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Hola MaHigh-School - August 2018

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Gene editing<br />

indistinguishable from naturally occurring mutations.”<br />

In short: the new technique Crispr-Cas9 gives us the opportunity<br />

to identify a piece of the DNA we wish to alter, cut it out and provide<br />

a new strand which might have been created by the scientist.<br />

It is not necessarily something which nature designed. We design<br />

it!<br />

Let us rewind a bit on this:<br />

We need to invent a ‘scissor’ that will recognise a specific sequence.<br />

What if this sequence is also found somewhere else in the<br />

strand of DNA, not where we want to cut? So we can cut something<br />

else and we might never know? Until we see the result? The<br />

organism does not do what we intended it to do. Because we cut<br />

the wrong piece! And what we inserted does not make sense at<br />

that place in the DNA.<br />

Now what? Exactly!<br />

We now insert a designer piece of DNA. Do we really know what<br />

it will code for? So we ‘edit’ a piece of DNA and insert it in a living<br />

organism and now we can see the change. Crop yields or immune<br />

to cancer. But if we get it a bit wrong? Exactly!

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