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Regeneration (Perspectives CSHL)
Sinopsis :
The formation of new cells, tissues, and organs enables
animals to recover from day-to-day wear and tear, injury, and
disease. Some animals, such as sea stars, planarians, and
lizards, can regenerate entire limbs and other body parts. But
in mammals, including humans, some tissues (e.g., heart
muscle) are more resistant to regeneration.Written and edited
by experts in the field, this collection from Cold Spring Harbor
Perspectives in Biology explores the biological basis of
regeneration in diverse animal species and how this
knowledge can be applied therapeutically in humans. The
contributors discuss the dramatic molecular and cellular
changes that occur when a regeneration program is initiated,
the progenitor cells and morphogenic signals involved, the

formation of a blastema, the roles of reprogramming and
polyploidy, the diversity of cell fates, the integration of new
structures with existing body parts, and our current
understanding of why some structures are more resistant to
regeneration than others. The importance of technologies
(e.g., single-cell RNA-seq) that have been instrumental in
deciphering various aspects of regeneration in recent years is
emphasized throughout.Examples of regeneration in
flatworms, Hydra, insects, salamanders, frogs, fish, and
mammals are described. Several chapters are also devoted to
regeneration in specific human organs&#8213th skin, retina,
heart, lung, pancreas, liver, skeletal muscle, and
intestine&#8213an examine possibilities for therapeutically
replacing injured or diseased structures and for managing agerelated
declines in function. This volume is therefore essential
reading for molecular, cell, and developmental biologists
studying regeneration in animals, as well as for all interested in
the development of regenerative therapies for clinical
application.