COLLEGIO DI DIREZIONE - Azienda Ospedaliera di Parma

from 27 patients with MR and persistent AF (group 1), 33 with MR in sinus rhythm (group 2), and 15 autopsy controls
(group 3) was used to measure myocyte diameter, percentage of myocytolytic myocytes, interstitial fibrosis, and
capillary density; RT-PCR and Western blotting were used to assess the mRNA and protein levels of SOD-1, SOD-2,
HO-1, calpain, MMP-2, MMP-9, TIMP-1, TIMP-2, and VEGF; immunofluorescence was used to locate these proteins.
Myocyte diameter was similar in groups 1 and 2, but larger than controls. Compared to group 2, group 1 had more
myocytolytic myocytes (20.8 +/- 5.6% vs 14.7 +/- 4.5%; P < 0.0001), increased interstitial fibrosis (10.4 +/- 5.1% vs 7.5
+/- 4.2%; P < 0.05), and decreased capillary density (923 +/- 107 No/mm(2) vs 1,040 +/- 100 No/mm(2); P < 0.0001).
All of the proteins were more expressed in groups 1 and 2 than in controls. The protein and mRNA levels of SOD-1,
SOD-2, MMP-2, and MMP-9 were higher in group 1 than in group 2. Conclusions: The LAPW of MR patients with or
without AF shows considerable SR. The former has more severe histopathological changes and higher levels of proteins
involved in SR, thereby reaching a threshold beyond which the sinus impulse cannot normally activate atrial
myocardium.
16) Costi, R; Le Bian, A; Cauchy, F; Diop, PS; Carloni, A; Catherine, L; Smadja, C (2012) Synchronous
pyogenic liver abscess and acute cholecystitis: how to recognize it and what to do (emergency
cholecystostomy followed by delayed laparoscopic cholecystectomy) SURGICAL ENDOSCOPY AND
OTHER INTERVENTIONAL TECHNIQUES 26(1):205-213 IF=3.436 [Article]
The treatment of synchronous pyogenic liver abscess (PLA) and acute cholecystitis (AC) may be challenging.
Moreover, because of the similarity of symptoms and the suboptimal accuracy of ultrasound (US), PLA(s) may be
undetected, unless a computer tomography (CT) scan is performed. The aims of this study were (1) to evaluate the
results of emergency cholecystostomy (CS) and late laparoscopic cholecystectomy (LC) in such a population and (2) to
identify the criteria for selecting patients with AC and a high risk of having synchronous PLA(s) for referral for a CT
scan. A retrospective analysis of the outcome of 12 patients with AC and PLA(s) treated by emergency CS followed by
delayed LC from January 1996 through May 2010 at a tertiary-care university hospital was performed. Clinical,
laboratory, and radiological data of patients with synchronous AC and PLA(s) are compared with those of 66 patients
with "simple" AC. The association of age > 55 years, temperature > 38A degrees C, WBC count > 12,000/ml, and
ASAT > 50 UI/l and/or ALAT > 75 UI/l allows for the selection of patients at high risk of PLA to undergo a CT scan
(sensitivity: 100%; specificity: 86%). All treated patients had a sudden improvement within 24 h following CS. PLA
was treated in 10/12 patients (83%). Hospital stay lasted 21.5 +/- A 3.5 days. Ten patients underwent elective LC 12 +/-
A 4 weeks after CS with no conversion and 30% perioperative morbidity. Operating time was 91 min. Hospital stay was
1.7 days [7 patients (70%) underwent surgery as an outpatient]. A simple algorithm is presented for the selection of
patients with AC to undergo a CT scan to identify synchronous PLA. Emergency CS followed by delayed LC is a
viable, first-line treatment option for synchronous PLA and AC.
17) Danese, E; Montagnana, M; Minicozzi, AM; Bonafini, S; Ruzzenente, O; Gelati, M; De Manzoni, G;
Lippi, G; Guidi, GC (2012) The role of resistin in colorectal cancer CLINICA CHIMICA ACTA 413(07-
ago):760-764 IF=2.388 [Article]