PURDUE UNIVERSITY

2 PURDUE
Arup Maiti, Muriel Cuendet, Vicki L. Croy, Denise C. En- mel, William E. Fogler, Gregory E. Agoston, Phillip E. Fan- tive Syk Tyrosine Kinase for the Study of Signaling Dynamdringer,
John M. Pezzuto and Mark Cushman, Synthesis and wick and Mark Cushman, Stereoselective Synthesis of 3,3- ics from the B Cell Antigen Receptor, J. Biol. Chem, 282,
Biological Evaluation of (±)-Abyssinone II and Its Ana- Diarylacrylonitriles as Tubulin Polymerization Inhibitors, J. 33760-33768 (2007).
logues as Aromatase Inhibitors for Chemoprevention of Org. Chem, 73, 4241-4244 (2008).
Fei Zhou, Jacob Galan, Robert L. Geahlen and W. Andy
Breast Cancer, J. Med. Chem, 50, 2799-2806 (2007).
Yunlong Song and Mark Cushman, The Binding Orienta- Tao, A Novel Quantitative Proteomics Strategy To Study
Takeshi Sakamoto, Matthew D. Cullen, Tracy L. Hartman, tion of a Norindenoisoquinoline in the Topoisomerase I- Phosphorylation-Dependent Peptide-Protein Interactions, J.
Karen M. Watson, Robert W. Buckheit, Christophe Pannec- DNA Cleavage Complex Is Primarily Governed by - Proteome Res, 6, 133-140 (2007).
ouque, Erik De Clercq and Mark Cushman, Synthesis and Stacking Interactions, J. Phys. Chem. B, 112, 9484-9489 Jun Wang, Ning Bao, Leela L. Paris, Hsiang-Yu Wang,
Anti-HIV Activity of New Metabolically Stable Alkenyldia- (2008). Robert L. Geahlen and Chang Lu, Detection of Kinase Transrylmethane
Non-Nucleoside Reverse Transcriptase Inhibitors Matthew Cullen, Deborah Miles, Arlene Rothwell, Connie location Using Microfluidic Electroporative Flow Cytometry,
Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadia- Bonham, Karl V. Wood and Mark Cushman, Hydrolysis of Anal. Chem. (Washington, DC, U. S.), 80, 1087-1093 (2008).
zole Systems, J. Med. Chem, 50, 3314-3321 (2007).
thioesters in an ion trap, Rapid Commun. Mass Spectrom, 22, Jun Wang, Ning Bao, Leela L. Paris, Robert L. Geahlen
Arup Maiti, Muriel Cuendet, Tamara Kondratyuk, Vicki L. 1094-1098 (2008). and Chang Lu, Total Internal Reflection Fluorescence Flow
Croy, John M. Pezzuto and Mark Cushman, Synthesis and
Cytometry, Anal. Chem. (Washington, DC, U. S.), 80, 9840-
Cancer Chemopreventive Activity of Zapotin, a Natural
Product from Casimiroa edulis, J. Med. Chem, 50, 350-355
(2007).
Andrew Morrell, Michael Placzek, Seth Parmley, Brian
Grella, Smitha Antony, Yves Pommier and Mark Cushman,
Optimization of the Indenone Ring of Indenoisoquinoline
Topoisomerase I Inhibitors, J. Med. Chem, 50, 4388-4404
(2007).
Andrew Morrell, Michael Placzek, Seth Parmley, Smitha
Antony, Thomas S. Dexheimer, Yves Pommier and Mark
Cushman, Nitrated Indenoisoquinolines as Topoisomerase I
Inhibitors: A Systematic Study and Optimization, J. Med.
Chem, 50, 4419-4430 (2007).
Matthew D. Cullen, Bo-Liang Deng, Tracy L. Hartman,
Karen M. Watson, Robert W. Buckheit, Jr., Christophe Pannecouque,
Erik De Clercq and Mark Cushman, Synthesis and
Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-
Nucleoside Reverse Transcriptase Inhibitors That Possess Increased
Hydrolytic Stability, J. Med. Chem, 50, 4854-4867
Juma Hoshino, Design and synthesis of analogs and metabolites
of resveratrol as chemopreventive agents. (M)
Katherine E. Peterson, Investigation of the stereochemical
effects of the indenoisoquinoline side chain on topoisomerase
i inhibition. (M)
Yanlei Zhang, Design, synthesis and bioevaluation of lumazine
synthase inhibitors. (M)
Andrew Edward O’Dell Morrell, Development of topoisomerase
I inhibitors as anticancer agents. (D)
Matthew David Cullen, Investigations on alkenyldiarylmethase
HIV-1 reverse transcriptase inhibitors: Mechanism of
action, synthesis, and metabolic evaluation of hydrolytically
stable analogues. (D)
DAVISSON, VINCENT JO (b.1955) Professor. B.A,
1978, Wittenberg University; M.S, 1983, Indiana Uni-
versity; Ph.D, 1988, University of Utah. Postdoctoral
Fellowship, 1987-1989, University of California, San
Francisco, Department of Biochemistry and Biophysics.
