PURDUE UNIVERSITY

4 PURDUE
drogen spin isomers of water, J. Inorg. Biochem, 102, 260-
267 (2008).
Jessica Kromkowski, Heather Hignite, Dorothy M. Morre
and D. James Morre, Response to lithium of a cell surface
ECTO-NOX protein with time-keeping characteristics, Neurosci.
Lett, 438, 121-125 (2008).
Xiaoyu Tang, D. James Morre and Dorothy M. Morre, Antisense
experiments demonstrate an exon 4 minus splice variant
mRNA as the basis for expression of tNOX, a cancer-specific
cell surface protein, Oncol. Res, 16, 557-567 (2008).
D. James Morre and Dorothy M. Morre, ENOX proteins,
copper hexahydrate-based ultridian oscillators of the cells’
biological clock, Ultradian Rhythms from Molecules to
Mind: A New Vision of Life, 43-84 (2008).
gy landscapes of proteins by using proteolysis as a structural
probe. By using proteolysis we can monitor protein
folding and unfolding under unconventional conditions,
such as cell lysates, or on a proteomic scale. We also develop
proteomic tools to identify cellular drug targets by
monitoring stability changes upon drug binding on a proteomic
scale. TEL: (765) 496-7513 FAX: (765) 494-
1414
Web: people.pharmacy.purdue.edu/~park6/index.html
Email: chiwook@purdue.edu
Chiwook Park, Sharleen Zhou, Jacqueline Gilmore and Susan
Marqusee, Energetics-based Protein Profiling on a Pro-
teomic Scale: Identification of Proteins Resistant to Proteolysis,
J. Mol. Biol, 368, 1426-1437 (2007).
Email: driese@purdue.edu
David J. Riese, II, Richard M. Gallo and Jeffrey Settleman,
Mutational activation of ErbB family receptor tyrosine ki-
nases: insights into mechanisms of signal transduction and
tumorigenesis, BioEssays, 29, 558-565 (2007).
Nadia Godin-Heymann, Ianthe Bryant, Miguel N. Rivera,
Lindsey Ulkus, Daphne W. Bell, David J. Riese, II, Jeffrey
Settleman and Daniel A. Haber, Oncogenic Activity of Epidermal
Growth Factor Receptor Kinase Mutant Alleles Is Enhanced
by the T790M Drug Resistance Mutation, Cancer
Res, 67, 7319-7326 (2007).
Richard M. Gallo and David J. Riese, II, The antibody sc-
33040-R fails to specifically recognize phosphorylation of
ErbB4 on tyrosine1056, Growth Factors, 25, 329-333
(2007).
NICHOLS, DAVID E. (b.1944) Professor. B.S, 1969,
University of Cincinnati; Ph.D, 1973, University of
Iowa. Postdoctoral Fellowship, 1973-1974, University of
Iowa. Medicinal and/or Pharmaceutical Chemistry; Neuroscience.
Synthesis and structure-activity relationships
of drugs affecting the central nervous system. Synthesis
of rigid analogs of neurotransmitters and related molecules.
Hallucinogens. Molecular pharmacology. Molecular
modeling of GPCRs. Drugs to treat Parkinson’s disease,
and to improve memory and cognitive deficits in
schizophrenia. TEL: (765) 494-1461 FAX: (765) 494-
1414
Web: www.mcmp.purdue.edu/faculty/nichols.php
Email: drdave@purdue.edu
Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie
J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate)
iodide, MTS-
MPP
Chiwook Park, Effects of salt and pH on binding and catalysis
by ribonuclease A. (D)
PARKER, LAURIE L. Assistant Professor. B.A,
2000, University of St. Thomas; Ph.D, 2003, University
of Glasgow. Postdoctoral Fellow, 2003-2008, University
of Chicago. Bioengineering; Chemical Biology. Ourlab
uses chemical biology and proteomics to develop biosen-
sors for intracellular phosphorylation signaling. We will
use synthetic peptide and protein chemistry to design and
synthesize probes for multiplexed analysis of cancer-related
signaling proteins e.g. Abl, other Src-family kinases,
receptor tyrosine kinases, etc. TEL: (765) 496-
3974 FAX: (765) 494-1414
Web: ccehub.org/groups/parkerlab
Email: llparker@purdue.edu
Ding Wu, Michael R. Mand, Darren R. Veach, Laurie L.
