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cover story UNLOCKING 16 / FUTURE MEDICINE / May 2019
ASTHMA THE mAb WAY The emergence of biologics as an add-on therapy has opened up an exciting front in the new era of severe asthma treatment S HARACHAND Asthma is a heterogeneous disease, characterised by inflammation of the air passages of the lungs. World over, an estimated 235 million people suffer from asthma, a chronic condition characterised by symptoms such as difficulty in breathing, tightness in the chest and wheezing. Caused by a combination of complex environmental and genetic interactions, the underlying mechanisms of this airway disorder is yet to be fully figured out. Since there is no known cure for the disease, symptoms are controlled through therapeutic interventions. Corticosteroids, mostly in the inhaled form, is the centerpiece of the current treatment to check the inflammatory process. Inhaled bronchodilators and/or leukotriene pathway inhibiting agents are also added if symptoms remain uncontrolled. The drug regimen, comprising inhaled corticosteroids (ICS) and long-acting beta agonists (LABA), has been used to manage asthma symptoms successfully in most of the patients. However, 10%–20% of patients do not achieve control with the current gold standard of care. This population of May 2019 / FUTURE MEDICINE / 17
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UNDERSTAND THE FUTURE NOW AND APPLY
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RNI Number KERENG/2012/44529
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