PURDUE UNIVERSITY

PURDUE 1
PURDUE UNIVERSITY
575 Stadium Mall Drive, MCMP Dept, 1333 Robert E.
Heine Pharmacy Building, Room 202
West Lafayette, IN 47907-2091
TEL: (765) 494-1403
FAX: (765) 494-1414
Web: www.mcmp.purdue.edu
Email: borch@purdue.edu
Department of Medicinal Chemistry and Molecular
Pharmacology
Richard F. Borch, M.D., Ph.D., Department Head.
Degrees Offered: M.S, Ph.D.
Fields of Specialization: Medicinal Chemistry, Pharmacology.
Interdisciplinary Program: Cancer Research Center,
Purdue University Interdisciplinary Life Science PhD
Program (PULSe).
bonds catalyzed by palladium: An efficient approach for high
throughput optimizations and kinetic studies, Advanced Synthesis
& Catalysis, 350, 71-75 (2008).
Shiyue Fang, Yousheng Guan, Ernest R. Blatchley, Chengyue
Shen and Donald E. Bergstrom, Conjugation of (E)-5-
[2-(Methoxycarbonyl)ethenyl]cytidine to Hydrophilic Microspheres:
Development of a Mobile Microscale UV Light Actinometer,
Bioconjugate Chem, 19, 592-597 (2008).
Mohammad Ahmadian and Donald E. Bergstrom, 5-substituted
nucleosides in biochemistry and biotechnology, Modified
Nucleosides in Biochemistry, Biotechnoloy and Medicine,
P. Herdewijn, ed. Wiley-VCH, Weinheim, 251-276
(2008).
E. R. Blatchley III, C. Shen , O. K. Scheible, J. P. Robinson,
K. Ragheb, D. E. Bergstrom and D. Rokjer, Validation
of large-scale, monochromatic UV disinfection systems for
drinking water using dyed microspheres, Water Research,
42, 677-688 (2008).
S. Abd-El-Mawla, Azocarboxamide ribonucleoside tri-
phosphates: synthesis, site-specific incorporation into RNA
and incorporation studies with bovine diarrhea virus polymerase.
(D)
Email: cjchang@pharmacy.purdue.edu
John M. Pezzuto, Richard C. Moon, Charles K.-H. Chang
and Ching-jer Chang, New approach for evaluating the antibreast
cancer activity of traditional Chinese medicine, Annals
of Traditional Chinese Medicine, 3, 321-346 (2007).
Her-Shyong Shiah, Wan-Shu Lee, Shin-Hun Juang, Pao-
Chiung Hong, Chia-Chi Lung, Ching-Jer Chang, Kai-Ming
Chou and Jang-Yang Chang, Mitochondria-mediated and
p53-associated apoptosis induced in human cancer cells by a
novel selenophene derivative, D-501036, Biochem. Pharma-
col, 73, 610-619 (2007).
Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun
Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah,
Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey-
uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu,
Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L.
Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang-
Yang Chang, D-501036, a novel selenophene-based triheter-
ocycle derivative, exhibits potent in vitro and in vivo antitumoral
activity which involves DNA damage and ataxia telangiectasia-mutated
nuclear protein kinase activation, Mol.
Cancer Ther, 6, 193-202 (2007).
ASHENDEL, CURTIS L. (b.1955) Associate Professor.
B.S, 1977, Michigan State University; Ph.D, 1982,
University of Wisconsin, Madison. Bioinformatics; Molecular
Biology. Current interest is computational genomics
and systems biology. Specific interest is in sup-
plementing genomic modeling and analysis algorithms
with automated scientific reasoning. Cellular regulatory
systems are my primary specific application area, includ-
ing gene regulatory networks. Major applications include
mechanisms of oncogenesis and other common human
diseases, including type II diabetes. TEL: (765) 494-
1479 FAX: (000) 000-0000
Web: www.mcmp.purdue.edu/faculty/ashendel.php
Email: ashendel@purdue.edu
Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun
Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah,
Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey-
uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu,
Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L.
Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang-
Yang Chang, D-501036, a novel selenophene-based triheter-
ocycle derivative, exhibits potent in vitro and in vivo antitu-
moral activity which involves DNA damage and ataxia telan-
giectasia-mutated nuclear protein kinase activation, Mol.
Cancer Ther, 6, 193-202 (2007).
BARKER, ERIC L. (b.1965) Associate Professor.
B.S, 1988, St. Louis College of Pharmacy; Ph.D, 1993,
Vanderbilt University. Research Associate, 1993-1995,
Emory University; NIH Fellowship, 1995-1998, Vanderbilt
University. Neuroscience; Pharmacology. Structurefunction
of neurotransmitter transporters. TEL: (765)
494-9940 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/barker.php
Email: barkerel@purdue.edu
Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie
J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate)
iodide, MTS-
MPP
BORCH, RICHARD F. (b.1941) Lilly Distinguished
Professor and Head. B.S, 1962, Stanford University;
Ph.D, 1965, Columbia University; M.D, 1975, University
of Minnesota. NIH Postdoctoral Fellowship, 1965-
1966, Harvard University. Medicinal and/or Pharmaceu-
tical Chemistry. Design, synthesis and mechanisms of
action of antitumor agents. Phosphopeptidomimetic prodrugs.
TEL: (765) 494-1403 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/borch.php
Email: borch@purdue.edu
Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak,
Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr.,
Raymond R. Mattingly, Richard F. Borch and Richard A.
Gibbs, Synthesis, Biochemical, and Cellular Evaluation of
Farnesyl Monophosphate Prodrugs as Farnesyltransferase Inhibitors,
J. Med. Chem, 50, 3274-3282 (2007).
Weidong Wu, Jennifer Sigmond, Godefridus J. Peters and
Richard F. Borch, Synthesis and Biological Activity of a
Gemcitabine Phosphoramidate Prodrug, J. Med. Chem, 50,
3743-3746 (2007).
Irene G. Boutselis, Xiao Yu, Zhong-Yin Zhang and Richard
F. Borch, Synthesis and Cell-Based Activity of a Potent
and Selective Protein Tyrosine Phosphatase 1B Inhibitor Prodrug,
J. Med. Chem, 50, 856-864 (2007).
Jun Young Choi and Richard F. Borch, Highly Efficient
Synthesis of Enantiomerically Enriched 2-Hydroxymethylaziridines
by Enzymatic Desymmetrization, Org. Lett, 9,
215-218 (2007).
Meihua Luo, Sarah Delaplane, Aihua Jiang, April Reed,
Ying He, Melissa Fishel, Rodney L. Nyland II, Richard F.
Borch, Xiaoxi Qiao, Millie M. Georgiadis and Mark R. Kel-
ley, Role of the Multifunctional DNA Repair and Redox Sig-
naling Protein Ape1/Ref-1 in Cancer and Endothelial Cells:
Small-Molecule Inhibition of the Redox Function of Ape1,
Antioxid. Redox Signaling, 10, 1853-1868 (2008).
Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde,
Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners,
Jr., Richard F. Borch and Raymond R. Mattingly, Induc-
tion of apoptosis in neurofibromatosis type 1 malignant pe-
ripheral nerve sheath tumor cell lines by a combination of
COLBY, DAVID A. (b.1977) Assistant Professor.
Ph.D, 2006, University of California, Irvine. Postdoctoral
Researcher, 2006-2008, The Scripps Research Institute.
Medicinal and/or Pharmaceutical Chemistry; Organic
Chemistry. Our research group blends the science
of medicinal chemistry and synthetic organic chemistry
through the use of natural product synthesis, the design
of structurally-related analogues for structure-activity investigations,
and the development of new synthetic
methodologies. Specifically, we seek to use natural products
as leads for drug discovery in drug-resistant cancer
and infectious diseases. Also, we develop new synthetic
methodologies to modify the structures of natural products.
TEL: (765) 496-3962 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/?uid=dcolby
Email: dcolby@purdue.edy
Hayato Ishikawa, David A. Colby and Dale L. Boger, Direct
Coupling of Catharanthine and Vindoline to Provide
Vinblastine: Total Synthesis of (+)- and ent-(-)-Vinblastine,
J. Am. Chem. Soc, 130, 420-421 (2008).
CUSHMAN, MARK (b.1945) Professor. Pharm.D,
1969, University of California, San Francisco; Ph.D,
1973, University of California, San Francisco. NIH Postdoctoral
Fellowship, 1973-1975, Massachusetts Institute
of Technology (MIT); Senior Fulbright Scholar, 1983-
1984, Munich Technical University. Medicinal and/or
Pharmaceutical Chemistry; Organic Chemistry. Design
and synthesis of potential antitumor, antiviral, and antibiotic
agents. TEL: (765) 494-1465 FAX: (765) 494-6790
Web: www.mcmp.purdue.edu/faculty/cushman.php
Email: cushman@purdue.edu
Johannes Kaiser, Boris Illarionov, Felix Rohdich, Wolfgang
Eisenreich, Sabine Saller, Jan Van Den Brulle, Mark
Cushman, Adelbert Bacher and Markus Fischer, A high-
throughput screening platform for inhibitors of the riboflavin
biosynthesis pathway, Anal. Biochem, 365, 52-61 (2007).
