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DEPARTMENTS OF CHEMISTRY BOSTON UNIVERSITY 1 

BOSTON UNIVERSITY 

velopment of an automated microfluidic reaction platform for 

multidimensional screening: reaction discovery employing 

Seldin and M. Skinner, Cardiac amyloidosis in African Americans: 

comparison of clinical and laboratory features of 

590 Commonwealth Avenue, Room 299 

Boston, MA 02215-2507 

TEL: (617) 353-2500 

FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/ 

Department of Chemistry 

John E. Straub, Chair. 

Lawrence Ziegler, Director of Graduate Studies. 

Degrees Offered: B.A, M.A, Ph.D. 

Fields of Specialization: Biochemistry, Inorganic 

Chemistry, Organic Chemistry, Physical Chemistry, 

Theoretical Chemistry. 

Interdisciplinary Program: Biotechnology (Department 

of Biology and the Department of Physics). 

Molecular Biology, Cell Biology and Biochemistry 

Program (Dept. of Biology and Dept. of Biomedical 

Engineering). Grad Program in Bioinformatics (Dept 

of Biology, Biomedical Engineering). 

See Biochemistry Section. 

ALLEN, KAREN (b.1962) Professor. B.S, 1984, Tufts 

University; Ph.D, 1989, Brandeis University. Doctoral 

Associate, 1989-1990, Massachusetts Institute of Technology; 

American Cancer Society Postdoctoral Fellow, 

1990-1993, Brandeis University. Enzymology; Structural 

Biology. Research in the Allen group is concerned with 

diverse aspects of protein structure, function, and design. 

The lab employs a multidisciplinary approach involving 

state-of-the-art X-ray crystallography and spectroscopy, 

molecular modeling, enzymology, and molecular biology 

to address fundamental problems at the interface of Enzymology 

and Structural Biology. Fundamental problems 

under study include mechanisms of phosphoryl 

transfer and evolution of enzymes. TEL: (617) 358-5544 

FAX: (617) 358-5554 

Web: chemhelp.bu.edu/groups/allengroup/ 

Email: drkallen@bu.edu 

J. Dai, L. Finci, C. Zhang, S. Lahiri, G. Zhang, E. Peisach, 

K. N. Allen and D. Dunaway-Mariano, Analysis of the structural 

determinants underlying discrimination between substrate 

and solvent in ß-phosphoglucomutase catalysis, Biochemistry, 

48, 1984-1995 (2009). 

K. N. Allen and D. Dunaway-Mariano, Markers of fitness 

in a successful enzyme superfamily, Curr. Opin. Struct. Biol, 

19, 658-665 (2009). 

Z. Lu, L. Wang, D. Dunaway-Mariano and K. N. Allen, 

Structure-function analysis of 2-keto-3-deoxy-D-glycero-Dgalactonononate-9-phosphate 

phosphatase defines specificity 

elements in type C0 haloalkanoate dehalogenase family 

members, J. Biol. Chem, 284, 1224-1233 (2009). 

M. Ho, J. Menetret, H. Tsuruta and K. N. Allen, The origin 

of the electrostatic perturbation in acetoacetate decarboxylase, 

Nature (London, U. K.), 459, 393-397 (2009). 

L. Wang, H. Huang, H. H. Nguyen, K. N. Allen, P. S. Mariano 

and D. Dunaway-Mariano, Divergence of biochemical 

function in the HAD superfamily: D-Glycero-D-manno-heptose-1,7-bisphosphate 

phosphatase (GmhB), Biochemistry, 

49, 1072-1081 (2010). 

H. H. Nguyen, L. Wang, H. Huang, E. Peisach, D. Dunaway-Mariano 

and K. N. Allen, Structural determinants of 

substrate recognition in the HAD superfamily member D- 

glycero-D-manno-Heptose-1,7-bisphosphate phosphatase 

(GmhB), Biochemistry, 49, 1082-1092 (2010). 

K. N. Allen and B. Imperiali, Lanthanide-tagged proteins: 

an illuminating partnership, Curr. Opin. Chem. Biol, 14, 247- 

254 (2010). 

G. N. Stowe, P. Silhar, M. S. Hixon, N. R. Silvaggi, K. N. 

Allen, S. T. Moe, A. R. Jacobson, J. T. Barbieri and K. D. 

Janda, Chirality holds the key for potent inhibition of the botulinum 

neurotoxin serotype A protease, Org. Lett, 12, 756- 

759 (2010). 

K. Daughtry, Insights into molecular evolution through 

structure function of the Rieske-type oxygenase family and 

haloalkanoate dehalogenase superfamily. (D) 

bicyclo[3.2.1]octanoid scaffolds, J. Org. Chem, 74, 6169- 

6180 (2009). 

C. Han, S. Rangarajan, A. C. Voukides, A. B. Beeler, R. 

Johnson and J. A. Porco, Reaction discovery employing macrocycles: 

transannular cyclizations of macrocyclic bis-lactams, 

Org. Lett, 11, 413-416 (2009). 

S. Kota, L. Scampavia, T. Spicer, A. B. Beeler, V. Takahashi, 

J. K. Snyder, J. A. Porco, Jr., P. Hodder and A. D. Strosberg, 

A time-resolved fluorescence-resonance energy transfer 

assay for identifying inhibitors of hepatitis C virus core dimerization, 

Assay Drug Dev. Technol, 8, 96-105 (2010). 

J. Qi, A. B. Beeler, Q. Zhang and J. A. Porco, Jr, Catalytic 

enantioselective alkylative dearomatization-annulation: total 

synthesis and absolute configuration assignment of hyperibone 

K, J. Am. Chem. Soc, 132, 13642-13644 (2010). 

H. Kinoshita, O. J. Ingham, W. W. Ong, A. B. Beeler and 

J. A. Porco, Jr, Tandem processes identified from reaction 

screening: nucleophilic addition to aryl N-phosphinylimines 

employing la(III)-TFAA activation, J. Am. Chem. Soc, 132, 

6412-6418 (2010). 

J. R. Goodell, B. Leng, T. K. Snyder, A. B. Beeler and J. 

A. Porco, Jr, Multidimensional screening and methodology 

development for condensations involving complex 1,2-diketones, 

Synthesis, 2254-2270 (2010). 

CARADONNA, JOHN P. (b.1957) Associate Professor. 

B.S./M.S, 1979, The Johns Hopkins University; 

M.A, 1980, Columbia University; M.Phil, 1985, Columbia 

University; Ph.D, 1985, Columbia University. NIH 

Postdoctoral Fellowship, 1985-1987, Harvard University. 

Biochemistry; Bioinorganic Chemistry. Structural and 

mechanistic studies of transition metal centers in biological 

systems; non-heme Fe active sites; high oxidation 

state iron-oxo species. TEL: (617) 353-1692 FAX: (617) 

353-6466 

Web: www.bu.edu/chemistry/faculty/caradonna/ 

Email: caradonn@bu.edu 

caradonn@chem.bu.edu 

P. J. Cappillino, P. C. Tarves, G. T. Rowe, A. J. Lewis, M. 

Harvey, C. Rogge, A. Stassinopoulos, W. Lo, W. H. Armstrong 

and J. P. Caradonna, Synthesis and characterization of a 

family of binuclear non-heme iron monooxygenase model 

compounds: evidence for a “phenolate/amide carbonyl 

(PAC) shift” upon oxidation, Inorg. Chim. Acta, 362, 2136- 

2150 (2009). 

G. T. Rowe, Kinetic and mechanistic investigations into 

the workings of a binuclear nonheme iron monooxygenase 

model compound. (D) 

P. J. Cappillino, Models of the structure and reactivity of 

mono- and binuclear nonheme iron oxygenase enzymes. (D) 

COKER, DAVID FREDERICK (b.1958) Professor. 

B.S, 1981, University of Sydney; Ph.D, 1985, Australian 

National University. Postdoctoral Fellowship, 1985- 

1987, Columbia University. Computational Chemistry; 

Theoretical Chemistry. Nonadiabatic excited state quantum 

dynamics in condensed phase systems. TEL: (617) 

353-2490 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/coker/ 

Email: coker@bu.edu 

J. Peng, T. C. Castonguay, D. F. Coker and L. D. Ziegler, 

Ultrafast H2 and D2 rotational raman responses in near criti- 

cal CO2: an experimental and theoretical study of anisotropic 

solvation dynamics, J. Chem. Phys, 131, 054501/1-054501/ 

17 (2009). 

P. Huo, S. Bonella, L. Chen and D. F. Coker, Linearized 

approximations for condensed phase non-adiabatic dynamics: 

multi-layered baths and Brownian dynamics implementation, 

Chem. Phys, 370, 87-97 (2010). 

P. Huo and D. Coker, Iterative linearized density matrix 

propagation for modeling coherent excitation energy transfer 

in photosynthetic light harvesting, J. Chem. Phys, 133 

(2010). 

D. Montemayor, Microscopic simulations of driven molecular 

systems: dissipation, dephasing, and decoherence free 

subspaces. (D) 

J. Zhang, Modeling photoexcited reactions of simple molecules 

in solution. (D) 

Y. Tambouret, A theoretical investigation of an excited 

state intramolecular proton transfer activated 1,3 dipolar cy- 

cloaddition. (D) 

transthyretin V122I amyloidosis and immunoglobulin light 

chain amyloidosis, Am. Heart J, 158, 607-614 (2009). 

P. B. Romesser, D. H. Perlman, D. V. Faller, C. E. Costello, 

M. E. McComb and G. V. Denis, Development of a malignancy-associated 

proteomic signature for diffuse large B- 

cell lymphoma, Am. J. Pathol, 175, 25-35 (2009). 

V. N. Bhatia, D. H. Perlman, C. E. Costello and M. E. 

McComb, Software tool for researching annotations of pro- 

teins: open-source protein annotation software with data visualization, 

Anal. Chem. (Washington, DC, U. S.), 81, 9819- 

9823 (2009). 

A. Leary, L. Assersohn, D. Cunningham, A. R. Norman, 

G. Chong, G. Brown, P. J. Ross, C. Costello, L. Higgins and 

J. Oates, A phase II trial evaluating capecitabine and irinotecan 

as second line treatment in patients with oesophago-gastric 

cancer who have progressed on, or within 3 months of 

platinum-based chemotherapy, Cancer Chemother. Pharma- 

col, 64, 455-462 (2009). 

A. Makkinje, R. I. Near, G. Infusini, P. Vanden Borre, A. 

Bloom, D. Cai, C. E. Costello and A. Lerner, AND-34/ 

BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation 

and breast cancer cell growth pattern, Cell Signal, 

21, 1423-35 (2009). 

A. Makkinje, R. I. Near, G. Infusini, P. V. Borre, A. 

Bloom, D. Cai, C. E. Costello and A. Lerner, AND-34/ 

BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation 

and breast cancer cell growth pattern, Cell. Signalling, 

21, 1423-1435 (2009). 

D. H. Perlman, S. M. Bauer, H. Ashrafian, N. S. Bryan, M. 

F. Garcia-Saura, C. C. Lim, B. O. Fernandez, G. Infusini, M. 

E. McComb, C. E. Costello and M. Feelisch, Mechanistic in- 

sights into Nitrite-induced cardioprotection using an integrat- 

ed metabolomic/proteomic approach, Circ. Res, 104, 796- 

804 (2009). 

K. L. Jones, R. J. Seward, G. Ben-Menachem, L. J. Glick- 

stein, C. E. Costello and A. C. Steere, Strong IgG antibody 

responses to Borrelia burgdorferi glycolipids in patients with 

Lyme arthritis, a late manifestation of the infection, Clin. Im- 

munol. (Amsterdam, Neth.), 132, 93-102 (2009). 

Y. Wang, A. B. Meriin, N. Zaarur, N. V. Romanova, Y. O. 

Chernoff, C. E. Costello and M. Y. Sherman, Abnormal pro- 

teins can form aggresome in yeast: aggresome-targeting sig- 

nals and components of the machinery, FASEB J, 23, 451- 

463 (2009). 

B. N. Singh, G. R. Hayes, J. J. Lucas, U. Sommer, N. Viseux, 

E. Mirgorodskaya, R. T. Trifonova, R. R. S. Sassi, C. 

E. Costello and R. N. Fichorova, Structural details and composition 

of Trichomonas vaginalis lipophosphoglycan in rele- 

vance to the epithelial immune function, Glycoconjugate J, 

26, 3-17 (2009). 

