Re-188 Bibliography - Oak Ridge National Laboratory

Published in 2009:
BIBLIOGRAPHY
Clinical and Research Applications of Rhenium-188 from the
Tungsten-188/Rhenium-188 Generator System
Updated/Prepared by Russ Knapp, ORNL, October 26, 2009
Barth, I., Rimper, A., Nikula, T., Schlip, M., Buck, O., Wengenmair, H., Leissner, G., Kopp, J. and
Sciuk, J. “Radiation Exposure of Staff During Endovascular Brachytherapy with Rhenium-188 after
PTA in the Peripheral Blood Stream,” Z. Med. Phys., 19, 193-199 (2009).
Bult, W., Vente, M. A. D., Zonnenberg, B. A., Van Het Schip, A. D. and Nijsen, J. F. ”Microsphere
Radioembolization of Liver Malignancies: Current Developments,” Q. J. Nucl. Med., 53, 325-335
(2009).
Cabral, P., Alonso, O., Castellano, G., Badano, A., Katz, A. and Savio, E. “Intracoronary
Radionuclide Therapy with Liquid 188 Re-Filled Balloons: Radiopharmaceutical and Dosimetry,”
ALASBIMN Journal, 10, July (2009).
Chakravarty, R., Dash, A., Kothari, K., Pillai, M. R. A. and Venkatesh, M. “A Novel 188 W/ 188 Re
Electrochemical Generator with Potential for Medical Applications,” Radiochim. Acta, 97, 309-317
(2009).
Chen, K.-T., Lee, T.-W. and Lo, J.-M. “In vivo Examination of 188 Re(I)-Tricarbonyl-labeled
Trastuzumab to Target HER2-Overexpressing Breast Cancer,” Nucl. Med. Biol., 36, 355-361
(2009).
Huang, F.-Y., Huang, L.-K., Lin, W.-Y., Luoi, T.-Y and Tsai, C.-S. “Development of a
Thermosensitive Hydrogel System for Local Dlivery of 188 Re Colloid Drugs,” Appl. Radit. Isot., 67,
1405-1411 (2009).
Lam, M. G. E. H., Bosma, T. B., van Rijk, P. P. and Zoonenberg, B. A. “ 188 Re-HEDP Combined with
Capecitabine in Hormone-Refractory Prostate Cancer Patients with Bone Metastases: A Phase I
Safety and Toxicity Study,” Eur. J. Nucl. Med. Mol. Imag., 36, 1425-1433 (2009).
Lambert, B. and Van De Wiele, C. “Selective Internal Radiation Therapy of HCC and Liver
Metastases: A Locoregional or Worldwide Therapy ?,” Q. J. Nucl. Med., 53, 302-304 (2009).
Lambert, B., Bacher, K. and DeFreyne, L. “Rhenium-188-Based Radiopharmaceuticals for
Treatment of Liver Tumors,” Q. J. Nucl. Med., 53, 305-310 (2009).
Lee, J. S., Lee, J.-S., Park, U.-J., Son, K.-J. and Han, H.-S. “Development of a High Performance
188 W/ 188 Re Generator Using Synthetic Alumina,” Appl. Radiat. Isot., 67, 1162-1166 (2009).
1

Liepe, K., Geidel, H. H., Bergmann, R., Haase, M., Runge, R. and Kotzerke, J. “Autoradiographic
Studies of Rhenium-188-Hydroxyethylidene Diphosphonate and Osteoblastic Bone Metastases in a
Rat Model of Metastatic Prostate Cancer,“ Nucl. Med. Commun., in press (2009).
Luo, T. Y., Tang, I. C., Wu, Y. L., Hsu, K. L., Liu, S. W., Kung, H. C., Lai, P. S. and Lin, W. J.
“Evaluating the Potential of 188 Re-SOCTA-Trastuzumab as a New Radiopharmaceutical for Breast
Cancer Treatment,” Nucl. Med., Biol., 36, 81-88 (2009).
Melendez-Alafort, L., Nadali, A., Zangoni, E., Banzato, A., Rondina, M., Rosato, A. and Mazzi, U.
“Biokinetic and Dosimetric Studies of 188 Re-Hyaluronic Acid: A New Radiopharmaceutical for
Treatment of Hepatocellular Carcinoma,” Nucl. Med. Biol., 36, 693-701 (2009).
Mutschler, J., Steinbach, G., Bunjes, D., Reske, S. N. and Buchmann, I. “Myeloablative
Radioimmunotherapy with 188 Re-CD66mAb Before Stem Cell Transplantation. No Increase of
Proinfammatory Cytokine Levels of TNF-Alpha,” Nuklearmedizin, 48, 30-36 (2009) (in German).
Oehme, L. and Kotzerke, J. “Radiological Considerations for Radioembolization with 188 Re-
Microspheres,“ Eur. J. Nucl. Med., 36, 322-325 (2009).
Percutanous Transluminal Angioplasty Device with Rhenium-188 from ITM Munich - Rhenium-PTA
and PTCA received full CE-certification and approvals in September 2008.
< http://www.itm.ag/content/view/49/92/>
Rheniumn-188-PT1-6D2 antibody in patients with metastatic melanoma. Pain Therapeutics, Inc. –
ClinicalTrials.gov identified – NCT00734188. Recruiting patients – Jan. 2009 - March 2010.
http://clinicaltrials.gov/ct2/show/NCT00734188?spons=%22Pain+Therapeutics%22&spons_ex=Y&r
ank=3
Sarkar, S. K., Venkatesh, M. and Ramammorthy, N. “Evaluation of Two Methods for Concentrating
Perrhenate ( 188 Re) Eluates Obtained from 188 W/ 188 Re Generator,” Appl. Radiat. Isot., 67, 234-239
(2009).
So, L. V., Nguyen, C. D., Pellegrini, P. and Bui, V. C. “Polymeric Titanium Oxychloride Sorbent for
188 W/ 188 Re Nuclide Pair Separation,” Sep. Sci. Tech., 44, 1074-1098 (2009).
Wiesinger, B., Farkas, E., Kehlbach, R., Bantleon, R., Werner, M. And Wiskirchen, J. ”Impact of
Rhenium-188, Gemcitabine and 5-Fluorouracil on Cholangiocellular Carcinoma Cells: An In Vivo
Study,“ Cardiovasc. Interven. Biol., in press (2009).
Xia, J., Wang, Y., Jungfeng, G. L., Yu, J. and Yin, D. “Synthesis of Pyridyl Derivatives for the
Future Functionalization of Biomolecules Labeled with the fac-[ 188 Re(CO)3(H2O)3] + Prescursor,” J.
Radioanalyt. Nucl. Chem., 279, 245-252 (2009).
2

Published in 2008:
Allard, E., Hindre, F., Passiran, C., Lemaire, L., Lepareur, N., Noiret, N., Menei, P. and Neoit, J.-P.
“ 188 Re-Loaded Lipid Nanocapsules as a Promising Radiopharmaceutical Carrier for Internal
Radiotherapy of Malignant Gliomas,” Eur. J. Nucl. Med. Mol. Imag., 35, 1838-1846 (2008).
Bal, C. S. and Kumar, A. “Radionuclide Therapy for Hepatocellular Carcinoma: Indication, Cost and
Efficacy,” Trop. Gastroenterol., 29, 62-70 (2008).
Bernal, .P, Raoul, J. L., Stare, J., Sereegotov, E., Sundram, F. X., Kumar, A., Jeong, J. M.,
Pusuwan, P., Divgi, C., Zanzonico, P., Vidmar, G., Buscombe, J., Chau, T. T., Saw, M. M., Chen,
S., Ogbac, R., Dondi, M. and Padhy, A. K. “International Atomic Energy Agency-Sponsored
Multination Study of Intra-arterial Rhenium-188-Labeled Lipiodol in the Treatment of Inoperable
Hepatocellular Carcinoma: Results with Special Emphasis on Prognostic Value of Dosimetric
Study,” Semin Nucl Med., 38(2), S40-5 (2008).
Chakravarty, R., Dash, A., and Ventakesh, V. “Development of a New 188 W/ 188 Re Generator Using
Polymer Embedded Nanocrystalline Tintania as the Sorbent Matrix,” Proceedings, Asia Oceania
Congress of Nuclear Medicine and Biology, New Delhi, India, October 31-November 4, 2008, Page
24.
Chen, L., Chang, C., Yu, C., Chang, Y., Wu, Y., Lee, W., Yeh, C., Lee, T. and Ting, G. “Therapeutic
Efficacy of Biomodality Nanotargeted 188 Re-(DXR)-Liposome in a C26 Colon Carcinoma Ascites
Mouse Model,” J. Nucl. Med., 49, 327P (2008).
Chen, L.-C., Chang, C.-H., Yu, C.-Y., Change, Y.-J., Wu, Y.-H., Lee, W.-C., Yeh, C.-H., Lee, T.-W.
and Ting, G. “Pharmacoklinetics, Mico-SPECT/CT Imaging and Therapeutic Efficacy of 188 Re-DXR-
Liposomes in C26 Colon Carcinoma Ascites Mice Model,” Nucl. Med. Biol., 35, 883-893 (2008).
Dadachova, E., Revskaya, E., Sesay, M. A., Damania, H., Boucher, R., Sellers, R. S., Howell, R.
C., Burns, L., Thornton, G. B., Natarajan, A., Mirick, G. R., Denardo, S. J., Denardo, G. L. and
Casadevall, A. “Pre-Clinical Evaluation and Efficacy Studies of a Melanin-Binding IgM Antibody
Labeled with 188 Re against Experimental Human Metastatic Melanoma in Nude Mice,” Can. Biol.
Ther., 7, 1116-1127 (2008).
Dadachova, E., Rivera, J., Reskaya, E., Nakouzi, A., Cahill, S. M., Blumenstein, M., Xiao, H.,
Rykunov, D. and Casadevell, A. “In Vitro Evaluation, Biodistribution and Scintigraphic Imaging in
Nude Mice of Radiolabeled Anthrax Toxins,” Nucl. Med. Biol., 35, 755-761 (2008).
Dadachova, E., Revskaya, E., Sesay, M., Howell, R. C., Thornton, G. B., Natarajan, A., Mirick, G.,
DeNardo, S. J., DeNardo, G. L. and Casadevall, A. “Pre-Clinical Development of a 188 Re-Labeled
Melanin-Binding Antibody for Phase I Clinical Trials in a Pateint with Metastatic Melanoma,” J.
Nucl. Med., 49, 327P (2008).
DeBecker, M., Bacher, K., Thierens, H., lgers, G., Dierckx, R. A. and De Vos, F. ”In Vitro and In
Vivo Evaluation of Direct Rhenium-188-Labeled anti-CD52 Monocloncal Antibody Alemtuzumab for
3

Radioimmunotherapy of B-Cell Chronic Lymphocytic Leukemia,“ Nucl. Med. Biol., 35, 599-604
(2008).
El-Mabhouh, A. A. and Mercer, J. R. “ 188 Re-Labelled Gemcitabine/Phosphonate (Gem/BP): A Multi-
Functional, Bone-Specific Agent as a Potential Treatment for Bone Metasatses,” Eur. Nucl. Med.
Mol. Imag., 35, 1240-1248 (2008).
Fernandez, S., Giglio, J., Teran, M., Incerti, M., Agorio, C., Chabalgoity, A. and Rey, A. “Preparation
and Preclinical Evaluation of Complex Mixtures of 188 Re(V) Oxo Complexes,” In, Abstracts,
ALSABAMIN, 3 rd Congress, Uruguay (2008) (in spanish).
Friesen, C., Lubatschofski, A., Glatting, G., Debatin, K. M. and Reske, S. N. “Activation of Intrinsic
Apoptotic Pathway by Re-188 Irradiation and Paclitaxel in Coronary Artery Smooth Muscle,” Quart.
J. Nucl. Med. Mol. Imag, 52, 2189-295 (2008).
Ferro-Flores, G., Arteaga de Murphy, C. “Pharmacokinetics and Domsietry of 188 Re-
Pharmaceuticals,” Adv. Drug Rev., 60, 1398-1401 (2008).
Grammaticos, P. C. “Highlights and Prizes of International Meeting,” Hell. J. Nucl. Med., 11, 146-
148 (2008) (i.e. Re-188-labeled bevacizumab).
Jeong, J. M. and Knapp, F. F., Jr. “Use of the Oak Ridge National Laboratory Tungsten-
188/Rhenium-188 Generator for Preparation of the Rhenium-188 HDD/Lipiodol Complex for Trans-
Arterial Liver Cancer Therapy,” Semin. Nucl. Med., 38(2), S19-29 (2008).
Jia, Z. Y., Deng, H. P., Pu, M. F. and Luo, S. Z. “Rhenium-188 Labelled Meso-Tetrakis[3,4bis(carboxymethyleneoxy)phenyl]porphyrin
for Targeted Radiotherapy: Preliminary Biological
Evaluation in Mice,” Eur. J. Nucl. Med. Mol. Imaging, in press (2008).
Kim, E., Yu, D., Mendez, R., Azhdarinia, A. and Yang, D. “Effect of 188 Re-Cisplatin-Hydrogel for
Locoregional Therapy of Breast and Prostate Cancer,” J. Nucl. Med., 49, 327P (2008).
Kim, J. H., Shin, J. H., Song, H. Y., Shim, T. S., Oh, Y. M., Oh, S. J. and Moon, D. H. “Liquid 188 Re-
Re-Filled Balloon Dilation for the Treatment of Refractory Benign Airway Strictures: Preliminary
Experience,” J. Vasc. Interv. Radiol., 19, 406-411 (2008).
Klein, M., Shibli, N., Friedman, N., Thornton, G. B., Chisn, R. and Lotem, “Imaging of Meatstatic
Melanoma (MM) with a 188 Re-Labeled Melanin Binding Antibody,” J. Nucl. Med. , 49, 52P (2008).
Luo, T.-Y., Wu, Y.-L., Tang, I.-C., Liu, S.-W., Lin, W.-J. and Chen, H.-J. ”Synthesis and
Characterization of 188 Re-HYNIC-Tratuzumab (Herceptin) as a Novel Radiopharmaceutical for
Breast Cancer Treatment,“ In, Proceedings, Asia Oceania Congress of Nuclear Medicine and
Biology, New Delhi, India, October 31-November 4, 2008, Page 24.
Padhy, A. K. and Dondi, M. A. Report on the Implementation Aspects of the International Atomic
Energy Agency's First Doctoral Coordinated Research Project, "Management of Liver Cancer Using
4