Ha Young Kim, Richard J. Kuhn, Chinmay Patkar, Ranjit
+, a novel scanning cysteine accessibility method
(SCAM) reagent for monoamine transporter studies, Bioorg.
Med. Chem, 15, 305-311 (2007).
novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol.
Exp. Ther, 326, 1-11 (2008).
Warrier and Mark Cushman, Synthesis of dioxane-based an-
tiviral agents and evaluation of their biological activities as
inhibitors of Sindbis virus replication, Bioorg. Med. Chem,
Ekaterina A. Placzek, Yasuo Okamoto, Natsuo Ueda and
Eric L. Barker, Mechanisms for recycling and biosynthesis of
endogenous cannabinoids anandamide and 2-arachidonylgly-
Rodney L Nyland II, Design and synthesis of novel quinones
targeting the redox function of APE1/REF-1. (D)
15, 2667-2679 (2007).
Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka
Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski,
cerol, J. Neurochem, 107, 987-1000 (2008).
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and
Eric L. Barker, Comparative molecular field analysis using
selectivity fields reveals residues in the third transmembrane
helix of the serotonin transporter associated with substrate
and antagonist recognition, J. Pharmacol. Exp. Ther, 325,
791-800 (2008).
Matthew J. McFarland, Tamera K. Bardell, Marla L.
Yates, Ekaterina A. Placzek and Eric L. Barker, RNA interference-mediated
knockdown of dynamin 2 reduces endocannabinoid
uptake into neuronal dCAD cells, Mol. Pharmacol,
74, 101-108 (2008).
BERGSTROM, DONALD E. (b.1943) Walther Professor.
B.S, 1965, University of Washington, Seattle,
WA; Ph.D, 1970, University of California, Berkeley.
Postdoctoral Fellowship, 1970-1972, University of Illi-
nois. Medicinal and/or Pharmaceutical Chemistry;
Nanochemistry. Nucleic acid chemistry; biotechnology
and nanotechnology of re-engineered nucleic acids; design
and synthesis of nucleoside analogs. TEL: (765)
494-6275 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/?uid=dbergstr
Email: bergstrom@purdue.edu
Roya R. Lahiji, Bridget D. Dolash, Donald E. Bergstrom
and Ronald Reifenberger, Oligodeoxyribonucleotide association
with single-walled carbon nanotubes studied by SPM,
Small, 3, 1912-1920 (2007).
Roman V. Rozhkov, V. Jo Davisson and Donald E. Bergstrom,
Fluorogenic transformations based on formation of CC
BOROWITZ, JOSEPH L. (b.1932) Professor. B.S,
1955, Ohio State University; M.S, 1957, Purdue Univer-
sity; Ph.D, 1959, Northwestern University. NSF Postdoc-
toral Fellow, 1960-1962, Harvard Medical School. Cell
Biology. trimethyltin neurotoxicology; mechanisms of
cyanide neurotoxicity. TEL: (765) 494-1407 FAX: (765)
494-1414
Web: www.mcmp.purdue.edu/faculty/borowitz.php
Email: borowitz@pharmacy.purdue.edu
Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph
L. Borowitz and Gary E. Isom, Interaction of Cyanide and
Nitric Oxide with Cytochrome c Oxidase: Implications for
Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008).
Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2
Diabetes, Toxicol. Sci, 103, 225-227 (2008).
CHANG, CHING-JER (b.1942) Professor. B.S, 1965,
National Taiwan Cheng Kung University; Ph.D, 1972,
Indiana University. Postdoctoral Fellowship, 1972, Pur-
due University. Medicinal and/or Pharmaceutical Chemistry;
Natural Products Chemistry. Discovery and design
of oncogene signal transduction inhibitors; isolation,
structure elucidation and synthesis of bioactive natural
products; natural chemopreventive agents; bioorganic
chemistry of cyclodextrins; enzymatic synthesis and biotransformation
of bioactive compounds. TEL: (765) 494-
1373 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/chang.php
Muthukaman Nagarajan, Andrew Morrell, Mark Cushman
and Yves Pommier, Novel Indenoisoquinolines NSC 725776
and NSC 724998 Produce Persistent Topoisomerase I Cleavage
Complexes and Overcome Multidrug Resistance, Cancer
Res, 67, 10397-10405 (2007).
Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka
Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski,
Muthukaman Nagarajan, Andrew Morrell, Mark Cushman
and Yves Pommier, Novel indenoisoquinolines NSC 725776
and NSC 724998 produce persistent topoisomerase I cleavage
complexes and overcome multidrug resistance. [Erratum
to document cited in CA148:092441], Cancer Res, 67, 12034
(2007).
Chan Yong Lee, Boris Illarionov, Young-Eun Woo, Kristina
Kemter, Ryu-Ryun Kim, Sabine Eberhardt, Mark Cush-
man, Wolfgang Eisenreich, Markus Fischer and Adelbert
Bacher, Ligand binding properties of the N-terminal domain
of riboflavin synthase from Escherichia coli, J. Biochem.
Mol. Biol, 40, 239-246 (2007).
Ekaterina Morgunova, Sabine Saller, Ilka Haase, Mark
Cushman, Adelbert Bacher, Markus Fischer and Rudolf Ladenstein,
Lumazine Synthase from Candida albicans as an
Anti-fungal Target Enzyme: Structural and Biochemical Ba-
sis for Drug Design, J. Biol. Chem, 282, 17231-17241
(2007).
Andrew Morrell, Michael S. Placzek, Jamin D. Steffen,
Smitha Antony, Keli Agama, Yves Pommier and Mark Cush-
man, Investigation of the Lactam Side Chain Length Neces-
sary for Optimal Indenoisoquinoline Topoisomerase I Inhibition
and Cytotoxicity in Human Cancer Cell Cultures, J.
Med. Chem, 50, 2040-2048 (2007).

2 PURDUE
Arup Maiti, Muriel Cuendet, Vicki L. Croy, Denise C. En- mel, William E. Fogler, Gregory E. Agoston, Phillip E. Fan- tive Syk Tyrosine Kinase for the Study of Signaling Dynamdringer,
John M. Pezzuto and Mark Cushman, Synthesis and wick and Mark Cushman, Stereoselective Synthesis of 3,3- ics from the B Cell Antigen Receptor, J. Biol. Chem, 282,
Biological Evaluation of (±)-Abyssinone II and Its Ana- Diarylacrylonitriles as Tubulin Polymerization Inhibitors, J. 33760-33768 (2007).
logues as Aromatase Inhibitors for Chemoprevention of Org. Chem, 73, 4241-4244 (2008).
Fei Zhou, Jacob Galan, Robert L. Geahlen and W. Andy
Breast Cancer, J. Med. Chem, 50, 2799-2806 (2007).
Yunlong Song and Mark Cushman, The Binding Orienta- Tao, A Novel Quantitative Proteomics Strategy To Study
Takeshi Sakamoto, Matthew D. Cullen, Tracy L. Hartman, tion of a Norindenoisoquinoline in the Topoisomerase I- Phosphorylation-Dependent Peptide-Protein Interactions, J.
Karen M. Watson, Robert W. Buckheit, Christophe Pannec- DNA Cleavage Complex Is Primarily Governed by - Proteome Res, 6, 133-140 (2007).
ouque, Erik De Clercq and Mark Cushman, Synthesis and Stacking Interactions, J. Phys. Chem. B, 112, 9484-9489 Jun Wang, Ning Bao, Leela L. Paris, Hsiang-Yu Wang,
Anti-HIV Activity of New Metabolically Stable Alkenyldia- (2008). Robert L. Geahlen and Chang Lu, Detection of Kinase Transrylmethane
Non-Nucleoside Reverse Transcriptase Inhibitors Matthew Cullen, Deborah Miles, Arlene Rothwell, Connie location Using Microfluidic Electroporative Flow Cytometry,
Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadia- Bonham, Karl V. Wood and Mark Cushman, Hydrolysis of Anal. Chem. (Washington, DC, U. S.), 80, 1087-1093 (2008).
zole Systems, J. Med. Chem, 50, 3314-3321 (2007).
thioesters in an ion trap, Rapid Commun. Mass Spectrom, 22, Jun Wang, Ning Bao, Leela L. Paris, Robert L. Geahlen
Arup Maiti, Muriel Cuendet, Tamara Kondratyuk, Vicki L. 1094-1098 (2008). and Chang Lu, Total Internal Reflection Fluorescence Flow
Croy, John M. Pezzuto and Mark Cushman, Synthesis and
Cytometry, Anal. Chem. (Washington, DC, U. S.), 80, 9840-
Cancer Chemopreventive Activity of Zapotin, a Natural
Product from Casimiroa edulis, J. Med. Chem, 50, 350-355
(2007).