D. C. Young, A. Kasmar, G. Moraski, T. Cheng, A. J. 

Walz, J. Hu, Y. Xu, G. W. Endres, A. Uzieblo, D. Zajonc, C. 

E. Costello, M. J. Miller and D. B. Moody, Synthesis of dideoxymycobactin 

antigens presented by CD1a reveals T cell 

fine specificity for natural lipopeptide structures, J. Biol. 

Chem, 284, 25087-25096 (2009). 

I. V. Rhijn, D. C. Young, A. D. Jong, J. Vazquez, T. 

Cheng, R. Talekar, D. Barral, L. Leon, M. B. Brenner, J. T. 

Katz, R. Riese, R. M. Ruprecht, P. B. O’Connor, C. E. Cos- 

tello, S. A. Porcelli, V. Briken and D. B. Moody, CD1c bypasses 

lysosomes to present a lipopeptide antigen with 12 

amino acids, J. Exp. Med, 206, 1409-1422 (2009). 

I. V. Rhijn, D. C. Young, A. D. Jong, J. Vazquez, T. 

Cheng, R. Talekar, D. C. Barral, L. Leon, M. B. Brenner, J. 

T. Katz, R. Riese, R. M. Ruprecht, P. B. O’Connor, C. E. 

Costello, S. A. Porcelli, V. Briken and D. B. Moody, CD1c 

bypasses lysosomes to present a lipopeptide antigen with 12 

amino acids. [Erratum to document cited in CA151:242943], 

J. Exp. Med, 206, 1831 (2009). 

M. Kilcoyne, M. Shah, J. Q. Gerlach, V. Bhavanandan, V. 

Nagaraj, A. D. Smith, K. Fujiyama, U. Sommer, C. E. Costello, 

N. Olszewski and L. Joshi, O-glycosylation of protein 

subpopulations in alcohol-extracted rice proteins, J. Plant 

Physiol, 166, 219-232 (2009). 

G. O. Staples, M. J. Bowman, C. E. Costello, A. M. Hitchcock, 

J. M. Lau, N. Leymarie, C. Miller, H. Naimy, X. Shi 

and J. Zaia, A chip-based amide-HILIC LC/MS platform for 

glycosaminoglycan glycomics profiling, Proteomics, 9, 686- 

695 (2009). 

W. Ying, D. H. Perlman, L. Li, R. Theberge, C. E. Costello 

and M. E. McComb, Highly efficient and selective enrich- 

ment of peptide subsets combining fluorous chemistry with 

reversed-phase chromatography, Rapid Commun. Mass Spec- 

trom, 23, 4019-4030 (2009). 

S. Rex, L. M. Beaulieu, D. H. Perlman, O. Vitseva, P. S. 

BEELER, AARON (b.1973) Research Assistant Pro- 

Blair, M. E. McComb, C. E. Costello and J. E. Freedman, 

fessor. B.S, 1998, Belmont University; Ph.D, 2002, 

University of Mississippi. Research Associate, 2002- 

2005, Boston University. Organic Chemistry. Professor 

Beeler leads efforts in the CMLD-BU’s library synthesis 

activities, and a collabrative project with MIT to develop 

an automated microflow synthesis system. TEL: (617) 

358-3487 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/beeler/ 

Email: beelera@bu.edu 

COSTELLO, CATHERINE Professor. A.B, 1964, 

Emmanuel College; M.S, 1967, Georgetown University; 

Ph.D, 1970, Georgetown University. Research Associate, 

1970-73, Massachusetts Institute of Technology. Biochemistry; 

Mass Spectrometry. Glycobiology, proteomics, 

protein misfolding, lipid structures, immunology. 

TEL: (617) 638-6490 FAX: (617) 638-6491 

Web: www.bumc.bu.edu/msr 

Email: cecmsms@bu.edu 

Immune versus thrombotic stimulation of platelets differentially 

regulates signalling pathways, intracellular protein-protein 

interactions, and a-granule release, Thromb. Haemostasis, 

102, 97-110 (2009). 

E. N. Ebbel, N. Leymarie, S. Schiavo, S. Sharma, S. Ge- 

vorkian, S. Hersch, W. R. Matson and C. E. Costello, Identi- 

fication of phenylbutyrate-generated metabolites in Huntington 

disease patients using parallel liquid chromatography/ 

electrochemical array/mass spectrometry and off-line tandem 

mass spectrometry, Anal. Biochem, 399, 152-161 (2010). 

J. R. Goodell, J. P. McMullen, N. Zaborenko, J. R. Malo- L. H. Connors, T. Prokaeva, A. Lim, R. Theberge, R. H. G. O. Staples, H. Naimy, H. Yin, K. Kileen, K. Kraiczek, 

ney, C. Ho, K. F. Jensen, J. A. Porco and A. B. Beeler, De- Falk, G. Doros, A. Berg, C. E. Costello, C. O’Hara, D. C. C. E. Costello and J. Zaia, Improved hydrophilic interaction

2 BOSTON UNIVERSITY DEPARTMENTS OF CHEMISTRY 

chromatography LC/MS of heparinoids using a chip with postcolumn 

makeup flow, Anal. Chem. (Washington, DC, U. 

S.), 82, 516-522 (2010). 

R. S. Zee, C. B. Yoo, D. R. Pimentel, D. H. Perlman, J. R. 

Burgoyne, X. Hou, M. E. McComb, C. E. Costello, R. A. Cohen 

and M. M. Bachschmid, Redox regulation of sirtuin-1 by 

S-glutathiolation, Antioxidants & redox signaling, 13, 1023- 

32 (2010). 

X. Li, C. Lin, L. Han, C. E. Costello and P. B. O’Connor, 

Charge remote fragmentation in electron capture and electron 

transfer dissociation, J. Am. Soc. Mass Spectrom, 21, 646- 

656 (2010). 

E. Palaima, N. Leymarie, D. Stroud, R. M. Mizanur, J. 

Hodgkin, M. J. Gravato-Nobre, C. E. Costello and J. F. Cipollo, 

The Caenorhabditis elegans bus-2 mutant reveals a 

new class of O-Glycans affecting bacterial resistance, J. Biol. 

Chem, 285, 17662-17672 (2010). 

Y. Wada, A. Dell, S. M. Haslam, B. Tissot, K. Canis, P. 

Azadi, M. Backstrom, C. E. Costello, G. C. Hansson, Y. 

Hiki, M. Ishihara, H. Ito, K. Kakehi, N. Karlsson, C. E. 

Hayes, K. Kato, N. Kawasaki, K. Khoo, K. Kobayashi, D. 

Kolarich, A. Kondo, C. Lebrilla, M. Nakano, H. Narimatsu, 

J. Novak, M. V. Novotny, E. Ohno, N. H. Packer, E. Palaima, 

M. B. Renfrow, M. Tajiri, K. A. Thomsson, H. Yagi, S. 

Yu and N. Taniguchi, Comparison of methods for profiling 

O-glycosylation—human proteome organisation human disease 

glycomics/proteome initiative multi-institutional study 

of IgA1, Mol. Cell. Proteomics, 9, 719-727 (2010). 

Jia Chen, Investigation of glycosylation of immunoglobulin 

A1 by mass spectrometry. (M) 

Elizabeth Palaima, Glycan characterization of microbacterium 

nematophilum resistant mutants of the nematode Caenorhabdtis 

elegans. (D) 

Krystyn B Ross, Mass spectrometry analysis of E-cadherin. 

(D) 

Y. Jiang, Mass spectrometric characterization of amyloidogenic 

immunoglobulin light chains from patients with primary 

amyloidosis. (D) 

Yan Wang, Neurodegeneration in yeast: Dissecting cellular 

pathways of protein aggregation. (D) 

DOERRER, LINDA H. (b.1968) Assistant Professor. 

try; Bioinorganic Chemistry. Voltammetric studies of 

metalloproteins; the enzymes involved in nitrogen, sulfur 

and selenium metabolism; bioremediation and metallic 

respiration; redox enzymology of oxidative stress; multielectron 

transfers in redox-active enzymes. TEL: (617) 

358-2816 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/profile/elliott.html 

Email: elliott@bu.edu 

D. W. Bak, J. A. Zuris, M. L. Paddock, P. A. Jennings and 

S. J. Elliott, Redox characterization of the FeS Protein Mito- 

NEET and impact of Thiazolidinedione drug binding, Biochemistry, 

48, 10193-10195 (2009). 

S. Mitra and S. J. Elliott, Oxidative disassembly of the 

[2Fe-2S] cluster of human Grx2 and redox regulation in the 

mitochondria, Biochemistry, 48, 3813-3815 (2009). 

C. F. Becker, N. J. Watmough, S. J. Elliott S. J, Electrochemical 

evidence for multiple peroxidatic heme states of the 

diheme cytochrome c peroxidase of Pseudomonas aeruginosa, 

Biochemistry, 48, 87-95 (2009). 

D. W. Bak, J. A. Zuris, M. L. Paddock, P. A. Jennings and 

S. J. Elliott, Redox characterization of the FeS protein Mito- 

NEET and impact of thiazolidinedione drug binding. [Erratum 

to document cited in CA151:502237], Biochemistry, 49, 

5620 (2010). 

H. Cong, C. F. Becker, S. J. Elliott, M. W. Grinstaff and J. 

A. Porco, Jr, Silver nanoparticle-catalyzed Diels-Alder cycloadditions 

of 2’-Hydroxychalcones, J. Am. Chem. Soc, 132, 

7514-7518 (2010). 

G. S. Pulcu, Biophysical characterization of bacterial redox 

proteins. (D) 

M. J. Hamill, Biophysical characterization of flavoen- 

zymes. (D) 

GEORGIADIS, ROSINA M. (b.1960) Associate Pro- 

fessor. B.S, 1982, Indiana University; Ph.D, 1988, University 

of California, Berkeley. Postdoctoral Research Fel- 

lowship, 1988, University of Oregon. Bioanalytical 

Chemistry; Physical Chemistry. Development and application 

of in-situ spectroscopies to investigate fundamental 

physical and chemical processes at solid/liquid interfaces, 

especially biomolecular interactions and binding. 

tion of articular cartilage using computed tomography: ex- 

ploiting electrostatic interactions for improved sensitivity, J. 

Am. Chem. Soc, 131, 13234-13235 (2009). 

N. S. Joshi, P. N. Bansal, R. C. Stewart, B. D. Snyder and 

M. W. Grinstaff, The effect of contrast agent charge on visu- 

alization of articular cartilage using computed tomography: 

Exploiting electrostatic interactions for improved sensitivity, 

J. Am. Chem. Soc, 131, 13234-13235 (2009). 

A. P. Griset, J. Walpole, R. Liu, A. Gaffey, Y. L. Colson 

and M. W. Grinstaff, Expansile nanoparticles: synthesis, 

characterization, and in vivo efficacy of an acid-responsive 

polymeric drug delivery system, J. Am. Chem. Soc, 131, 

2469-2471 (2009). 

X. Huang, S. Zauscher, B. Klitzman, G. A. Truskey, W. M. 

Reichert, D. J. Kenan and M. W. Grinstaff, Peptide interfa- 

cial biomaterials improve endothelial cell adhesion and 

spreading on synthetic polyglycolic acid materials, Annals of 

Biomedical Engineering, 38, 1965-1976 (2010). 

R. Liu, J. B. Wolinsky, J. Walpole, E. Southard, L. R. Chi- 

rieac, M. W. Grinstaff and Y. L. Colson, Prevention of local 

tumor recurrence following surgery using low-dose chemotherapeutic 

polymer films, Annals of Surgical Oncology, 17, 

1203-1213 (2010). 

C. Ceballos, S. Khiati, C. A. H. Prata, X. X. Zhang, S. 

Giorgio, P. Marsal, M. W. Grinstaff, P. Barthelemy and M. 

Camplo, Cationic nucleoside lipids derived from universal 

bases: a rational approach for siRNA transfection, Bioconju- 

gate Chem, 21, 1062-1069 (2010). 

X. X. Zhang, C. A. H. Prata, T. J. McIntosh, P. Barthelemy 

and M. W. Grinstaff, The effect of charge-reversal Amphiphile 

spacer composition on DNA and siRNA delivery, Bio- 

conjugate Chem, 21, 988-993 (2010). 

