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1.4.12 Smorodintsev Research Institute of Influenza
Currently, the Smorodintsev Research Institute of Influenza
Ministry of Health of the Russian Federation is one of the
leading research centers for solving key issues of virology,
epidemiology, clinic and pathogenesis of viral infections,
development of highly sensitive diagnostic medicines and
effective means of protecting the population from influenza
and other dangerous viral infections. The Federal Influenza
and ARI Center and the WHO National Influenza Center
successfully operate on the basis of the Institute as an integral
part of the system of global surveillance of infections. The
most important part of the scientific activity is the study of molecular-genetic and
phylogenetic peculiarities of actual viruses. Research institute develops ways to predict
directions of variability of influenza viruses and other viral agents.
Research institute conducts studies in order to identify genetic determinants of
pathogenicity of existing and emerging viruses, to predict the evolution of influenza viruses.
The Institute has created a hardware and methodological infrastructure that allows to
conduct a wide range of biochip studies, as well as to develop its own diagnostic methods
based on protein and DNA biochips.
On the basis of research institute methods of immune-enzyme analysis are being improved,
new highly sensitive diagnostic test systems for influenza and other ARD viruses based on
monoclonal antibodies and rapid diagnostic preparations are being developed and produced.
The Institute is developing and testing new influenza vaccines and has made progress in their
design and production technologies. The institute pays special attention to vaccine safety.
Further research on recombinant influenza vaccine based on hybrid protein M2eHBc, a live
attenuated replication-deficient Fluvak influenza vaccine is promising and feasible.
Employees of the Institute conduct research and directed synthesis of antiviral medications
and develop new dosage forms.
New scientific directions in medications development include the following:
§ chemotherapeutic agents (Russian innovative projects);
§ antiviral and antibacterial medications based on peptides and recombinant proteins.
The research institute of influenza has a specialized clinic. The clinic provides consultative
and diagnostic assistance to patients, treats influenza and other acute respiratory infections,
herpes infections, chronic hepatitis, and conducts clinical trials of new therapeutic and
prophylactic medicines.
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