Andrew Morrell, Michael Placzek, Seth Parmley, Brian
Grella, Smitha Antony, Yves Pommier and Mark Cushman,
Optimization of the Indenone Ring of Indenoisoquinoline
Topoisomerase I Inhibitors, J. Med. Chem, 50, 4388-4404
(2007).
Andrew Morrell, Michael Placzek, Seth Parmley, Smitha
Antony, Thomas S. Dexheimer, Yves Pommier and Mark
Cushman, Nitrated Indenoisoquinolines as Topoisomerase I
Inhibitors: A Systematic Study and Optimization, J. Med.
Chem, 50, 4419-4430 (2007).
Matthew D. Cullen, Bo-Liang Deng, Tracy L. Hartman,
Karen M. Watson, Robert W. Buckheit, Jr., Christophe Pannecouque,
Erik De Clercq and Mark Cushman, Synthesis and
Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-
Nucleoside Reverse Transcriptase Inhibitors That Possess Increased
Hydrolytic Stability, J. Med. Chem, 50, 4854-4867
Juma Hoshino, Design and synthesis of analogs and metabolites
of resveratrol as chemopreventive agents. (M)
Katherine E. Peterson, Investigation of the stereochemical
effects of the indenoisoquinoline side chain on topoisomerase
i inhibition. (M)
Yanlei Zhang, Design, synthesis and bioevaluation of lumazine
synthase inhibitors. (M)
Andrew Edward O’Dell Morrell, Development of topoisomerase
I inhibitors as anticancer agents. (D)
Matthew David Cullen, Investigations on alkenyldiarylmethase
HIV-1 reverse transcriptase inhibitors: Mechanism of
action, synthesis, and metabolic evaluation of hydrolytically
stable analogues. (D)
DAVISSON, VINCENT JO (b.1955) Professor. B.A,
1978, Wittenberg University; M.S, 1983, Indiana Uni-
versity; Ph.D, 1988, University of Utah. Postdoctoral
Fellowship, 1987-1989, University of California, San
Francisco, Department of Biochemistry and Biophysics.
9844 (2008).
Thibaud Lebouvier, Timothy M. E. Scales, Diane P. Hanger,
Robert L. Geahlen, Bernard Lardeux, C. Hugh Reynolds,
Brian H. Anderton and Pascal Derkinderen, The microtubuleassociated
protein tau is phosphorylated by Syk, Biochim.
Biophys. Acta, Mol. Cell Res, 1783, 188-192 (2008).
Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu,
Robert L. Geahlen and Marietta L. Harrison, The SH3 domain
of Lck modulates T-cell receptor-dependent activation
of extracellular signal-regulated kinase through activation of
Raf-1, Mol. Cell. Biol, 28, 630-641 (2008).
Yajie Zhang, Hyunju Oh, Robert A. Burton, John W.
Burgner, Robert L. Geahlen and Carol Beth Post, Tyr130
phosphorylation triggers Syk release from antigen receptor
by long-distance conformational uncoupling, Proc. Natl.
Acad. Sci. U. S. A, 105, 11760-11765 (2008).
GHOSH, ARUN K.—See Chemistry Section, Purdue
University, Department of Chemistry.
(2007).
Allison B. Edsall, Gregory E. Agoston, Anthony M. Treston,
Stacy M. Plum, Robert H. McClanahan, Tian-Sheng
Lu, Wei Song and Mark Cushman, Synthesis and in Vivo
Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate,
17-Phosphate, and 3,17-Diphosphate, J. Med. Chem, 50,
6700-6705 (2007).
Yanlei Zhang, Boris Illarionov, Adelbert Bacher, Markus
Fischer, Gunda I. Georg, Qi-Zhuang Ye, David Vander
Velde, Phillip E. Fanwick, Yunlong Song and Mark Cushman,
A Novel Lumazine Synthase Inhibitor Derived from
Oxidation of 1,3,6,8-Tetrahydroxy-2,7-naphthyridine to a
Tetraazaperylenehexaone Derivative, J. Org. Chem, 72,
2769-2776 (2007).
Arindam Talukdar, Boris Illarionov, Adelbert Bacher,
Markus Fischer and Mark Cushman, Synthesis and Enzyme
Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine
Substrate of Lumazine Synthase and
Product of Riboflavin Synthase, J. Org. Chem, 72, 7167-
7175 (2007).
Yanlei Zhang, Guangyi Jin, Boris Illarionov, Adelbert
Bacher, Markus Fischer and Mark Cushman, A New Series
of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-Dribityl-1H-pyrazolo[3,4-d]pyrimidinedione
as Inhibitors of
Lumazine Synthase: Design, Synthesis, and Evaluation, J.
Org. Chem, 72, 7176-7184 (2007).
Muriel Cuendet, Carol P. Oteham, Arup Maiti, Bruce A.
Craig, Mark Cushman, Richard C. Moon and John M. Pezzuto,
Zapotin prevents mouse skin tumorigenesis during the
stages of initiation and promotion, Anticancer Research, 28,
3705-3709 (2008).
Tsyr-Yan Yu, Robert D. O’Connor, Astrid C. Sivertsen,
Colby Chiauzzi, Barbara Poliks, Markus Fischer, Adelbert
Bacher, Ilka Haase, Mark Cushman and Jacob Schaefer,
15N{31P} REDOR NMR studies of the binding of phosphonate
reaction intermediate analogues to saccharomyces cerevisiae
lumazine synthase, Biochemistry, 47, 13942–13951
(2008).
Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay,
Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit,
Christophe Pannecouque, Erik De Clercq and Mark
Cushman, Investigation of the alkenyldiarylmethane non-nucleoside
reverse transcriptase inhibitors as potential cAMP
phosphodiesterase-4B2 inhibitors, Bioorg. Med. Chem. Lett,
18, 1530-1533 (2008).
Matthew D. Cullen, Taradas Sarkar, Ernest Hamel, Tracy
L. Hartman, Karen M. Watson, Robert W. Buckheit, Christophe
Pannecouque, Erik De Clercq and Mark Cushman, Inhibition
of tubulin polymerization by select alkenyldiarylmethanes,
Bioorg. Med. Chem. Lett, 18, 469-473 (2008).
Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer,
Evan S. Scher, Yves Pommier and Mark Cushman, Design,
Synthesis, and Biological Evaluation of 14-Substituted Aromathecins
as Topoisomerase I Inhibitors, J. Med. Chem, 51,
4609-4619 (2008).
Ze Li, Mansoora Khaliq, Zhigang Zhou, Carol Beth Post,
Richard J. Kuhn and Mark Cushman, Design, Synthesis, and
Biological Evaluation of Antiviral Agents Targeting Flavivirus
Envelope Proteins, J. Med. Chem, 51, 4660-4671 (2008).
Yanlei Zhang, Boris Illarionov, Ekaterina Morgunova,
Guangyi Jin, Adelbert Bacher, Markus Fischer, Rudolf Ladenstein
and Mark Cushman, A New Series of N-[2,4-Dioxo-
6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic
Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin
Synthase: Design, Synthesis, Biochemical Evaluation,
Crystallography, and Mechanistic Implications, J. Org.
Chem, 73, 2715-2724 (2008).
Zhenglai Fang, Yunlong Song, Taradas Sarkar, Ernest Ha-
Chemical Biology; Medicinal and/or Pharmaceutical
Chemistry. Medicinal Chemistry and cellular pharmacology
of natural product drugs. Cell based and biomolecular
assay tools for drug discovery and development in
cancer and neurodegenerative diseases. Targeting of
small molecules to disease-specific receptors; analysis of
small molecules agonists and antagonists of regulatory
protein interactions. TEL: (765) 494-5238 FAX: (765)
494-1414
Web: www.mcmp.purdue.edu/faculty/davisson.php
Email: davisson@purdue.edu
R. E. Amaro, R. S. Myers, V. J. Davisson and Z. A. Luthey-Schulten,
A network of conserved interactions regulates
the allosteric signal in a glutamine amidotransferase, Biochemistry,
46, 2156-2173 (2007).
D. Schweitzer, J. Zhu, G. Jarori, J. J. Kane, J. Tanaka, T.
Higa, V. J. Davisson and P. Helquist, Synthesis of carbamate
derivatives of iejimalides. Retention of normal antiproliferative
activity and localization of binding in cancer cells,
Bioorganic and Medicinal Chemistry, 15, 3208-3216 (2007).
R. Rozhkov, V. J. Davisson and D. E. Bergstrom, Fluorogenic
tranformations based on formation of C-C bonds cata-
lyzed by palladium: An efficient approach for high through-
put optimizations and kinetic studies, Advanced Synthesis
and Catalysis, 350, 71-75 (2008).