Radionuclide Methods With Special Emphasis on Trans-Arterial Radio-Conjugate Therapy and
Internal Dosimetry," Semin Nucl Med., 38(2), S5-S12 (2008).
Safi, B., Mertens, J., Kersemans, K. and Geerlings, P. “A Critical Quantum Chemical and
Experimental Study of the Potentiality of Direct Labeling of the CN Group with [ 99m Tc(CO)3] + or
[ 186/188 Re(CO)3] + in CN-Containing Biomolecules,” Nucl. Med. Biol., 35, 747-753 (2008).
Sedda, A. F., Rossi, G., Cipriani, C., Carrozza, A. M. and Donati, P. “Dermatological High-Dose-
Rate Brachytherapy for the Treatment of Basal and Squamous Cell Carcinoma,” Clin. Exp.
Dermatol., 33, 745-749 (2008). (i.e. use of Re-188 impregnated topical resin).
Shamim, S. A., Kumar, R., Halanaik, D., Shukla, J. and Bandopadyaha, G. P. ”Two Year Follow-up
of Chronic Knee Arthritis Patients Treated with Re-188 Tin Colloid Radiosynovectomy Who Were
Refractory to Conventional Treatments,“ J. Nucl. Med., 49, 102P (2008).
Shin, J. H., Lee, S. K., Song, H. Y., Kim, J. S., Choe, H., Kim, E. H., Lee, I. G., Kim, T. H., Kim, E.
Y., Woo, C. W. and Nah, K. H. “The Effects of 188 Re-Filled Balloon Dilation Following Bare Stent
Palcement in a Rabbitt Oesophageal Model,” Br. J. Radiol., 81, 413-421 (2008).
Sishir, K., Sarkar, K. and Arjun, G. “Development of Methodology for Preparation of Alumina
Column-Based 188 W/ 188 Re Generator System,” In, Proceedings, Asia Oceania Congress of
Nuclear Medicine and Biology, New Delhi, India, October 31-November 4, 2008, Page 63.
Torres-Garcia, E., Ferro-Flores, G., Artega de Murphy, C., Corres-Gonzales, L. and Pichardo-
Romero, P. A., “Biokinetics and Dosimetry of (188)-Re-anti-CD-20 in Patients with Non-Hodgkin’s
Lymphoma: Preliminary Results,” Arch. Med. Res., 39, 100-109 (2008).
Wang, G.-Q., Zhang, J., Luo, S.-Z., Wang, N., Wei, H.-Y., Wang, W.-J., Yang, Y.-Q., Liu, G.-P. and
Yu, X.-Q. ”Syntehsis and Primary Biological Evaluation of 188 Re-N-NEMPTDD,“ J. Radioanalyt.
Nucl. Chem., 277, 365-369 (2008).
Wohlgemuth, W. A., Leissner, G., Wengenmair, H., Bohndorf, K. And Kirschf, K. „Endovascular
Brachytherapy in the Femoropopliteat Segment Using 192 Ir and 188 Re,” Cardiovas. Intervent.
Radiol., 31, 698-708 (2008).
Wunderlich, G., Hartmann, H., Andreef, M. and Kotzerke, J. ”A Semi-Automated System for
Concentration of Rhenium-188 for Radiopharmaceutical Applications,“ Appl. Radit. Isot., 66, 1876-
1880 (2008).
Xia, J., Wang, Y., Y. J., Li, S., Tang, L., Zheng, M., Liu, X., Li, G., Cheng, D., Liang, S. and Yin, D.
“Synthesis, in vitro and in vivo Behaviour of 188 Re(I)-Tricarbonyl Complexes for the Future
Functionalization of Biomolecules,” J. Radioanalyt. Nucl. Chem., 275, 325-330 (2008).
Xiong, Q. F. and Chen, Y. “Deoxyglucose Compounds Labeled with Isotopes Different from F-18:
Is There a Future in Clinical Practice ?,” Can. Biother Radiopharm., 23, 376-381 (2008).
5

Zanzonico, P. B. and Divgi, C. “Patient-Specific Radiation Dosimetry for Radionuclide Therapy of
Liver Tumors with Intrahepatic Artery Rhenium-188 Lipiodol,” Semin Nucl Med., 38(2), S30-9
(2008).
Published in 2007:
Bernal, P., Raoul, J. L., Sereegotov, E., Sundram, F. X., Kumar, A., Jeong, J. M., Pusuwan, P.,
Divgi, C., Zanzonica, P, Stare, J., Buscombe, J. Thi Minh, C. T., Chen, S., Ogbac, R. and Pady, A.
K., “Intra-Arterial Rehnium-188 Lipiodol in the Treament of Inoperable Hepatocellular Carcinoma:
Results of an IAEA-Sponosred Multination Study,” Int. J. Radiat. Oncol. Biol. Phys., 69, 1448-1455
(2007).
Boerman, O. C., Koppe, M, J., Postema, E. J., Corstens, F. H. and Oyen, W. J. “Radionuclide
Therapy of Cancer with Radiolabeled Antibodies,” Anti-Can. Agents in Med. Chem., 7, 335-343
(2007).
Chen, Y., Xiong, Q., Yang, X., Huang, Z. and He, L. “Preparation and Imaging Research on 188 Re-
DTPA-Deoxyglucose in MCF-7 Tumor-Bearing Mice.,” Can. Biother. Radiopharm., 22, 400-402
(2007).
Chen, L.-C., Chang, C.-H., Yu, C.-Y., Chang, Y.-J., Hsu, W.-C., Ho, C.-L., Yeh, C.-H., Luo, T.-Y.,
Lee, T.-W. and Ting, G. “Biodistribution, Pharmacokinetics and Imaging of 188 Re-BMEDA-Labeled
Pegylated Liposomes after Intraperintoneal Injection in a C26 Colon Carcinoma Ascites Mouse
Model,” Nucl. Med. Biol., 34, 415-423 (2007).
Cheon, G. J., Chung, H. K., Choi, J. A., Lee, S. J., Ahn, S. H., Lee, T. S., Choi, C. W. and Lim, S.
M. “Cellular Metabolic Response of PET Radiotracers to (188)Re- Radiation in an MCF7 Cell Line
Containing Dominant-Negative Mutant p53,” Nucl. Med. Biol., 34, 425-432 (2007).
Chung, H. K., Cheon, G. J., Choi, C. W., Kim, M. J., Lee, S. J. and Lim, S. M. “Comparison of
Cellular Metabolic Response of (18)F-FDG According to the Effect of Beta Irradiation in p53 Wild
Type and Deleted Cell Lines,” Can. Biother. Radiopharm., 22, 636-643 (2007).
Cyr, J. E., Pearson, D. A., Wilson, D. M., Nelson, C. ., Guaraldi, M., Azure, M. T., Lister-James, J.,
Dinkelborg, L. M. and Dean, R. T. “Somatostatin Receptor Binding Peptides Suitable for Tumor
Radiotherapy with Re-188 or Re-186. Chemistry and Initial Biologcial Studies,” J. Med. Chem., 50,
1354-1364 (2007).
Dadachova, E., Bryan, R. A., Hunag, X., Ortiz, G., Moadel, T. and Cassadevall, A. “Comparative
Evaluation of Capsular Polysaccharide-Specific IgM and IgG Antibodies and F(ab’)2 and Fab
Fragments as Delivery Vehicles for Radioimmunotherapy of Fungal Infection,” Clin. Can. Res., 13,
5629s-56345s (2007).
Dadachova, Wang, X.-G. and and Cassadevall, A. “Targeting the Virus with Radioimmunotherapy in
Virus-Associated Cancers,” Can. Biother. Radiopharm., 22, 303-307 (2007).
6

Duatti, A., Pasquali, M., Uccelli, L., Boschi, A. and Giganti, M. “Radiopharmaceuticals for Treatment
of HCC,” Quar. J. Nucl. Med., 51, 380 (2007); In, Proceedings, IRIST Conference, “Beta Days in
Capri – Current Status in Radionuclide Therapy,” Capril, Italy, Sepetmber 20-22, 2007.
Friesen, C., Lubatschofski, A., Glatting, G., Dbatin, K. M. and Reske, S. N. ”Activation of Intrinsic
Apoptotic Pathway by Re-188 Irradiation and Paclitaxel in Coronary Artery Smooth Muscle Cells,“
Q. J. Nucl. Med. Imaging, in press (2007).
Hafeli, U. O., Pauer, G. J., Unnithan, J. and Prayson, R. A. “Fibrin Glue Systems for Adjuvant
Brachytherapy of Brain Tumors with 188 Re and 186 Re-Labeled Microspheres,” Eur. J. Pharm.
Biopharm., 65, 282-288 (2007).
Jia, Z., Deng, H. and Pu, M. “Synthesis and Preliminary Biological Studies of the Novel Conjugate
188 Re-Labeled meso-tetrakis(4-sulfophenyl)porphyrin in Mice,” Nucl. Med. Biol., 34, 643-649
(2007).
Knapp, F. F., Jr., Mirzaeh, S., and Garland, M. “The Continuing Important Role of High Flux
Reactors for Production of Therapeutic Medical Radioisotopes,” In, Trends in Radiopharmaceuticals
(ISTR-2005),” Proceedings of the International Symposium, Vienna, Austria, November 14-18,
2005; Vol. I, pp. 301-321 (2007).
Kumar, A., Srivastava, D. N., Chau, T. T., Long, H. D., Bal, C., Chandra, P. Chien le, T., Hoa, N. V.,
Thulkar, S., Sharma, S., Tam., le, H., Xuan, T. Q., Canh, N. X., Pant, G. S. and Bandopadhyaya, G.
P. “Inoperable Hepatocellular Carcinoma: transarterial 188 Re HDD-Iodized Oil for Treatment –
Prospective Multicentre Clinical Trial,” Radiology, 243, 509-519 (2007).
Lambert, B. “Rhenium-188-based Treatment Strategies for Liver Tumors,” Quar. J. Nucl. Med., 51,
383 (2007); Proceedings of IRIST Conference, “Beta Days in Capri – Current Status in
Radionuclide Therapy,” Capril, Italy, Sepetmber 20-22, 2007.
Lee, S. W., Park, S. W., Park, D. W., Lee, S. W., Kim, S. H., Jang, J. S., Jeong, Y. H., Kim, Y. H.,
Lee, S. C., Hong, M. K., Yun, S. C., Kim, J. J. and Park, S. J.,, “Comparison of Six-Month
Angiographic and Three-Year Outcomes after Stirolimus-Eluting Stent Implantation Versus
Brachytherapy for Bare Metal In-Stent Restenosis,” Am. J. Cardiol., 100, 425-430 (2007).
Liang, S., Wang, Y., Yu, Z., Zhang, X., Xia, J. and Yin, D. ”Surface-Modified Superparamagnetic
Iron Oxide Nanoparticles: As a New Carrier for Bio—Magnetically Targeted Therapy,“ Mater. Sci.
Mater. Med., 18, 2297-2302 (2007).
Liepe, K., Brogsitter, C., Leonhard, J., Wunderlich, G., Hliscs, R., Pinkert, J., Folprecht, G. and
Kotzerke, J. “Feasibility of High Activity Rhenium-188-Microsphere in Hepatic Radioembolization,“
Jpn. J. Clin. Oncol., 37, 942-950 (2007).
Liu, G. and Hnatowich, D. J. “Labeling of Biomolecules with Radiorhenium – A Review of the
Bifunctional Chelators, Anti-Can. Agents in Med. Chem., 7, 367-377 (2007).
Monroy-Guzman, F., Badillo Almaraz, V. E., Flores de la Torre, J. A., Cosgrove, J. M. and
Knapp, F. F., Jr. “Hydroxyapatite-Based Mo-99/Tc-99m and W-188/Re-188 Generator
7