Richard M. Gallo and David J. Riese, II, Activating mutations
of ErbB family receptor tyrosine kinases, Recent Prog.
Cancer Res, 1-10 (2007).
Jennifer L. GIlmore, Jeffrey A. Scott, Zhor Bouizar, Alex
Robling, Sarah E. Pitfield, David J. Riese, II and John Foley,
Amphiregulin-EGFR signaling regulates PTHrP gene expression
in breast cancer cells, Breast Cancer Res. Treat, 110,
493-505 (2008).
S. Michael Rothenberg, Jeffrey A. Engelman, Sheila Le,
David J. Riese, II, Daniel A. Haber and Jeffrey Settleman,
Modeling oncogene addiction using RNA interference, Proc.
Natl. Acad. Sci. U. S. A, 105, 12480-12484 (2008).
Ianthe Nancy Bryant-Gawthrop, Regulation of tumor suppression
by ErbB4. (M)
Richard Michael Gallo, ErbB4 signal transduction and subcellular
localization during prostate tumor suppression. (D)
ROCHET, JEAN-CHRISTOPHE (b.1969) Asso-
+ , a novel scanning cysteine accessibility method
(SCAM) reagent for monoamine transporter studies, Bioorg.
Med. Chem, 15, 305-311 (2007).
Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul
W. Czoty, David E. Nichols and Michael A. Nader, Ambient
temperature effects on 3,4-methyl-
enedioxymethamphetamine-induced thermodysregulation
and pharmacokinetics in male monkeys, Drug Metab. Dispos,
35, 1840-1845 (2007).
Jonathan D. Urban, William P. Clarke, Mark von Zastrow,
David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan
A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M.
Sexton, Keith J. Miller, Michael Spedding and Richard B.
Mailman, Functional selectivity and classical concepts of
quantitative pharmacology, J. Pharmacol. Exp. Ther, 320, 1-
13 (2007).
Michael R. Braden and David E. Nichols, Assessment of
the roles of serines 5.43(239) and 5.46(242) for binding and
potency of agonist ligands at the human serotonin 5-HT2A receptor,
Mol. Pharmacol, 72, 1200-1209 (2007).
Danuta Marona-Lewicka and David E. Nichols, Further
evidence that the delayed temporal dopaminergic effects of
LSD are mediated by a mechanism different than the first
temporal phase of action, Pharmacol., Biochem. Behav, 87,
453-461 (2007).
Jennifer Selken and David E. Nichols, 1-Adrenergic receptors
mediate the locomotor response to systemic administration
of (±)-3,4-methylenedioxymethamphetamine
(MDMA) in rats, Pharmacol., Biochem. Behav, 86, 622-630
(2007).
Matthew A. Parker, Deborah M. Kurrasch and David E.
Nichols, The role of lipophilicity in determining binding affinity
and functional activity for 5-HT2A receptor ligands, Bioorg.
Med. Chem, 16, 4661-4669 (2008).
David E. Nichols, Stewart P. Frescas, Benjamin R. Che-
mel, Kenneth S. Rehder, Desong Zhong and Anita H. Lewin,
High specific activity tritium-labeled N-(2-methoxybenzyl)-
2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity
5-HT2A receptor-selective agonist radioligand, Bioorg.
Med. Chem, 16, 6116-6123 (2008).
Danielle M. Schultz, Jennifer A. Prescher, Stephanie Kidd,
Danuta Marona-Lewicka, David E. Nichols and Aaron
Monte, Hybrid benzofuran-benzopyran congeners as rigid
analogs of hallucinogenic phenethylamines, Bioorg. Med.
Chem, 16, 6242-6251 (2008).
David E. Nichols and Charles D. Nichols, Serotonin Re-
ceptors, Chem. Rev. (Washington, DC, U. S.), 108, 1614-
1641 (2008).
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and
Eric L. Barker, Comparative molecular field analysis using
selectivity fields reveals residues in the third transmembrane
helix of the serotonin transporter associated with substrate
and antagonist recognition, J. Pharmacol. Exp. Ther, 325,
791-800 (2008).