S. K. Deb, B. Davis, D. Ben-Amotz and V. J. Davisson,
Accurate concentration measurements using surface-enhanced
raman and deuterium exchanged dye pairs, Applied
Spectroscopy, 62, 1001-1007 (2008).
G. M. Knudsen, B. M. Davis, S. K. Deb, Y. Loethen, R.
Gudihal, P. Perera, D. Ben-Amotz and V. J. Davisson, Quantification
of isotope encoded proteins in 2-D gels using surface
enhanced resonance raman, Bioconjugate Chem, 19,
2212-2220 (2008).
S. M. Firestine, W. Wu, H. Youn and V. J. Davisson, Interrogating
the mechanism of a tight binding inhibitor of AIR
carboxylase, Bioorganic and Medicinal Chemistry, 17, 794-
803 (2008).
F. Liu, J. Hindupur, J. L. Nguyen, K. J. Ruf, J. Zhu, J. L.
Schieler, C. C. Bonham, K. V. Wood, V. J. Davisson and J.-
L. Rochet, Methionine sulfoxide reductase A protects dopaminergic
cells from Parkinson’s disease-related insults, Free
Radical Biology & Medicine, 45, 242-255 (2008).
S. K. Deb, B. Davis, G. M. Knudsen, R. Gudihal, D. Ben-
Amotz and V. J. Davisson, Detection and relative quantification
of proteins by surface enhanced raman using isotopic labels,
J. Am. Chem. Soc, 30, 9624-9625 (2008).
Y. L. Loethen, G. M. Knudsen, B. Davis, R. Gudihal, V. J.
Davisson and D. Ben-Amotz, Protein quantitation in 2-D gels
using fluorescence with water raman as an internal standard,
J. Proteome Res, 7, 1341-1345 (2008).
GEAHLEN, ROBERT L. (b.1953) Professor. B.S,
1975, University of Southern Colorado; Ph.D, 1978,
University of Wyoming. Postdoctoral Fellowship, 1978,
University of Washington; NIH Fellowship, 1978, University
of Washington; Juvenile Diabetes Foundation
Fellowship, 1980, University of Washington. Biochemistry;
Immunology. Protein-tyrosine kinases and lymphocyte
activation; tyrosine kinases and breast cancer; protein
acylation; antitumor agents. TEL: (765) 494-1457
FAX: (765) 494-9193
Web: www.mcmp.purdue.edu/faculty/geahlen.php
Email: geahlen@purdue.edu
Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison
and Robert L. Geahlen, Generation of an Analog-sensi-
GIBBS, RICHARD A. (b.1961) Professor. B.S, 1983,
Johns Hopkins University; Ph.D, 1988, University of California,
Riverside. NSF Fellowship, 1988-1991, Penn
State University. Chemical Biology; Medicinal and/or
Pharmaceutical Chemistry. Chemical probes of protein
prenylation; mechanistic studies of the enzyme proteinfarnesyl
transferase; inhibitors of the enzyme isoprenylcysteine
methyltransferase; novel methods for the synthesis
of isoprenoid analogs. TEL: (765) 494-1456 FAX:
(765) 494-1414
Web: www.mcmp.purdue.edu/faculty/gibbs.php
Email: rgibbs@purdue.edu
Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June
E. Pais, Misty Handley, Marietta L. Harrison, Carol A.
Fierke and Richard A. Gibbs, Combinatorial Modulation of
Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007).
Amanda J. Krzysiak, Sarah A. Scott, Katherine A. Hicks,
Carol A. Fierke and Richard A. Gibbs, Evaluation of protein
farnesyltransferase substrate specificity using synthetic peptide
libraries, Bioorg. Med. Chem. Lett, 17, 5548-5551
(2007).
Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak,
Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr.,
Raymond R. Mattingly, Richard F. Borch and Richard A.
Gibbs, Synthesis, Biochemical, and Cellular Evaluation of
Farnesyl Monophosphate Prodrugs as Farnesyltransferase In-
hibitors, J. Med. Chem, 50, 3274-3282 (2007).
Linda Henneman, Arno G. van Cruchten, Simone W.
Denis, Michael J. Amolins, Andrew T. Placzek, Richard A.
Gibbs, Willem Kulik and Hans R. Waterham, Isoprenoid de-
tection by tandem mass spectrometry, Analytical Biochemis-
try, 383, 18-24 (2008).
Michelle Maynor, Sarah A. Scott, Emily L. Rickert and
Richard A. Gibbs, Synthesis and evaluation of 3- and 7-sub-
stituted geranylgeranyl pyrophosphate analogs, Bioorg. Med.
Chem. Lett, 18, 1889-1892 (2008).
Diwan S. Rawat, Amanda J. Krzysiak and Richard A.
Gibbs, Synthesis and Biochemical Evaluation of 3,7-Disubstituted
Farnesyl Diphosphate Analogues, J. Org. Chem, 73,
1881-1887 (2008).
Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde,
Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners,
Jr., Richard F. Borch and Raymond R. Mattingly, Induction
of apoptosis in neurofibromatosis type 1 malignant pe-
ripheral nerve sheath tumor cell lines by a combination of
novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol.
Exp. Ther, 326, 1-11 (2008).
Amanda J. Krzysiak, Modulating Farnesyltransferase substrate
specificity: Tools for altering protein function in vivo.
(D)
James L. Donelson, A new solid-phase route to prenylcysteine
derivatives: Development of isoprenylcysteine carboxyl
methyltransferase inhibitors. (D)
HARRISON, MARIETTA L. (b.1948) Professor.
B.A, 1970, University of New Hampshire; Ph.D, 1980,
University of Wyoming. Cancer Research Institute Fellowship,
1980, Fred Hutchinson Cancer Research Cen-
ter; NIH Fellowship, 1981, Fred Hutchinson Cancer Research
Center and Purdue University. Biochemistry; Immunology.
Our research involves investigating the role of
cellular protein-tyrosine kinases in cell division and dif-
ferentiation. TEL: (765) 494-1442 FAX: (765) 494-9193
Web: www.mcmp.purdue.edu/faculty/harrison.php

PURDUE 3
Email: harrisom@purdue.edu
Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June
E. Pais, Misty Handley, Marietta L. Harrison, Carol A.
Fierke and Richard A. Gibbs, Combinatorial Modulation of
Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007).
Maia M. Donahue, Wei Zhang, Marietta L. Harrison, Jianghai
Hu and Ann E. Rundell, Employing optimization and
sensitivity analyses tools to generate and analyze mathematical
models of T cell signaling events, AIP Conf. Proc, 953,
43-63 (2007).
Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison
and Robert L. Geahlen, Generation of an Analog-sensitive
Syk Tyrosine Kinase for the Study of Signaling Dynamics
from the B Cell Antigen Receptor, J. Biol. Chem, 282,
33760-33768 (2007).
Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu,
Robert L. Geahlen and Marietta L. Harrison, The SH3 domain
of Lck modulates T-cell receptor-dependent activation
of extracellular signal-regulated kinase through activation of
Raf-1, Mol. Cell. Biol, 28, 630-641 (2008).
A. T. Krans, Dephosphorylation of Phosphoserine 59 in the
Protein Tyrosine Kinase, Lck. (M)
M. B. Baker, The Effect of Serine 59 Phosphorylation on
the Conformation of the Protein Binding Domains of the Pro-
tein Tyrosine Kinase Lck. (D)
M. D. Handley, Anchors away: An alternative role for farnesylation
of Ras. (D)
M. L. Vázquez, Biological Consequences of the Phosphorylation
of Serine 59 on the Tyrosine Kinase Lck. (D)
HAZBUN, TONY R. Assistant Professor. B.Sc, 1989,
University of Queensland; Ph.D, 1997, University of Notre
Dame. Research Associate, 1998-2005, Howard
Hughes Medical Institute. Bioinformatics; Genetics.
Functional genomics, Systems Biology, Mitosis, Proteinprotein
interactions, Two-hybrid, Chemical genetics, Aurora
kinase, Bub1 kinase, genetic interactions. TEL:
(765) 496-8228 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/?uid=hazbun
Email: thazbun@purdue.edu
J. Wong, Y. Nakajima, S. Westermann, C. Shang C. Goodner,
P. Houshmand, C. Chan, S. Fields, D. G. Drubin, G.
Barnes and T. Hazbun, A protein interaction map of the mitotic
spindle, Mol Biol Cell, 18, 3800-09 (2007).
