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Monozygotic (MZ) or identical twins occur when a single egg is fertilized

to form one zygote (hence, “monozygotic”) which then divides

into two separate embryos. The chances of having identical twins is

relatively rare – around 3 or 4 in every 1,000 births.

Monozygotic twins are genetically nearly identical and they are always

the same sex unless there has been a mutation during development.

The children of monozygotic twins test genetically as half-siblings (or

full siblings, if a pair of monozygotic twins reproduces with another

pair or with the same person), rather than first cousins. Identical twins

do not have the same fingerprints however, because even within the

confines of the womb, the fetuses touch different parts of their environment,

giving rise to small variations in their corresponding prints and

thus making them unique.

Another cause of difference between monozygotic twins is epigenetic

modification, caused by differing environmental influences throughout

their lives. Epigenetics refers to the level of activity of any particular

gene. A gene may become switched on, switched off, or could become

partially switched on or off in an individual. This epigenetic modification

is triggered by environmental events. Monozygotic twins can have

markedly different epigenetic profiles. A study of 80 pairs of monozygotic

twins ranging in age from three to 74 showed that the youngest

twins have relatively few epigenetic differences. The number of epigenetic

differences increases with age. Fifty-year-old twins had over three

times the epigenetic difference of three-year-old twins. Twins who had

spent their lives apart (such as those adopted by two different sets of

parents at birth) had the greatest difference. However, certain characteristics

become more alike as twins age, such as IQ and personality.

In January 2021, new research from a team of researchers in Iceland

was published in the journal Nature Genetics suggesting that identical

twins may not be quite as identical as previously thought. The four-year

study of monozygotic (identical) twins and their extended families

revealed that these twins have genetic differences that begin in the early

stages of embryonic development.

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