Parker, Bayard Clarkson and Stephen J. Kron, A solid-phase
Bcr-Abl kinase assay in 96-well hydrogel plates, Anal. Biochem,
375, 18-26 (2008).
Laurie L. Parker and Stephen J. Kron, Kinase activation in
circulating cells: opportunities for biomarkers for diagnosis
and therapeutic monitoring, Expert Opin. Med. Diagn, 2, 33-
46 (2008).
L. L. Parker, A. Engel-Hall, K. Drew, G. Steinhardt, D. L.
Helseth, D. S. Angulo, D. Jabon, S. B. H. Kent and S. J.
Kron, Investigating quantitation of phosphorylation using
MALDI-TOF mass spectrometry, Journal of Mass Spectrometry,
43, 518-527 (2008).
POST, CAROL B. (b.1952) Professor. B.A, 1975,
University of Arizona; Ph.D, 1981, University of California,
San Diego. NIH Fellowship, 1982, Harvard University.
Biophysics/Biophysical Chemistry; Computation-
al Chemistry. Protein structure, protein-ligand interac-
tions, and enzymatic catalysis using experimental NMR
and molecular dynamics. TEL: (765) 494-5980 FAX:
(765) 496-1189
Web: bilbo.bio.purdue.edu/~postgrp
Email: cbp@purdue.edu
Carol B. Post, Transition states: substrate-induced conformational
transitions, Handb. Proteins, 1, 541-547 (2007).
Z. Zhou, C. Patkar, J. Suk, M. Khaliq, L. Li and C. B. Post,
Antiviral compounds discovered by virtual screening of
small-molecule libraries against dengue virus E protein, ACS
Chemical Biology (cover title), 3, 765-775 (2008).
Z. Li, M. Khaliq, Z. Zhou, C. B. Post, R. J. Kuhn and M.
Cushman, Design, synthesis, and biological evaluation of an-
tiviral agents targeting flavivirus envelope protein, J. Med.
Chem, 1, 4660-4671 (2008).
V. M. Dadarlat and C. B. Post, Contribution of charged
groups to the enthalpic stabilization of the folded states of
globular proteins, J. Phys. Chem. B, 112, 6159-6167 (2008).
Y. Zhang, H. Oh, R. A. Burton, J. W. Burgner, R. L. Geahlen
and C. B. Post, Tyr130 phosphorylation triggers Syk release
from antigen receptor by long-distance conformational
uncoupling, PNAS, 105, 11760-11765 (2008).
E. Ozkirmili, S. Singh, W. T. Miller and C. B. Post, An
electrostatic network is functional in the long-range regula-
tion of Src kinases, Protein Science (cover illustration),
(2008).
Elif Ozkirimli, Src kinase activation investigated by computational
methods. (D)
Jae-eun Suk, Structure and dynamic studies of viral capsid
proteins. (D)
Yajie Zhang, Characterization of structural and dynamic
properties of Syk tandem SH2 domain and its interaction
with diphosphorylated-ITAM Important in B cell signaling
regulation. (D)
ciate Professor. B.Sc, 1991, University of Alberta; Ph.D,
1998, University of Alberta. Post-doctoral Fellow, 1999-
2002, Harvard Medical School. Biochemistry; Neuroscience.
Neurodegeneration, Parkinson’s disease, protein
misassembly, amyloid, aggresome, synuclein, synuclein-
opathy, protein-membrane interactions, chaperones,
Hsp70, Hsp27, proteasome, autophagy, protein oxida-
tion, mitochondria, mitochondrial toxins, neuroprotective
agents, antioxidant response, DJ-1, methionine sulfoxide
reductase, endoplasmic reticulum stress, neuron-glia interactions,
methamphetamine neurotoxicity. TEL: (765)
494-1413 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/rochet.php
Email: jrochet@purdue.edu
rochet@pharmacy.purdue.edu
Stephanie D. Tammam, Jean-Christophe Rochet and Marie
E. Fraser, Identification of the cysteine residue exposed by
the conformational change in pig heart succinyl-CoA:3-keto-
acid coenzyme A transferase on binding coenzyme A, Biochemistry,
46, 10852-10863 (2007).
Stanislav D. Zakharov, John D. Hulleman, Elena A. Dutseva,
Yuri N. Antonenko, Jean-Christophe Rochet and William
A. Cramer, Helical -Synuclein Forms Highly Conductive
Ion Channels, Biochemistry, 46, 14369-14379 (2007).