HOCKERMAN, GREGORY H. (b.1961) Associate
Professor. B.S, 1983, Olivet Nazarene College; Ph.D,
1991, University of Wisconsin. NIH Fellowship, 1991-
1997, University of Washington. Pharmacology; Physi-
ology. Molecular determinants of dihydropyridine, phenylalkylamine
and benzothiazepine block of L-type cal-
cium channels; synthesis of novel calcium channel
blockers as research tools, L-type calcium channel mod-
ulation of insulin secretion. TEL: (765) 496-3874 FAX:
(765) 494-1414
Web: www.mcmp.purdue.edu/faculty/hockerman.php
Email: gregh@pharmacy.purdue.edu
Kenneth B. Walsh, Jining Zhang, John W. Fuseler, Nathan
Hilliard and Gregory H. Hockerman, Adenoviral-mediated
expression of dihydropyridine-insensitive L-type calcium
channels in cardiac ventricular myocytes and fibroblasts,
Eur. J. Pharmacol, 565, 7-16 (2007).
X. Wang, R. Xu, G. Abernathey, J. Taylor, M. Alzghoul,
K. Hannon, G. H. Hockerman and A Pond, Kv11.1 channel
subunit composition varies developmentally in mouse cardiac
muscle, Developmetal Dynamics, 237, 2430-2437 (2008).
Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng
Hu and Val J. Watts, Ligand-dependent oligomerization of
dopamine D2 and adenosine A2A receptors in living neuronal
cells, Mol. Pharmacol, 74, 544-551 (2008).
Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu,
Visualization of ternary complexes in living cells by using a
BiFC-based FRET assay, Nat. Protoc, 3, 1693-1702 (2008).
Y. John Shyu, Susan M. Hiatt, Holli M. Duren, Ronald E.
Ellis, Tom K. Kerppola and Chang-Deng Hu, Visualization
of protein interactions in living Caenorhabditis elegans using
bimolecular fluorescence complementation analysis, Nat.
Protoc, 3, 588-596 (2008).
Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu,
Visualization of AP-1-NF-B ternary complexes in living
cells by using a BiFC-based FRET, Proc. Natl. Acad. Sci. U.
S. A, 105, 151-156 (2008).
Y. John Shyu and Chang-Deng Hu, Fluorescence complementation:
An emerging tool for biological research, Trends
Biotechnol, 26, 622-630 (2008).
Susan M. Hiatt, Understanding AP-1 dimerization in vivo:
Genetic and BiFC analysis of C. elegans FOS-1 and JUN-1
in regulation of ovulation. (D)
Yeong-Shiun John Shyu, Understanding the role of ATF-1
homodimers in Caenorhabditis elegans development using a
novel bimolecular fluorescence complementation-based
dominant dimeric repressor assay. (D)
ISOM, GARY E. (b.1946) Professor. B.S, 1969, Idaho
State University; Ph.D, 1973, Washington State University.
Neuroscience; Toxicology. Biochemical mechanisms
of neurotoxicity; excitotoxic neurotransmitters in
xenobiotic neurotoxicity. TEL: (765) 494-5905 FAX:
(765) 494-1414
Web: www.mcmp.purdue.edu/faculty/isom.php
Email: geisom@purdue.edu
Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph
L. Borowitz and Gary E. Isom, Interaction of Cyanide and
Nitric Oxide with Cytochrome c Oxidase: Implications for
Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008).
Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2
Diabetes, Toxicol. Sci, 103, 225-227 (2008).
LACOUNT, DOUGLAS J. (b.1970) Assistant professor.
B.S, 1992, University of Wisconsin-Madison; Ph.D,
1998, University of Wisconsin-Madison. post-doc, 1998-
1002, University of Iowa; post-doc, 2001-2005, University
of Washington. Molecular Biology; Virology. My
current research focuses on interactions between host
cells and obligate intracellular parasites. We seek to
identify physical interactions between host cell proteins
and viral or malaria proteins in order to better understand
how intracellular parasites manipulate their hosts and to
discover host cell proteins that are required for growth of
multiple pathogens. TEL: (765) 496-7835 FAX: (765)
494-1414
Web: www.mcmp.purdue.edu/faculty/?uid=dlacount
Email: dlacount@pharmacy.purdue.edu
M. Vignali A. McKinlay, D. J. LaCount, R. Chettier, R.
Bell, S. Sahasrabudhe, R. E. Hughes and S. Fields, Interaction
of an atypical Plasmodium falciparum ETRAMP with
human apolipoproteins, Malar J, 20, 211 (2008).
LILL, MARKUS A. (b.1974) Assistant Professor.
M.Sc, 1998, University of Erlangen-Nuernberg, Germany;
Ph.D, 2002, Max Planck Institute for Biophysics,
Germany. Research Associate, 2002-2006, Biographics
Louisiana State University; Ph.D, 1968, University of
California, Berkeley. Postdoctoral Fellowship, 1968-
1970, University of California, Berkeley, Department of
Biochemistry. Bioorganic Chemistry; Chemistry Education.
Chemical mechanisms, bioorganic chemistry,
chemical education with emphasis on organic chemistry.
TEL: (765) 494-1462 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/loudon.php
Email: loudonm@purdue.edu
Animesh Aditya, David E. Nichols and G. Marc Loudon,
Borohydride reduction of estrone. Demonstration of diaster-
eoselectivity in the undergraduate organic chemistry labora-
tory, Journal of Chemical Education, 85, 1585-1587 (2008).
MORRÉ, D. JAMES (b.1935) Dow Distinguished
Professor. B.S, 1957, University of Missouri; M.S, 1959,
Purdue University; Ph.D, 1963, Caltech; D.h.c, 1985,
University of Geneva; D.h.c, 2000, Universite Victor
Segalen, Bordeaux, France. Biochemistry. Researches
the biochemistry of cell growth and dynamics of intracellular
membranes and is familiar with a wide range of in-
vestigative approaches to elucidation of structure-function
correlations in cell biology, subcellular biochemis-
try, and medicinal chemistry. Recently described a novel
universal cancer marker, designated tNOX, a protein lo-
cated at the cell surface and having protein disulfide-thiol
interchange/NADH oxidase activity that is growth re-
lated and inhibited by anticancer drugs. TEL: (765) 494-
1388 FAX: (765) 494-4007
Web: www.mcmp.purdue.edu/faculty/morre.php
Email: morred@purdue.edu
Xiaoyu Tang, Zengsui Tian, Pin-Ju Chueh, Ssuhen Chen,
Dorothy M. Morre and D. James Morre, Alternative Splicing
as the Basis for Specific Localization of tNOX, a Unique Hy-
droquinone (NADH) Oxidase, to the Cancer Cell Surface,
Biochemistry, 46, 12337-12346 (2007).
Raymond Cooper, Talash A. Likimani, D. James Morre
and Dorothy M. Morre, Catechins and caffeine in tea: A review
of health risks and benefits, Caffeine Act. Theory, 351-
364 (2007).
D. James Morre and Hilton H. Mollenhauer, Microscopic
morphology and the origins of the membrane maturation
model of Golgi apparatus function, Int. Rev. Cytol, 262, 191-
218 (2007).
Kader Yagiz, Lion-Ying Wu, Charles P. Kuntz, D. James
Morre and Dorothy M. Morre, Mouse embryonic fibroblast
cells from transgenic mice overexpressing tNOX exhibit an
altered growth and drug response phenotype, J. Cell. Biochem,
101, 295-306 (2007).
D. James Morre, Steve Heald, Jason Coleman, John Orczyk,
Ziying Jiang and Dorothy M. Morre, Structural observa-
tions of time dependent oscillatory behavior of copper (II)
chloride solutions measured via extended X-ray absorption
fine structure, J. Inorg. Biochem, 101, 715-726 (2007).
D. James Morre, P.-J. Chueh, Kader Yagiz, Andrew Balicki,
Chinpal Kim and Dorothy M. Morre, ECTO-NOX target
for the anticancer isoflavene phenoxodiol, Oncol. Res,
16, 299-312 (2007).
Connie M. Weaver, Stephen Barnes, J. Michael Wyss, Hel-
en Kim, Dorothy M. Morre, D. James Morre, James E. Si-
mon, Mary Ann Lila, Elsa M. Janle and Mario G. Ferruzzi,
Botanicals for age-related diseases: from field to practice,
Am. J. Clin. Nutr, 87, 493S-497S (2008).
D. James Morre, Sara Dick, Elena Bosneaga, Andrew Bal-
icki, Lian-Ying Wu, Nicole McClain and Dorothy M. Morre,
tNOX (ENOX1) target for chemosensitization—low-dose re-
Sarah Melissa P. Jacobo, Dichotomy of Cav1.2 and Cav1.3
L-type Ca2+ channel function and modulation in GLP-1mediated
insulin exocytosis and ERK1/2 activation in pancreatic
beta cells. (D)
HU, CHANG-DENG (b.1961) Associate Professor.