X. Khoo, G. A. O’Toole, S. A. Nair, G. A. O’Toole, B. D. 

Snyder, D. J. Kenan and M. W. Grinstaff, Staphylococcus 

aureus resistance on titanium coated with multivalent PEGylated-peptides, 

Biomaterials, 9285-9252 (2010). 

K. A. V. Zubris, O. V. Khullar, A. P. Griset, S. Gibbs- 

Strauss, J. V. Frangioni, Y. L. Colson and M. W. Grinstaff, 

Ease of synthesis, controllable sizes, and in vivo large-animal-lymph 

migration of polymeric nanoparticles, ChemMed- 

Chem, 5, 1435-1438 (2010). 

M. Wathier, S. S. Stoddart, M. J. Sheehy and M. W. Grinstaff, 

Acidic polysaccharide mimics via Ring-Opening Me- 

B.A, 1991, Cornell University; Ph.D, 1997, Massachusetts 

Institute of Technology. NSF Postdoctoral Fellow, 

1996-1997, Oxford University; Junior Research Fellow, 

1997-1999, St. John’s College, Oxford University. Inorganic 

Chemistry. One area of interest is highly fluorinated 

aryloxide and alkoxide ligands for the stabilization of 

high oxidation states in first-row transition metals. Reactivity 

studies of anions of the form [M(OR)n]m- with 

strong oxidizing agents are underway. Investigations of 

metallophilicity in combination with electrostatics to 

form chains of metal atoms that can be prepared with 

odd numbers of spins and investigated as low-dimensional 

conductors are also in progress. TEL: (617) 358- 

4335 FAX: (617) 353-6466 

Web: avengingmanateestudio.us/DoerrerGroup/index. 

html 

Email: doerrer@bu.edu 

M. I. Kahn, J. A. Golen, A. L. Rheingold and L. H. Doerr- 

er, Bromido(2,2’:6’,2’-terpyridine)platinum(II) dibromidoaurate(I) 

dimethyl sulfoxide solvate, Acta Crystallogr., Sect. E: 

Struct. Rep. Online, E65, m1135 (2009). 

R. J. Allenbaugh, A. L. Rheingold, L. H. Doerrer, Tris(tbutyl)terpyridine-copper(II) 

complexes and ligand field effects, 

Dalton Trans, 1155-1163 (2009). 

B. N. Zheng, M. O. Miranda, A. G. Di Pasquale, J. A. Golen, 

A. L. Rheingold and L. H. Doerrer, Synthesis and electronic 

spectra of fluorinated Aryloxide and Alkoxide [NiX4] 

TEL: (617) 353-7218 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/profile/georgiadis. 

html 

Email: rgeorgia@bu.edu 

rgeorgia@chem.bu.edu 

M. S. Golden, A. C. Bjonnes and R. M. Georgiadis, Distance- 

and wavelength-dependent dielectric function of Au 

Nanoparticles by Angle-Resolved surface plasmon resonance 

imaging, J. Phys. Chem. C, 114, 8837-8843 (2010). 

J. Ruemmele, Improving biomolecular sensing at surfaces 

and investigating oligomeric DNA hybridization kinetics in 

solution. (D) 

GRINSTAFF, MARK WILLIAM (b.1965) Associate 

Professor of Chemistry/Biomedical Engineering. 

A.B, 1987, Occidental College; Ph.D, 1992, University 

of Illinois at Urbana-Champaign. NIH Postdoctoral Fellow, 

1993-1995, California Institute of Technology. Materials 

Chemistry; Polymer Science. Synthesis and characterization 

of dendrimers; biomaterials; interfacial 

chemistry; combinatorial chemistry and biology; nanomaterials; 

biotechnology; synthetic gene vectors; elec- 

tron-transfer reporters for DNA; chemical biology. TEL: 

(617) 358-3429 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/grinstaff/ 

tathesis Polymerization, J. Am. Chem. Soc, 132, 15887- 

15889 (2010). 

H. Cong, C. F. Becker, S. J. Elliott, M. W. Grinstaff and J. 

A. Porco, Jr, Silver nanoparticle-catalyzed diels-alder cycloadditions 

of 2’-hydroxychalcones, J. Am. Chem. Soc, 132, 

7514-7518 (2010). 

J. B. Wolinsky, R. Liu, J. Walpole, L. R. Chirieac, Y. L. 

Colson and M. W. Grinstaff, Prevention of in vivo lung tu- 

mor growth by prolonged local delivery of hydroxy- 

camptothecin using poly(ester-carbonate)-collagen compo- 

sites, J. Controlled Release, 144, 280-287 (2010). 

M. Wathier and M. W. Grinstaff, Synthesis and creep-re- 

covery behavior of a neat Viscoelastic Polymeric network 

formed through electrostatic interactions, Macromolecules 

(Washington, DC, U. S.), 43, 9529-9533 (2010). 

P. N. Bansal, N. S. Joshi, V. Entezari, M. W. Grinstaff and 

B. D. Snyder, Contrast enhanced computed tomographic can 

predict the glycosaminoglycan content and biomechanical 

properties of articular cartilage, Osteoarthritis and Cartilage, 

18, 184-191 (2010). 

M. W. Grinstaff, Expansile nanoparticles: synthesis, char- 

acterization, and in vivo efficacy in lung and mesothelioma 

tumor models, PMSE Prepr, No pp. given (2010). 

M. W. Grinstaff, Supramolecular ionic networks, Polym. 

Prepr. (Am. Chem. Soc., Div. Polym. Chem.), 51, 104 (2010). 

X. Lin, M. Wathier, B. Suki and M. W. Grinstaff, Synthesis 

and characterization of supramolecular polymer networks 

via ionic interactions, Polym. Prepr. (Am. Chem. Soc., Div. 

2- 

anions, Inorg. Chem. (Washington, DC, U. S.), 48, 4274- 

4276 (2009). 

F. G. Baddour, M. I. Kahn, J. A. Golen, A. L. Rheingold 

and L. H. Doerrer, Platinum(IV)-� 

Email: mgrin@bu.edu 

J. P. Berdahl, C. S. Johnson, A. D. Proia, M. W. Grinstaff 

and T. Kim, Comparison of sutures and dendritic polymer 

adhesives for corneal laceration repair in an in vivo chicken 

Polym. Chem.), 51, 477 (2010). 

A. M. Oelker, Synthesis and charactization of hydrogels 

for application as corneal implants and ophthalmic surgical 

3-terpyridine complexes: 

synthesis with spectroscopic and structural characterization, 

Chem. Commun. (Cambridge, U. K.), 46, 4968-4970 (2010). 

L. H. Doerrer, Steric and electronic effects in metallophilic 

double salts, Dalton Trans, 39, 3543-3553 (2010). 

S. A. Cantalupo, J, S. Lum, M. C. Buzzeo, C. Moore, A. G. 

Di Pasquale, A. L. Rheingold and L. H. Doerrer, Three-coordinate 

late transition metal fluorinated alkoxide complexes, 

Dalton Trans, 39, 374-383 (2010). 

V. Phillips, K. J. Willard, J. A. Golen, C. J. Moore, A. L. 

Rheingold and L. H. Doerrer, Electronic influences on metallophilic 

interactions in [Pt(tpy)X][Au(C6F5)2] double salts, 

Inorg. Chem. (Washington, DC, U. S.), 49, 9265-9274 

(2010). 

A. De Masi, S. W. Cho, L. F. J. Piper, A. R. H. Preston, K. 

E. Smith, R. J. Allenbaugh, W. A. Barksdale and L. H. 

Doerrer, Electronic structure of N,N’-ethylene-bis(1,1,1trifluoropentane-2,4-dioneiminato)-copper(ii) 

(Cu-TFAC), 

from soft X-ray spectroscopies and density functional theory 

calculations, Phys. Chem. Chem. Phys, 12, 3171-3177 

(2010). 

model, Arch. Ophthalmol. (Chicago, IL, U. S.), 127, 442-447 

(2009). 

C. S. Johnson, M. Wathier, M. W. Grinstaff and T. Kim, In 

vitro sealing of clear corneal cataract incisions with a novel 

biodendrimer adhesive, Archives of Ophthalmology, 127, 

430-434 (2009). 

S. Khiati, N. Pierre, S. Andriamanarivo, M. W. Grinstaff, 

N. Arazam, F. Nallet, L. Navailles and P. Barthelemy, Anionic 

nucleotide-lipids for in vitro DNA transfection, Bioconjugate 

Chem, 20, 1765-1772 (2009). 

C. Ceballos, C. A. H. Prata, S. Giorgio, F. Garzino, D. 

Payet, P. Barthelemy, M. W. Grinstaff and M. Camplo, Cationic 

nucleoside lipids based on a 3-Nitropyrrole universal 

base for siRNA delivery, Bioconjugate Chem, 20, 193-196 

(2009). 

S. R. Meyers, X. Khoo, X. Huang, E. B. Walsh, M. W. 

Grinstaff and D. J. Kenan, The development of peptide-based 

interfacial biomaterials for generating biological functionali- 

ty on the surface of bioinert materials, Biomaterials, 30, 277- 

286 (2009). 

X. Khoo, P. Hamilton, G. A. O’Toole, B. D. Snyder, D. J. 

adhesives. (D) 

JASTI, RAMESH (b.1975) Assistant Professor. B.S, 

1998, University of North Carolina at Chapel Hill; Ph.D, 

2006, University of California, Irvine. Postdoctoral Research 

Fellow, 2006-2009, University of California, 

Berkeley and The Lawrence Berkeley National Laboratory. 

Nanochemistry; Organic Chemistry. The Jasti 

Group is highly interdisciplinary, working at the interface 

of organic synthesis and nanoscience. They aim to 

develop and utilize modern techniques of organic synthesis 

in order to construct molecules with unique physical 

properties, ranging from the nanometer to the millimeter 

length-scale. TEL: (617) 358-5543 FAX: (617) 353-6466 

Web: people.bu.edu/jasti/ 

Email: jasti@bu.edu 

R. Jasti, J. Bhattacharjee, J. B. Neaton and C. R. Bertozzi, 

The synthesis, characterization, and theory of [9]-, [12]-, and 

[18]cycloparaphenylene: Carbon nanohoop structures, J. Am. 

ELLIOTT, SEAN J. (b.1971) Associate Professor. 

B.A, 1994, Amherst College; Ph.D, 2000, Caltech. 

EMBO Post-doctoral Fellow, 2000-2002, Inorganic 

Chemistry Laboratory, University of Oxford. Biochemis- 

Kenan and M. W. Grinstaff, Directed assembly of PEGylated-peptide 

coatings for infection-resistant titanium metal, J. 

Am. Chem. Soc, 131, 10992-10997 (2009). 

N. S. Joshi, P. N. Bansal, R. C. Stewart, B. D. Snyder and 

M. W. Grinstaff, Effect of contrast agent charge on visualiza- 

Chem. Soc, 130, 17646-17647 (2008). 

R. Jasti and C. R. Bertozzi, Progress and challenges for the 

bottom-up synthesis of carbon nanotubes with discrete chirality, 

Chem. Phys. Lett, 494, 1-7 (2010). 

R. Jasti and C. R. Bertozzi, Progress and challenges for the


bottom-up synthesis of carbon nanotubes with discrete chiral- cally [1-2H] labeled fluorinated substrate analogues of IspH Biology. The research the Perlstein Group lies at the inity, 

Chem. Phys. Lett, 494, 1-7 (2010). enzyme in the deoxyxylulose phosphate pathway, Tetrahe- terface of chemistry and biology with a focus on bioinordron 

Lett, 50, 309-311 (2009). ganic chemistry. We are currently developing new pro- 

Ramesh Jasti, A mechanistic study of the Prins cyclization Y. Xiao, R. L. Nyland, II, C. L. Freel Meyers and P. Liu, jects that will use the tools of chemical biology, includreaction. 

(D) Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylu- ing biophysical techniques, enzymology, microscopy, 

lose phosphate pathway: synthesis from an epoxide and meand 

molecular biology to understand iron-sulfur cluster 

KEYES, THOMAS (b.1945) Professor. B.S, 1967, chanisms, Chem. Commun. (Cambridge, U. K.), 46, 7220- 

7222 (2010). 

containing proteins and bacterial cell division. TEL: 

Yale University; Ph.D, 1971, University of California, (617) 358-6180 FAX: (617) 353-6466 

Los Angeles. NSF Fellowship, 1971-1973, Massachu- 

MOHR, SCOTT CHALMERS (b.1940) Professor. 

