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CASE REPORT MEDICAL PRACTICE PULMONOLOGY GENETICS<br />
FUTUREMEDICINEINDIA.COM<br />
Golimumab improves insulin<br />
production in T1D<br />
Among children and<br />
young adults with<br />
newly diagnosed overt<br />
type 1 diabetes, the human<br />
monoclonal antibody<br />
golimumab resulted<br />
in better endogenous<br />
insulin production and<br />
less exogenous insulin,<br />
revealed a new study<br />
published in the New<br />
England Journal of<br />
Medicine.<br />
However, it is unknown<br />
if golimumab could<br />
preserve beta-cell function<br />
in youth with overt<br />
type 1 diabetes. Type 1<br />
diabetes is an autoimmune<br />
disease characterized<br />
by progressive loss of<br />
pancreatic beta cells<br />
that leads to lifelong<br />
dependence on insulin<br />
therapy.<br />
A partial-remission<br />
response was observed in<br />
43% of participants in the<br />
golimumab group and in<br />
7% of those in the placebo<br />
group. The therapy<br />
increased glycaemic<br />
control and glycated<br />
haemoglobin level.<br />
Antenatal fiu vaccination<br />
improves perinatal outcomes<br />
Pregnant women had<br />
0·7–0·9% risk of<br />
influenza for each month<br />
of pregnancy spent in<br />
the influenza season, find<br />
a recent multinational<br />
study conducted including<br />
pregnant women in India,<br />
Peru, and Thailand.<br />
The findings showed<br />
that antenatal influenza<br />
was associated with<br />
late pregnancy loss<br />
and a reduction in<br />
birthweight. Though<br />
influenza vaccination<br />
during pregnancy prevents<br />
influenza among women<br />
and their infants, it still<br />
remains underused.<br />
Metformin use<br />
cuts neonatal<br />
adiposity<br />
Metformin<br />
use during<br />
pregnancy for<br />
type 2 diabetes<br />
mellitus was found<br />
associated with<br />
better glycaemic<br />
control in pregnant<br />
women and<br />
reduced neonatal<br />
adiposity, finds the<br />
MiTy trial.<br />
Women in<br />
metformin group in<br />
the study showed<br />
better glycaemic<br />
control at 34<br />
weeks’ gestation<br />
than that of the<br />
usual insulin<br />
regimen. The<br />
participants in the<br />
group also gained<br />
less weight of<br />
about 7·2 kg when<br />
compared with 9<br />
kg in the placebo<br />
group. Women<br />
given metformin<br />
were also less<br />
likely to require<br />
caesarean section<br />
delivery.<br />
New drug<br />
could improve<br />
reproductive<br />
health in women<br />
Scientists at Imperial<br />
College London<br />
recently discovered that<br />
a kisspeptide activating<br />
drug could effectively treat<br />
a range of reproductive<br />
conditions that affect<br />
fertility such as polycystic<br />
ovary syndrome (PCOS) and<br />
hypothalamic amenorrhea<br />
(HA).<br />
A single dose of the<br />
drug MVT-602 can induce a<br />
longer duration of hormonal<br />
stimulation in women<br />
than naturally occurring<br />
kisspeptin KP54 without<br />
causing side-effects. The<br />
oligopeptide kisspeptin-1<br />
receptor agonist MVT-602<br />
was found to induce more<br />
potent signalling of the<br />
kisspeptin system.<br />
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VOL 6 | ISSUE 1<br />
PAGES 100<br />
MAY 2019<br />
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<strong>December</strong> <strong>2020</strong> / FUTURE MEDICINE / 75
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