M.D, 1984, Bengbu Medical College, China; M.S, 1987,
Tongji Medical University, China; Ph.D, 1997, Kobe
University School of Medicine, Japan. Research Investigator/Specialist,
2000-2003, Univ. of Michigan School
of Medicine. Cell Biology; Developmental Biology. Our
lab is developing novel technologies to study AP-1 in
cancer cells and in C. elegans. Our recent publications
include papers published in The EMBO Journal,
(25:1058,2006), BioTechniques(40:61, 2006), Nature
protocol (3:588, 3:1693, 2008), PNAS (105:101, 2008),
Cancer Research (68:9663, 2008), and Trends in Biotechnology
(26:622, 2008). TEL: (765) 496-1971 FAX:
(765) 494-1414
Web: www.mcmp.purdue.edu/faculty/hu.php
Email: cdhu@pharmacy.purdue.edu
Xuehong Deng, Han Liu, Jiaoti Huang, Liang Cheng, Evan
T. Keller, Sarah J. Parsons and Chang-Deng Hu, Ionizing radiation
induces prostate cancer neuroendocrine differentiation
through interplay of CREB and ATF2: Implications for
Laboratory 3R and University of Basel. Computational
Chemistry; Medicinal and/or Pharmaceutical Chemistry.
Development of novel concepts for computer-aided drug
discovery with incorporation of protein flexibility. Focus
on quantifying binding affinities. Application focus on
lead optimization and drug metabolism. TEL: (765) 496-
9375 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/?uid=mlill
Email: mlill@purdue.edu
Angelo Vedani, Martin Zumstein, Markus A. Lill and Beat
Ernst, Simulating / selectivity at the human thyroid hormone
receptor: consensus scoring using multidimensional
QSAR, ChemMedChem, 2, 78-87 (2007).
Markus A. Lill and Angelo Vedani, Computational modeling
of receptor-mediated toxicity, Comput. Toxicol, 315-351,
4 plates (2007).
Markus A. Lill, Multi-dimensional QSAR in drug discovery,
Drug Discovery Today, 12, 1013-1017 (2007).
Nima Sharifi, Ernest Hamel, Markus A. Lill, Prabhakar
Risbood, Charles T. Kane, Jr., Md Tafazzal Hossain, Amanda
Jones, James T. Dalton and William L. Farrar, A bifunctional
colchicinoid that binds to the androgen receptor, Mol.
Cancer Ther, 6, 2328-2336 (2007).
Qing Jiang, Xinmin Yin, Markus A. Lill, Matthew L. Danielson,
Helene Freiser and Jianjie Huang, Long-chain carbox-
ychromanols, metabolites of vitamin E, are potent inhibitors
sponses in the hormetic concentration range, Amer. J. Pharmacol.
Toxicol, 3, 16-26 (2008).
Ziying Jiang, Nina M. Gorenstein, Dorothy M. Morre and
D. James Morre, Molecular cloning and characterization of a
candidate human growth-related and time-keeping constitu-
tive cell surface hydroquinone (NADH) oxidase, Biochemis-
try, 47, 14018-14038 (2008).
Dorothy M. Morre, D. James Morre, Winfield Rehmus and
Dale Kern, Supplementation with CoQ10 lowers age-related
(ar) NOX levels in healthy subjects, BioFactors, 32, 221-230
(2008).
D. James Morre and Dorothy M. Morre, arNOX activity of
saliva as a non-invasive measure of coenzyme Q10 response
in human trials, BioFactors, 32, 231-235 (2008).
Kader Yagiz, P. W. Snyder, D. James Morre and Dorothy
M. Morre, Cell size increased in tissues from transgenic mice
overexpressing a cell surface growth-related and cancer-spe-
cific hydroquinone oxidase, tNOX, with protein disulfide-thiol
interchange activity, J. Cell. Biochem, 105, 1437-1442
(2008).
Elsa Janle, Dorothy M. Morre, D. James Morre, Q. Zhou,
H. Chang and Y. Zhu, Pharmacokinetics of green tea catech-
ins in extract and sustained-release preparations, J. Dietary
Supplements, 5, 248-263 (2008).
D. James Morre, Ziying Jiang, Milorad Marjanovic, John
Orczyk and Dorothy M. Morre, Response of the regulatory
behavior of copperII disease progression, Cancer Res, 68, 9663-9670 (2008). of cyclooxygenases, Proc. Natl. Acad. Sci, 105, 20464-20469
-containing ECTO-NOX proteins and
CuII Susan M. Hiatt, Y. John Shyu, Holli M. Duren and Chang- (2008).
Cl2 in solution to electromagnetic fields, J. Inorg. Biochem,
102, 1812-1818 (2008).
Deng Hu, Bimolecular fluorescence complementation (BiFC)
analysis of protein interactions in Caenorhabditis elegans,
Methods (Oxford, U. K.), 45, 185-191 (2008).
LOUDON, G. MARC (b.1942) Cwalina Distinguished
Professor of Med. Chem. & Mol. Pharm. B.S, 1964,
D. James Morre, John Orczyk, Heather Hignite and Chinpal
Kim, Regular oscillatory behavior of aqueous solutions of
CuII salts related to equilibrium dynamics of ortho/para hy-

4 PURDUE
drogen spin isomers of water, J. Inorg. Biochem, 102, 260-
267 (2008).
Jessica Kromkowski, Heather Hignite, Dorothy M. Morre
and D. James Morre, Response to lithium of a cell surface
ECTO-NOX protein with time-keeping characteristics, Neurosci.
Lett, 438, 121-125 (2008).
Xiaoyu Tang, D. James Morre and Dorothy M. Morre, Antisense
experiments demonstrate an exon 4 minus splice variant
mRNA as the basis for expression of tNOX, a cancer-specific
cell surface protein, Oncol. Res, 16, 557-567 (2008).
D. James Morre and Dorothy M. Morre, ENOX proteins,
copper hexahydrate-based ultridian oscillators of the cells’
biological clock, Ultradian Rhythms from Molecules to
Mind: A New Vision of Life, 43-84 (2008).
gy landscapes of proteins by using proteolysis as a structural
probe. By using proteolysis we can monitor protein
folding and unfolding under unconventional conditions,
such as cell lysates, or on a proteomic scale. We also develop
proteomic tools to identify cellular drug targets by
monitoring stability changes upon drug binding on a proteomic
scale. TEL: (765) 496-7513 FAX: (765) 494-
1414
Web: people.pharmacy.purdue.edu/~park6/index.html
Email: chiwook@purdue.edu
Chiwook Park, Sharleen Zhou, Jacqueline Gilmore and Susan
Marqusee, Energetics-based Protein Profiling on a Pro-
teomic Scale: Identification of Proteins Resistant to Proteolysis,
J. Mol. Biol, 368, 1426-1437 (2007).
Email: driese@purdue.edu
David J. Riese, II, Richard M. Gallo and Jeffrey Settleman,
Mutational activation of ErbB family receptor tyrosine ki-
nases: insights into mechanisms of signal transduction and
tumorigenesis, BioEssays, 29, 558-565 (2007).
Nadia Godin-Heymann, Ianthe Bryant, Miguel N. Rivera,
Lindsey Ulkus, Daphne W. Bell, David J. Riese, II, Jeffrey
Settleman and Daniel A. Haber, Oncogenic Activity of Epidermal
Growth Factor Receptor Kinase Mutant Alleles Is Enhanced
by the T790M Drug Resistance Mutation, Cancer
Res, 67, 7319-7326 (2007).
Richard M. Gallo and David J. Riese, II, The antibody sc-
33040-R fails to specifically recognize phosphorylation of
ErbB4 on tyrosine1056, Growth Factors, 25, 329-333
(2007).
NICHOLS, DAVID E. (b.1944) Professor. B.S, 1969,
University of Cincinnati; Ph.D, 1973, University of
Iowa. Postdoctoral Fellowship, 1973-1974, University of
Iowa. Medicinal and/or Pharmaceutical Chemistry; Neuroscience.
Synthesis and structure-activity relationships
of drugs affecting the central nervous system. Synthesis
of rigid analogs of neurotransmitters and related molecules.
Hallucinogens. Molecular pharmacology. Molecular
modeling of GPCRs. Drugs to treat Parkinson’s disease,
and to improve memory and cognitive deficits in
schizophrenia. TEL: (765) 494-1461 FAX: (765) 494-
1414
Web: www.mcmp.purdue.edu/faculty/nichols.php
Email: drdave@purdue.edu
Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie
J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate)
iodide, MTS-
MPP
Chiwook Park, Effects of salt and pH on binding and catalysis
by ribonuclease A. (D)
PARKER, LAURIE L. Assistant Professor. B.A,
2000, University of St. Thomas; Ph.D, 2003, University
of Glasgow. Postdoctoral Fellow, 2003-2008, University
of Chicago. Bioengineering; Chemical Biology. Ourlab
uses chemical biology and proteomics to develop biosen-
sors for intracellular phosphorylation signaling. We will
use synthetic peptide and protein chemistry to design and
synthesize probes for multiplexed analysis of cancer-related
signaling proteins e.g. Abl, other Src-family kinases,
receptor tyrosine kinases, etc. TEL: (765) 496-
3974 FAX: (765) 494-1414
Web: ccehub.org/groups/parkerlab
Email: llparker@purdue.edu
Ding Wu, Michael R. Mand, Darren R. Veach, Laurie L.
