Clinical Evaluation Systematic Literature Review - Apec-ahc.org
Clinical Evaluation Systematic Literature Review - Apec-ahc.org
Clinical Evaluation Systematic Literature Review - Apec-ahc.org
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Methodology for <strong>Systematic</strong> <strong>Review</strong><br />
• Data Extraction Strategy<br />
• Extracted directly to tables<br />
• Double checked to reduce errors<br />
• Quality Assessment Strategy<br />
• Whether the cohort was consecutive or not<br />
• Whether the intention to treat principle was used<br />
• Number of cases lost to follow-up<br />
• Other, in-depth evaluation<br />
• Methods of Data Analysis and Synthesis<br />
• Key study characteristics and clinical performance data presented<br />
<strong>Evaluation</strong> of Type II Study<br />
• All studies analyzed as below<br />
• Not all parameters included<br />
Re<br />
f<br />
No<br />
Ref<br />
Stud<br />
y<br />
Name Level<br />
of<br />
Evidence<br />
1 XX Prospectiv<br />
e<br />
Comparati<br />
ve Study<br />
2 YYY Prospectiv<br />
e<br />
Comparati<br />
ve Study<br />
Study<br />
Design<br />
Selection<br />
Criteria<br />
Clear?<br />
Groups<br />
comparabl<br />
e at<br />
baseline?<br />
Adequate<br />
controls for<br />
potential<br />
confounders<br />
?<br />
Groups<br />
Lost To<br />
follow up<br />
comparabl<br />
e at<br />
baseline?<br />
Blinded<br />
Outcome<br />
assessors<br />
?<br />
Follow Up<br />
Adequate<br />
?<br />
Consecutiv<br />
e cases?<br />
Any<br />
exclusion<br />
s from<br />
the<br />
analysis?<br />
Number of<br />
withdrawal<br />
s and<br />
follow up<br />
the same in<br />
each<br />
group?<br />
Yes Yes Yes Yes No Yes No No Yes 2<br />
• <strong>Evaluation</strong> of other study types omitted for brevity<br />
Lost<br />
to<br />
Follo<br />
w up<br />
Yes Yes Yes Yes Yes Yes No No Yes 4 in<br />
each<br />
cohor<br />
t<br />
40
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