John D. Hulleman, Hamid Mirzaei, Emmanuel Guigard,
Kellie L. Taylor, Soumya S. Ray, Cyril M. Kay, Fred E. Regnier
and Jean-Christophe Rochet, Destabilization of DJ-1 by
Familial Substitution and Oxidative Modifications: Implica-
tions for Parkinson’s Disease, Biochemistry, 46, 5776-5789
(2007).
Lee R. Cambrea, Farzin Haque, Jeremy L. Schieler, Jean-
Christophe Rochet and Jennifer S. Hovis, Effect of ions on
the organization of phosphatidylcholine/phosphatidic acid bilayers,
Biophys. J, 93, 1630-1638 (2007).
J.-C. Rochet, Novel therapeutic strategies for the treatment
of protein misfolding diseases, Expert Rev. Mol. Med, 9, 1-34
(2007).
S. Padalkar, J. D. Hulleman, R. Colby, P. Deb, K. Cunze-
man, J.-C. Rochet, E. Stach and L. Stanciu, Diameter con-
trolled silver and platinum nanowires on a new biological
template, Nanotechnology, 18 (2007).
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M.
Altmann, Irina Kufareva, Katherine E. Strathearn, Allison M.
Amore, Catherine B. Volk, Michele M. Maxwell, Jean-Christophe
Rochet, Pamela J. McLean, Anne B. Young, Ruben
Abagyan, Mel B. Feany, Bradley T. Hyman and Aleksey G.
Kazantsev, Sirtuin 2 Inhibitors Rescue -Synuclein-Mediat-
ed Toxicity in Models of Parkinson’s Disease, Science
(Washington, DC, U. S.), 317, 516-519 (2007).
Fang Liu, Jagadish Hindupur, Jamie L. Nguyen, Katie J.
Ruf, Junyi Zhu, Jeremy L. Schieler, Connie C. Bonham, Karl
V. Wood, V. Jo Davisson and Jean-Christophe Rochet, Me-
thionine sulfoxide reductase A protects dopaminergic cells
J. P. Cueva, Inquiry into the structural and conformational
requirements of -phenyldopamine-type ligands for selective
dopamine D1 receptor activation. (D)
M. R. Braden, Towards a biophysical understanding of hallucinogen
action. (D)
PARK, CHIWOOK Assistant Professor. B.S, 1991,
Seoul National University; M.S, 1993, Seoul National
University; Ph.D, 2000, University of Wisconsin-Madison.
Postdoctoral Researcher, 2001-2005, University of
California, Berkeley. Biophysics/Biophysical Chemistry;
Structural Biology. We investigate conformational ener-
RIESE, DAVID J., II (b.1965) Associate Professor.
A.B, 1987, Wabash College; M.Phil, 1989, Yale Univer-
sity; Ph.D, 1993, Yale University. USAMRMC Fellow,
1993-1995, Yale University; ASAMRMC Assoc. Research
Scientist, 1995-1997, Yale University. Molecular
Biology; Pharmacology. ErbB family receptor tyrosine
kinase signal transduction; Epidermal Growth Factor receptor
(EGFR); tumor cell biology; mammary, prostate,
lung, and pancreatic tumorigenesis. TEL: (765) 494-
6091 FAX: (765) 494-1414
Web: www.mcmp.purdue.edu/faculty/riese.php
from Parkinson’s disease-related insults, Free Radical Biol.
Med, 45, 242-255 (2008).
J.-C. Rochet and J. L. Schieler, The use of cell-free systems
to characterize Parkinson’s disease-related gene products,
In: Nass, R. & Przedborski, S., eds. Parkinson’s Disease:
Molecular and Therapeutic Insights from Model Sys-
tems. San Diego, CA: Elsevier, 597-627 (2008).
J.-C. Rochet and J. D. Hulleman, Alpha-synuclein self-assembly
in Parkinson’s disease: Insights from biophysical
analyses, In: Outeiro, T. F., ed. Protein Misfolding in Biolo-
gy and Disease. Trivandrum, India: Research Signpost, 151-
180 (2008).
R. Colby, J. D. Hulleman, S. Padalkar, J.-C. Rochet and L.