Richard M. Gallo and David J. Riese, II, Activating mutations
of ErbB family receptor tyrosine kinases, Recent Prog.
Cancer Res, 1-10 (2007).
Jennifer L. GIlmore, Jeffrey A. Scott, Zhor Bouizar, Alex
Robling, Sarah E. Pitfield, David J. Riese, II and John Foley,
Amphiregulin-EGFR signaling regulates PTHrP gene expression
in breast cancer cells, Breast Cancer Res. Treat, 110,
493-505 (2008).
S. Michael Rothenberg, Jeffrey A. Engelman, Sheila Le,
David J. Riese, II, Daniel A. Haber and Jeffrey Settleman,
Modeling oncogene addiction using RNA interference, Proc.
Natl. Acad. Sci. U. S. A, 105, 12480-12484 (2008).
Ianthe Nancy Bryant-Gawthrop, Regulation of tumor suppression
by ErbB4. (M)
Richard Michael Gallo, ErbB4 signal transduction and subcellular
localization during prostate tumor suppression. (D)
ROCHET, JEAN-CHRISTOPHE (b.1969) Asso-
+ , a novel scanning cysteine accessibility method
(SCAM) reagent for monoamine transporter studies, Bioorg.
Med. Chem, 15, 305-311 (2007).
Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul
W. Czoty, David E. Nichols and Michael A. Nader, Ambient
temperature effects on 3,4-methyl-
enedioxymethamphetamine-induced thermodysregulation
and pharmacokinetics in male monkeys, Drug Metab. Dispos,
35, 1840-1845 (2007).
Jonathan D. Urban, William P. Clarke, Mark von Zastrow,
David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan
A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M.
Sexton, Keith J. Miller, Michael Spedding and Richard B.
Mailman, Functional selectivity and classical concepts of
quantitative pharmacology, J. Pharmacol. Exp. Ther, 320, 1-
13 (2007).
Michael R. Braden and David E. Nichols, Assessment of
the roles of serines 5.43(239) and 5.46(242) for binding and
potency of agonist ligands at the human serotonin 5-HT2A receptor,
Mol. Pharmacol, 72, 1200-1209 (2007).
Danuta Marona-Lewicka and David E. Nichols, Further
evidence that the delayed temporal dopaminergic effects of
LSD are mediated by a mechanism different than the first
temporal phase of action, Pharmacol., Biochem. Behav, 87,
453-461 (2007).
Jennifer Selken and David E. Nichols, 1-Adrenergic receptors
mediate the locomotor response to systemic administration
of (±)-3,4-methylenedioxymethamphetamine
(MDMA) in rats, Pharmacol., Biochem. Behav, 86, 622-630
(2007).
Matthew A. Parker, Deborah M. Kurrasch and David E.
Nichols, The role of lipophilicity in determining binding affinity
and functional activity for 5-HT2A receptor ligands, Bioorg.
Med. Chem, 16, 4661-4669 (2008).
David E. Nichols, Stewart P. Frescas, Benjamin R. Che-
mel, Kenneth S. Rehder, Desong Zhong and Anita H. Lewin,
High specific activity tritium-labeled N-(2-methoxybenzyl)-
2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity
5-HT2A receptor-selective agonist radioligand, Bioorg.
Med. Chem, 16, 6116-6123 (2008).
Danielle M. Schultz, Jennifer A. Prescher, Stephanie Kidd,
Danuta Marona-Lewicka, David E. Nichols and Aaron
Monte, Hybrid benzofuran-benzopyran congeners as rigid
analogs of hallucinogenic phenethylamines, Bioorg. Med.
Chem, 16, 6242-6251 (2008).
David E. Nichols and Charles D. Nichols, Serotonin Re-
ceptors, Chem. Rev. (Washington, DC, U. S.), 108, 1614-
1641 (2008).
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and
Eric L. Barker, Comparative molecular field analysis using
selectivity fields reveals residues in the third transmembrane
helix of the serotonin transporter associated with substrate
and antagonist recognition, J. Pharmacol. Exp. Ther, 325,
791-800 (2008).
Parker, Bayard Clarkson and Stephen J. Kron, A solid-phase
Bcr-Abl kinase assay in 96-well hydrogel plates, Anal. Biochem,
375, 18-26 (2008).
Laurie L. Parker and Stephen J. Kron, Kinase activation in
circulating cells: opportunities for biomarkers for diagnosis
and therapeutic monitoring, Expert Opin. Med. Diagn, 2, 33-
46 (2008).
L. L. Parker, A. Engel-Hall, K. Drew, G. Steinhardt, D. L.
Helseth, D. S. Angulo, D. Jabon, S. B. H. Kent and S. J.
Kron, Investigating quantitation of phosphorylation using
MALDI-TOF mass spectrometry, Journal of Mass Spectrometry,
43, 518-527 (2008).
POST, CAROL B. (b.1952) Professor. B.A, 1975,
University of Arizona; Ph.D, 1981, University of California,
San Diego. NIH Fellowship, 1982, Harvard University.
Biophysics/Biophysical Chemistry; Computation-
al Chemistry. Protein structure, protein-ligand interac-
tions, and enzymatic catalysis using experimental NMR
and molecular dynamics. TEL: (765) 494-5980 FAX:
(765) 496-1189
Web: bilbo.bio.purdue.edu/~postgrp
Email: cbp@purdue.edu
Carol B. Post, Transition states: substrate-induced conformational
transitions, Handb. Proteins, 1, 541-547 (2007).
Z. Zhou, C. Patkar, J. Suk, M. Khaliq, L. Li and C. B. Post,
Antiviral compounds discovered by virtual screening of
small-molecule libraries against dengue virus E protein, ACS
Chemical Biology (cover title), 3, 765-775 (2008).
Z. Li, M. Khaliq, Z. Zhou, C. B. Post, R. J. Kuhn and M.
Cushman, Design, synthesis, and biological evaluation of an-
tiviral agents targeting flavivirus envelope protein, J. Med.
Chem, 1, 4660-4671 (2008).
V. M. Dadarlat and C. B. Post, Contribution of charged
groups to the enthalpic stabilization of the folded states of
globular proteins, J. Phys. Chem. B, 112, 6159-6167 (2008).
Y. Zhang, H. Oh, R. A. Burton, J. W. Burgner, R. L. Geahlen
and C. B. Post, Tyr130 phosphorylation triggers Syk release
from antigen receptor by long-distance conformational
uncoupling, PNAS, 105, 11760-11765 (2008).
E. Ozkirmili, S. Singh, W. T. Miller and C. B. Post, An
electrostatic network is functional in the long-range regula-
tion of Src kinases, Protein Science (cover illustration),
(2008).
Elif Ozkirimli, Src kinase activation investigated by computational
methods. (D)
Jae-eun Suk, Structure and dynamic studies of viral capsid
proteins. (D)
Yajie Zhang, Characterization of structural and dynamic
properties of Syk tandem SH2 domain and its interaction
with diphosphorylated-ITAM Important in B cell signaling
regulation. (D)
ciate Professor. B.Sc, 1991, University of Alberta; Ph.D,
1998, University of Alberta. Post-doctoral Fellow, 1999-
2002, Harvard Medical School. Biochemistry; Neuroscience.
Neurodegeneration, Parkinson’s disease, protein
misassembly, amyloid, aggresome, synuclein, synuclein-
opathy, protein-membrane interactions, chaperones,
Hsp70, Hsp27, proteasome, autophagy, protein oxida-
tion, mitochondria, mitochondrial toxins, neuroprotective
agents, antioxidant response, DJ-1, methionine sulfoxide
reductase, endoplasmic reticulum stress, neuron-glia interactions,
methamphetamine neurotoxicity. TEL: (765)
494-1413 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/rochet.php
Email: jrochet@purdue.edu
rochet@pharmacy.purdue.edu
Stephanie D. Tammam, Jean-Christophe Rochet and Marie
E. Fraser, Identification of the cysteine residue exposed by
the conformational change in pig heart succinyl-CoA:3-keto-
acid coenzyme A transferase on binding coenzyme A, Biochemistry,
46, 10852-10863 (2007).
Stanislav D. Zakharov, John D. Hulleman, Elena A. Dutseva,
Yuri N. Antonenko, Jean-Christophe Rochet and William
A. Cramer, Helical -Synuclein Forms Highly Conductive
Ion Channels, Biochemistry, 46, 14369-14379 (2007).
John D. Hulleman, Hamid Mirzaei, Emmanuel Guigard,
Kellie L. Taylor, Soumya S. Ray, Cyril M. Kay, Fred E. Regnier
and Jean-Christophe Rochet, Destabilization of DJ-1 by
Familial Substitution and Oxidative Modifications: Implica-
tions for Parkinson’s Disease, Biochemistry, 46, 5776-5789
(2007).
