Integrated Biomaterials Science

1036 Index
Tissue engineering (Cont.)
current status, 907–908
mesenchymal stem cells, 914–916
in vitro and in vivo studies (cell
therapy), 910–911
artificial skin
dermis, 902–906
epidermis, 901–902
generally, 900–901
progress in, 907
biological materials, medical applications,
20–22
cell culture and in vitro tissue development,
888–899
ECM composition, 889–892
ECM receptors, 892–894
gene therapy and, 897–899
signal transduction, 894
testing of biomaterials and new
strategies, 895–897
definitions, 885
extracellular matrix (ECM), 886–888
goals of, 885–886
liver, 925–936
anatomy, 926
extracellular matrix, 927
liver cell function, 928–936
microarchitecture, 926
overview, 925–926, 936
parenchymal and nonparenchymal cells,
927
Tissue factor, coagulative cascade, polymeric
materials, 64–65
Tissue fibrosis regulation, extracellular
matrix/biomaterial interactions,
659–660
Tissue reactivity, infection/sterilization, 816
Tissues, 339–345. See also Bone tissue; Soft
tissue
hard tissue, 342–344
overview, 339–340
soft tissue, 340–342
Titanium, metallic biomaterial applications,
292–294
Titanium alloys, metallic biomaterial
applications, 292–294
Titanium-aluminum phase diagram, metallic
materials, 269–271
Titanium-vanadium phase diagram, metallic
materials, 269–271
Tool machining, metallic materials, working
technologies, 288
Tooth structure properties, 589–599. See also
Dental implant materials; Dental
materials
mechanical properties, 592–597
fracture toughness, 595–597
hardness, 595
static, 592–594
overview, 589–591
physical properties, 591–592
Total knee arthroplasty (TKA), 527–532. See
also Knee joint replacement
Toxicity, inflammatory response (to metals
and ceramics), 767–770
Trabecular bone, 917–918
Transdermal systems (drug delivery systems
(DDS)), 859–864. See also Drug
delivery systems (DDS)
monolithic devices, 860–861
reservoir devices, 861–862
skin permeability enhancers, 862–864
Transport properties, soft tissue, 352–353
Tribological performance, bioceramics, 199
Tricalcium phosphate, thermal
transformation, 224–225
Tsai-Hill (maximum work) criterion,
unidirectional lamina failure,
continuous-fiber-reinforced composite
mechanics, 98–99
Two phases
Lever rule and, metallic materials, phase
diagrams, 266–267
metallic alloy structures, 263
U
Ultrasonic modulated devices, drug delivery
systems (DDS), 856
Ultrasound analysis, bone mechanics,
468–469
Undegradable devices, unswellable devices
and, drug delivery systems (DDS),
864–867
Undegradable matrices, swellable matrices
and, drug delivery systems (DDS),
drug release mechanisms, 867–868
Unicompartmental knee arthroplasty,
historical perspective, 534–536. See
also Knee joint replacement