Fluka - Sigma-Aldrich

Fluka
Chemika
Preface
The field of organosilicon chemistry has
undergone explosive growth in the past
thirty years, and many reviews and monographs
have appeared covering different
topics. Nevertheless, due to the rapidly
increasing volume of literature, there is
always a necessity for up-to-date reviews.
The silylation of organic compounds for synthetic
and analytical purposes, an important
part of organosilicon chemistry, is the subject
matter of this totally revised and enlarged
monograph.
The term “silylation” is defined as the substitution
of a hydrogen atom bound to a hetero
atom (–OH, =NH, –SH) by a silyl group,
forming a silicon hetero atom bond, without
any further alteration of the molecule.
Excluded from this review are therefore the
silylation of carbon atoms, hydrosilylation,
cleavage reactions etc., as well as the introduction
of silicon-containing protecting
groups which does not involve the formation
of a silicon hetero atom bond. Silylation of
the surface of organic and inorganic material
(as glass, silica etc.) is likewise excluded from
this treatise but some references are mentioned
in special cases.
The monograph describes the different silyl
groups and the reagents available from Fluka
for their introduction. Due to the comprehensive
program of organosilicon compounds
available from Fluka, including many
exclusive specialities, all of the major and
most of the special silyl groups and silylating
agents are mentioned. Hence this treatise
represents an almost comprehensive compilation
of current information on the subject.
All literature till the end of 1986 was taken
into consideration and in some cases references
from 1987 are cited. References from
the primary literature are given for the
important and the more recent publications,
and for those papers which are not cited in
the secondary literature. In all other cases
reviews or leading references are cited.
My apology in advance for any omissions
and errors, which are unavoidable in a work
of this nature.
I would like to express my gratitude to Miss
Irene Singer for preparing the typescript, to
Mrs. Joan Forrer for correcting the manuscript,
to Dr. Jörg Widmer for assistance in
literature research and to Prof. Dr. Gerhard
Simchen for helpful suggestions. Last but not
least, my grateful thanks are due to
Dr. Walter Graf for proposals and critical
discussion and for his engagement in the
technical realisation of this monograph.
Gert van Look
Fluka Chemie AG
Second Edition
There have been numerous important developments
in synthetical and analytical application
since the first edition of “Silylating
Agents” was published. Thus we decided to
revise the first edition thoroughly and to
bring it up to date. All literature till the end
of 1993 was taken into consideration and in
some cases references from 1994 are cited.
Among the more notable developments are
2-(trimethylsilyl)ethanol and 2-(trimethylsilyl)ethoxymethylene
chloride protecting
groups, but many others containing silicon
have been included as well.
Methods for carbosilylation are described for
some silylating agents.
After the description of silylating and protecting
agents, we have added typical procedures
for protection of the more important
silylating agents.
The preparative user of this brochure can
find a summary of most of the functional
groups and their application in the final
chapter. Now, it is easier to select the best
protecting group for each functional group.
The chapter “Silanisation” gives a short list
of reagents, which can be used for surfaces
like glass or silica gel, used for example in
material sciences or in sealing techniques.
Although dealing in principle with silylationprocesses,
silanisation reactions are not used
normally for analytical or preparative applications
in synthetic chemistry. We have
therefore excluded this topic from a broader
discussion in this brochure.
We wish to thank Dr. H. Schlemper and
Mrs. J. Forrer for their exceedingly helpful
assistance, also, Dr. M. Metzulat for his
detailed review of new published papers.
J. Heberle
Prof. Dr. G. Simchen
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