9844 (2008).
Thibaud Lebouvier, Timothy M. E. Scales, Diane P. Hanger,
Robert L. Geahlen, Bernard Lardeux, C. Hugh Reynolds,
Brian H. Anderton and Pascal Derkinderen, The microtubuleassociated
protein tau is phosphorylated by Syk, Biochim.
Biophys. Acta, Mol. Cell Res, 1783, 188-192 (2008).
Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu,
Robert L. Geahlen and Marietta L. Harrison, The SH3 domain
of Lck modulates T-cell receptor-dependent activation
of extracellular signal-regulated kinase through activation of
Raf-1, Mol. Cell. Biol, 28, 630-641 (2008).
Yajie Zhang, Hyunju Oh, Robert A. Burton, John W.
Burgner, Robert L. Geahlen and Carol Beth Post, Tyr130
phosphorylation triggers Syk release from antigen receptor
by long-distance conformational uncoupling, Proc. Natl.
Acad. Sci. U. S. A, 105, 11760-11765 (2008).
GHOSH, ARUN K.—See Chemistry Section, Purdue
University, Department of Chemistry.
(2007).
Allison B. Edsall, Gregory E. Agoston, Anthony M. Treston,
Stacy M. Plum, Robert H. McClanahan, Tian-Sheng
Lu, Wei Song and Mark Cushman, Synthesis and in Vivo
Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate,
17-Phosphate, and 3,17-Diphosphate, J. Med. Chem, 50,
6700-6705 (2007).
Yanlei Zhang, Boris Illarionov, Adelbert Bacher, Markus
Fischer, Gunda I. Georg, Qi-Zhuang Ye, David Vander
Velde, Phillip E. Fanwick, Yunlong Song and Mark Cushman,
A Novel Lumazine Synthase Inhibitor Derived from
Oxidation of 1,3,6,8-Tetrahydroxy-2,7-naphthyridine to a
Tetraazaperylenehexaone Derivative, J. Org. Chem, 72,
2769-2776 (2007).
Arindam Talukdar, Boris Illarionov, Adelbert Bacher,
Markus Fischer and Mark Cushman, Synthesis and Enzyme
Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine
Substrate of Lumazine Synthase and
Product of Riboflavin Synthase, J. Org. Chem, 72, 7167-
7175 (2007).
Yanlei Zhang, Guangyi Jin, Boris Illarionov, Adelbert
Bacher, Markus Fischer and Mark Cushman, A New Series
of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-Dribityl-1H-pyrazolo[3,4-d]pyrimidinedione
as Inhibitors of
Lumazine Synthase: Design, Synthesis, and Evaluation, J.
Org. Chem, 72, 7176-7184 (2007).
Muriel Cuendet, Carol P. Oteham, Arup Maiti, Bruce A.
Craig, Mark Cushman, Richard C. Moon and John M. Pezzuto,
Zapotin prevents mouse skin tumorigenesis during the
stages of initiation and promotion, Anticancer Research, 28,
3705-3709 (2008).
Tsyr-Yan Yu, Robert D. O’Connor, Astrid C. Sivertsen,
Colby Chiauzzi, Barbara Poliks, Markus Fischer, Adelbert
Bacher, Ilka Haase, Mark Cushman and Jacob Schaefer,
15N{31P} REDOR NMR studies of the binding of phosphonate
reaction intermediate analogues to saccharomyces cerevisiae
lumazine synthase, Biochemistry, 47, 13942–13951
(2008).
Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay,
Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit,
Christophe Pannecouque, Erik De Clercq and Mark
Cushman, Investigation of the alkenyldiarylmethane non-nucleoside
reverse transcriptase inhibitors as potential cAMP
phosphodiesterase-4B2 inhibitors, Bioorg. Med. Chem. Lett,
18, 1530-1533 (2008).
