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1.4.11 Scientific and Clinical Center of Toxicology named after
academician S.N. Golikov
The Institute of Toxicology is a medical scientific institution conducting
fundamental researches in the field of toxicology, pharmaceutical
chemistry and pharmacology, as well as the creation on this basis of new
tools and methods of prevention and treatment of poisoning.
Currently, the main task of the Institute is to obtain new scientific
knowledge in the field of natural sciences and use it in the interests of
public health, ensuring the defense and national security, as well as environmental
protection.
Toxicology of xenobiotics remains one of the main areas of scientific research at the
Institute. This traditional area of research is related to the study of the mechanisms of toxic
action, the identification of molecular-receptor and physiological targets of poisons and the
assessment of the severity of intoxication manifestations and toxicometric parameters of a
wide range of chemical compounds.
Another important direction of research is development and implementation of special
means of medical protection and pharmacotherapy of poisoning. The solution of this
problem involves two basic approaches. The first one is experimental therapy of intoxication
using available pharmacological agents, including the development of schemes and
evaluation of the therapy efficacy, as well as the creation of combined dosage forms. The
second approach involves creation of original antidotes and therapeutics for intoxication,
which includes the entire process from the idea of chemical synthesis to the industrial release
of the drug.
One of the few centers in Russia for the creation and practical implementation of effective
medical protectors (antidotes and pathogenetic therapy means) against poisonings with
highly toxic chemicals based on the study of patterns of chemical-biological interaction and
mechanisms of toxic action.
Along with pharmacotherapy of poisoning, this sphere allows to develop and implement
medicines used in clinics for various pathological conditions.
The Institute of Toxicology is one of the organizations performing preclinical studies of
medicines. Leading specialists have state and international certificates (Helm global group
company Ireland and Bioindustry initiative program of state department USA) confirming
their qualification in the field of preclinical studies according to GLP system.
The Preclinical Research Center of Toxicology Institute of Federal biomedical agency of
Russia complies with the principles of appropriate laboratory practice of OECD (GLP OECD).
Two Dissertation Councils (DS 208.030.01 since 2010, DS 208.006.01 since 2011) are currently
working at the Institute. Councils have the right to consider doctoral and candidate
dissertations in the following specialties: 14.03.04 - toxicology (medical and biological
sciences); 14.03.06 - pharmacology, clinical pharmacology (biological sciences).
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