Systems,” In, Trends in Radiopharmaceuticals (ISTR-2005),” Proceedings of the International
Symposium, Vienna, Austria, November 14-18, 2005; Vol. I, pp. 333-348 (2007).
Muller, C., Schubiger, P. A., and Schibli, R. “Isostructural Folate Conjugates Radiolabeled with the
Matched Pair 99m Tc/ 188 Re: A Potential Strategy for Diagnosis and Therapy of Folate Receptor-
PositiveTumors,“ Nucl. Med. Biol., 34, 595-601 (2007).
Mushtaq, A., Bukhari, T. H. and Khan, I. U. “Extraction of Medically Interesting 188 Re-Perrhenate in
Methyl Ethyl Ketone for Concentration Purposes,” Radiochim. Acta, 95, 535-537 (2007).
Newsline, Journal of Nuclear Medicine, “RIT Targeting of HIV-Infected Cells,” 48, 14N (2007)
(Summarizes publications on the use of rhenium-188-labeled antibodies for treatment of chronically
infected human T cells and acutely HIV-1 infected human peripheral blood hPBMC cells in vitro)..
Padhy, A. J., Bernal, P., Buscombe, R. J., Chau, T., Chen, S. L., Divgi, C., Jeong, J. M., Knapp, F.
F., Jr., Kumar, A., Ogbac, R., Pusuwan, P., Raoul, J.-L., Saw, M. M., Sereegotov, E., Stare, J.,
Sundram, F. X., Turner, J. H., Vidmar, G. and Zanzonica, P. “Rhenium-188 Lipiodol Therapy of
Hepatocellular Carcinoma: Results of a Multicentre-Multinational Study,” World J. Nucl. Med., 6 , S-
55-57 (2007).
Park, J.-Y., Lee, T.-S., Choi, T.-H., Cheon, G.-J., Choi, C.-W. and Awh, O.-D. “A Comparative Study
of 188 Re(V)-meso-DMSA and 188 Re(V)-rac-DMSA: Preparation and in vivo Evaluation in Nude
Mice Xenografted with a Neuroendocrine Tumor,” Nucl. Med. Biol., 34, 1029-1036 (2007).
Polatom, description of tungsten-188/rhenium-188 generator –
http://www.polatom.pl/product/list?group=5.
“Safety Study of 188 Re-PTI-6D2 in Patients with Metastatic Melanoma,” Sponsored by Pain
Therapeutics, Inc.; , NCT00399113 (This study is not yet open for patient
recruitment).
Schweitzer, A. D., Rakesh, V., Revskaya, E., Datta, A., Casadevall, A., and Dadchova, E.
“Computational Model Predicts Effective Delivery of 188Re-Labeled Melanin-Binding Antibody to
Metastatic Melanoma Tumors with Wide Range of Melanin Concentrations,” Melanoma Res., 17,
291-303 (2007)..
Shukla, J., Bandopadhyaya, G. P., Shamim, S. A. and Kumar, R. “Characterization of Re-188-Sn
Microspheres Used for Synovitis Treatment,” Int. J. Pharm., 338, 43-47 (2007).
Shukla, J., Bandopadhyaya, G. P., Varma, I. K., Kumar, R. and Maulik, S. K. “Morphology and
Release Kinetics of Technetium-99m(V) Dimercaptosuccinic Acid Loaded, Poly(lactic-coglycolic)acid
Microsphere Delivery System. An Experimentla Approach That May be Used for
Targeted Radiation Therapy,” Hell. J. Nucl. Med., 10, 9-13 (2007).
Su, C. H., Hsieh, B. T., Leung, S. W., Wu, C. J., Chiu, S. Y. and Lin, C. S. ”Increased Expression of
Nuclear NF-kappaB after Corornary Artery Balloon Injury Can be Inhibited by Intracoronary Beta-
Irradation,“ Int. J. Radiat. Biol., 83, 707-716 (2007).
8

Turner, H. J. “From the WFNMB Summit on Radionuclide Therapy,” from, Newsline, J. Nucl. Med.,
48, pp. 40N-41N (2007). (Discussion of advantages of use of the tungsten-188/rhenium-188
generator to obtain rhenium-188 for therapy).
Vente, M. A., Hobbelink, M. G., van Het Schip, A. D., Zonnenberg, B. A. and Nijsen, J. F.
”Radionuclide Liver Cancer Therapies: From Concept to Currnet Cliniclal Status,“ Antican. Agents
Med. Chem., 7, 441-459 (2007).
Wang, X. G., Reskaya. E., Bryan, R. A., Strikler, H. D., Burk, R. D., Casadevall, A. and Dadchova,
E. “Treating Cancer as an Infectious Disease – Viral Antigens as Novel Targets for Treatment and
Potential Prevention of Tumors of Viral Etiology,” PLos ONE, 2, e1114 (2007).
Woehrle, J., Nusser, T., Krause, B. J., Kochs, M., Habig, T., Mottaghy, F. M., Kestler, H. A.,
Hombach, V. and Reske, S. N. “Patients with In-Stent Restenosis: Comparison of Intracorornary
beta-Brachytherapy using a Rhenium-188 Filled Balloon Catheter with the Polymer-Based
Paclitaxel-Eluting Taxus-Express Stent,“ Nukelamedizin, 46, 185-191 (2007).
Xiong, Q.-F., Chen, Y., He., L., Denbg, C.-L., Huang, Z.-W. and Li, J.-L. “Study of Apoptosis
Induced by 188 Re-DTPA-DG in MCF-7 Breast Carcinoma and A549 Pulmonary Carcinoma Cells,”
Can. Biother. Radiopharm., 22, 543-550 (2007).
Published in 2006:
“Targeted Irradiation: A New Weapon Against HIV ?,” In, Medical News Today – 11/9/06 –
discussion of rhenium-188-labeled antibodies – discussion of research reported by Dadachova, et
al., in PLos Med.
Baranov, N., Stepchenkov, D., Petriev, V., Minko, Y., Semenova, A., Sulim, E., Poddublenko, V.,
Zinchenko, M. and Skvortsov, V. “Development of Stationary tungsten-188/rhenium-188 Generator
of High Activity and Set of Cold Kits Intended for Radiotherapy on the Basis of Rhenium-188
Eluate,” Eur. J. Nucl. Med., 33, Suppl. 2, S310 (Abstract # P417) (2006).
Chen, Y., Xiong, F. Q., Yang, Q. X., Huang, W. Z. and He., L. “Preparation and Imaging Research
of 188 Re-DTPA-Deoxyglucose ( 188 Re-DTPA-DG) in MCF-7 Mice,” Eur. J. Nucl. Med., 33, Suppl. 2,
S376 (Abstract # P760) (2006).
Choudry, U. and Blower, P. J. “ 188 Re(V)-DMSA as a Core Complex for Synthesis of Phosphonate
Derivatives for Treatment of Bone Metastases,” Eur. J. Nucl. Med., 33, Suppl. 2, S310 (Abstract #
P416) (2006).
Dadachova, E., Patel, M. C., Apostolidis, C., Morgenstern, A., Brechbiel, M. W., Gorny, M. K.,
Zolla-Pazner, S., Casadevall, A. and Goldstein, H. “Targeted Killing of Virally Infected Cells by
Radiolabeled Antibodies to Viral Proteins,” PLoS Med., 3 (2006).
Dadachova, E., and Casadevall, A. “Treatment of Infection with Radiolabeled Antibodies,” Quart. J.
Nucl. Med., Mol. Imaging, 50, 193-204 (2006).
Francesconi, L. C., Cantorias, M., Howell, R. C., Todaro, L., Bernard, M. and Rohmer, M.
“Stabilization of Tc and Re Peptide Diastereomers,” J. Nucl. Med., 47, 30P (2006) (Abstract).
9

Garayoa, E. G., Blanc, A., Gasser, O., Blauenstein, P., Schibli, R., and Schubiger, P. A. “Paul
Scherrer Institute (PSI), PSI Scientific Report 2006, pp. 54-55 (2006).
Garin, E., Rakotonirina, H., Lejeune, F., Denizot, B., Roux, J., Noiret, N., Mesbah, H., Herry, J.-Y.,
Bourguet, P. and Lejeune, J.-J. “Effect of 188 Re-SSS Lipiodol/ 131 I-Lipiodol Mixture, 188 Re-SSS
Lipiodol Alone or 131 I-Lipiodol Alone on the Survival of Rats with Hepatocellular Carcinoma,” Nucl.
Med. Commun., 27, 363-370 (2006).
Glatting, G., Kull, T., Blumstein, N. M., Bunjes, S., Neumaier, B., Buck, A. K. and Reske, S. N.
”Dosimetry with 188 Re-Labelled Monoclonal Anti-CD66 Antibodies. A Simplified Approach Based
on a Single Measurement 3 h p.i.,” Nukelarmedizin, 45, 134-138 (2006).
IAEA-TECDOC-1489, “Radiological Protection Issues for Endocvascular Use of Radiation Sources”
– Includes guidelines for use of liquid-filled balloons for coronary irradiation - IAEA, February 2006.
Kehlbach, R., Dittmann, H., Schmid, T., Khorchidi, S., Bantleon, R., Rodermann, H. P., Claussen C.
D., Duda, S. H. and Wiskirchen, J. ”Early Effects of Rhenium-188 Treatment on Proliferation,
Migration and Matrix Synthesis of Cultured Human Aortic Smooth Muscle Cells,“ Strahlenther.
Onkol., 182, 164-171 (2006).
Kumar, A. First Prize for Young Investigator Award; For, Rhenium-188 HCC Therapy, Society of
Nuclear Medicine, Annual Meeting, 2006.
Kumar, A., Bal, C., Srivastava, D. N., Thulkar, S. P., Sharma, S., Acharya, S. K. and Duttagupta, S.
“Management of Multiple Intrahepatic Recurrences after Radiofrequency Ablation of Hepatocellular
Carcinoma with Rhenium-188-HDD-Lipiodol,” Eur. J. Gastroenterol. Hepatol., 18, 219-223 (2006).
Kumar, A., Srivastava, D. N. and Bal, C. “Management of Postsurgical Recurrence of
Hepatocellular Carcinoma with Rhenium-188-HDD Labeled Iodized Oil,” J. Vasc. Interv. Radiol., 17,
157-161 (2006).
Kumar, A., Bal, C., Srivastava, D. N., Thulkar, S. P., Sharma, S., Acharya, S. K. and Duttagupta, D.
S. “Management of Multiple Intrahepatic Recurrences after Radiofrequency Ablation of
Hepatocellular Carcinoma with Rhenium-188-HDD-Lipiodol,” Eur. J. Gastroenterol. Hepatol., 18,
(2006).
Kumar, A., Bal, C., Srivastava, D. N., Chandra, P., Acharya, S. K., Pant, G. S. and Bandopadhyaya
G. P. “Dosimetric and Therapeutic Evaluation of Trans-Arterial Rhenium-188 in Cases of
Inoperable Hepatocellular Carcinoma (HCC),” J. Nucl. Med., 47, 105P (2006) (Abstract).
Kuznetsov, R. A., Tarasov, V. A., Klimov, S. I., Pakhomov, A. N. and Bubas, O. V. “Production of
W-188 at SSC RIAR Using the SM High-Flux Reactor,” In Proceedings, 9 th International Symposium
on the Syntehsis and Applications of Isotopes and Isotopically Labelled Compounds, Edinburgh,
Scotland, July 16-20, 2006; Abstract O-51, p.69.
Lambert, B. and de Klerk, J. M. H. “Clinical Applications of 188 Re-Labelled Radionuclides for
Radionuclide Therapy,” Nucl. Med. Commun., 27, 223-230 (2006).
10

Lambert, B., Bacher, K., Defreyne, L., Van Vlierberghe, H., Jeong, J. M., Wang, R. F., van
Meerbeeck, J., Smeets, P., Troisi, R., Thierens, H., De Vos, F. and Van de Wiele, C. “ 188 Re-
HDD/Lipiodol Therapy for Hepatocellular Carcinoma: An Activity Escalation Study,” Eur. J. Nucl.
Med., 33, 344-352 (2006).
Lambert, B. and de Klerk, J. M. H. ”Clinical Applications of 188 Re-Labelled Radiopharmaceuticals
for Radionuclide Therapy,” Nucl. Med. Commun., 27, 223-230 (2006).
Lambert, B., Ridder, L. D., Vos, F. D., Slegers, G., de Gelder, V., de Wiele, C. V. and Thierens, H.
“Assessment of Supra-Additive Effects of Cytotoxic Drugs and Low Dose Rate Irradiation in an in
vitro Model of Hepatocellular Carcinoma,” Can. J. Physiol. Pharmacol., 84, 1021-1028 (2006).
Lee, S. W., Park, S. W., Hong, M. K., Kim, Y. H., Han, K. H., Kim, J., Park, J. H., Oh, S. J., Moon,
D. H., Oh. S. J., Lee, C. W., Kim., J. J. and Park, S. J. “Incidence and Predictors of Late Recurrence
after Beta-Irradiation Therapy with Re-188-MAG3-Filled Balloom for Diffuse In-Stent Restenosis,”
Am. Heart J., 151, 158-163 (2006).
Li, P., YU, J., Cen, G., Jiang, X., Tand, Z., Chen, S., Jiang, L., Tang, L. and Yin, D. “Applied
Radioactivity in Radiation Synovectomy with 188Re-Rhenium Sulfide Suspension,” Nucl. Med.
Commun., 27, 603-609 (2006).
Lim, S. J., Kim, E. H., Woo, K. S., Chung, W. S.,Choi, C. W. and Lim, S. M. “Induction of G2 Arrest
and Apoptosis of Raji Cells by Continuous Low-Dose Beta Irradiation with 188 Re-Perrhenate,” Can.
Biother. Radiopharm., 21, 314-320 (2006).
Liu, X., Rushcowski, M., Dou, S. and Hnatowich, D. J. “Successful Radiotherapy by Pretargeting to
Tumored Mice Using 188 Re-Labeled cMORF,” J. Nucl. Med., 47, 102P (2006) (Abstract).
Liu, G., Dou, S., Jiang, H., Dongguang, Y., Gupta, S., Zhang, S., Wang, Y., Rusckowski, M. and
Hnatowich, D. J. “Radiolabeling of MAG3-Mopholino Oliomers with 188 Re at High Labeling
Efficiency and Specifc Radioactivity for Tumor Pretargeting,” Appl. Radiat. Isot., 64, 971-978 (2006).
Luo, T. Y., Lo, A. R., Hseih, B.-T. and Lin, W. J. “A Design for Automated Preparation of Highly
Concentrated 188 Re-Perrhenate Solution,” Appl. Radiat. Isot., 65, 21-25 (2006).
Park, S. H., Seifert, S. and Pietzsch, H.-J. “Novel and Efficient Preparation of Precursor
[ 188 Re(OH2)3(CO)3] + for the Labeling of Biomolecules,“ Bioconj. Chem., 17, 223-225 (2006).
Park, S. H., Gwon, H. J., Jang, S. H. and Byun, M. W. “A Room Temperatur 188 Re Labeling for a
Bifunctional Chelating Agent for the Preparation of Therapeutic Radiopharmaceuticals,” In
Proceedings, 9 th International Symposium on the Synthesis and Applications of Isotopes and
Isotopically Labelled Compounds, Edinburgh, Scotland, July 16-20, 2006; Abstract P-104, p.201.
Petriev, V. M., Ryzhikova, T. P., Tarasova, T. A., Demidova, N. A., Skvortsov, V. G., Stepchenkov,
D. V. and Baranov, N. G. “Development of Albumin Re-188-Microspheres for Radionuclide Therapy
of Tumors,” Eur. J. Nucl. Med., 33, Suppl. 2, S310 (Abstract # P415) (2006).
11

