CELL BIOLOGY OF THE NEURON Polarity ... - Tavernarakis Lab

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Cell Biology of the Neuron: <strong>Polarity</strong>, Plasticity and Regeneration, Crete 2011 Class-specific Dendrite Morphology Control by the Actin Bundling Protein Fascin Julia Negele 1 , Caroline Delandre 2 , Yun Zhang 1 , Friedrich Förstner 3 , Adrian Moore 2 , Gaia Tavosanis 1 1 Dendrite differentiation group, Dept. of Molecular Neurobiology, MPI of Neurobiology, 82152 Munich- Martinsried, Germany 2 Disease Mechanism Research Core, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan 3 Dept. of Systems and Computational Neurobiology, MPI of Neurobiology, 82152 Munich- Martinsried, Germany The branched morphology of dendrites represents a functional hallmark of distinct neuronal types. Indeed, there is a wide range of neuronal class-specific dendrite morphologies. Nonetheless, how distinct branches are generated is not yet understood. In particular, while transcription factor combinations define dendrite patterns, it remains to be elucidated how such programs are executed. We have investigated specific classes of sensory neurons of Drosophila larvae to address the role of the conserved actin bundling molecule fascin. In time-lapse recordings, we found that terminal branchlets of different classes of neurons have distinctive dynamics. Furthermore, they are formed on the basis of molecularly separable mechanisms, since certain neurons require fascin for terminal branching and others do not. Fascin defines the morphological distinction between two classes of neurons as revealed by loss and gain of function experiments. Finally, fascin is a major effector of the transcription factor Cut to define class-specific dendrite morphology. We propose that the distinction between dendrite morphologies requires dedicated molecular mechanisms. Presented by: Tavosanis, Gaia 52
Cell Biology of the Neuron: <strong>Polarity</strong>, Plasticity and Regeneration, Crete 2011 EB3 Stably links Microtubules to Ankyrin G in the Axon Initial Segment Christophe Leterrier , Hélène Vacher , Marie-Pierre Fache , Stéphanie Angles d'Ortoli , Francis Castets , Amapola Autillo-Touati , Bénédicte Dargent INSERM U641 The Axon Initial Segment (AIS) plays a key role in maintaining the molecular and functional polarity of the neuron. The relationship between the AIS architecture and the microtubules (MTs) supporting axonal transport is unknown. Here we identify a direct and specific interaction between the AIS scaffold protein ankyrin G (ankG) and the microtubule plus-end binding (EB) protein EB3. AnkG concentrates and stabilizes EB3 along MTs in the AIS, contrasting with the role of EB3 as a dynamic MT plus-end tracking protein (+TIP). In addition, EB3 participates in AIS stability, and AIS disassembly leads to a cellwide up-regulation of EB3. Thus, EB3 coordinates a molecular and functional interplay between ankG and the AIS MTs that supports the central role of ankG in the maintenance of neuronal polarity. Presented by: Leterrier, Christophe 53
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Dr. Christian Alfano INSERM U636, N
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Prof. Graeme W. Davis University of
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Prof. Zhigang He Harvard Medical Sc
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Dr. Bernhard Lohkamp Karolinska Ins
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Mr. Abhishek Shrikant Sahasrabudhe
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