Web: www.bu.edu/chemistry/faculty/perlstein/ 

setts Institute of Technology. Biophysics/Biophysical 

B.A, 1962, Williams College; M.A, 1966, Harvard Univ- Email: dperl@bu.edu 

Chemistry; Theoretical Chemistry. Theoretical and comersity; 

Ph.D, 1968, Harvard University. NIH Fellowship, D. L. Perlstein, Y. Zhang and T. S. Wang, The direction of 

putational biochemistry: The mechanism and dynamics 

1968-1969, Cornell University; Visiting Fellow, 2006- glycan chain elongation by peptidoglycan Glycosyltransferof 

protein folding, binding of ligands to proteins, all- 

2007, Massachusetts Institute of Technology. Bioengiases, J. Am. Chem. Soc, 129 (2007). 

atom descriptions of viruses, solvation, and theory of the 

neering; Bioinformatics. Mitochondrial proteins, riboso- B. Ostash, E. H. Doud, C. Lin, I. Ostash, D. L. Perlstein, S. 

associated spectral probes. Unifying themes are the esmal 

proteins—structure, function and molecular evolu- Fuse, M. Wolpert, D. Kahne and S. Walker, Complete charsential 

role of polarization, the surprisingly broad applition; 

protein engineering; synthetic biology; biosecurity. 

acterization of the seventeen step moenomycin biosynthetic 

cability of classical mechanics when polarization is prop- pathway, Biochemistry, 48, 8830-8841 (2009). 

erly included, and the application and design of acceler- TEL: (617) 353-2172 FAX: (617) 353-6466 

T. J. Lupoli, T. Taniguchi, T. S. Wang, D. L. Perlstein, S. 

ated simulation algorithms. TEL: (617) 353-4730 FAX: Web: www.bu.edu/chemistry/faculty/profile/mohr.html 

Walker and D. E. Kahne, Studying a cell division amidase 

(617) 353-6466 Email: mohr@bu.edu 

using defined peptidoglycan substrates, J. Am. Chem. Soc, 

Web: www.bu.edu/chemistry/faculty/profile/keyes.html scmohr@gmail.com 

131, 18230-18231 (2009). 

Email: keyes@bu.edu 

T. Kaya, N. Swamy, K. S. Persons, S. Ray, S. C. Mohr and D. L. Perlstein, T. S. Andrew Wang, E. H. Doud, D. Kahne 

J. Kim, T. Keyes and J. E. Straub, Replica exchange statis- 

R. Ray, Covalent labeling of nuclear vitamin D receptor with and S. Walker, The role of the substrate lipid in processive 

tical temperature Monte Carlo, J. Chem. Phys, 130, 124112/ 

affinity labeling reagents containing a cross-linking probe at glycan polymerization by the peptidoglycan Glycosyltransf- 

1-124112/10 (2009). 

three different positions of the parent ligand: structural and erases, J. Am. Chem. Soc, 132, 48-49 (2010). 

A. K. Sangha and T. Keyes, Proteins fold by subdiffusion 

biochemical implications, Bioorg. Chem, 37, 57-63 (2009). 

of the order parameter, J. Phys. Chem. B, 113, 15886-15894 

M. V. Tres, S. Mohr, M. Di Luccio and J. Vladimir Oli- 

PORCO, JOHN A., JR. (b.1963) Professor. B.A, 

(2009). 

veira, Low-pressure solubility of propane and n-butane in refined 

soybean oil, J. Chem. Thermodyn, 41, 1378-1381 

1985, College of the Holy Cross; M.S, 1988, Yale Univ- 

J. Kim, T. Keyes and J. E. Straub, Relationship between 

(2009). 

ersity; Ph.D, 1992, Harvard University. Investigation of 

protein folding thermodynamics and the energy landscape, Antibody Glycosidases, 1992-1993, Scripps Research In- 

Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys, 79, 030902/ 

PANEK, JAMES STEPHEN (b.1956) Samour Fami- stitute. Organic Chemistry. My research group is in- 

1-030902/4 (2009). 

ly Professor. B.S, 1979, State University of New York at volved in the development of new methodologies for 

J. Kim, T. Keyes and J. E. Straub, Generalized replica ex- 

change method, J. Chem. Phys, 132, 224107/1-224107/10 Buffalo; M.S, 1982, University of Kansas; Ph.D, 1984, chemical synthesis and their application to synthesis of 

(2010). 

University of Kansas. NIH Fellowship, 1984-1986, Yale complex natural products and natural product-like mo- 

University. Organic Chemistry. Development of new lecules. In a number of projects, “streamlined” synthesis 

A. K. Sangha, Sub-diffusive dynamics of protein folding reaction methodology, acyclic stereocontrol, new ring methods will be emphasized and developed. Targets for 

and protein folding under confinement. (D) forming reactions and synthesis of complex natural pro- synthesis will include pharmacologically active natural 

ducts. TEL: (617) 353-2484 FAX: (617) 353-6466 and non-natural products where the preparation of struc- 

LAURSEN, RICHARD ALLAN (b.1938) Professor Web: www.bu.edu/chemistry/faculty/panek/ 

tural variants will allow us to dissect regulatory interac- 

Emeritus. B.S, 1961, University of California, Berkeley; Email: Panek@bu.edu 

tions with biomolecules. We place a special emphasis on 

Ph.D, 1964, University of Illinois. NIH Fellow, 1964- I. E. Wrona, J. T. Lowe, T. J. Turbyville, T. R. Johnson, J. investigations to define the structure-function relation- 

1966, Harvard University. Analytical Chemistry; Bioor- Beignet, J. A. Beutler and J. S. Panek, Synthesis of a 35- ships of natural or designed agents in efforts to underganic 

Chemistry. Development of new techniques (e.g., member stereoisomer library of bistramide A: evaluation of stand the origin of their biological properties. In many 

using HPLC and mass spectrometry) for the analysis of effects on actin state, cell cycle and tumor cell growth, J. instances, we will attempt to redesign particular target 

natural dyes in materials of historical interest; e.g., dyes Org. Chem, 74, 1897-1916 (2009). molecules and fine-tune their molecular structure 

in ancient textiles. TEL: (617) 353-2491 FAX: (617) Y. Zhang and J. S. Panek, Stereocontrolled synthesis of through the use of combinatorial or parallel synthesis ap- 

353-6466 

spirooxindoles through Lewis acid-promoted [5 + 2]-annula- proaches. TEL: (617) 353-2493 FAX: (617) 353-2847 

Web: www.bu.edu/chemistry/faculty/laursen/ 

tion of chiral silyl alcohols, Org. Lett, 11, 3366-3369 (2009). Web: www.bu.edu/chemistry/faculty/profile/porco.html 

Email: laursen@bu.edu 

R. A. Brawn and J. S. Panek, Synthesis of enantioenriched Email: porco@bu.edu 

homopropargylic sulfonamides by a three component reac- 

X. Zhang and R. Laursen, Application of LC-MS to the an- porco@chem.bu.edu 

tion of aldehydes, sulfonamides, and chiral allenylsilanes, 

alysis of dyes in objects of historical interest, Int. J. Mass Org. Lett, 11, 4362-4365 (2009). 

S. Dong, E. Hamel, R. Bai, D. G. Covell, J. A. Beutler and 

Spectrom, 284, 108-114 (2009). J. Lee and J. S. Panek, Total synthesis of brevisamide, J. A. Porco, Jr, Enantioselective synthesis of (+)-chamaecy- 

X. Zhang, D. Cardon, J. L. Cabrera and R. Laursen, The Org. Lett, 11, 4390-4393 (2009). 

panone C: a novel microtubule inhibitor, Angew. Chem., Int. 

role of glycosides in the light stabilization of 3-hydroxy- R. A. Brawn and J. S. Panek, Annulations of enantioen- Ed, 48, 1494-1497 (2009). 

flavone (flavonol) dyes as revealed by HPLC, Microchim. riched allenylsilanes with in situ generated iminium ions: J. R. Goodell, J. P. McMullen, N. Zaborenko, J. R. Malo- 

Acta, 169, 327-334 (2010). stereoselective synthesis of diverse heterocycles, Org. Lett, ney, C.-X. Ho, K. F. Jensen, J. A. Porco and A. B. Beeler, 

X. Zhang, C. Mouri, M. Mikage and R. Laursen, Identifi- 11, 473-476 (2009). 

Development of an automated microfluidic reaction platform 

cation of sources of protoberberine alkaloids used as yellow J. Wu and J. S. Panek, Total synthesis of (-)-virginiamycin for multidimensional screening: reaction discovery employdyes 

in Asian objects of historical interest, Studies Conserv, M2, Angew. Chem., Int. Ed, 49, 6165-6168 (2010). 

ing bicyclo[3.2.1]octanoid scaffolds, J. Org. Chem, 74, 6169- 

554, 177-185 (2010). I. E. Wrona, A. Gozman, T. Taldone, G. Chiosis and J. S. 6180 (2009). 

Panek, Synthesis of reblastatin, autolytimycin, and non-ben- B. Mitasev and J. A. Porco, Manganese(III)-mediated 

LIU, PINGHUA Assistant Professor. B.S, 1993, Nan- zoquinone analogues: potent inhibitors of heat shock protein transformations of phloroglucinols: A formal oxidative [4 + 

kai University; M.Sc, 1996, Chinese Academy of Sci- 90, J. Org. Chem, 75, 2820-2835 (2010). 

2] cycloaddition leading to bicyclo[2.2.2]octadiones, Org. 

ences; Ph.D, 2001, University of Minnesota. Postdocto- J. Wu, Y. Chen and J. S. Panek, Vinylogous aldol products Lett, 11, 2285-2288 (2009). 

ral Associate, 2001-2005, Massachusetts Institute of from chiral crotylsilanes obtained by enantioselective Rh(II) M. P. Castaldi, D. M. Troast and J. A. Porco, Stereoselec- 

Technology. Chemical Biology; Enzymology. My re- and Cu(I) carbenoid Si-H insertion, Org. Lett, 12, 2112-2115 tive synthesis of spirocyclic oxindoles via Prins cyclizations, 

searches focus on the chemical basis of pathogen and (2010). 

Org. Lett, 11, 3362-3365 (2009). 

host interactions as well as the chemical nature of bio- R. A. Brawn, M. Welzel, J. T. Lowe and J. S. Panek, Re- C. Han, S. Rangarajan, A. C. Voukides, A. B. Beeler, R. 

logical clock. The long-range goals of these projects are 

gioselective intramolecular dipolar cycloaddition of azides Johnson and J. A. Porco, Reaction discovery employing ma- 

and unsymmetrical alkynes, Org. Lett, 12, 336-339 (2010). crocycles: transannular cyclizations of macrocyclic bis-lacdeveloping 

broad-spectrum antibiotics, elucidating the 

R. A. Brawn and J. S. Panek, Stereoselective C-Glycosida- tams, Org. Lett, 11, 413-416 (2009). 

mechanism of isoprenoid biosynthesis pathway in- tions with achiral and enantioenriched allenylsilanes, Org. R. Cencic, M. Carrier, G. Galicia-Vazquez, M.-E. Bordetermediate 

triggered human innate-immune responses, as Lett, 12, 4624-4627 (2010). leau, R. Sukarieh, A. Bourdeau, B. Brem, J. G. Teodoro, H. 

well as unraveling the time recording mechanism inside Greger, M. L. Tremblay, J. A. Porco, Jr. and J. Pelletier, Anthe 

cell and its relationship to both aging and develop- H. L. Qin, Total synthesis of the HSP90 inhibitor geldana- titumor activity and mechanism of action of the cyclopenta 

ment. TEL: (617) 353-2481 FAX: (617) 353-6466 mycin. (D) [b]benzofuran, silvestrol, PLoS One, 4, No pp. given (2009). 

