects that could have resulted in their death. 

This is simply unacceptable. 

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14. Rimonabant tablet Recipe 

Rimonabant tablet is formulated from the following ingredients which are 

known to support rapid weight loss* in the body safely: 

• Rimonabant powder– This is the active ingredient in the supplement and 

also where it gets its name from. It helps in suppressing the user’s appetite 

and also increasing* metabolism in the body leading to increased rate of 

burning fat. 

• Meratrim – This is a clinically researched and approved ingredient that 

helps to lose* fat around the waist where most of the bad fat is contained. It 

ensures safe weight loss* and also that the user gets back into that attractive 

figure. 

• Chromium Polynicotinate – This is a combination of chromium and niacin 

and it increases* the absorption of the supplement into the user’s body. This 

ensures that the supplement works effectively. 

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15. Does Rimonabant powder also aid smoking cessation? 

• Rimonabant powder (Zimulti in the US) was studied by Sanofi-Aventis as an 

aid to smoking cessation based on studies for up to one year in over 6,500 

smokers motivated to quit smoking. 

• Sanofi-Aventis submitted a New Drug Application to the FDA, which in turn 

issued a non-approvable letter for rimonabant powder for use in smoking 

cessation. In June of 2007, the FDA's Endocrine and Metabolic Drugs 

Advisory Committee recommended against the approval of rimonabant 

powder due to concerns over serious side effects such as suicidality. 

16. What were the results of Rimonabant powder clinical 

trial studies? 

• In clinical studies, Rimonabant powder was has been shown to improve a 

wide array of cardiometabolic risk factors as well as promoting sustained 

weight loss.5,6 

• Approximately half of the observed improvement in HDL-cholesterol, 

triglycerides and HbA1C (an indicator of blood sugar control) in patients who 

received Rimonabant powder 20mg was beyond that expected from weight 

loss alone. 

• Serious psychological adverse effects, such as suicidality and depression led 

to the eventual global withdrawal of rimonabant powder by Sanofi-Aventis. 

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17. Rimonabant for prevention of cardiovascular events 

(1) Background 

Blockade of the endocannabinoid receptor reduces obesity and improves 

metabolic abnormalities such as triglycerides, HDL cholesterol, and fasting 

blood glucose. We assessed whether rimonabant would improve major 

vascular event-free survival. 

(2) Methods 

This double-blind, placebo-controlled trial was undertaken in 974 hospitals in 

42 countries. 18 695 patients with previously manifest or increased risk of 

vascular disease were randomly assigned to receive either rimonabant 20 mg 

(n=9381) or matching placebo (n=9314). Randomisation was stratified by 

centre, implemented with an independent interactive voice response system, 

and all study personnel and participants were masked to group assignment. 

The primary endpoint was the composite of cardiovascular death, myocardial 

infarction, or stroke, as determined via central adjudication. Analysis was by 

13


intention to treat. This study is registered with ClinicalTrials.gov, number 

NCT00263042. 

(3) Findings 

At a mean follow-up of 13·8 months (95% CI 13·6–14·0), the trial was 

prematurely discontinued because of concerns by health regulatory 

authorities in three countries about suicide in individuals receiving 

rimonabant. All randomised participants were analysed. At the close of the 

trial (Nov 6, 2008), the composite primary endpoint of cardiovascular death, 

myocardial infarction, or stroke occurred in 364 (3·9%) patients assigned to 

rimonabant and 375 (4·0%) assigned to placebo (hazard ratio 0·97, 95% CI 

0·84–1·12, p=0·68). With rimonabant, gastrointestinal (3038 [33%] vs 2084 

[22%]), neuropsychiatric (3028 [32%] vs 1989 [21%]), and serious psychiatric 

side-effects (232 [2·5%] vs 120 [1·3%]) were significantly increased compared 

with placebo. Four patients in the rimonabant group and one in the placebo 

group committed suicide. 

(4) Interpretation 

The premature termination of this trial has important lessons for drug 

development. A drug that was being marketed for weight loss, but being tested 

for improving cardiovascular outcomes, induced a level of serious 

neuropsychiatric effects that was deemed unacceptable by regulatory 

authorities, and both the drug and the trial were abruptly terminated. 

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(1) Buy Rimonabant Powder Questions & Answers 

Q: What are the ingredients in Rimonabant? 

A: Rimonabant powder is the major ingredient contained in this drug. 

Q: What are the side effects of Rimonabant powder? 

A: Rimonabant can induce mental issues such as depression in the users. 

Furthermore, this drug is also known to induce suicidal tendencies in the user 

as well as abnormal changes in moods. Other side effects may include itching 

and excessive sweating. 

Q: How do I know if Rimonabant powder is right for me? 

A: Choosing the right product is the #1 question asked by DietSpotlight 

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Q: Does Rimonabant powder work? 

A: Yes, the drug stood true to its claims and helped its users to reduce their 

appetite, thereby curbing obesity. 

Q: What is the price of Rimonabant powder? 

A: The price of Rimonabant is 2600/kg, USD350/100g. The min purity is 

98%. 

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Q: Where can I buy Rimonabant powder? 

Whatsapp:+8618928439036 

A: You can order Rimonabant powder online at www.aasraw.com 

Q: How should I take Rimonabant powder? 

A: Rimonabant powder is available in a low dose of 5mg to a high dose of 

20mg. Your need for it and how to administer it must come from the advice of 

a diet expert. Rimonabant powder is not set out to work alone. It is designed 

to be used in conjunction with proper diet and exercise to improve a person’s 

wellbeing while reducing the size of your waistline. 

Q: How do I contact Rimonabant customer service? 

A: • To contact us by our email inquiry system,or online skypecustomer 

service representative(CSR). 

• To provide us your inquired quantity and address. 

• Our CSR will provide you the quotation, payment term, tracking number, 

delivery ways and estimated arrival date(ETA). 

• Payment done and the goods will be sent out in 12 hours(For order within 

10kg). 

• Goods received and give comments. 

Q: Can I return Rimonabant powder? 

A: Yes, Rimonabant powder can be returned according to the return policy of 

its distributor or supplier. 

Q: What are the most common complaints about Rimonabant powder? 

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A: Some consumers have raised complaints regarding the unsettling side 

effects of Rimonabant powder. 

(2) Rimonabant powder for sale 

There are a lot of weight loss products on the market, and Rimonabant 

powder is one of them, which is loved by many obese people. While 

Rimonabant powder is prohibited to use in many countries, but because of its 

powerful control appetite in order to reach the effect reducing weight, still 

have a large demand in the market, the corresponding Rimonabant powder 

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1) Parcel can be sent out in 24 hours after payment. Tracking number 

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2) Secure and discreet shipment. Various transportation methods for your 

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3) High quality, competitive price, fast delivery, first-class service gain the 

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The Most Effective Weight Loss Supplement - Rimonabant Powder (AASraw)

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