Matthew D. Cullen, Taradas Sarkar, Ernest Hamel, Tracy
L. Hartman, Karen M. Watson, Robert W. Buckheit, Christophe
Pannecouque, Erik De Clercq and Mark Cushman, Inhibition
of tubulin polymerization by select alkenyldiarylmethanes,
Bioorg. Med. Chem. Lett, 18, 469-473 (2008).
Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer,
Evan S. Scher, Yves Pommier and Mark Cushman, Design,
Synthesis, and Biological Evaluation of 14-Substituted Aromathecins
as Topoisomerase I Inhibitors, J. Med. Chem, 51,
4609-4619 (2008).
Ze Li, Mansoora Khaliq, Zhigang Zhou, Carol Beth Post,
Richard J. Kuhn and Mark Cushman, Design, Synthesis, and
Biological Evaluation of Antiviral Agents Targeting Flavivirus
Envelope Proteins, J. Med. Chem, 51, 4660-4671 (2008).
Yanlei Zhang, Boris Illarionov, Ekaterina Morgunova,
Guangyi Jin, Adelbert Bacher, Markus Fischer, Rudolf Ladenstein
and Mark Cushman, A New Series of N-[2,4-Dioxo-
6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic
Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin
Synthase: Design, Synthesis, Biochemical Evaluation,
Crystallography, and Mechanistic Implications, J. Org.
Chem, 73, 2715-2724 (2008).
Zhenglai Fang, Yunlong Song, Taradas Sarkar, Ernest Ha-
Chemical Biology; Medicinal and/or Pharmaceutical
Chemistry. Medicinal Chemistry and cellular pharmacology
of natural product drugs. Cell based and biomolecular
assay tools for drug discovery and development in
cancer and neurodegenerative diseases. Targeting of
small molecules to disease-specific receptors; analysis of
small molecules agonists and antagonists of regulatory
protein interactions. TEL: (765) 494-5238 FAX: (765)
494-1414
Web: www.mcmp.purdue.edu/faculty/davisson.php
Email: davisson@purdue.edu
R. E. Amaro, R. S. Myers, V. J. Davisson and Z. A. Luthey-Schulten,
A network of conserved interactions regulates
the allosteric signal in a glutamine amidotransferase, Biochemistry,
46, 2156-2173 (2007).
D. Schweitzer, J. Zhu, G. Jarori, J. J. Kane, J. Tanaka, T.
Higa, V. J. Davisson and P. Helquist, Synthesis of carbamate
derivatives of iejimalides. Retention of normal antiproliferative
activity and localization of binding in cancer cells,
Bioorganic and Medicinal Chemistry, 15, 3208-3216 (2007).
R. Rozhkov, V. J. Davisson and D. E. Bergstrom, Fluorogenic
tranformations based on formation of C-C bonds cata-
lyzed by palladium: An efficient approach for high through-
put optimizations and kinetic studies, Advanced Synthesis
and Catalysis, 350, 71-75 (2008).
S. K. Deb, B. Davis, D. Ben-Amotz and V. J. Davisson,
Accurate concentration measurements using surface-enhanced
raman and deuterium exchanged dye pairs, Applied
Spectroscopy, 62, 1001-1007 (2008).
G. M. Knudsen, B. M. Davis, S. K. Deb, Y. Loethen, R.
Gudihal, P. Perera, D. Ben-Amotz and V. J. Davisson, Quantification
of isotope encoded proteins in 2-D gels using surface
enhanced resonance raman, Bioconjugate Chem, 19,
2212-2220 (2008).
S. M. Firestine, W. Wu, H. Youn and V. J. Davisson, Interrogating
the mechanism of a tight binding inhibitor of AIR
carboxylase, Bioorganic and Medicinal Chemistry, 17, 794-
803 (2008).
F. Liu, J. Hindupur, J. L. Nguyen, K. J. Ruf, J. Zhu, J. L.
Schieler, C. C. Bonham, K. V. Wood, V. J. Davisson and J.-
L. Rochet, Methionine sulfoxide reductase A protects dopaminergic
cells from Parkinson’s disease-related insults, Free
Radical Biology & Medicine, 45, 242-255 (2008).