Web: www.bu.edu/chemistry/faculty/profile/liu.html I. Wrona, Total synthesis of reblastatin and bistramide A: S. P. Roche, R. Cencic, J. Pelletier and J. A. Porco, Jr, 

Email: pinghua@bu.edu Preparation and preliminary biological evaluation of structur- Biomimetic photocycloaddition of 3-hydroxyflavones: syn- 

pinghua_liu@yahoo.com al and stereochemical analogs. (D) 

thesis and evaluation of rocaglate derivatives as inhibitors of 

Y. Xiao, G. Zahariou, Y. Sanakis and P. Liu, IspG enzyme 

J. Lowe, Development and application of enantioenriched eukaryotic translation, Angew. Chem., Int. Ed, 49, 6533-6538 

activity in the Deoxyxylulose phosphate pathway: roles of 

crotylsilane reagents: Total synthesis of bistramide A and (— (2010). 

the iron-sulfur cluster, Biochemistry, 48, 10483-10485 

)-kendomycin. (D) S. Kota, L. Scampavia, T. Spicer, A. B. Beeler, V. Takaha- 

(2009). 

W. Youngsaye, I. Total synthesis, stereochemical reassign- shi, J. K. Snyder, J. A. Porco, Jr., P. Hodder and A. Donny 

R. L. Nyland, II, Y. Xiao, P. Liu and C. L. Freel Meyers, 

ment, and biological evaluation of (+)-neopeltolide and relat- Strosberg, A time-resolved fluorescence-resonance energy 

IspG converts an epoxide substrate analogue to (E)-4-Hyed 

stereoisomers. II. Development of chiral benzylsilanes: transfer assay for identifying inhibitors of hepatitis C virus 

droxy-3-methylbut-2-enyl diphosphate: implications for IspG 

Reagents for stereoselective, silicon-mediated Oxa-Pictet- core dimerization, Assay Drug Dev. Technol, 8, 96-105 

catalysis in isoprenoid biosynthesis, J. Am. Chem. Soc, 131, 

Spengler reactions. (D) (2010). 

17734-17735 (2009). 

Y. Chen, Stereochemical and skeletal diversity employing J. Qi, A. B. Beeler, Q. Zhang and J. A. Porco, Jr, Catalytic 

Y. Xiao, L. Chu, Y. Sanakis and P. Liu, Revisiting the 

azide functionalized chiral organosilanes. (D) enantioselective alkylative dearomatization-annulation: total 

IspH catalytic system in the Deoxyxylulose phosphate path- 

Y. Zhang, Total synthesis of herboxidiene/gex 1A and de- synthesis and absolute configuration assignment of hyperiway: 

achieving high activity, J. Am. Chem. Soc, 131, 9931velopment 

of chiral organosilane based [5+2] annulations. bone K, J. Am. Chem. Soc, 132, 13642-13644 (2010). 

9933 (2009). 

(D) Q. Zhang, B. Mitasev, J. Qi and J. A. Porco, Jr, Total syn- 

Y. Xiao, M. Machacek, K. Lee, T. Kuzuyama and P. Liu, 

thesis of plukenetione A, J. Am. Chem. Soc, 132, 14212- 

Prenyltransferase substrate binding pocket flexibility and its PERLSTEIN, DEBORAH Assistant Professor. B.S, 14215 (2010). 

application in isoprenoid profiling, Mol. BioSyst, 5, 913-917 1998, Tulane University; Ph.D, 2005, Massachusetts In- H. Kinoshita, O. J. Ingham, W. W. Ong, A. B. Beeler and 

(2009). 

stitute of Technology. Postdoctoral Fellow, 2010, Har- J. A. Porco, Jr, Tandem processes identified from reaction 

Y. Xiao and P. Liu, Synthesis of [1-13C] and stereo-specifi- vard Medical School. Bioinorganic Chemistry; Chemical screening: nucleophilic addition to aryl N-phosphinylimines


employing La(III)-TFAA activation, J. Am. Chem. Soc, 132, dent gene regulation in Neisseria meningitidis, Microbiology, ic band structure information of GdN extracted from x-ray 

6412-6418 (2010). 156, 2316-2326 (2010). 

absorption and emission spectroscopy, Appl. Phys. Lett, 96, 

H. Cong, C. F. Becker, S. J. Elliott, M. W. Grinstaff and J. G. Rong, H. Wang and B. M. Reinhard, Insights from a na- 032101/1-032101/3 (2010). 

A. Porco, Jr, Silver nanoparticle-catalyzed Diels-Alder cycloadditions 

of 2’-hydroxychalcones, J. Am. Chem. Soc, 132, 

7514-7518 (2010). 

J. L. Treece, J. R. Goodell, D. Vander Velde, J. A. Porco, 

Jr. and J. Aube, Reaction discovery using microfluidic-based 

multidimensional screening of polycyclic iminium ethers, J. 

Org. Chem, 75, 2028-2038 (2010). 

J.-C. Marie, Y. Xiong, G. K. Min, A. R. Yeager, T. Taniguchi, 

N. Berova, S. E. Schaus and J. A. Porco, Jr, Enantioselective 

synthesis of 3,4-chromanediones via asymmetric rearrangement 

of 3-allyloxyflavones, J. Org. Chem, 75, 4584- 

4590 (2010). 

R. Cencic, M. Carrier, A. Trnkus, J. A. Porco, M. Minden 

and J. Pelletier, Synergistic effect of inhibiting translation initiation 

in combination with cytotoxic agents in acute myelogenous 

leukemia cells, Leuk. Res, 34, 535-541 (2010). 

M. R. Medeiros, R. S. Narayan, N. T. McDougal, S. E. 

Schaus and J. A. Porco, Jr, Skeletal diversity via cationic rearrangements 

of substituted dihydropyrans, Org. Lett, 12, 

3222-3225 (2010). 

B. Liang, S. Kalidindi, J. A. Porco, Jr. and C. R. J. Stephenson, 

Multicomponent reaction discovery: three-component 

synthesis of spirooxindoles, Org. Lett, 12, 572-575 (2010). 

J. R. Goodell, B. Leng, T. K. Snyder, A. B. Beeler and J. 

A. Porco, Jr, Multidimensional screening and methodology 

development for condensations involving complex 1,2-dike- 

tones, Synthesis, 2254-2270 (2010). 

noparticle minuet: Two-dimensional membrane profiling 

through silver plasmon ruler tracking, Nano Lett, 10, 230-238 

(2010). 

SCHAUS, SCOTT EDWARD (b.1973) Associate 

Professor of Chemistry and Pharmacology. B.A, 1995, 

Boston University; Ph.D, 1999, Harvard University. NIH 

Postdoctoral Fellow, 1999-2001, Harvard University. 

Medicinal and/or Pharmaceutical Chemistry; Organic 

Chemistry. Research interests include the development 

of asymmetric catalytic reactions for synthesis, new 

methodologies for library synthesis, and drug target identification 

and validation. TEL: (617) 353-2489 FAX: 

(617) 353-6466 

Web: www.bu.edu/chemistry/faculty/schaus/ 

Email: seschaus@bu.edu 

J. A. Bishop, S. Lou and S. E. Schaus, Enantioselective addition 

of boronates to acyl imines catalyzed by chiral biphe- 

nols, Angew. Chem., Int. Ed, 48, 4337-4340 (2009). 

D. S. Barnett, P. N. Moquist and S. E. Schaus, The mechanism 

and an improved asymmetric allylboration of ke- 

tones catalyzed by chiral biphenols, Angew. Chem., Int. Ed, 

48, 8679-8682 (2009). 

J. M. Goss, P. Dai, S. Lou and S. E. Schaus, Enantioselective 

preparation of dihydropyrimidones, Org. Synth, 86, 236- 

251 (2009). 

P. N. Moquist, T. Kodama and S. E. Schaus, Enantioselec- 

S. W. Cho, L. F. J. Piper, A. De Masi, A. R. H. Preston, K. 

E. Smith, K. V. Chauhan, R. A. Hatton and T. S. Jones, Soft 

x-ray spectroscopy of C60/copper phthalocyanine/MoO3 interfaces: 

role of reduced MoO3 on energetic band alignment 

and improved performance, J. Phys. Chem. C, 114, 18252- 

18257 (2010). 

S. W. Cho, L. F. J. Piper, A. De Masi, A. R. H. Preston, K. 

E. Smith, K. V. Chauhan, P. Sullivan, R. A. Hatton and T. S. 

Jones, Electronic structure of C60/phthalocyanine/ITO inter- 

faces studied using soft x-ray spectroscopies, J. Phys. Chem. 

C, 114, 1928-1933 (2010). 

T. Learmonth, P.-A. Glans, J.-H. Guo, M. Greenblatt and 

K. E. Smith, Electronic excitations in the correlated metal 

BaV0.98Ti0.02S3 studied using resonant inelastic soft x-ray 

scattering, J. Phys.: Condens. Matter, 22, 025504/1-025504/ 

5 (2010). 

B. Freelon, A. Augustsson, J.-H. Guo, P. G. Medaglia, A. 

Tebano, G. Balestrino, C. L. Dong, C. L. Chang, P. A. Glans, 

T. Learmonth, K. E. Smith, J. Nordgren and Z. Hussain, Low 

energy electronic spectroscopy of an infinite-layer cuprate: A 

resonant inelastic X-ray scattering study of CaCuO2, Phys. C 

(Amsterdam, Neth.), 470, 187-192 (2010). 

A. De Masi, S. W. Cho, L. F. J. Piper, A. R. H. Preston, K. 

E. Smith, R. J. Allenbaugh, W. A. Barksdale and L. H. 

Doerrer, Electronic structure of N,N’-ethylene-bis(1,1,1trifluoropentane-2,4-dioneiminato)-copper(ii) 

(Cu-TFAC), 

from soft x-ray spectroscopies and density functional theory 

calculations, Phys. Chem. Chem. Phys, 12, 3171-3177 

A. R. Germain, Studies toward the synthesis of azaphilone 

natural products. (D) 

J. Qi, Synthetic studies toward the synthesis of polyprenylated 

phloroglucinol natural products. (D) 

tive addition of boronates to chromene acetals catalyzed by a 

chiral Bronsted acid/Lewis acid system, Angew. Chem., Int. 

Ed, 49, 7096-7100 (2010). 

J.-C. Marie, Y. Xiong, G. K. Min, A. R. Yeager, T. Taniguchi, 

N. Berova, S. E. Schaus and J. A. Porco, Jr, Enantios- 

(2010). 

L. F. J. Piper, S. W. Cho, Y. Zhang, A. DeMasi, K. E. 

Smith, A. Y. Matsuura and C. McGuinness, Soft x-ray spectroscopy 

study of the element and orbital contributions to the 

electronic structure of copper hexadecafluoro-phthalocya- 

REINHARD, BJOERN M. (b.1974) Assistant Professor. 

B.S, 1974, Bielefeld University; M.A, 2000, Technical 

University Munich; Ph.D, 2003, Technical University 

Kaiserslautern. DFG Forschungsstipendium, 2004-2006, 

elective synthesis of 3,4-chromanediones via asymmetric rearrangement 

of 3-allyloxyflavones, J. Org. Chem, 75, 4584- 

4590 (2010). 

M. R. Medeiros, R. S. Narayan, N. T. McDougal, S. E. 

Schaus and J. A. Porco, Jr, Skeletal diversity via cationic renine, 

Phys. Rev. B: Condens. Matter Mater. Phys, 81, 

045201/1-045201/12 (2010). 

L. F. J. Piper, A. R. H. Preston, A. Fedorov, S. W. Cho, A. 

De Masi and K. E. Smith, Direct evidence of metallicity at 

ZnO (0001)-(1×1) surfaces from angle-resolved photoemis- 

University of California, Berkeley. Biophysics/Biophysi- arrangements of substituted dihydropyrans, Org. Lett, 12, sion spectroscopy, Phys. Rev. B: Condens. Matter Mater. 

cal Chemistry; Biotechnology. My group is interested in 3222-3225 (2010). 

Phys, 81, 233305/1-233305/4 (2010). 

the design, implementation, and characterization of new 

tools for imaging and manipulation of “hard” (inorganic) 

and “soft” (biological) materials. We are currently also 

developing new probes and sensing schemes to charac- 

terize the function and dynamics of individual biological 

molecules and complexes. The ultimate goal of these studies 

is to generate reliable tools that can grant insight 

into fundamental biological processes on a single molecule 

level. TEL: (617) 353-8669 FAX: (617) 353-6466 

Web: www.bmreinhard.net 

Email: bmr@bu.edu 

B. Yan, A. Thubagere, W. R. Premasiri, L. D. Ziegler, L. 

Dal Negro and B. M. Reinhard, Engineered SERS substrates 

with multiscale signal enhancement: nanoparticle cluster arrays, 

ACS Nano, 3, 1190-1202 (2009). 

