Drosophila HP1 Polyclonal Antibody (PRB-291C) - Eurogentec
Drosophila HP1 Polyclonal Antibody (PRB-291C) - Eurogentec
Drosophila HP1 Polyclonal Antibody (PRB-291C) - Eurogentec
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Description:<br />
<strong>Polyclonal</strong> <strong>Antibody</strong> against <strong>Drosophila</strong><br />
<strong>HP1</strong><br />
Form:<br />
Antiserum<br />
Host:<br />
Rabbit<br />
Species Reactivity:<br />
<strong>Drosophila</strong><br />
<strong>Drosophila</strong> <strong>HP1</strong> <strong>Polyclonal</strong> <strong>Antibody</strong><br />
Catalog Number: <strong>PRB</strong>-<strong>291C</strong><br />
Available Size: 0.2 mL<br />
Specificity:<br />
The <strong>Drosophila</strong> <strong>HP1</strong> protein, product of the Su(var)2-5 locus, is a dose-dependent regulator of gene silencing. <strong>HP1</strong> interacts<br />
with compacted chromatin (heterochromatin) via its chromodomain (CD). <strong>HP1</strong> antisera staining of polytene chromosomes<br />
decorates pericentric heterochromaticn and a banded heterochromatic pattern on the small 4th chromosome. The <strong>HP1</strong> protein<br />
is also known to interact with a number of transcriptional regulators via its chromoshadow domain (CSD), suggesting that <strong>HP1</strong> is<br />
a bridging factor that couples particular chromatin structures with effects on gene expression. This antibody was raised against<br />
full-length recombinant <strong>Drosophila</strong> <strong>HP1</strong> protein, and has been shown to specifically stain <strong>Drosophila</strong> polytene chromosomes.<br />
Uses:<br />
This antibody is effective in immunostaining.<br />
Suggested Working Dilution:<br />
The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory<br />
research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior<br />
written approval.<br />
• Immunostaining: 1:200<br />
www.covance.com<br />
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Storage:<br />
Store at -20°C. Upon initial thawing, apportion into working<br />
aliquots and store at -20°C. Avoid repeated freeze-thaw<br />
cycles to prevent denaturing the antibody. For long-term<br />
storage, keep the antibody at -80°C.<br />
References:<br />
Eissenberg JC, Elgin SC. The <strong>HP1</strong> protein family: getting a grip on<br />
chromatin. Curr. Opin. Genet. Dev. 10(2):204-210, 2000.<br />
Cryderman DE, Morris EJ, Biessmann H, Elgin SC, Wallrath LL.<br />
Silencing at <strong>Drosophila</strong> telomeres: nuclear organization and chromatin<br />
structure play critical roles. EMBO J. 18:3724-3735, 1999.<br />
Warranty/Conditions:<br />
Covance products may not be resold or modified for resale without prior<br />
written approval.All sales are subject to Covance <strong>Antibody</strong> Products<br />
Terms and Conditions of Sale.<br />
Datasheet Revision Date:<br />
03/13/2011<br />
<strong>Antibody</strong> Products:<br />
Email:<br />
+1.800.922.2226<br />
+1.510.594.3800<br />
ab.products@covance.com<br />
www.covance.com<br />
<strong>Drosophila</strong> <strong>HP1</strong> <strong>Polyclonal</strong> <strong>Antibody</strong><br />
Catalog Number: <strong>PRB</strong>-<strong>291C</strong><br />
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