S. K. Deb, B. Davis, G. M. Knudsen, R. Gudihal, D. Ben-
Amotz and V. J. Davisson, Detection and relative quantification
of proteins by surface enhanced raman using isotopic labels,
J. Am. Chem. Soc, 30, 9624-9625 (2008).
Y. L. Loethen, G. M. Knudsen, B. Davis, R. Gudihal, V. J.
Davisson and D. Ben-Amotz, Protein quantitation in 2-D gels
using fluorescence with water raman as an internal standard,
J. Proteome Res, 7, 1341-1345 (2008).
GEAHLEN, ROBERT L. (b.1953) Professor. B.S,
1975, University of Southern Colorado; Ph.D, 1978,
University of Wyoming. Postdoctoral Fellowship, 1978,
University of Washington; NIH Fellowship, 1978, University
of Washington; Juvenile Diabetes Foundation
Fellowship, 1980, University of Washington. Biochemistry;
Immunology. Protein-tyrosine kinases and lymphocyte
activation; tyrosine kinases and breast cancer; protein
acylation; antitumor agents. TEL: (765) 494-1457
FAX: (765) 494-9193
Web: www.mcmp.purdue.edu/faculty/geahlen.php
Email: geahlen@purdue.edu
Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison
and Robert L. Geahlen, Generation of an Analog-sensi-
GIBBS, RICHARD A. (b.1961) Professor. B.S, 1983,
Johns Hopkins University; Ph.D, 1988, University of California,
Riverside. NSF Fellowship, 1988-1991, Penn
State University. Chemical Biology; Medicinal and/or
Pharmaceutical Chemistry. Chemical probes of protein
prenylation; mechanistic studies of the enzyme proteinfarnesyl
transferase; inhibitors of the enzyme isoprenylcysteine
methyltransferase; novel methods for the synthesis
of isoprenoid analogs. TEL: (765) 494-1456 FAX:
(765) 494-1414
Web: www.mcmp.purdue.edu/faculty/gibbs.php
Email: rgibbs@purdue.edu
Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June
E. Pais, Misty Handley, Marietta L. Harrison, Carol A.
Fierke and Richard A. Gibbs, Combinatorial Modulation of
Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007).
Amanda J. Krzysiak, Sarah A. Scott, Katherine A. Hicks,
Carol A. Fierke and Richard A. Gibbs, Evaluation of protein
farnesyltransferase substrate specificity using synthetic peptide
libraries, Bioorg. Med. Chem. Lett, 17, 5548-5551
(2007).
Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak,
Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr.,
Raymond R. Mattingly, Richard F. Borch and Richard A.
Gibbs, Synthesis, Biochemical, and Cellular Evaluation of
Farnesyl Monophosphate Prodrugs as Farnesyltransferase In-
hibitors, J. Med. Chem, 50, 3274-3282 (2007).
Linda Henneman, Arno G. van Cruchten, Simone W.
Denis, Michael J. Amolins, Andrew T. Placzek, Richard A.
Gibbs, Willem Kulik and Hans R. Waterham, Isoprenoid de-
tection by tandem mass spectrometry, Analytical Biochemis-
try, 383, 18-24 (2008).
Michelle Maynor, Sarah A. Scott, Emily L. Rickert and
Richard A. Gibbs, Synthesis and evaluation of 3- and 7-sub-
stituted geranylgeranyl pyrophosphate analogs, Bioorg. Med.
Chem. Lett, 18, 1889-1892 (2008).
Diwan S. Rawat, Amanda J. Krzysiak and Richard A.
Gibbs, Synthesis and Biochemical Evaluation of 3,7-Disubstituted
Farnesyl Diphosphate Analogues, J. Org. Chem, 73,
1881-1887 (2008).
Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde,
Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners,
Jr., Richard F. Borch and Raymond R. Mattingly, Induction
of apoptosis in neurofibromatosis type 1 malignant pe-
ripheral nerve sheath tumor cell lines by a combination of
novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol.
Exp. Ther, 326, 1-11 (2008).
Amanda J. Krzysiak, Modulating Farnesyltransferase substrate
specificity: Tools for altering protein function in vivo.
(D)
James L. Donelson, A new solid-phase route to prenylcysteine
derivatives: Development of isoprenylcysteine carboxyl
methyltransferase inhibitors. (D)
HARRISON, MARIETTA L. (b.1948) Professor.
B.A, 1970, University of New Hampshire; Ph.D, 1980,
University of Wyoming. Cancer Research Institute Fellowship,
1980, Fred Hutchinson Cancer Research Cen-
ter; NIH Fellowship, 1981, Fred Hutchinson Cancer Research
Center and Purdue University. Biochemistry; Immunology.
Our research involves investigating the role of
cellular protein-tyrosine kinases in cell division and dif-
ferentiation. TEL: (765) 494-1442 FAX: (765) 494-9193
Web: www.mcmp.purdue.edu/faculty/harrison.php