H. Wang and B. M. Reinhard, Monitoring simultaneous 

distance and orientation changes in discrete dimers of DNA 

linked gold nanoparticles, J. Phys. Chem. C, 113, 11215- 

11222 (2009). 

A. Gopinath, S. V. Boriskina, W. R. Premasiri, L. Ziegler, 

B. M. Reinhard and L. Dal Negro, Plasmonic nanogalaxies: 

Multiscale aperiodic arrays for surface-enhanced Raman 

sensing, Nano Lett, 9, 3922-3929 (2009). 

M. Nasra, D. Goode, N. Nguyen, G. Rong, L. Yang, B. M. 

Reinhard, B. Saleha and M. Teich, Quantum optical coherence 

tomography of a biological sample, Opt. Comm, 282, 

A. Ting, Asymmetric addition of acylimines toward synthesis 

of chiral amine adducts and heterocycles. (D) 

J. Giguere, Convergent synthesis of natural product-based 

chemical libraries. (D) 

S. Rodgen, Development of asymmetric methodologies toward 

the sythesis of asmarine B. (D) 

SMITH, KEVIN E. (b.1961) Professor. B.A, 1983, 

Trinity College Dublin; M.Sc, 1985, Yale University; 

M.Phil, 1987, Yale University; Ph.D, 1988, Yale Univer- 

sity. Visiting Research Associate, 1988-1990, Brookha- 

ven National Laboratory; Research Associate, 1988- 

1991, University of Oregon. Materials Science; Physical 

Chemistry. Research interests are in the electronic struc- 

ture of novel materials. Synchrotron radiation-based 

spectroscopies are used to probe bulk, surface and interface 

electronic structure. Experimental techniques include 

photoemission, x-ray emission, and resonant inelastic 

x-ray scattering. Systems under investigation include 

low dimensional and highly correlated transition 

metal oxides, thin film organic semiconductors and superconductors, 

and wide band gap nitride semiconductors. 

TEL: (617) 353-6117 FAX: (617) 353-9393 

Web: nml.bu.edu 

Email: ksmith@bu.edu 

SNYDER, JOHN K. (b.1951) Professor. B.S, 1973, 

Denison University; S.M, 1975, University of Chicago; 

Ph.D, 1979, University of Chicago. Postdoctoral Fellow- 

ship, 1979-1983, Columbia University; Resident Fellow, 

1983, National Academy of Science, Committee for 

Scholarly Communication with People’s Republic of 

China, Institute of Materia Medica, Shanghai. Natural 

Products Chemistry; Organic Chemistry. Applications of 

inverse electron demands Diels-Alder methodology to 

heterocyclic synthesis and library development for biological 

screening. Discovery of new transition metal catalyzed 

cyclization processes for the synthesis of complex, 

novel chemotypes. Natural products as scaffolds in 

library synthesis. TEL: (617) 353-2621 FAX: (617) 353- 

6466 

Web: www.bu.edu/chemistry/faculty/profile/snyder.html 

Email: jsnyder@bu.edu 

W. Wei, C. Cai, S. Kota, V. Takahashi, F. Ni, A. Donny 

Strosberg and J. K. Snyder, New small molecule inhibitors of 

hepatitis C virus, Bioorg. Med. Chem. Lett, 19, 6926-6930 

(2009). 

A. L. Jones and J. K. Snyder, Intramolecular rhodium-cata- 

lyzed [2+2+2] cyclizations of diynes with enones, J. Org. 

Chem, 74, 2907-2910 (2009). 

S. Kota, L. Scampavia, T. Spicer, A. B. Beeler, V. Takaha- 

1154-1159 (2009). L. F. J. Piper, A. DeMasi, S. W. Cho, K. E. Smith, F. shi, J. K. Snyder, J. A. Porco, Jr., P. Hodder and A. Donny 

A. Gopinath, S. V. Boriskina, B. M. Reinhard and L. Dal Fuchs, F. Bechstedt, C. Koerber, A. Klein, D. J. Payne and R. Strosberg, A time-resolved fluorescence-resonance energy 

Negro, Deterministic aperiodic arrays of metal nanoparticles 

for surface-enhanced Raman scattering (SERS), Opt. 

G. Egdell, Electronic structure of In2O3 from resonant x-ray 

emission spectroscopy, Appl. Phys. Lett, 94, 022105/1transfer 

assay for identifying inhibitors of hepatitis C virus 

core dimerization, Assay Drug Dev. Technol, 8, 96-105 

Express, 17, 3741-3753 (2009). 022105/3 (2009). 

(2010). 

L. R. Skewis and B. M. Reinhard, Control of colloid sur- Ian Reid, Yufeng Zhang, Alex Demasi, Andrew Blueser, A. L. Jones and J. K. Snyder, Synthesis of unique scaffolds 

face chemistry through matrix confinement: Facile prepara- Louis Piper, James E. Downes, Anne Matsuura, Greg via Diels-Alder cycloadditions of tetrasubstituted cyclo- 

tion of stable antibody functionalized silver nanoparticles, Hughes and Kevin E. Smith, Electronic structure of the or- hexadienes, Org. Lett, 12, 1592-1595 (2010). 

ACS Appl. Mater. Interfaces, 2, 35—40 (2010). ganic semiconductor copper tetraphenylporphyrin (CuTPP), A. L. Jones, X. Liu and J. K. Snyder, Enantioselective 

A. Thubagere and B. M. Reinhard, Nanoparticle induced Appl. Surf. Sci, 256, 720-725 (2009). 

syntheses of candenatenins B and C using a chiral anthracene 

apoptosis propagates through hydrogen-peroxide mediated T. Learmonth, C. McGuinness, P.-A. Glans, B. Kennedy, auxiliary, Tetrahedron Lett, 51, 1091-1094 (2010). 

bystander killing: Insights from a human intestinal epitheli- J. St. John, J.-H. Guo, M. Greenblatt and K. E. Smith, Reso- A. Donny Strosberg, S. Kota, V. Takahashi, J. K. Snyder 

um in vitro model, ACS Nano, 4, 3611-3622 (2010). nant soft x-ray inelastic scattering and soft x-ray emission and G. Mousseau, Core as a novel viral target for Hepatitis C 

L. Yang, B. Yan, W. R. Premasiri, L. D. Ziegler, L. Dal 

Negro and B. M. Reinhard, Engineering nanoparticle cluster 

study of the electronic structure of �-MoO3, Phys. Rev. B: 

Condens. Matter Mater. Phys, 79, 035110/1-035110/8 

drugs, Viruses, 2, 1734-1751 (2010). 

arrays for bacterial biosensing: The role of the building block (2009). 

X. Liu, Chiral anthracenes as stereocontrolling elements in 

in multiscale SERS substrates, Adv. Funct. Mater, 20, 2619- T. Arnold, D. J. Payne, A. Bourlange, J. P. Hu, R. G. Eg- organic synthesis. (D) 

2628 (2010). dell, L. F. J. Piper, L. Colakerol, A. De Masi, P.-A. Glans, T. 

Y. Chen, X. Wang, M. K. Hong, C. L. Rosenberg, B. M. 

Reinhard, S. Erramilli and P. Mohanty, Nanoelectronic detection 

of breast cancer biomarker, Appl. Phys. Lett, 97, 

233702-1—233702-3 (2010). 

L. Yang, H. Wang, B. Yan and B. M. Reinhard, Calibration 

of silver plasmon rulers in the 1-25 nm separation range: 

experimental indications of distinct plasmon coupling regimes, 

J. Phys. Chem. C, 114, 4901-4908 (2010). 

B. Yan and B. M. Reinhard, Identification of tumor cells 

through spectroscopic profiling of the cellular surface chemistry, 

J. Phys. Chem. Lett, 1, 1595-1598 (2010). 

Learmonth, K. E. Smith, J. Guo, D. O. Scanlon, A. Walsh, B. 

J. Morgan and G. W. Watson, X-ray spectroscopic study of 

the electronic structure of CuCrO2, Phys. Rev. B: Condens. 

Matter Mater. Phys, 79, 075102/1-075102/9 (2009). 

D. Shin, J. S. Foord, D. J. Payne, T. Arnold, D. J. Aston, R. 

G. Egdell, K. G. Godinho, D. O. Scanlon, B. J. Morgan, G. 

W. Watson, E. Mugnier, C. Yaicle, A. Rougier, L. Colakerol, 

P. A. Glans, L. F. J. Piper and K. E. Smith, Comparative study 

of bandwidths in copper delafossites from x-ray emission 

spectroscopy, Phys. Rev. B: Condens. Matter Mater. Phys, 

80, 233105/1-233105/4 (2009). 

STANLEY, H. EUGENE (b.1941) William Fairfield 

Warren Distinguished Professor, Professor of Physics, 

Professor of Chemistry. B.A, 1962, Wesleyan University; 

Ph.D, 1967, Harvard University. Miller Fellow, 1968, 

University of California, Berkeley. Chemical Physics; 

Polymer Science. Liquid water, econophysics, networks, 

statistical mechanics. TEL: (617) 353-2617 FAX: (617) 

353-9393 

Web: polymer.bu.edu/hes/ 

Email: hes@bu.edu 

J. R. Mellin, R. McClure, D. Lopez, O. Green, B. Reinhard A. R. H. Preston, B. J. Ruck, W. R. L. Lambrecht, L. F. J. M. Mazza, K. Stokely, E. Strekalova, H. E. Stanley and G. 

and C. Genco, Role of Hfq in iron-dependent and -indepen- Piper, J. E. Downes, K. E. Smith and H. J. Trodahl, Electron- Franzese, Cluster Monte Carlo and numerical mean field ana-


lysis for the water liquid-liquid phase transition, Computer lecules (PLMs): A journey from peptide bond isosteres to energy transfer pathways in heme proteins, J. Phys. Chem. B, 

Physics Communications, 180, 497-502 (2009). gramicidin S mimetics and mitochondrial targeting agents, 113, 825-830 (2009). 

L. Xu, S. V. Buldyrev, N. Giovambattista, C. A. Angell Chimia, 63, 764-775 (2009). 

J. Kim, T. Keyes and J. E. Straub, Relationship between 

and H. E. Stanley, A monatomic system with a liquid-liquid J. M. R. Narayanam, J. W. Tucker and C. R. J. Stephenson, protein folding thermodynamics and the energy landscape, 

critical point and two distinct glassy states, J. Chem. Phys, Electron-transfer photoredox catalysis: development of a tin- Phys. Rev. E, 79, 030902/1-030902/4 (2009). 

130, 054505 (2009). 

free reductive dehalogenation reaction, J. Am. Chem. Soc, G. Reddy, J. E. Straub and D. Thirumalai, Dynamics of 

E. P. Raposo, S. V. Buldyrev, M. G. E. Da Luz, G. M. Vis- 131, 8756-8757 (2009). 

locking of peptides onto growing amyloid fibrils, Proc. Natl. 

wanathan and H. E. Stanley, Lévy flights and random J. W. Tucker, J. D. Nguyen, J. M. R. Narayanam, S. W. Acad. Sci. U. S. A, 106, 11948-11953 (2009). 

searches, J. Phys. A: Math. Theor, 42, 434003 (2009). Krabbe and C. R. J. Stephenson, Tin-free radical cyclization J. E. Straub and D. Thirumalai, Principles governing oli- 

L. Xu, F. Mallamace, Z. Yan, F. W. Starr, S. V. Buldyrev reactions initiated by visible light photoredox catalysis, gomer formation in amyloidogenic peptides, Curr. Opin. 

and H. E. Stanley, Appearance of a fractional Stokes-Einstein Chem. Commun. (Cambridge, U. K.), 46, 4985-4987 (2010). Struct. Biol, 20, 187-195 (2010). 

relation in water and a structural interpretation of its onset, A. G. Condie, J. C. Gonzalez-Gomez and C. R. J. Stephen- J. Kim, T. Keyes and J. E. Straub, Generalized replica ex- 

Nature Physics, 5, 565–569 (2009). 

son, Visible-light photoredox catalysis: Aza-Henry reactions change method, J. Chem. Phys, 132, 224107/1-224107/10 

L. Cruz, D. L. Roe, B. Urbanc, A. Inglis, H. E. Stanley and via C-H functionalization, J. Am. Chem. Soc, 132, 1464-1465 (2010). 