Reichmann, K., Guhlke, S., Roedel, R., Ezziddin, S., Brockmann, H., Bucerus, J. and Biersack, H.-
J. “Repeated Radionuclide Therapy of Bone Metastases with Rhenium-188 HEDP: A Kinetic
Study,” Eur. J. Nucl. Med., 33, Suppl. 2, S374 (Abstract # P750) (2006).
Reynen, K., Kropp, J., Koeckeritz, U., Wunderlich, G, Knapp, F. F., Schmeisser, A. and Strasser, R.
H. ”Intracoronary Radiotherapy with a Rhenium-188 Liquid-Filled Angioplasty Balloon System in In-
Stent Restenosis: A Single Center, Prospective, Randomized, Placebo-Controlled, Double-Blind
Evaluation,” Coronary Artery Disease, 17, 371-377 (2006).
Saw, M. M., Kurz, P., Agorastos, N., Hor, T. S. A., Sundram, F. X., Yan, Y. K. and Alberto, R.
“Complexes with the fac-{M(CO)3} + (M = 99m Tc, Re) Moiety and Long Alkyl Chain Ligands as
Lipiodol Surrogates,” Inorg. Chim. Acta, 359, 4087-4094 (2006).
Seifert, S. and Pietzsch, H.-J. “The 188 Re(III)-EDTA Complex – A Multipurpose Starting Material for
the Preparation of Relevant 188 Re Complexes under Mild Conditions,” Appl.. Radiat. Isot., 64, 223-
227 (2006).
Seifert, S., Heinrich, T., Jentschal, C., Smuda, C., Bergmann, R. and Pietzsch, H.-J. “Preparation
and Biological Characterization of Isomers 188 Re(V) Oxocomplexes with Tetradentate S4 Ligands
Dervived from meso-Dimercaptosuccinic Acid for Labeling of Bimolecules,“ Bioconj. Chem., 17,
1601-1606 (2006).
Shin, J. H., Song, H. Y., Moon, D. H., Oh, S. J., Kim, T. H. and Lim, J. O. “Rhenium-188
Mercaptoacetyltriglycine-Filled Balloon Dilation in the Treatment of Recurrent Urethral Strictures:
Initial Experience with Five Patients,” J. Vasc. Intervent. Radiol., 17, 1471-1477 (2006).
Tkachuk, D. A. “Extraction Generator of 188 Re,” Eur. J. Nucl. Med., 33, Suppl. 2, S384 (Abstract #
TP24) (2006).
Wohrle, J., Krause, B. J., Nusser, T., Mottaghy, F. M., Habig, T., Kochs, M., Kotzerke, J., Reske, S.
N., Hombach, V. and Hoher, M. “Intracorornary Beta-Brachytherapy Using a Rhenium-188-Filled
Balloon Catheter in Restenotic Lesions of Native Coronary Arteries and Venous Bypass Grafts,”
Eur. J.Nucl. Med. Mol. Imaging, 33, 1314-1320 (2006).
Wohrle, J., Krause, B. J., Nusser, T., Kochs, M. and Hoher, M. ”Repeat Intracoronary Beta-
Brachytherapy Using a Rhenium-188-Filled Balloon Catheter for Recurrent Restenosis in Patients
who Failed Intarcoronary Radiation Therapy,“ Cardiovasc. Revasc. Med., 7, 2-6 (2006).
Zenz, T., Shlenk, R. F., Glatting, G., Neumaier, B., Blumstein, N., Buchmann, I., von Harsdorf, S.,
Ringhoffer, E., Stilgenbauer, S., Dohner, H., Reske, S. N. and Bunjes, D. “Bone Marrow
Transplantation Nephropathy after an Intensified Conditioning Regimen with Radioimmunotherapy
and Allogenic Stem Cell Transplantation,“ J. Nucl. Med., 47, 278-286 (2006).
Zenz, T., Glatting, G., Schlenk, R. F., Buchmann, I., Dohner, H., Reske, S. N. and Bunjes, D. „
“Targeted Marrow Irradiation with Radioactivity Labeled anti-CD66 Monoclonal Antibody prior to
Allogenic Stem Cell Transplantation for Patients with Leukemia: Results of a Phase I-II Study,“
Haematologica, 91, 285-286 (2006).
12

Published in 2005:
Azhdarinia, A., Yang, D. J., Yu, D. F., Mendez, R., Oh, C., Kohanim, S., Bryant, J. and Kim, E. E.
“Regional Radiochemotherapy Using In Situ Hydrogel,” Pharm. Res., 22,776-783 (2005).
Dadachova, E., Nguyen, A., Lin, E. Y., Gnatovskiv, L., Lu, P. and Pollard, J. W. “Treatment with
Rhenium-188-Perrhenate and Iodine-131 of NIS-Expressing Mammary Cancer in a Mouse Model
Remarkably Inhibted Tumor Growth,” Nucl. Med. Biol., 32, 695-700 (2005).
El-Mabhouh, A. and Mercer, J. R. “ 188 Re-Labeled Bisphosphonates as Potential Bifunctional
Agents for Therapy in Patients with Bone Metastases,” Appl. Radiat. Isot, 62, 541-549 (2005).
Ferro-Flores, G., Torres-Garcia, E., Garcia-Pedroza, L., Arteaga de Murphy, C., Pedraza-Lopez, M.
and Garnica-Garza, H. “An Efficient, Reproducible and Fast Preparation of 188 Re-anti-CD20 for the
Treatment of non-Hodjkin’s Lymphoma,” Nucl. Med. Commun., 26 , 793-799 (2005).
Finlay, I. G., Mason, M. D. and Shelley, M. “Radioisotopes for the Palliation of Metastatic Bone
Cancer: A Systematic Review,” Lancet Oncol., 6, 392-400 (2005).
Flores de la Torre, J. A., Monroy-Guzman, F., Badillo Almaraz, V. E. and Knapp, F. F., Jr.
”Hydroxyapatite-Based 99 Mo/ 99m Tc and 188 W/ 188 Re Generator Systems,” In, Proceedings,
International Symposium on Trends in Radiopharmaceuticals (ISTR)-2005), p. 51; IAEA, Vienna,
Nov. 14-18, 2005 (IAEA-CN-130/030).
Garin, E., Denizot, B., Roux, J., Noiret, N., Lepareur, N., Moreau, M., Mesba, H., Laurent, J. F.,
Herry, J. Y., Bourguet, P., Benoit, J. P. and Lejeune, J. J. “Description and Technical Pitfalls of a
Hepatoma Model and of Intra-Arterial Injection of Radiolabelled Lipiodol in the Rat,” Lab. Anim., 39,
314-320 (2005).
Greenland, W. E. and Blower, P. J. “Water-Soluble Phosphines for Direct Labeling of Peptides with
Technetium and Rhenium: Insights from Electrospray Mass Spectrometry,” Bioconj. Chem., 16,
939-948 (2005).
Iller, E., Zekel, Z., Konior, M., Sawlewicz, K., Staniszewska, J. and Mikolajjczak, R. “Technological
Line for Production of Carrier-Free 188 Re in the Form of Sterile, Isotonic Solution of Sodium
Perrhenate (VII),” In, Proceedings, International Symposium on Trends in Radiopharmaceuticals
(ISTR)-2005), pp. 49- 50; IAEA, Vienna, Nov. 14-18, 2005 (IAEA-CN-130/030).
Jaeckel, B., Cripps, R., Guentay, S. and Bruchertseifer, H. “Development of Semi-Automated
System for Preparation of 188 Re Aqueous Solutions of High and Reproducible Activity
Concentrations,” Appl. Radiat. Isot., 63, 299-304 (2005).
Kim, K., Bae, J., Koo, B. K., Youn, T. J., Kim, S. H., Cahe, I. H., Him, H. S., Sohn,m D. W., Oh, B.
H., Lee, M. M., Park, Y. B. and Choi, Y. S. “Long-Term Clinical Outcomes of Dissections after
Intarcoronary Beta-Radiation with Rhenium-188-diethylenetraimminepentaacetic Acid-Filled Balloon
System,” Int. J. Cardiol., 104, 190-196 (2005).
13

Kotzerke, J., Bunjes, D. and Scheinberg, D. A. „Radioimmunoconjugates in Acute Leukemia
Tretament: The Future is Radinat,“ Bone Marrow Transplant., 36, 1021-1026 (2005).
Kumar, A., Bal, C. S., Srivastava, D. N., Acharya, S. K., Thulkar, S. P. Sharma, S. and Duttagupta,
S. “Transarterial Radionuclide Therapy with Re-188-HDD-Lipiodol in Case of Unresectable
Hepatocellular Carcinoma with Extensive Portal Vein Thrombosis,” Eur. J. Radiology, 1-8 (2005).
Lambert, B., Bacher, K., Defryne, L., Gemmel, F., Van Vlierberghe, H., Jeong, J. M., Dierckx, R. A.,
Van de Wiele, C., Thierens, H. and De Vos, F. “ 188 Re-HDD/Lipiodol Therapy for Hepatocellular
Carcinoma: A Phase I Clinical Trial,“ J. Nucl. Med., 46, 60-66 (2005).
Lee, S. W., Park, S. W., Hong, M. K., Lee, J. H., Kim, Y. H., Moon, D. H., Oh, S. J., Lee, C. W., Kim,
J. J. and Park, S. J.. “Comparison of Angiographic and Clinical Outcomes Between Rotational
Atherectomy versus Balloon Angioplasty Followed by Radiation Therapy with a Rhenium-188-
Mercaptoacetyltriglycine-Filled Balloon in the Treatment of Diffuse In-Stent Restenosis,” Int. J.
Cardiol., 102, 179-185 (2005).
Lee, S. W., Park, S. W., Hong, M. K., Kim, Y. H., Han, K. H., Moon, D. H., Oh, S. J., Lee, C. W.,
Kim, J. J. and Park, S. J. “Comparison of Angiographic and Clinical Outcomes Between Rotational
Atherectomy and Cutting Balloon Angioplasty Followed by Radiation Therapy with a Rhenium-188-
Mercaptoacetyltriglycine-Filled Balloon in the Treatment of Diffuse In-Stent Restenosis,” Am. Heart
J., 150, 577-582 (2005).
Liepe, K., Runge, R. and Kotzerke, J. ”Systemic Radionuclide Therapy of Pain Palliation,“ Am. J.
Hosp. Appliat. Care, 22, 457-464 (2005).
Liepe, K., Runge, R. and Kotzerke, J. “The Benefit of Bone-Seeking Radiopharmaceuticals in the
Treatment of Metastatic Bone Pain,“ J. Can. Res. Clin. Oncol., 131, 60-66 (2005).
Liepe, K. and Kotzerke, J. ”Advantage of 188 Re-Radipharmaceuticals in Heptacellular Cancer and
Liver Metastases,“ Letter to the Editor, J. Nucl. Med., 46, 1407-1408 (2005).
Lambert, B. ”Advantage of 188 Re-Radipharmaceuticals in Heptacellular Cancer and Liver
Metastases,“ Reply to Letter to the Editor, J. Nucl. Med., 46, 1408 (2005).
Li, G., Wang, Y., Huang, K., Zhang, H., Peng, W. and Zhang, C. ”The Experimental Study of the
Radioimmunotherapy of the Nasopharyngeal Carcinoma Overexpressing HER2/neu in Nude Mice
Model with Intramural Injection of 188 Re-Herceptin,“ Nuc. Med. Biol., 32, 59-65 (2005).
Lo, A.-R., Hsieh, B.-T., Huang, T.-C. and Luo, T.-Y. “Apparatus and Method for Automatic
Preparation of 188 Re-Perrhenate,” US Patent Application # 20050255010, Noc. 17, 2005.
Marczewski, B., Dias, C. R., Moraes, V. and Osso, J. A., Jr. “Liquid Kit for Preparation of 188 -
Rhenium Etidrontae,” Braz. Arch. Biol. Tech., 48, (2005).
Miao, Y., Owen, N. K., Fischer, D. R., Hoffman, T. J. and Quinn, T. P. ”Therapeutic Efficacy of a
188 Re-Labeled α-Melanocyte-Stimulating Hormone Peptide Analog in Murine and Human
Melanoma-Bearing Mouse Models,” J. Nucl. Med., 46, 121-129 (2005).
14

