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SUPRAdisc AKS Carbon Impregnated Depth Filter Modules AKS 5 General Characteristics The SUPRAdisc AKS 5 depth filter modules has been specially developed for the requirements of the pharmaceutical industry (e.g. for decolorization of blood products, glucose, solutions and antibiotics). The carbon used in the AKS 5 meets the requirements of the European and US Pharmacopeia. Applications For decolorization of blood products such as albumin, SUPRAdisc AKS 5 can be successfully applied during the Cohn fractionation process and also for the removal or reduction of • Hemoglobin traces • Biliverdin traces • Lipids • Anticoagulants • Detergents In addition SUPRAdisc AKS 5 depth filter modules are used for the filtration of products such as • Antibiotics • Glucose solutions • Enzymes • Vitamins The recommended flow velocities for decolorization of albumin and other pharmaceutical products is 100 - 200 L/m2h, for decolorization and deodorizing of sugar solutions 350 - 400 L/m2h and for dechlorination of water 50 - 150 L/m2h. Diagram of Albumin Production Including Adsorption Step with SUPRAdisc AKS 5 Separation Fraction I Fibrinogen ▼ Separation Fraction II/III Immunoglobuline ▼ Fraction V Albumin ▼ Removal of pastes and precipitates SUPRAdur ® 50 P support sheets ▼ <strong>Filtra</strong>tion SUPRAdisc BIO 10 or BIO 20 modules ▼ Adsorption/Decolorization, SUPRAdisc AKS 5 PKA removal SUPRAdisc AKS 6 ▼ Dialyze ▼ Ultrafiltration ▼ Sterile <strong>Filtra</strong>tion ▼ Filling
AKS 5 Adsorption capacity The outstanding feature of the pharmacopeiaen-grade activated carbon used for depth filter modules is the very high adsorption capacity due to the special pore structure and the unusually high degree of activation of the carbon. This way the pharmacopeial requirements are not only met but even surpassed. ( The main criteria for pharmacopeian – grade activated carbon is the adsorption capacity of methylene blue). If suspended, colloidal or emulsified particles are removed prior to filtration, the adsorption capacity of the SUPRAdisc AKS 5 modules can be increased even further, this can be carried out with Pall prefilter systems prior to the adsorption process step. Extractables SUPRAdisc modules contain very low amounts of extractables such as aluminum, iron etc. For further details, please contact Pall. Endotoxin content AKS 5 contains < 0.02 EU/mL after 50 L/m 2 flushing with WFI (AKS 5 doesn’t contain LAL inhibiting or enhancing substances) Advantages of the SUPRAdisc SD AKS5 Filter Modules Economy • Very economical due to high adsorption capacity • Low protein adsorption Quality • Very high purity (meets the USP/EUR requirements) • Very low content of extractables, e.g. aluminium irons and endotoxins • Very low pH-shift SUPRAdisc AKS Carbon Impregnated Depth Filter Modules
Page 1 and 2: USD 2244 Pall ® SUPRAdisc AKS Carb
Page 3: AKS 6 General Characteristics AKS 6
Page 7 and 8: Parameters Affecting the Adsorption

USD 2159 AVL - Filtra

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