D. L. Rosene, Age-related reduction in microcolumnar struc- (2010). 

ture correlates with cognitive decline in ventral but not dorsal L. Furst, B. S. Matsuura, J. M. R. Narayanam, J. W. Tuck- E. K. Rivera, Computational examination of the effects of 

area 46 of the rhesus monkey, Neuroscience, 158, 1509–1520 er and C. R. J. Stephenson, Visible light-mediated intermole- environment and sequence in the aggregation of amyloido- 

(2009). 

cular C-H functionalization of electron-rich heterocycles genic peptides. (D) 

J. Shao, S. V. Buldyrev, L. A. Braunstein, S. Havlin and H. with malonates, Org. Lett, 12, 3104-3107 (2010). 

Y. Zhang, Probing the principles of energy transfer in pro- 

E. Stanley, Structure of shells in complex networks, Phys. C. Dai and C. R. J. Stephenson, Total synthesis of syringo- teins. (D) 

Rev. E, 80, 036105 (2009). 

lin A, Org. Lett, 12, 3453-3455 (2010). 

S. Han, P. Kumar and H. E. Stanley, Hydrogen-bond dynamics 

of water in a quasi-two-dimensional hydrophobic nanopore 

slit, Phys. Rev. E, 79, 041202 (2009). 

P. Ch. Ivanov, Q. D. Y. Ma, R. P. Bartsch, J. M. Hausdor, 

L. A. N. Amaral, V. Schulte-Frohlinde, H. E. Stanley and M. 

Yoneyama, Levels of complexity in scale-invariant neural 

signals, Phys. Rev. E, 79, 041920 (2009). 

B. Podobnik, D. Horvati, J. N. Tenenbaum and H. E. Stan- 

ley, Asymmetry in power-law magnitude correlations, Phys. 

Rev. E Rapid Communications, 80, 015101 (2009). 

J. Shao, S. Havlin and H. E. Stanley, Dynamic opinion model 

and invasion percolation, Phys. Rev. Lett, 103, 018701 

(2009). 

Y. Wang and H. E. Stanley, Statistical approach to partial 

equilibrium analysis, Physica A, 388, 1173–1180 (2009). 

R. Parshani, M. Dickison, R. Cohen, H. E. Stanley and S. 

Havlin, Dynamic networks and directed percolation, Eur. 

Phys. Lett, 90, 38004 (2010). 

L. Xu, S. V. Buldyrev, N. Giovambattista and H. E. Stanley, 

Liquid-liquid phase transition and glass transition in a 

monoatomic model system, Int. J. Mol. Sci, 11, 5184-5200 

(2010). 

F. Mallamace, C. Branca, C. Corsaro, N. Leone, J. Spooren, 

H. E. Stanley and S.-H. Chen, Dynamical crossover and 

breakdown of the Stokes-Einstein relation in confined water 

and in methanol-diluted bulk water, J. Phys. Chem. B, 114, 

1870–1878 (2010). 

T. Preis and H. E. Stanley, Switching phenomena in a system 

with no switches, J. Stat. Phys, 138, 431–446 (2010). 

P. F. McMillan and H. E. Stanley, Going supercritical, Na- 

ture Physics, 6, 479-480 (2010). 

S. Han, M. Y. Choi, P. Kumar and H. E. Stanley, Phase 

transitions in confined water nanofilms, Nature Physics, 6, 

685–689 (2010). 

M. Kitsak, L. K. Gallos, S. Havlin, F. Liljeros, L. Muchnik, 

H. E. Stanley and H. A. Makse, Identification of influential 

spreaders in complex networks, Nature Physics, 6, 

888-893 (2010). 

E. Lascaris, G. Malescio, S. V. Buldyrev and H. E. Stan- 

ley, Cluster formation, waterlike anomalies, and re-entrant 

melting for a family of bounded repulsive interaction potentials, 

Phys. Rev. E, 81, 031201 (2010). 

A. M. Petersen, F. Wang and H. E. Stanley, Methods for 

measuring the citations and productivity of scientists across 

time and discipline, Phys. Rev. E, 81, 036114 (2010). 

D. Corradini, S. V. Buldyrev, P. Gallo and H. E. Stanley, 

Effect of hydrophobic solutes on the liquid-liquid critical 

point, Phys. Rev. E, 81, 061504 (2010). 

M. Sperl, E. Zaccarelli, F. Sciortino, P. Kumar and H. E. 

Stanley, Disconnected glass-glass transitions and diffusion 

anomalies in a model with two repulsive length scales, Phys. 

Rev. Lett, 104, 145701 (2010). 

G. Li, S. D. S. Reis, A. A. Moreira, H. E. Stanley, S. Havlin 

and J. S. Andrade Jr, Towards design principles for optimal 

transport networks, Phys. Rev. Lett, 104, 018701 (2010). 

K. Stokely, M. G. Mazza, H. E. Stanley and G. Franzese, 

Effect of hydrogen bond cooperativity on the behavior of water, 

Proc. Natl. Acad. Sci. USA, 107, 1301-1306 (2010). 

F. Mallamace, C. Branca, C. Corsaro, N. Leone, J. Spooren, 

S.-H. Chen and H. E. Stanley, Transport properties of 

glass-forming liquids suggest the dynamic crossover temperature 

is as important as the glass transition temperature, Proc. 

Natl. Acad. Sci. USA, 107, 22457-22462 (2010). 

STEPHENSON, COREY Assistant Professor. B.Sc, 

1998, University of Waterloo; Ph.D, 2005, University of 

Pittsburgh. Postdoctoral Fellow, 2005-2007, ETH- 

Hönggerberg. Catalysis; Organic Chemistry. Research in 

our group is focused primarily upon the development of 

new strategies and methodologies for the synthesis of natural 

products. Of particular interest are the discovery of 

practical new processes which utilize the redox chemistry 

of visible light activated metal complexes which offer 

improved chemoselectivity over current approaches while 

also enabling the reduction of stoichiometric waste byproducts. 

TEL: (617) 358-5089 FAX: (617) 353-6466 

Web: people.bu.edu/crjsteph/index.shtml 

Email: crjsteph@bu.edu 

P. Wipf, J. Xiao and C. R. J. Stephenson, Peptide-like mo- 

J. W. Tucker, J. M. R. Narayanam, S. W. Krabbe and C. R. 

J. Stephenson, Electron transfer photoredox catalysis: intra- 

molecular radical addition to indoles and pyrroles, Org. Lett, 

12, 368-371 (2010). 

B. Liang, S. Kalidindi, J. A. Porco, Jr. and C. R. J. Stephenson, 

Multicomponent reaction discovery: three-component 

synthesis of spirooxindoles, Org. Lett, 12, 572-575 (2010). 

STRAUB, JOHN E. (b.1960) Professor. B.S, 1982, 

University of Maryland at College Park; M.A, 1984, Co- 

lumbia University; M.Phil, 1986, Columbia University; 

Ph.D, 1987, Columbia University. NIH Postdoctoral Fellowship, 

1987-1990, Harvard University. Biophysics/ 

Biophysical Chemistry; Computational Chemistry. Com- 

putational research in the field of biophysics. Computer 

simulations of protein folding, misfolding, and aggregation 

and the relation to amyloid disease. Quantum and 

classical simulations of energy flow in biomolecular systems 

and the relation to signaling. Development of algor- 

ithms for enhanced configurational sampling in con- 

densed phase simulations using Monte Carlo and Molecular 

Dynamics, including the development and application 

of multi-scale, coarse-grained simulation models. 

TEL: (617) 353-6816 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/straub/ 

Email: straub@bu.edu 

E. Rivera, J. Straub and D. Thirumalai, Sequence and 

crowding effects in the aggregation of a 10-residue fragment 

derived from islet amyloid polypeptide, Biophys. J, 96, 4552- 

4560 (2009). 

H. Fujisaki, K. Yagi, J. E. Straub and G. Stock, Quantum 

and classical vibrational relaxation dynamics of N-methylacetamide 

on ab initio potential energy surfaces, Int. J. 

Quantum Chem, 109, 2047-2057 (2009). 

N. Miyashita, J. E. Straub and D. Thirumalai, Structures of 

ß-Amyloid Peptide 1-40, 1-42, and 1-55-the 672-726 fragment 

of APP-in a membrane environment with Implications 

for interactions with �-secretase, J. Am. Chem. Soc, 131, 

17843-17852 (2009). 

N. Miyashita, J. E. Straub, D. Thirumalai and Y. Sugita, 

Transmembrane structures of amyloid precursor protein dimer 

predicted by replica-exchange molecular dynamics simulations, 

J. Am. Chem. Soc, 131, 3438-3439 (2009). 

Y. Zhang, H. Fujisaki and J. E. Straub, Direct evidence for 

mode-specific vibrational energy relaxation from quantum 

time-dependent perturbation theory. I. Five-coordinate ferrous 

iron porphryin model, J. Chem. Phys, 130, 025102/1- 

025102/10 (2009). 

Y. Zhang and J. E. Straub, Direct evidence for mode-specific 

vibrational energy relaxation from quantum time-dependent 

perturbation theory. II. The v4 and v7 modes of ironprotoporphyrin 

IX and iron porphine, J. Chem. Phys, 130, 

095102/1-095102/9 (2009). 

J. Kim, T. Keyes and J. E. Straub, Replica exchange statistical 

temperature Monte Carlo, J. Chem. Phys, 130, 124112/ 

1-124112/10 (2009). 

J. Kim and J. E. Straub, Optimal replica exchange method 

combined with Tsallis weight sampling, J. Chem. Phys, 130, 

144114/1-144114/11 (2009). 

Y. Zhang and J. E. Straub, Direct evidence for mode-spe- 

cific vibrational energy relaxation from quantum time-dependent 

perturbation theory. III. The v4 and v7 modes of nonplanar 

nickel porphyrin models, J. Chem. Phys, 130, 215101/1- 

215101/10 (2009). 

Y. Zhang, H. Fujisaki and J. E. Straub, Mode-specific vib- 

rational energy relaxation of amide I’ and II’ modes in N- 

methylacetamide/water clusters: intra- and intermolecular energy 

transfer mechanisms, J. Phys. Chem. A, 113, 3051-3060 

(2009). 

G. Reddy, J. E. Straub and D. Thirumalai, Influence of pre- 

formed Asp23-Lys28 salt bridge on the conformational fluc- 

tuations of monomers and dimers of Aß peptides with implications 

for rates of fibril formation, J. Phys. Chem. B, 113, 

1162-1172 (2009). 

E. P. O’Brien, Y. Okamoto, J. E. Straub, B. R. Brooks and 

D. Thirumalai, Thermodynamic perspective on the dock-lock 

growth mechanism of amyloid fibrils, J. Phys. Chem. B, 113, 

14421-14430 (2009). 

Y. Zhang and J. E. Straub, Diversity of solvent dependent 

TULLIUS, THOMAS D. (b.1952) Professor. B.S, 

1973, University of California, Los Angeles; Ph.D, 1979, 

Stanford University. NIH Postdoctoral Fellowship, 1979- 

1982, Columbia University. Bioinformatics; Chemical 

Biology. Mapping DNA structure in the genome; evolu- 

tionary conservation of DNA shape in the human ge- 

nome; new chemical methods for determining the structure 

of DNA, RNA, and DNA-protein complexes; in 

vivo footprinting of DNA-protein complexes; structure 

and recognition of oxidatively damaged DNA. TEL: 

(617) 353-2482 FAX: (617) 353-6466 

Web: dna.bu.edu/tullius/ 

Email: tullius@bu.edu 

S. C. J. Parker, L. Hansen, H. Ozel Abaan, T. D. Tullius 

and E. H. Margulies, Local DNA topography correlates with 

functional noncoding regions of the human genome, Science 

(Washington, DC, U. S.), 324, 389-392 (2009). 

L. Xu, Oxidative damage to DNA: I. Isolation of proteins 

involved in the recognition of oxidatively damaged DNA II. 

Development of next-generation hydroxyl radical footprinting. 

(D) 

VAJDA, SANDOR (b.1949) Professor. B.Sc, 1972, 

Gubkin Institute, Moscow; M.S, 1976, Veszprem University, 

Hungary; B.Sc, 1980, Eotvos Lorend University, 

Hungary; Ph.D, 1983, Hungarian Academy of Science. 

Research Fellow, 1985-1986, University of Warwick, 

UK; Research Staff Member, 1986-1987, Princeton 

University. Bioinformatics; Computational Chemistry. 