Miller, W. H., Hartmann-Siantur, C., Fisher, D., Descalle, M.-A., Daly, T., Lehmann, J., Lewis, M. R.,
Hoffman, T., Smith, J., Situ, P. D. and Volkert, W. A. “Evaluation of Beta-Adsorbed Fractions in a
Mouse Model for 90 Y, 188 Re, 166 Ho, 140 Pm, 64 Cu and 177 Lu Radionuclides,” Can. Biother.
Radiopharm., 20, 436-449 (2005).
Morandeau, L., Benoist, E., Loussouarn, A., Quadi, A., Lesaec, P. Mougin, M., Faivre-Chauvet, A.,
Le Boterff, J., Chatal, J. F., Barbet, J. and Gestin, J. F. “Synthesis of New Bivalent Peptides for
Applications in the Affinity Enhancement System,” Bioconjug. Chem., 16, 184-193 (2005).
Oliver, Y. P., Robles, A. M., Trinidade, V., Cabral, G. P., Tortarolo, V., Nappa, A., Rodriguez, G. and
Balter, H. S. “Labelling and Biological Evalution of anti-CD-20 for Treatment of Non-Hodgkin’s
Lymphomma,” In, Proceedings, International Symposium on Trends in Radiopharmaceuticals
(ISTR)-2005), pp. 78- 79; IAEA, Vienna, Nov. 14-18, 2005 (IAEA-CN-130/030).
Ringhofer, M., Blumstein, N., Neumaier, B., Glatting, G., van Harsdorf, S., Buchmann, I., Wiesneth,
M., Kotzerke, J., Zenz, T., Buck, A. K., Schauwecker, P., Stigenbauer, S., Dohner, H., Reske, S. N.
and Bunjes, D. ” 188 Re or 90 Y-Labelled anti-CD66 Antibody as part of a Dose-Reduced Conditioning
Regimen for Patients with Acute Leukaemia or Myeodysplastic Syndrome over the Age of 55:
Results of Phasde I-II Study,” Br. J. Haematol., 130, 604-613 (2005).
Roy, D., Souey, J.-P., Hareman, N. G., Janicki, C., Weill, F. G., Papineau, K. and Raymond, J. “In
Situ {beta}-Irradiation of a Brain Arteriovenous Malformation Model,” Stroke, 36, 2475-2478 (2005).
Schiller, E., Seifert, S., Tisato, F., Refosco, F., Kraus, W., Spies, H. and Pietzsch, H. J. “Mixed-
Ligand Rhenium-188 Complexes with Tetradentate/Monodentate NS3/P ('4 + 1') Coordination:
Relation of Structure with Antioxidation Stability,” Bioconjug. Chem., 16, 634-643 (2005).
Yu., J., Hafeli, U. O., Xia, J., Li, S., Dong, M., Yin, D. and Wang, X. “Radiolabelling of a
Poly(Histidine)Derivatized Biodegradable Microspheres with the 188 Re Tricarbonyl Complex
( 188 Re(CO)3(H20)3]+,” Nucl. Med. Commun., 26, (2005).
Weiner, R. E. and Thakur, M. L. ”Radiolabeled Peptides in Oncology: Role in Diagnosis and
Treatment,“ BioDrugs, 19, 145-163 (2005).
Wunderlich, G., Drews, A. and Kotzerke, J. ”A Kit for Labeling of [ 188 Re] Human Serum Albumin
Microspheres for Therapeutic Use in Nuclear Medicine,“ Appl. Radiat. Isot., 62, 915-918 (2005).
Wunderlich, G., Pinkert, J., Stintz, M. and Kotzerke, J. “Labeling and Biodistribution of Different
Particle Materials for Radioembolization Therapy with 188 Re,“ Appl. Radiat. Isot., 62, 745-750
(2005).
Published in 2004:
Alonso, O., Chae, I. H., Chung, J. K., Guiterrez, C., Kropp, J., Onsel, C., Peix, A., Szilvasi, I. and
Padhy, A. K. “Prevention of Coronary Restenosis with a Liquid-Filled Re-188 Balloon: Preliminary
15

Results of an International Atomic Energy Agency (IAEA) Multicenter Trial,” J. Nucl. Med., 45, 249P
(2004).
Azhdarinia, D. J., Yang, D., Yu, D. F., Oh, C., Kohanim, S., Mendez, R., Ito, M., Bryant, J. L., Kim,
E. E. and Podoloff, D. A. “Local Regional Chemotherapy and Radiotherapy using an In Situ
Hydrogel and Planar Imaging for Assessment of Tumor Growth,” J. Nucl. Med., 45, 398P (2004).
Bae, J. W., Koo, B. K., Kim, K. I., Kang, H. J., Cho, Y. S., Youn, T. J., Chung, W. Y., Chae, I. H.,
Kim, H. S., Lee, M. M., Oh, B. H. and Park, Y. B. “Two-Year Outcomes of Repeated Brachytherapy
in Patients with Restenosis after Intracoronary Radiation Therapy,” Am. J. Cardiol., 94, 1061-1063
(2004).
Basu, S., Nair, N., Awasare, S., Tiwari, B. P., Asopa, R. and Nair, C. “ 99m Tc(V)DMSA Scintigraphy
in Skeletal Metastases and Superscans Arising from Various Malignacies: Diagnosis, Treatment
Minitoring and Therapeutic Implications,” Brit. J. Radiol., 77, 347-361 (2004).
Bernal, P. I., Osorio, M., Esguerra, R., Ucros, G., Divgi, C., Zanzonico, P. and Padhy, A. K.
“Evaluation of Rhenium-188-Lipiodol Dosimetry in the Treatment of Liver Cancer: Experience from
Colombia,” J. Nucl. Med., 45, 387P (2004).
Bernal, P., Osorio, M., Guiterrez, C., Esguerra, R., Cerquera, A. M., Ucros, G., Arevalo, S., Velez,
O., Divgi, C., Zanzonico, P., Sundram, F. and Padhy, A. K. “Evaluation of Rhenium-188 Lipiodol in
the Treatment of Liver Cancer: Experience in Colombia Between 2001-2003,” World J. Nucl.
Med., 3, S128 (2004); Proceedings, International Symposium on Nuclear Oncology, Porto Alegre,
Brazil, January 19-23, 2004.
Boschi, A., Uccelli, L., Duatti, A., Colamussi, P., Cittanti, C., Filice, A., Rose, A. H., Martindale, A.
A., Lanringbold, P. G., Kearney, D., Galeotti, R., Turner, J. H. and Giganti, M. “A Kit Formulation of
the Preparation of Re-188-Lipiodol: Preclinical Studies and Preliminary Therapeutic Evaluation in
Patients with Unresectable Hepatocellular Carcinoma,” Nucl. Med. Commun., 25, 691-699 (2004).
Cao, J., Wang, Y., Yu, J., Xia, J., Zhang, C., Yin, D. and Hafeli, U. O. “Preparation and
Radiolabeling of Surface-Modified Magnetic Nanoparticles with Rhenium-188 for Magnetic Targeted
Therapy,” J. Magnetism and Mag. Mat., 277, 165-174 (2004).
Chau, T. T. M. “Some Preliminary Experiences on Treatment of Inoperable Liver Cancer with Re-
188 HTDD Lipiodol,” World J. Nucl. Med., 3, S128 (2004); Proceedings, International Symposium
on Nuclear Oncology, Porto Alegre, Brazil, January 19-23, 2004.
Chaudakshetrin, P., Osorio, M., Padhy, A. K., Divgi, C. and Zanzonico, P. “Rhenium-188 Lipiodol
Therapy of Liver Cancer: Optimization of Conjugate View Imaging of 188 Re for Patient-Specific
Dosimetry,” World J. Nucl. Med., 3, S128 (2004); Proceedings, International Symposium on
Nuclear Oncology, Porto Alegre, Brazil, January 19-23, 2004.
Chen, S. L., Wang, W. D. and Shi, H. C. “Endovascular Brachytherapy for the Prevention of
Neointimal Hyperplasia with Re-188 Filled Balloon in a Rabbit Restenosis Model,” J. Nucl. Med., 45,
221P (2004).
16

Chen, S. L., Wang, W. D., Chen, Y. C. and Knapp, F. F. ”Generator Elution and Concentration of
Rhenium-188,“ J. Nucl. Med., 45, 484P (2004) (Abstract).
Chen, Y., Geng, J., Tian, J., Yin, D. and Chen, S. “Dosimetry of Beta Nuclide Filled Balloon
Catheter in Endovascular Barchytherapy,” Biomed. Mat. Eng., 14, 337-339 (2004).
Cho, Y. S., Kim, M. A., Hwang, K. K., Koo, B. K., Oh, S., Chae, I. H., Kim, H. S., Lee, D. S., Oh, B.
H., Lee, M. M., Park, Y. B. and Choi, Y. S. “Two-Year Clinical Follow-Up Results of Intracoronary
Radiation Therapy with Rhenium-188-Diethylenetriaminepentaacetic Acid-Filled Balloon,” Catheter
Cardiovasc Interv. , 63,274-281 (2004).
Chung, H. K., Woo, K. S., Chung, W. S., Choi, T. H., Lee, T. S., Ahn, M. J., Youn, S. H., Choi, C.
W., Cheon, C. W., Kim, S. and Lim, S. M. “Cellular Metabolic Response to Re-188 Dose Rate Beta-
Irradiation in MCF7 Cell Line with P53 Dominat Negative Mutation,” J. Nucl. Med., 45, 27 (2004).
Crudo, J. L., Edreira, M. M., Obenau, E. R. and de Castiglia, S. G. “Labeling of the Anti-Melanoma
14f7 Monoclonal Antibody with Rhenium-188-MAG3 Chelate: Conjugation Optimization, in vitro
Stability and Animal Studies,” J. Radioanalyt. Nucl. Chem., 261, 337-342 (2004).
Dadachova, E., Nosanchuk, J. D., Schweitzer, A. D., Bryan, R. A., Moadel, T., Zhang, T. and
Casadevall, A. ”Anti Melanoma Antibodies and Peptides for Targeted Radiotherapy of Melanoma,”
J. Nucl. Med., 45, 207P (2004) (Abstract).
Dadachova, E., Nosanchuk, J. D., Shi, L., Schweitzer, A. D., Frenkel, A., Nosanchuk, J. S. and
Casadevall, A. “Dead Cells in Melanoma Tumors Provide Abundant Antigen for Targeted Delivery
of Ionizing Radiation by a mAb to Melanin,” Proc. Nat. Acad. Sci., 101, 14865-14870 (2004).
Dadachova, E., Howell, R. W., Bryan, R. A., Frankel, B. A., Nosanchuk, J. D. and Casadevall, A.,
“Susceptibility of Human Pathogenic Fungi Cryptococcus neoformans and Histoplasma capsulatum
to γ-Radiation Versus Radioimmunotherapy with α- and β-Emitting Radioisotopes,” J. Nucl. Med.,
45, 313-320 (2004).
DeCristoforo, C., von Guggenburg, E., Gabriel, M., Moncayo, R. and Watfah-Rychlinski, C.,
“Preparation of 186/188 Re-DMSA(V) from a Commercial Kit and Therapeutic Trial of a Patient with
Advanced Medullary Thyroid Carcinoma,” Nuklearmedizin, 6, A172 (2003)(Abstract # 15.7); 52 nd
Badgastein Symposium, Bad Gastein, Austria, January 14-17, 2004.
De Ruyck, K., Lambert, B., Bacher, K., Gemmel, F., De Vos, F., Vral, A., de Ridder, L., Dierckx, R.
A. and Thierens, H. ”Biologic Dosimetry of 188 Re-HDD/Lipiodol Versus 131 I-Lipiodol Therapy in
Patients with Hepatcellular Carcinoma,“ J. Nucl. Med., 45, 612-618 (2004).
Eidherr, H., Neumaier, B., Knee, H., Reske, S. N., Bartosch, E., Mitterhauser, M., Wadsak, W.,
Krcal, A., Havlik, E., Viernstein, H., Kletter, K. and Dudczak, R. “The Viennese Rhenium-188-
Concentration System,” Nuklearmedizin, 6, A180 (2003)(Abstract # 15.2); 52 nd Badgastein
Symposium, Bad Gastein, Austria, January 14-17, 2004.
Eidherr, H., Seitz, B., Neumaier, B., Mahren, B., Reske, S. N., Bechere, A., Hoffman, M.,
Mitterhauser, M., Wadzak, W., Wagner, L., Girschele, F., Bartosch, E., Vierstein, H., H., Kletter, K.
17

