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Monozygotic (MZ) or identical twins occur when a single egg is fertilized
to form one zygote (hence, “monozygotic”) which then divides
into two separate embryos. The chances of having identical twins is
relatively rare – around 3 or 4 in every 1,000 births.
Monozygotic twins are genetically nearly identical and they are always
the same sex unless there has been a mutation during development.
The children of monozygotic twins test genetically as half-siblings (or
full siblings, if a pair of monozygotic twins reproduces with another
pair or with the same person), rather than first cousins. Identical twins
do not have the same fingerprints however, because even within the
confines of the womb, the fetuses touch different parts of their environment,
giving rise to small variations in their corresponding prints and
thus making them unique.
Another cause of difference between monozygotic twins is epigenetic
modification, caused by differing environmental influences throughout
their lives. Epigenetics refers to the level of activity of any particular
gene. A gene may become switched on, switched off, or could become
partially switched on or off in an individual. This epigenetic modification
is triggered by environmental events. Monozygotic twins can have
markedly different epigenetic profiles. A study of 80 pairs of monozygotic
twins ranging in age from three to 74 showed that the youngest
twins have relatively few epigenetic differences. The number of epigenetic
differences increases with age. Fifty-year-old twins had over three
times the epigenetic difference of three-year-old twins. Twins who had
spent their lives apart (such as those adopted by two different sets of
parents at birth) had the greatest difference. However, certain characteristics
become more alike as twins age, such as IQ and personality.
In January 2021, new research from a team of researchers in Iceland
was published in the journal Nature Genetics suggesting that identical
twins may not be quite as identical as previously thought. The four-year
study of monozygotic (identical) twins and their extended families
revealed that these twins have genetic differences that begin in the early
stages of embryonic development.