Lee R. Cambrea, Farzin Haque, Jeremy L. Schieler, Jean-
Christophe Rochet and Jennifer S. Hovis, Effect of ions on
the organization of phosphatidylcholine/phosphatidic acid bilayers,
Biophys. J, 93, 1630-1638 (2007).
J.-C. Rochet, Novel therapeutic strategies for the treatment
of protein misfolding diseases, Expert Rev. Mol. Med, 9, 1-34
(2007).
S. Padalkar, J. D. Hulleman, R. Colby, P. Deb, K. Cunze-
man, J.-C. Rochet, E. Stach and L. Stanciu, Diameter con-
trolled silver and platinum nanowires on a new biological
template, Nanotechnology, 18 (2007).
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M.
Altmann, Irina Kufareva, Katherine E. Strathearn, Allison M.
Amore, Catherine B. Volk, Michele M. Maxwell, Jean-Christophe
Rochet, Pamela J. McLean, Anne B. Young, Ruben
Abagyan, Mel B. Feany, Bradley T. Hyman and Aleksey G.
Kazantsev, Sirtuin 2 Inhibitors Rescue -Synuclein-Mediat-
ed Toxicity in Models of Parkinson’s Disease, Science
(Washington, DC, U. S.), 317, 516-519 (2007).
Fang Liu, Jagadish Hindupur, Jamie L. Nguyen, Katie J.
Ruf, Junyi Zhu, Jeremy L. Schieler, Connie C. Bonham, Karl
V. Wood, V. Jo Davisson and Jean-Christophe Rochet, Me-
thionine sulfoxide reductase A protects dopaminergic cells
J. P. Cueva, Inquiry into the structural and conformational
requirements of -phenyldopamine-type ligands for selective
dopamine D1 receptor activation. (D)
M. R. Braden, Towards a biophysical understanding of hallucinogen
action. (D)
PARK, CHIWOOK Assistant Professor. B.S, 1991,
Seoul National University; M.S, 1993, Seoul National
University; Ph.D, 2000, University of Wisconsin-Madison.
Postdoctoral Researcher, 2001-2005, University of
California, Berkeley. Biophysics/Biophysical Chemistry;
Structural Biology. We investigate conformational ener-
RIESE, DAVID J., II (b.1965) Associate Professor.
A.B, 1987, Wabash College; M.Phil, 1989, Yale Univer-
sity; Ph.D, 1993, Yale University. USAMRMC Fellow,
1993-1995, Yale University; ASAMRMC Assoc. Research
Scientist, 1995-1997, Yale University. Molecular
Biology; Pharmacology. ErbB family receptor tyrosine
kinase signal transduction; Epidermal Growth Factor receptor
(EGFR); tumor cell biology; mammary, prostate,
lung, and pancreatic tumorigenesis. TEL: (765) 494-
6091 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/riese.php
from Parkinson’s disease-related insults, Free Radical Biol.
Med, 45, 242-255 (2008).
J.-C. Rochet and J. L. Schieler, The use of cell-free systems
to characterize Parkinson’s disease-related gene products,
In: Nass, R. & Przedborski, S., eds. Parkinson’s Disease:
Molecular and Therapeutic Insights from Model Sys-
tems. San Diego, CA: Elsevier, 597-627 (2008).
J.-C. Rochet and J. D. Hulleman, Alpha-synuclein self-assembly
in Parkinson’s disease: Insights from biophysical
analyses, In: Outeiro, T. F., ed. Protein Misfolding in Biolo-
gy and Disease. Trivandrum, India: Research Signpost, 151-
180 (2008).
R. Colby, J. D. Hulleman, S. Padalkar, J.-C. Rochet and L.

A. Stanciu, Biotemplated synthesis of metallic nanoparticle
chains on an alpha-synuclein fiber scaffold, J. Nanosci. Nanotechnol,
8, 973-978 (2008).
Fang Liu, Jamie L. Nguyen, John D. Hulleman, Li Li and
Jean-Christophe Rochet, Mechanisms of DJ-1 neuroprotection
in a cellular model of Parkinson’s disease, J. Neurochem,
105, 2435-2453 (2008).
S. Padalkar, J. D. Hulleman, J.-C. Rochet, E. A. Stach and
L. A. Stanciu, Protein-templated semiconductor nanoparticle
chains, Nanotechnology, 19 (2008).
Aaron D. Gitler, Brooke J. Bevis, James Shorter, Katherine
E. Strathearn, Shusei Hamamichi, Linhui Julie Su, Kim A.
Caldwell, Guy A. Caldwell, Jean-Christophe Rochet, J. Michael
McCaffery, Charles Barlowe and Susan Lindquist, The
Parkinson’s disease protein -synuclein disrupts cellular Rab
homeostasis, Proc. Natl. Acad. Sci. U. S. A, 105, 145-150
(2008).
J. D. Hulleman, Regulation of DJ-1 structure and function:
Implications for Parkinson’s disease. (D)
SVENSSON, CRAIG K. (b.1957) Dean and Professor.
D.Phil, 1981, University of Maryland; Ph.D, 1985,
State University of New York at Buffalo. Postdoctoral
Research Associate, 1984-1985, State University of New
York at Buffalo. Pharmacology. Adverse Drug Reactions;
Drug Hypersensitivity. TEL: (765) 494-1368
FAX: (765) 494-7880
Web: www.mcmp.purdue.edu/faculty/?uid=svensson
Email: svensson@purdue.edu
Sanjoy Roychowdhury, Albert E. Cram, Al Aly and Craig
K. Svensson, Detection of haptenated proteins in organotypic
human skin explant cultures exposed to dapsone, Drug Metab.
Dispos, 35, 1463-1465 (2007).
Sanjoy Roychowdhury, Piyush M. Vyas and Craig K.
Svensson, Formation and uptake of arylhydroxylamine-haptenated
proteins in human dendritic cells, Drug Metab. Dispos,
35, 676-681 (2007).
Farah D. Khan, Piyush M. Vyas, Anthony A. Gaspari and
Craig K. Svensson, Effect of arylhydroxylamine metabolites
of sulfamethoxazole and dapsone on stress signal expression
in human keratinocytes, J. Pharmacol. Exp. Ther, 323, 771-
777 (2007).
Craig K. Svensson and Jean-Michel Scherrmann, Current
advances and future directions for CNS delivery, AAPS Journal,
10, 587-588 (2008).
Craig K. Svensson, Drug Eruptions, Clinical and Basic Immunodermatology,
263-276 (2008).
Sree D. Panuganti and Craig K. Svensson, Drug clearance,
Preclin. Dev. Handb.: ADME Biopharm. Prop, 715-742
(2008).
WATTS, VAL J. (b.1966) Associate Professor. B.S,
1990, Ohio Northern University; Ph.D, 1994, University
of North Carolina. NARSAD Young Investigator, NIH
Training Fellowship, 1995-1998, Oregone Health and
Science University. Neuroscience; Pharmacology. D2
dopamine receptor signaling, selective modulators of D1
and D5 dopamine receptors, G proteins, Dexras1, PKC
modulation of adenylyl cyclases, RGS proteins, heterologous
sensitization of recombinant adenylyl cyclases, behavioral
sensitization. TEL: (765) 496-3872 FAX: (765)
494-1414
Web: people.pharmacy.purdue.edu/~vwatts/
Email: wattsv@pharmacy.purdue.edu
V. J. Watts, Adenylyl cyclase isoforms as novel therapeutic
targets: an exciting example of excitotoxicity neuroprotection,
Mol. Interventions, 7, 70-73 (2007).
J. A. Chester and V. J. Watts, Adenylyl cyclase 5: A new
clue in the search for the “fountain of youth‘?, Sci STKE,
pe64 (2007).
P. A. Vidi, J. Chen, J. M. K. Irudayaraj and V. J. Watts,
Adenosine A2A receptors assemble into higher-order oligomers
at the plasma membrane, FEBS Letters, 582, 3985-
3990 (2008).
F. S. Willard, Z. Zheng, J. Guo, G. J. Digby, A. J. Kimple,
J. M. Conley, C. A. Johnston, D. Bosch, M. D. Willard, V. J.
Watts, K. A. Lambert, S. R. Ikeda, Q. Du and D. P. Siderovski,
A point mutation to Galphai selectively blocks GoLoco
motif binding: Direct evidence for Galpha.GoLoco complexes
in mitotic spindle dynamics, J. Biol. Chem, 283,
36698-36710 (2008).
P. A. Vidi, B. R. Chemel, C.-D. Hu and V. J. Watts, Ligand-dependent
oligomerization of dopamine D2 and adenosine
A2A receptors in living neuronal cells, Mol. Pharmacol,
74, 544-551 (2008).
PURDUE 5