and Dudczak, R. “Viennese Experiences with Technetium-99m and Rhenium-188 Direct Labeling
Technique of Different Antibodies,” Nuklearmedizin, 6, A180 (2003)(Abstract # 15.3) ; 52 nd
Badgastein Symposium, Bad Gastein, Austria, January 14-17, 2004.
Faintuch, B. L., Faintuch, S. and Muramoto, E. “Preparation and Evaluation of Two New 188 Re-
Radiopharmaceuticals for Endovascular Irradiation,” J. Radioanalyt. Nucl. Chem., 260, 363-368
(2004).
Frier, M. “Rhenium-188 and Copper-67 Radiopharmaceuticals for Treatment of Bladder Cancer,”
Mini Rev. Med. Chem., 4, 61-68 (2004).
Garin, E., Noire, N., Malbert, C., Lepareur, N., Roucoux, A., Caulet-Maugendre, S., Moisan, A.,
Lecloirec, J., Henry, J. Y. and Bourgeut, P. “Development and Biodistribution of 188 Re-SSS Lipiodol
Following Injection into the Hepatic Artery of Healthy Pigs, “ Eur. J. Nucl. Med., 31, 542-546 (2004).
Garin, E., Denizot, B., Noiret, N., Lepareur, N., Roux, J. C., Moreau, M., Herry, J.-Y., Bourguet, P.,
Benoit, J.-P. and Lejeune, J.-J. “ 188 Re-SSS Lipioldol: Radiolabeling and Biodistribution Following
Injection into the Hepatic Artery of Rats Bearing Hepatoma,” Nucl. Med. Commun., 25 , 1007-1014
(2004).
Hafeli, U., Zhang, H., Bahrenhmand, F. and Reynaert, N. ”Development of an Automated
Electroplater and Dosimetry System for the Electrodeposition and Quality Control of Radioactive
Stents,“ Appl. Radiat. Isot., 61, 1313-1321 (2004).
Henning, E., Dittmann, H., Wiskirchen, J., Bantleon, R., Kehlbach, R., Claussen, C. D. and Duda, S.
H. “Dose Dependent Effects of the Combined Beta-Gamma-Emitter 188-Rhenium on the Growth of
Human Vessel Wall Cells,“ Rofo., 176, 404-408 (2004) (In Polish).
Kim, K. I., Bae, J., Kang, H. J., Koo, B. K., Youn, T. J., Kim, S. H., Chae, I. H., Kim, H. S., Sohn, D.
W., Oh, B. H., Lee, M. M., Park, Y. B., Choi, Y. S. and Lee, D. S. ”Three-year Clinical Follow-Up
Results of Intracoronary Radiation Therapy Using a Rhenium-188 DTPA-Filled Balloon System,“
Circ. J., 68, 532-537 (2004).
Knapp, F F., Jr., Turner, J. H. and Padhy, A. K. “Issues Associated with the Use of the Tungsten-
188/Rhenium-188 Generator and Concentrator System and Preparation of Re-188 HDD: A Report,”
World J. Nucl. Med., 3, 137-143 (2004).
Koo, B.-K., Lee, M.-M., Oh, S., Park, Y.-B., Choi, Y.-S. and Lee, D. S. “Effects of β-Radiation with a
188
Re-Filled Balloon Catheter System on Non-Stented Adjacent Coronary Artery Segments,” Int. J.
Cardiol., 96, 73-77 (2004). (The “SPARE” Trial).
Kropp, J., Reynen, K., Koerkeritz, U., Wunderlich, G., Smeisser, A., Knapp, F. F. and Strasser, R.
R. “Intracoronary Radiotherapy with a Re-188 Liquid-Filled Balloon: The Dresden Prospective,
Randomized, Placebo-Controlled, Double-Blind, In-Stent Restenosis Trial (DRAIN),” J. Nucl. Med.,
45, 249P (2004) (Abstract).
Kumar, A. J., Srivastava, D. N., Acharya, S. K., Pant, G. S., Bandopadhyaya, G. P., Sudaram, K.
R., Duttagupta, S., Pandey, G. K., Malhorta, A. and Bal, C. S.”Trans-Hepatic-Arterial Re-188
18

Labeled Lipiodol Therapy (TART) in Cases of Inoperable Hepatocellular Carcinoma (IHCC): A
Prospective Multicentric Clinical Trial,” J. Nucl. Med., 45, 147P (2004) (Abstract).
Kumar, V. “Radiopharmacology of Re-188 DMSA(V),” World J. Nucl. Med., 3, S128 (2004);
Proceedings, International Symposium on Nuclear Oncology, Porto Alegre, Brazil, January 19-23,
2004.
Lazarova, N. P., Babich, J. and Zubieta, J. A. ”Rhenium Tricarbonyl Core Complexes with Thiol and
Thioether Based Ligands,” J. Nucl. Med., 45, 470P (2004).
Li, P. Y., Jiang, X. F. and Yu, J. F. ”Adsorbed Dose in Synovium of Rabbitt Model with Re-188-
Rhenium Sulfide Radiation Synovectomy,” J. Nucl. Med., 45, 437P (2004) (Abstract).
Lin, U.-T., Chu, C.-H., Hiseh, B.-T. and Hwang, W.-S. “Dose Evaluation and Measurement of the
188 Re Liquid-Filled Balloon in Intravascular Bractyherapy,” Appl. Radiat. Isot., 61, 1323-1333
(2004).
Luo, T.-Y., Hsieh, B.-T., Wang, S.-J., Lin, W.-Y., Lee, T.W., Shen, L.-H. and Su, M.-J. “Preparation
and Biodistribution of Rhenium-188 ECD/Lipiodol in Rats Following Hepatic Arterial Injection,” Nucl.
Med. Biol., 31, 671-677 (2004).
Mitra, A., Mulholland, J., Nan, A., Ghandehari, H., McNeill, E. O., Babich, J. W. and Line, B. R.
”Biodistribution of Angiogenesis Targeting Tc-99m and Re-188 N-(2-hyroxypropyl)methacrylamide
(HPMA)-RGD4C Conjugates in SCID Mice Bearing Human Prostate Carcinoma,” J. Nucl. Med., 45,
456P (2004) (Abstract).
Mitterhauser, M., Togel, S., Wadsak, W.,Eidherr, H., Wiesner, K., Viernstein, H., Kletter, K. and
Dudczak, R. ”Binding Studies of [(18)F]-fluoride and Polyphosphonates Radiolabeled with [(111)In],
[(152)Sm], and [(188)Re] on Bone Compartments: A New Model for the Pre in vivo Evaluation of
Bone Seekers,“ Bone, 34, 835-844 (2004).
Mitterhauser, M., Wadsak, W., Eidherr, H., Krcal, A., Kletter, K., Dudczak, R., Viernstein, H. and
Pirich, C. ”Labeling of EDTMP (Multibone®) with [ 111 In], [ 99m Tc], and [ 188 Re] Using Different
Carriers for “Cross Complexation,” Appl. Radiat. Isot., 60, 653-658 (2004).
Moka, D., Baer, F., Barth, I., Rimpler, A. and Schicha, H. “Beta Radiation Exposure of Medical
Personnel during Vascular Brachytherapy with Re-188,” Nuklearmedizin, 6, A178 (2003)(Abstract
# 18.4) ); 52 nd Badgastein Symposium, Bad Gastein, Austria, January 14-17, 2004.
Mushtaq, A. ”Concentration of 99m Tc04-/ 188 Re04 - By a SIngle, Compact, Anion Exchange
Cartridge,“ Nucl. Med. Commun., 25, 957-962 (2004).
Onkhuudai, P., Gonchigsuren, D., Erdenechimeg, S., Lamjav, Ch. and Tsevelmaa, L. ”Transarterial
Radionuclide Re-188-Lipiodol Treatment of HCC,” World J. Nucl. Med., 3, S128 (2004);
Proceedings, International Symposium on Nuclear Oncology, Porto Alegre, Brazil, January 19-23,
2004 (Abstract).
19

Osso, J. A., Jr., Oliveria, A., Marczewski, B. S. and Faintuch, B. L. “Viability Studies for the
Preparation of 188 W/ 188 Re Generators at IPEN/CNEN-SP,” World J. Nucl. Med., 3, S128 (2004);
Proceedings, International Symposium on Nuclear Oncology, Porto Alegre, Brazil, January 19-23,
2004 (Abstract).
Padhy, A. K. “IAES Initiatives in Liver Cancer,“ World J. Nucl. Med., 3, S128 (2004); Proceedings,
International Symposium on Nuclear Oncology, Porto Alegre, Brazil, January 19-23, 2004
(Abstract).
Park, S.-W., Hong, K.-K., Oh, S. J. and Moon, D. H. “Intracoronary Brachytherapy for In-Stent
Restenosis: Will It Remain a Viable Therapy ?” Eur. J. Nucl. Med. Mol. Imag., 31, 1219-1223
(2004).
Reynen, K., Kockeritz, U., Kropp, J., Wunderlich, G., Knapp, F. F., Jr., Schmeisser, A. and Strasser,
R. H. “Intracoronary Radiotherapy with a Re-188 Liquid-Filled PTCA Balloon System in In-Stent
Restenosis: Acute and Long-Term Angiographic Results, As Well as 1-Year Clinical Follow-up,” Int.
J. Cardiol., 95, 29-34 (2004).
Savio, E., Ures, M. C., Zeledon, P., Triondade, V., Paolino, A., Mockford, V., Malanga, A.,
Fernandez, M. and Gaudiano, J. “ 188 Re Radiopharmaceuticals for Radiosynovectomy: Evaluation
and Comparison of Tin Colloid, Hydroxyapatite and Tin-Ferric Hydroxide Macroaggregates,”
BioMed Central, 4(1), 1 (2004).
Shin, J. H., Song, H. Y., Moon, D. H., Oh, S. J., Kim, J. S., Kim, T. H., Choi, W. C., Suh, J. Y., Kang,
W., Seol, H. Y. and Lee, J. H. “Reduction of Tissue Hyperplasia with a Rhenium-188 MAG3-Filled
Balloon: Preliminary Study in a Canine Urethral Model,” J. Vasc. Interven. Radiol., 15, 737-743
(2004).
Shukla, J. and Bandopadhyaya, G. P. ”Rhenium-188(V) DMSA Loaded PLGA Biodgradable
Polymeric Microspheres as Radiotherapeutics: Synthesis, Characterization, In Vitro and In Vivo
Assessment,” J. Nucl. Med., 45, 207P (2004) (Abstract).
Sun, X. G., Xiu, Y. and Huang, G. “Comparative Study of the Therapeutic Effect of Intratumoral
Injection of Re-188-Lebeled Stannic Sulfur Suspension and Chemical Agents for Hepatoma in an
Animal Model,” J. Nucl. Med., 45, 296P (2004).
Sundram, F., Chaur, T. C. M., Onkhuudai, P., Bernal, P. and Padhy, A. K. “Preliminary Results of
Transarterial Rhenium-188 HDD Lipiodol Treatment of Inoperable Primary Hepatocellular
Carcinoma,“ Eur. J. Nucl.Med., 31, 250-257 (2004).
Sundram, F.. “Preliminary Results of Transarterial Rhenium-188 HDD-Lipiodol in Treatment of
Inoperable Primary Hepatocellular Carcinoma,” World J. Nucl. Med., 3, S128 (2004); Proceedings,
International Symposium on Nuclear Oncology, Porto Alegre, Brazil, January 19-23, 2004
(Abstract).
Trujillo, P. B., Osorio, M., de Garcia, M. M., Rodriguez, G. U., Esguerra, R., Gomez, R., Padhy, A.
K., Divgi, C., Sundram, F., Cerquuera, A. M., Velez, O., Guiterrez, C., Restrepo, J. M., Idrovo, V.
20

and Acosta, F. “Tratameinto de Lesiones Hepaticas Tumorales con RENIO-188-LIPIODOL.
Experiencia en Colombia,” ALASBAMIN, 6 (2004).
Varvarigou, A., Bouziotis, P., Zikos, C., Scopinaro, F. and De Vincentis, G. “Gastrin-Releasing
Peptide (GRP) Analogues for Cancer Imaging,” Cancer Biother. Radiopharm., 19, 219-229 (2004).
Wang, S.-J., Lo, T.-Y., Hiseh, B.-T., Cheng, K.-Y., Lin, Wan-Yu, and Shen, L.-H. ”A New Technique
for Labeling of Lipiodol with 188 Re in the Treament of Hepatic Tumor,“ J. Radioanalyt. Nucl. Chem.,
261, 189-193 (2004).
Wei, L., Babich, J. W. and Zubieta, J. A. ”Unusual Reactivity of the {\MO\} +3 Core: Synthesis and
Characterization of Novel Rhenium Halide Complexes with N-Methyl-O-Diaminobenzene,” J. Nucl.
Med., 45, 468P (2004) (Abstract).
Yoon, C. J., Chung, J. W., Park, J. H., Kim, Y. I., Lee, K. H., Jeong, J. M. and Paeng, J. C.
“Transcatheter Arterial Embolization with Rhenium-188-HDD-Labeled Iodized Oil in Rabbit VX2
Liver Tumor,” J. Vasc. Interven. Radiol., 15, 1121-1128 (2004).
Yue, N., Roberts, K. and Nath, R. “Effects of Vessel Curvature on Dose Distributions in Catheter-
Based Intravscular Brachytherapy for Various Radionuclides,” Cardiovas. Radiat. Med., 5, 142-150
(2004).
Zuckier, L. S., Dohan, O., Chang, C. J., Carrasco, N. and Dadachova, E. “Kinetics of Perrhenate
Uptake and Comparative Biodistribution of Perrhenate, Pertechnetate and Iodide by NaI Symporter-
Expressing Tissues In Vivo,” J. Nucl. Med., 45, 500-507 (2004).
Published In 2003:
Babich, J. W. and Zubeita, J. A. “Radiopharmaceutical Models Incorporating the [Re(CO)3] +1 Core
with Tridentate Chelates Linked to Bioactive Molecules,” J. Nucl. Med., 44, 304P (2003) (Abstract).
Banerjee, S. R., Lazarova, N., Wei, L., Levadala, M. K., Maresca, K. P., Valliant, J. F., Babaich, J.
W. and Zubieta, J. A. “Single Amino Acid Based Biofunctional Chelates for Labeling of
Biomolecules with the [M(CO)3] +1 Core and a Novel [M(X)3] Core (M = Tc/Re)”, J. Nucl. Med., 44,
50P (2003) (Abstract).
Bernal, P., Osorio, M., Guiterrez, C., Esguerra, R., Cerquerra, A. M., Ucros, M., Arevalo, S., Velez,
O., Divgi, C., Zanzonico, P. and Padhy, A. K. “Evaluation of Rhenium-188 Lipiodol In the Treatment
of Liver Cancer: Experience in Columbia,” J. Nucl. Med., 44, 176P (1003) (Abstract).
Boschi, A., Bolzati, C., Uccelli, L. and Duatti, A. “High-Yield Synthesis of the Terminal 188 Re-Nitrile
Multiple Bond from Generator-Produced [ 188 Re04] - ,“ Nucl. Med. Biol., 4, 381-387 (2003).
Chaudakshetrin, P. Osorio, M., Somanesan, S., Sundram, F. X., Padhy, A. K., Divgi, C. R. and
Zanzonico, P. B. “Rhenium-188 Lipiodol Therapy of Liver Cancer: Optimization of Conjugate-View
Imaging of Re-188 for Patient-Specific Dosimetry,” J. Nucl. Med., 44, 324P (2003) (Abstract).
21