My research in computational biophysics/biochemistry 

and structural bioinformatics focuses on molecular re- 

cognition, primarily on protein-protein interactions and 

on docking small ligands to proteins. My specific areas 

of interest are (1) the development of efficient protein 

docking algorithms; (2) the analysis of ligand-protein in- 

teractions and the characterization of binding sites; and 

(3) the development of methods for fragment-based drug 

design. TEL: (617) 353-4757 FAX: (617) 353-6766 

Web: www.bu.edu/chemistry/faculty/profile/ 

VajdaProfile.html 

Email: vajda@bu.edu 

C-H Ngan, D. Beglov, A. N. Rudnitskaya, D. Kozakov, D. 

J. Waxman and S. Vajda, The structural basis of pregnane X 

receptor binding promiscuity, Biochemistry, 48, 11572- 

11581 (2009). 

R. Brenke, D. Kozakov, G-Y Chuang, D. Beglov, D. Hall, 

M. R. Landon, C. Mattos and S. Vajda, Fragment-based iden- 

tification of druggable hot spots’ of proteins using Fourier 

domain correlation techniques, Bioinformatics, 25, 621-627 

(2009). 

Gwo-Yu Chuang, Dima Kozakov, Ryan Brenke, Dmitri 

Beglov, Frank Guarnieri and Sandor Vajda, Binding hot 

spots and amantadine orientation in the influenza A virus M2 

proton channel, Biophys. J, 97, 2846-2853 (2009). 

S. Vajda and D. Kozakov, Convergence and combination 

of methods in protein-protein docking, Curr. Opin. Struct. 

Biol, 19, 164-170 (2009). 

M. R. Landon, R. L. Lieberman, Q. Q. Hoang, S. Ju, J. M. 

M. Caaveiro, S. D. Orwig, D. Kozakov, R. Brenke, G-Y 

Chuang, D. Beglov, S. Vajda, G. A. Petsko and D. Ringe, 

Detection of ligand binding hot spots on protein surfaces via 

fragment-based methods: application to DJ-1 and glucocerebrosidase, 

J. Comput.-Aided Mol. Des, 23, 491-500 (2009). 

D. Beglov, C-J Lee, A. De Biasio, D. Kozakov, R. Brenke, 

S. Vajda and N. Beglova, Structural insights into recognition 

of ß2-glycoprotein I by the lipoprotein receptors, Proteins: 

Struct., Funct., Bioinf, 77, 940-949 (2009). 

Y. Lei, F. Mehmood, S. Lee, J. Greeley, B. Lee, S. Seifert, 

R. E. Winans, J. W. Elam, R. J. Meyer, P. C. Redfern, D. 

Teschner, R. Schloegl, M. J. Pellin, L. A. Curtiss and S. Vaj- 

da, Increased silver activity for direct propylene epoxidation 

via subnanometer size effects, Science (Washington, DC, U. 

S.), 328, 224-228 (2010). 

WANG, FENG (b.1975) Assistant Professor. B.Sc, 

1998, Peking University; Ph.D, 2003, University of Pitts-


burgh. Postdoctoral Research Fellow, 2003-2005, Univ- B. Linghu, E. S. Snitkin, Z. Hu, Y. Xia and C. DeLisi, Ge- 

ersity of Utah. Computational Chemistry; Theoretical nome-wide prioritization of disease genes and identification 

Chemistry. Development of a new method for generating 

high quality force field from high level electronic structure 

calculations. Study of the free energy difference bet- 

ween different phases of water and clathrate hydrates. Si- 

mulation of slow dynamics using the Kinetic Monte Carlo 

method. Development of enhanced sampling methods. 

TEL: (617) 353-2082 FAX: (617) 353-6466 

Web: wanglab.bu.edu 

Email: fengwang@bu.edu 

of disease-disease associations from an integrated human 

functional linkage network, Genome Biol, 10, R91 (2009). 

E. Franzosa, B. Linghu and Y. Xia, Computational reconstruction 

of protein-protein interaction networks: algorithms 

and issues, Methods Mol. Biol, 541, 89-100 (2009). 

E. A. Franzosa and Y. Xia, Structural determinants of pro- 

tein evolution are context-sensitive at the residue level, Mol. 

Biol. Evol, 26, 2387-2395 (2009). 

Y. Wang, X-S Zhang and Y. Xia, Predicting eukaryotic 

transcriptional cooperativity by Bayesian network integration 

G. Lindberg , T. Berkelbach and F. Wang, Optimizing the of genome-wide data, Nucleic Acids Res, 37, 5943-5958 

switching function for non-equilibrium free-energy calcula- (2009). 

tions: An on-the-fly approach, J. Chem. Phys, 130, 174705 C. Pan, Q. Gao, J. Xie, Y. Xia and I. R. Epstein, Precipita- 

(2009). 

tion patterns with polygonal boundaries between electrolytes, 

O. Akin-Ojo and F. Wang, Improving the point-charge Phys. Chem. Chem. Phys, 11, 11033-11039 (2009). 

description of hydrogen bonds by adaptive force matching, J. Y. Xia, E. A. Franzosa and M. B. Gerstein, Integrated as- 

Phys. Chem. B, 113, 1237 (2009). 

sessment of genomic correlates of protein evolutionary rate, 

E. Pinnick, S. Erramilli and F. Wang, The potential of PLoS Comput. Biol, 5, e1000413 (2009). 

mean force of nitrous oxide in 1,2-dimyristoylphosphatidyl- Y. Wang, E. A. Franzosa, X.-S. Zhang and Y. Xia, Protein 

choline lipid bilayer, Chem. Phys. Lett, 489, 96—98 (2010). evolution in yeast transcription factor subnetworks, Nucleic 

D. Wei and F. Wang, Mimicking coarse-grained simula- Acids Res, 38, 5959-5969 (2010). 

tion without coarse-graining, enhanced sampling through J. R. Parikh, B. Klinger, Y. Xia, J. A. Marto and N. Blueshort-range 

damped potential, J. Chem. Phys, 133, 084101 thgen, Discovering causal signaling pathways through gene- 

(2010). 

expression patterns, Nucleic Acids Res, 38, W109-W117 

Y. Song, O. Akin-ojo and F. Wang, Correcting for disper- (2010). 

sion interaction and beyond in density functional theory W.-H. Yu, H. Hu, Q. Zhou, Y. Xia and S. Amar, Bioinfor- 

through force matching, J. Chem. Phys, 133, 174115 (2010). matics analysis of macrophages exposed to porphyromonas 

H. L. Tierney, C. E. Calderon, A. E. Baber, E. Charles, H. gingivalis: implications in acute vs. chronic infections, PLoS 

Sykes and F. Wang, Understanding the rotational mechanism ONE, 5, e15613 (2010). 

of a single molecule: STM and DFT investigations of 

dimethyl sulfide molecular rotors on Au(111), J. Phys. ZIEGLER, LAWRENCE D. (b.1950) Professor. B.S, 

Chem, 114, 3152 (2010). 

E. Pinnick, S. Erramilli and F. Wang, Computational investigation 

of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine 

lipid at three hydration levels, Molecular Physics, 

108, 2027-2036 (2010). 

1971, SUNY at Stony Brook; Ph.D, 1978, Cornell University. 

NIH Fellowship, 1979, University of Oregon; Na- 

tional Research Council Fellowship, 1981, Naval Re- 

search Laboratory. Bioanalytical Chemistry; Chemical 

Physics. Chemical physics; nonlinear spectroscopy of 

G. E. Lindberg, Molecular dynamics investigation of the 

free energy of melting of methane clathrate and ice IH. (D) 

molecules in gas and condensed phases; ultrafast dynamics 

and light scattering; ultrafast dynamics of semicon- 

ductors; resonance Raman scattering and femtosecond 

WHITTY, ADRIAN (b.1964) Associate Professor. 

B.Sc, 1985, King’s College, University of London; M.S, 

1988, University of Illinois at Chicago; Ph.D, 1991, 

University of Illinois at Chicago. Postdoctoral Research 

Fellow, 1990-1993, Brandeis University. Biochemistry. 

My group engages in two main lines of research: (1) Pursuing 

a quantitative, mechanistic understanding of how 

cell surface receptors allow cells to sense and respond to 

their environment, and; (2) drug discovery, and particularly 

the discovery of small molecule antagonists of protein-protein 

interactions. We use a wide range of biochemical 

and biophysical approaches, often in collabora- 

UV/Vis/IR spectroscopy; applications of pulse shaping 

technologies; surface enhanced Raman spectroscopy of 

pathogens. TEL: (617) 353-8663 FAX: (617) 353-6466 

Web: www.bu.edu/chemistry/faculty/ziegler/ 

Email: lziegler@bu.edu 

B. Yan, A. Thubagere, W. R. Premasiri, L. D. Ziegler, L. 

Dal Negro and B. M. Reinhard, Engineered SERS substrates 

with multiscale signal enhancement: nanoparticle cluster ar- 

rays, ACS Nano, 3, 1190-1202 (2009). 

J. Peng, T. C. Castonguay, D. F. Coker and L. D. Ziegler, 

Ultrafast H2 and D2 rotational Raman responses in near criti- 

cal CO2: an experimental and theoretical study of anisotropic 

solvation dynamics, J. Chem. Phys, 131, 054501/1-054501/ 

tion with other groups that contribute distinct expertise 17 (2009). 

or technologies. TEL: (617) 353-2488 FAX: (617) 353- A. Gopinath, S. V. Boriskina, W. R. Premasiri, L. Ziegler, 

6466 

Web: www.bu.edu/chemistry/faculty/profile/ 

WhittyProfile.html 

Email: whitty@bu.edu 

M. P. Pollastri, A. Whitty, J. Cassidy Merrill, X. Tang, T. 

D. Ashton and S. Amar, Identification and characterization of 

kava-derived compounds mediating TNF-A suppression, 

Chem. Biol. Drug Des, 74, 121-128 (2009). 

B. M. Reinhard and L. Dal Negro, Plasmonic nanogalaxies: 

multiscale aperiodic arrays for surface-enhanced Raman 

sensing, Nano Lett, 9, 3922-3929 (2009). 

L. Yang, B. Yan, W. R. Premasiri, L. D. Ziegler, L. Dal 

Negro and B. M. Reinhard, Engineering nanoparticle cluster 

arrays for bacterial biosensing: the role of the building block 

in multiscale SERS substrates, Adv. Funct. Mater, 20, 2619- 

2628 (2010). 

Michelle R. Arkin and Adrian Whitty, The road less traveled: 

modulating signal transduction enzymes by inhibiting 

their protein-protein interactions, Curr. Opin. Chem. Biol, 13, 

284-290 (2009). 

A. Whitty, Small-molecule inhibitors of protein-protein interactions: 

challenges and prospects, Gene Fam. Targeted 

Mol. Des, 199-233, 2 plates (2009). 

N. di Clemente, S. P. Jamin, A. Lugovskoy, P. Carmillo, 

C. Ehrenfels, J. Y. Picard, A. Whitty, N. Josso, R. B. Pepinsky 

and R. L. Cate, Processing of anti-mullerian hormone regulates 

receptor activation by a mechanism distinct from 

TGF-beta, Molecular Endocrinology, 24, 2193-2206 (2010). 

L. Chieffo, Vibrational energy relaxation in neat water and 

biological water. (D) 

XIA, YU (b.1973) Assistant Professor. B.S, 1995, Peking 

University; Ph.D, 2003, Stanford University. Postdoctoral 

Fellow, 2003-2006, Yale University. Bioinformatics; 

Computational Chemistry. My research is focused 

on computational biology and bioinformatics. 

Computational techniques are developed to model the 

structure, function, and evolution of complex bio-molecular 

systems, such as proteins and protein networks. 

Specific projects include: Modeling and simulation of 

proteins and protein networks; comparative and evolutionary 

analysis of proteins and protein networks; protein 

sequence-structure-function relationships; prediction of 

protein structure and function. TEL: (617) 358-2302 

FAX: (617) 353-4814 

Web: xialab.bu.edu 

Email: yuxia@bu.edu 

K. Voevodski, S-H Teng and Y. Xia, Finding local communities 

in protein networks, BMC Bioinformatics, 10, 297 

(2009). 

K. Voevodski, S.-H. Teng and Y. Xia, Spectral affinity in 

protein networks, BMC Syst. Biol, 3, 112 (2009).

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