Prof. Dr.Mohamed Hamdy Abouel-Hassan

Review of literature
During the full-erection phase, partial compression of the deep dorsal and
circumflex veins between Buck's fascia and the engorged corpora c
contribute to glanular tumescence, although the spongiosum and glans
essentially function as a large arteriovenous shunt during this phase. In the
rigid-erection phase, the. Ischiocavernosus and B
cavernosum,
Italiano
ulbocavernous
avernosa
muscles
forcefully compress the spongiosum and penile veins, which results in
further engorgement and increased pressure in the glans and spongiosum.
Smooth Muscle Physiology
Spontaneous contractile activity of cavernous smooth muscle has corpus
Mandrek (1994) demonstrated spontaneous been recorded in
vitro and in vivo .In isolated strips of rabbit mechanical activity with a
frequency of 6 to 30 contractions per minute accompanied by fluctuations in
membrane potential. Stimulation of the tissue with tetraethylammonium
chloride and norepinephrine produced strong tonic contractions with relative
electrical silence. In a human study, Y
arnitsky
and colleagues (1995) found
two types of electrical activity recorded from the corpus c
spontaneous and activity-induced. Levin and coworkers (1994) reported that
in vitro spontaneous contractile activity is correlated with a phasic increase
in intracellular calcium and a biphasic change in the N
ADH/
NAD
avernosum:
ratio,
suggesting an initial increase and then a decrease of intracellular energy.
and coworkers (1998) suggested that phasic contraction of the penis
is through the enzyme N
a-K-ATPase
and the resting tone is mediated by the
endothelium through the release of prostaglandin Fla. Field stimulation
results in a decrease in tension and intracellular calcium at low frequencies
and an increase in tension with increased intracellular calcium at high
frequencies. In general, the response to pharmacologic agents correlates with
the change in intracellular calcium: for example, phenylephrine produces