Cherung, W.-J., Hsieh, B.-T., Wang, C.-H., Hung, M.-J., Cheng, K. Y., Yen, T.-T. and Lee, N.
“Vascular Response to Endovascular Irradiation of 188 Re in the Rabbitt Model after Angioplasty,“ J.
Radioanalyt. Nucl. Chem., 257, 255-260 (2003).
Cisar, A. and Admas, T. “Generator for 188 Re,” U. S. Patent No. 0235530 A1, Issued December 25,
2003.
Dadachova, E., Nabouzi, A., Bryan R. A. and Casadevall, A. “Ionizing Radiation Delivered by
Specific Antibody Againts a Fungal infection,” PNAS, 16, 10942-10947 (2003).
Faintuch, B. L., Faintuch, S. and Muramoto, E. “Complexation of 188 Re-Phosphonates: in vitro
and in vivo Studies,” Radiochim. Acta., 91, 607-612 (2003).
Fanituch, B. L., Pereira, N. P. S., Faintuch, S., Muramoto, E. and Silva, C. P. G. “Direct Labeling of
Octapeptides with Rhenium-188,” Radiochim. Acta., 7, 427-432 (2003).
Faintuch, B. L., Pereira, N. P. S., Faintuch, S., Muramoto, E. and Silva, C. P. G. “Direct Labeling
Studies of Octapeptides with Rhenium-188,” Radiochim. Acta, 91, 427-432 (2003).
Friesen, C., Lubatschofski, A., Kotzerke, J., Buchmann, J., Reske, S. N. and Debatin, K. M. “Beta-
Irradiation Used in Systemic Radioimmunotherapy Induces Apoptosis and Activates Apotosis
Pathways in Leukemia Cells,“ Eur. J. Nucl. Med., 30, 1251-1261 (2003).
Hang, C. L., Fu., M., Hsieh, B.-T., Leung, S. W., Wu, C.-J., Yip, H.-K. and Ting, G. “Intracoronary
[Beta]-Irradiation with Liquid Rhenium-188: Results of the Taiwan Radiation in Prevention of Post-
Pure Balloon Angioplasty Restenosis Study – Clinial Investigations,” Chest, 2003.
Hang, C. L., Fu, M., Hsieh, B.-T., Leung, S. W., Wu, C. J. and Ting, G. “Intracoronary Beta-
Irradiation with Liquid Rhenium-188 to Prevent Restenosis Following Pure Balloon Angioplasty:
Results from the TRIPPER-1 Study,” Chang Gung Med. J., 26, 98-106 (2003).
Hang, C. L., Fu, M., Hsieh, B. T., leung, S. W., Wu, C. J., Yip, H. K. and Ting, G. “Intracoronary
Beta-Irradiation with Liquid Rhenium-188: Results of the Taiwan Radiation in Prevention of Post-
Pure Balloon Angiolplasty Restnosis Study,” Chest, 124, 1284-1293 (2003).
He, J., Liu, C., Vanderheyden, J. L., Liu, G., Dou, S., Ruschowsvi, M. and Hnatowich, D. J.
“Radiolabeling Morpholinos with 188 Re Carbonyl Provides Improved In Vitro and In Vivo Stability to
Re-Oxidation,” J. Nucl. Med., 44, 100P (2003) (Abstract).
Hoher, M., Wohrle, J., Wohlfrom, M. Kamenz, J., Nusser, T., Grebe, O. C., Hanke, H., Kochs, M.,
Reske, S. N., Hombach, V. and Kotzerke, J. “Intracoronary Beta-Irradiation with Rhenium-188-
Filled Balloon Catheter: A Randomized Trial in Patients with de novo and Restenotic Lesions,”
Circ., 107, 3022-3027 (2003).
Hong, M. K., Park, S. W., Moon, D. H., Oh, S. J., Lee, C. W., Kim, Y. H., Lee, J. W., Song, J. M.,
Kang, D. H., Song, J. K., Kim, J. J. and Park, S. J. “Intravascular Ultrasound Analysis of Nonstented
Adjacent Segments in Diffuse In-Stent Restenosis Treated with Radiation Therapy with a Rhenium-
188-Filled Balloon,” Cather Cardiovasc. Interven., 58, 428-433 (2003).
22

Hong, M. K., Park, S. W., Moon, D. H., Oh, S. J., Lee, C. W., Kim, Y. H., Kim, J. H., Zhang, Y.,
Song, J. M./, Song, J. K., Kim, J. J. and Park, S. J. “Extra-Stent Vascular Remodeling in In-Stent
Restenosis after 188 Re-MAG3 Radiation Therapy, “ Int. J. Cardiol., 92, 187-191 (2003).
Iznaga-Escobar, N., Ramirez, I. L., Izquierdo, J. C., Suarez, L., Morales, D. and Perez-Rodriguez,
R. “ 188 Re-Labeled Anti-Epidermal Growth Factor Receptor Humanized Monoclonal Antibody h-R3:
Labeling Conditions, In Vitro and In Vivo Stability,” Methods Find. Exp. Clin. Pharmacol. , 25, 703-
711 (2003).
Jeong, J. M. and Chung, J.-K. “Update: Therapy with 188 Re-Labeled Radiopharmaceuticals: An
Overview of Promising Results from Initial Clinical Studies,” Can Biother. Radiopharm., 18, 707-718
(2003).
Jeong, J. M., Lee, Y. J., Kim, E.-H., Chang, Y. S., Kim, Y. J., Son, M., Lee, D. S., Chung, J.-K. and
Lee, M. C. “Preparation of 188 Re-Labeled Paper for Treating Skin Cancer,” Appl. Radiat. Isot., 58,
551-555 (2003).
Kang, J. H., Chung, J. K., Lee, Y. L., Shin, J. H., Kim, K. I., Oh, H. J., Jeong, J. M., Lee, D. S., and
Lee, M. C. “Application of Radiounclide Gene Therapy to Human Hepatocellular Carcinoma Cell
Line Using Sodium/Iodide Symporter,” J. Nucl. Med., 44, 336P (2003) (Abstract # 1203).
Knapp, F. F., Jr. “Applications of Rhenium-188-Labeled Agents in Oncology,” In, Proceedings, the
11 th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, Athens, Greece,
May 28-30, Mediterrea Pub., Athens (ISBN 960-86437-2-4); pp. 147-156 (2003).
Kothari, K., Suresh, S., Sarma, H. D., Meera V. and Pillai, M. R. A. “ 188 Re-Labeled Hydroxyapatite
Particles for Radiation Synovectomy” Appl. Radiat. Isot., 58, 463-468 (2003).
Kropp, J., Pinkert, J., Wunderlich, G. and Knapp, F. F., Jr. “Radiochemistry, Evaluation and First
Clinical Results in the Treatment of Oncologic Diseases with Rhenium-188-Labeled Microspheres,”
In, Proceedings, the 11 th Mediterranean Symposium on Nuclear Medicine and
Radiopharmaceuticals, Athens, Greece, May 28-30; Mediterrea Pub., Athens (ISBN 960-86437-2-
4); pp. 157-166 (2003).
Liepe, K., Kropp, J., Runge, R. and Kotzerke, J. ”Therapeutic Efficacy of Rhenium-188-HEDP in
Human Prostate Cancer Skeletal Metastases,“ Brit. J. Cancer, 89, 625-629 (2003).
Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W.-G. “Radiation
Dosimetry of Rhenium-188-HEDP in Human Prostate Cancer Skeletal Metastases,” J. Nucl. Med.,
44, 953-960 (2003).
Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Kotzerke, J. ”Rhenium-188 HEDP
Dosimetry in Bone Pain Induced by Prostate Cancer,” In, Proceedings, the 11 th Mediterranean
Symposium on Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 28-30;
Mediterrea Pub., Athens (ISBN 960-86437-2-4 ); pp. 69-82 (2003).
23

Lee, E. B., Shin, K. C., Lee, Y.-J., Cheon, G.-J., Jeong, J. M., Son, M. W, and Song, Y. W. “ 188 Re-
Tin-Colloid As A New Therapeutic Agent for Rheumatoid Arthritis,” Nucl. Med. Commun., 24, 689-
696 (2003).
Magram, M. Y., Edelman, M. J., Forero, A., Meredith, R. F., Shen, S., Stubbs, J. B., Rudoltz, M. S.,
Schlief, R. and Line, B. R. “A Novel Rhenium-188 Labeled Somatostatin Receptor (SSTR)
Targeting Peptide, P2045, As Potential Targeting Therapy for Lung Cancer,” J. Nucl. Med., 44,
137P (2003) (Abstract No. 447).
Meyer, J. M., Nowak, B., Schuermann, K., Buecker, A., Moltzahn, F., Kulisch, A., Heussen, N.,
Gorgen, T., Bull, U. and Gunther, R. W. ”Inhibition of Neointimal Proliferation with 188 Re-Labeled
Self-Expanding Nitinol Stent in a Sheep Model,“ Radiology, 229, 847-854 (2004).
Miao, Y., Whitener, D., Fang, W., Owen, N. K., Chen, J. and Quinn, T. P. “Evaluation of the Human
Melanoma Targeting Properties of Radiolabeled α-Melanocyte Stimulating Hormone Peptide
Analogues,” Bioconj. Chem., 14, 1177-1184 (2003).
Miao, Y., Owen, N. K., Hoffman, T. J. and Quinn, T. P. “Therapeutic Efficiacy of Re-188 Labeled
Alpha-MSH Peptide in a Human Melanoma Xenografted SCID Mouse Model,” J. Nucl. Med., 44,
178P (1003) (Abstract).
Moka, D., Baer, F., Barth, I., Rimpler, A. and Schicha, H. “Beta Radiation Exposure of Medical
Personnel During Vascular Brachytherapy with Re-188,” J. Nucl. Med., 44, 327P (1003) (Abstract
# 1170).
A. Mushtaq, “Preparation of High Specific Volume Solutions of Technetium-99m and Rhenium-188,”
Appl. Radiat. Isot., 58, 309-314 (2003).
Oh, S. J., Moon, D. H., Lee, W. W., Park, S.-W., Hong, K.-K., Park, S.-J., Shin, D.-I. and Lee, H. K.
“Automated Preparation of 188 Re-Labeled Radiopharmaceuticals for Endovascular Radiation
Therapy,” Appl. Radit. Isot., 59, 225-230 (2003).
Paeng, J. C., Jeong, J. M., Chang, C. J., Lee, Y.-S., Suh, Y.-G., Chung, J. W., Park, J. H., Chung,
J.-K., Son, M. and Lee M. C. “Lipiodol Solution of 188 Re-HDD as a New Therapeutic Agent for
Transhepatic Arterial Embolization in Liver Cancer: Preclinical Study in a Rabbit Liver Cancer
Model,” J. Nucl. Med., 44, 2033-2038 (2003).
Paeng, J. C., Lee, D. S., Kang, W. J., Yang, H. M., Chung, J. K., Jeong, J. M., Chae, I. H., Lee, M.
M. and Lee M. C. “Dosimetry in Leakage of 188 Re-DTPA During Intracoronary Balloon
Brachytherapy,” Eur. J. Nucl. Med. Mol. Imaging, 30, 1263-1265 (2003).
Palmedo, H., Manka-Waluch, A., Albers, P., Schmidt, W., Guhlke, S., Reinhardt, M., Ezziddin, S.,
Joe, A., Roedel, R., Fimmers, H., Knapp, F. F., Jr. and Biersack, H.-J. “Repeated Bone Targeted
Therapy for Hormone-Refractory Prostate Carcinoma: Randomized Phase II Trial with the New,
High-Energy Radiopharmaceutical Rhenium-188-HEDP,” J. Clin. Oncol., 21, 2869-2875 (2003).
Palmedo, H., Manka-Waluch, A., Albers, P., Scmidt-Wolf, I., Reinhardt, M., Ezziddin, S., Joe, A.,
Fimmers, R., Guhlke, S. and Biersack, H.-J. “Repeated Bone Targeted Therapy for Hormone-
24

Refractory Prostate Carcinoma: Randomized Phase II Trial with the New, High Energy
Radiopharmaceutical Rheium-188-HEDP,” J. Nucl. Med., 44, 174P (1003) (Abstract # 568).
Sailerova, E. and Billinghurst, M. W. “A Study of Factors Affecting the Labelling of Tartrate with
188 Re and the Transchelation of the 188 Re from the Tartrate to Protein,” Appl. Radiat. Isot., 5, 353-
359 (2003).
Sailerova, E. and Billinghurst, M. W. “Storage Conditions for 188 Re-Perrhenate Solutions and Thier
Impact on the Use of 188 Re-Perrhenate in the Preparation of 188 Re-Labeled Compounds,” Appl.
Radiat. Isot., 5, 353-359 (2003).
Scheffler, J., Derejko, M., Bandurski, T. and Romanowicz, G. ”Application of Rhenium-188 HEDP
in Bone Metastases Therapy,“ Nucl. Med. Rev. Cent. East Eur., 6, 55-57 (2003).
Shin, C. Y., Son, M., Ko, J. I., Jung, M. Y., Lee, I. K., Kim, S. H., Kim, W. B., Jeong, J. M. and Song,
Y. W. “DA-7911, 188 Re-Tin-Colloid, As A New Therapeutic Agent of Rheumatoid Arthritis,” Arch.
Pharm. Res., 26, 168-172 (2003).
Smith, C. J., Sieckman, G. L., Owen, N. K., Hayes, D. L., Mazuru, D. G., Volkert, W. A. and
Hoffman, T. J. “Radiochemical Investigation of [ 188 Re(H2O)(CO)3-Diaminopropionic Acid-SSS-
Bombesin(7-14)NH2]: Synthesis, Radiolabeling and in vitro/in vivo CRP Receptor Targeting
Studies,“ Anticancer Res., 23(1A), 63-70 (2003).
Vucina, J. and Han, R. “Production and Therapeutic Use Rhenium-186, 188 – The Future of
Radionuclides,” Med. Preg., 56, 632-365 (2003) (in Croatian).
Wuu, C. S., Schiff, P., Maryanski, M. J., Liu, T., Borzillary, S. and Weinberger, J. “Dosimetry Study
of Re-188 Liquid-Filled Balloon for Intravascular Brachytherapy Using Polymer Gel Dosimeters and
Laser-Beam Optical CT Scanner,” Med. Phys., 30, 132-137 (2003).
Yang, D. J., Azhdarinia, A., Oh, C., Mendez, R., Yukihiro, M., Yu, D., Kim, E. E. and Podoloff, D. A.
“Noninvasive Assessment of Tumor Hypoxia with 99m Tc and 188 Re-EC-Metronidazole,” J. Nucl.
Med., 44, 100P (1003) (Abstract).
Zhang, H., Tian, M., Li, S., Liu, J., Tanada, S. and Endo, K. “Rhenium-188-HEDP Therapy for the
Palliation of Pain Due to Ossesous Metastases in Lung Cancer Patients,” Can Biother.
Radiopharm., 18, 719-726 (2003).
Published In 2002:
Boschi, A., Uccelli, L., Bolzati, C., Marinelli, M. and Duatti, A. “Comparison of Two Different
Procedures for Labeling Antibodies with Rhenium-188,” In, Proceedings, 6 th International
Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, Sept. 4-7, 2002.
Buchmann, I., Bunjes, D., Kotzerke, J., Martin, H., Glatting, G., Seitz, U., Rattat, D., Buck, A.,
Doehner, H. and Reske, S. N. “Myeloablative Radioimmunotherapy with Re-188-anti-CD66-
Antibody for Conditioning of High-Risk Leukemia Patients Prior to Stem Cell Transplantation:
25

Biodistribution, Biokinetics and Immediate Toxicities,” Cancer Biother. Radiopharm., 17, 151-164
(2002).
Buchmann, I., Schultz, A., Sparber, M. and Reske, S. N. “Myeoablative Radioimmunotherapy with
188 Re- ANTI CD-36-mAB in Pediatric Leukemia Patients: A Phase I Trial,” J. Nucl. Med., 43, 37P
(2002) (Abstract).
Bugaj, J. E., Bickel, E. M., Azure, M. T., Friebe, M., Lister-James, J., Dean, R. T. and Dinkelborg, L.
M. “Radiotherapeutic Efficacy of a SSTR-Targeting Peptide ( 188 Re-P2045) in a Small Cell Lung
Cancer (SCLC) Mouse Model,” J. Nucl. Med., 43, 123P (2002) (Abstract).
Bunjes, D. “ 188 Re-Labeled anti-CD66 Monoclonal Antibody in Stem Cell Transplantation for
Patients with High-Risk Acute Myeloid Leukemia,” Leuk. Lymphoma., 43, 2125-2131 (2002).
Chen, J., Chen, Z., Miao, Y., Jurrison, S. S. and Quinn, T. P. “Alpha-Melanocyte-Stimulating
Hormone Peptide Analogs Labeled with Technetium-99m and Indium-111 for Malignant Melanoma
Targeting,” Cancer, 94 (Suppl. 2), 1196-1201 (2002).
Cheng, Z., Chen, J., Miao, Y., Owen, N. K., Quinn, T. P. and Jurisson, S. S. “Modification of the
Structure of a Metallopeptide: Synthesis and Biological Evaluation of 111 In-Labeled DOTA-
Conjugated Rhenium-Cyclized Alpha MSH Analogues,” J. Med. Chem., 45, 3048-3056 (2002).
Crudo, J. L., Edreira, M. M., Obenaus, E. R., Chinol, M., Paganelli, G. and de Castiglia S. G.
“Optimization of Antibody Labeling with Rhenium-188 using a Prelabeled MAG3 Chelate,” Int. J.
Pharm., 248, 173-182 (2002).
Crudo, J., Sudati, F., Chinol, M. and de Castiglia, S. G. “Preparation of 188 Re-Norbiotinamine Using
S-Benzoyl-MAG3 as Chelating Agent,” In, Proceedings, 6 th International Symposium on Technetium
in Chemistry and Nuclear Medicine, Bressanone, Italy, Sept. 4-7, 2002.
Crudo, J. L., Edreira, M. M., Obenaus, E. R., Chinol, M., Paganelli, G and de Castiglia, S. G.
“Optimization of Antibody Labeling with Rhenium-188 Using a Prelabeled MAGs Chelate,” Int. J.
Pharm., 248, 173-182 (2002).
Dadachova, M. S., So, L. V., Lambrecht, R. M. and Dadachova, E. “Development of a Titanium
Tungstate-Based 188 W/ 188 Re Gel Generator Using Tungsten of Natural Isotopic Abundance,” Appl.
Radiat. Tech., 57, 641-646 (2002).
Dadachova, E., Bouzahzah, B., Zuckier, L. S. and Pestell, R. G. “Rhenium-188 as an Alternative to
Iodine-131 for Treatment of Breast Tumors Expressing the Sodium/Iodide Symporter (NIS),” Nucl.
Med. Biol., 29, 13-18 (2002).
Dadachova, E., Russell, R. and Zuckier, L. S. “Assessment of Maximal Tolerated Dose of 188 Re-
Perrhenate, A Potential Agent for Treatment of NIX-Expressing Tumors in a Mouse Model,” J. Nucl.
Med., 43, 120 P (2002) (Abstract).
26

Donamov, V. P. “Thermochromatographic Isolation of Os, Ru, Re and Tc Radioisotopes in the
Form of Lower Oxides,” Radiochemistry, 44 (2), 109-113 (2202); translated from Radiokhimiya, 44
(2), 102-105 (2002).
Duatti, A., Martindale, A. A., Tuner, J. A., Boschi, A., Giganti, M., Bolzati, C. and Uccelli, L.
“Rhenium-188 Lipidol Kit Formulation for Therapy of Hepatocellular Carcinoma (HCC),” World J.
Nucl. Med., 1, Suppl. 2, S180 (2002).
Ferro-Flores, G., Ramirez, F. De M., Martinez-Mendosa, M. G., de Murphy, C. A., Pedraza-Lopez,
M. and Garcia-Salinas, L. “Peptide Labeling Using 188 Re, 188 Re-MAG3 and 153 Sm-HETA: A
Comparison on Their In Vitro Stability,” J. Radioanalyt. Nucl. Chem., 251, 7-13 (2002).
Fox, R. A. “Intravascular Brachytherapy of the Coronary Arteries,” Phys. Med. Biol., 47, R1-30
(2002).
Hambye, A. S., Dobbelier, A., Vervaet, A. M., and Knapp, F. F., Jr. “Image Quality with Rhenium-
188 and Technetium-99m: Comparative Planar and SPECT Evaluation in a Phantom Study and
Implications for Dosimetry,” World J. Nucl. Med., 1, 12-20 (2002).
Hindorf, C., Linden, O., Tennvall, J., Winghardh, K. and Strand, S. E. “Time Dependence of the
Activity Concentration Ratio of Red Marrow to Blood and Implications for Red Marrow Dosimetry,”
Cancer, 94 (Suppl), 1235-1239 (2002).
Hoeher, M., Wohrie, J., Wohlfrom, M., Greba, O., Nusser, T., Kathnetz, J., Hanck, H., Koche, M.,
Reske, S. N. and Kotzerke, J. “Intraocoronary β-Irradiation with a Liquid Rhenium-188 Filled Balloon
Reduces Restenosis Following Angioplasty of De-Novo and Restenotic Lesions - Final Results of
Randomized ECRIS-II Trial,” Circ., 106, Suppl. 3070 (2002) (Abstract).
Haefliger, P., Ortner, K., Agroastos, N. and Alberto, R. “A DNA-intercalating Complex of a Pyrene
Derivative with the 188 Re-(CO)3-Moiety as a Potentially Improved Radiotherapeutic Drug,” In,
Proceedings, 6 th International Symposium on Technetium in Chemistry and Nuclear Medicine,
Bressanone, Italy, Sept. 4-7, 2002.
Hang, C. L., Fu, M., Hsieh, B. T., Leung, S. W., Wu, C. J., Yip, H. K. and Ting, G. “Intracoronary
Beta-Irradiation with Liquid Rhenium-188: Results of the Taiwan Radiation in Prevention of Post-
Pure Balloon Angioplasty Restenosis Study,” Chest, 124, 1284-1293 (2003).
Iznaga-Escobar, N., Ramirez, H., Izquierdo, J. C., Suarez, L., Morales, D. and Perez-Rodriguez, R.
“ 188 Re-labeled Antidepidermal Growth factor Receptor Humanized Monclonal Antibody h-R3:
labeling Condityions, in vitro and in vivo Stability,” Methods Find Exp. Clin Pharmacol., 25, 703-711
(2003).
Jeong, J. M. and Chung, J. K. “Therapy with 188 Re-Labeled Radiopharmaceuticals: An Overview of
Promnising Results from Initial Clincial Trials,” Can. Biother. Radiopharm., 18, 707-717 (2003).
Karczmarcyzk, U., Mikolajczak, A., Markiewics, A., Sawlewicz, K. and Zulczyk, W. “Rhenium-
188/Rhenium-186 and technetium-99m Hydroxyethylidene Diphosphonate: Kit Formulation for the
27

Treatment of Bone Metastases,” In, Proceedings, 6 th International Symposium on Technetium in
Chemistry and Nuclear Medicine, Bressanone, Italy, Sept. 4-7, 2002.
Kassing, W. M., McGoron, A. J., Thomas, S. R., Elson, H. R. and Pipes, D. W. “Monte Carlo
Calculations of Dose Distribution for Intrarmural Delivery of Radioisotopes Using a Direct Injection
Balloon Catheter,” Cardiovasc. Rad. Med., 3, 44-48 (2002).
Keng. G. H., Sundram, F. X., Yu, S. W., Somanesan, S., Premaraj, J., Oon, C. J., Kwok, R., and
Htoo, M. M. “Preliminary Experience in Radionuclide Therapy of Hepatocellular Carcinoma Using
Hepatic-Arterial Radioconjugates,” Ann. Acad. Med. Singapore, 31, 382-386 (2002).
Kim, E. H., Moon, D. H., Oh, S. J., Choi, C. W., Lim, S. M., Hong, M. K. and Park, S. W. “Monte
Carlo Dose Simulation for Intracoronary Radiation Therapy with a Rhenium-188 Solution-Filled
Balloon with Contrast Medium,” J. Nucl. Cardiol., 9, 312-218 (2002).
Klein, S. A., Hermann, S., Dietrich, J. W., Hoelzer, D. And Martin, H. “Transplantation-Related
Toxicity and Acute Intestinal Graft-Versus-Host Disease after Conditioning Regimens Intensified
with Rhenium-188-Labeled anti-CD66 Monoclonal Antibodies,” Blood, 99, 2270-2271 (2002).
Knapp, F. F., Jr. “Rhenium-188-Labeled Radiopharmaceuticals,” In, Proceedings, 25 th International
Symposium on Radioactive Isotopes in Clinical Medicine and Research, Bad Gastein, Austria,
January 8-11, 2002 (Abstract).
Kothari, K. K., Gali, H., Prabhu, K. R., Pillarsetty, N., Owen, N. K., Katti, K. V., Hoffman, T. J. and
Volkert, W. A. “Synthesis and Characterization of 99m Tc and 188 Re Complexes with a Diamidodihydroxymethylenephosphine-Based
Bifunctional Chelating Agent (N2P2-BFCA),” Nucl. Med. Biol.,
29, 83-89 (2002).
Kotzerke, J., Gabelmann, J. and Hanke, H. “Recurrent Renal Artery Stenosis - Endovascular
Brachytherapy With a Rhenium-188 Filled Balloon Catheter,” Rofo Fortschr. Geg. Rontgentr. Neuen
Bildgeb Verfahr 2002, 174, 1176-1178 (2002) (In German).
Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser, A., Strasser, R. H. and Knapp,
F. F., Jr. “Prevention of In-Stent Stenosis with Liquid Filled 188 Re Balloon: The Dresden In-Stent
Restenosis Trial (DIRRT),” World J. Nucl. Med., 1, Suppl. 2, S13 (Abstract).
Lavi, E., Kijel, D., Sayaq, E. and Bettan, Y. M. “In-situ Generated Solid Radiation Source Based on
Tungsten-188/Rhenium-188 and Use Thereof,” U. S. Patent # US6409943, issued June 25, 2002.
Lee, Y.-S., Jeong, J. M., Kim, Y. J., Chung, J. W., Park, J. H., Suh, Y.-G., Lee, D. S., Chung, J.-K.
and Lee, M. C. “Synthesis of 188 Re-Labeled Long Chain Alkyl Diaminedithiol for Therapy of Liver
Cancer,” Nucl. Med. Commun., 23, 237-242 (2002).
Liepe, K., Kropp, J., Runge, R. And Kotzerke, J. „Therapeutic Efficiency of Rhenium-188-HEDP in
human Prostate Cancer Skeletal Metastases,“ Brit. J. Cancer, 18, 625-629 (2003).
28

Liepe, K., Hliscs, R., Runge, R. and Kropp, J. “Which is the Favorable Time for the Post-
Therapeutic Scan in Dosimetry After 188 Re HEDP Application ?,” J. Nucl. Med., 43, 358P (2002)
(Abstract).
Lim, S. J., Kim, E. H., Woo, K. S., Jung, W. S., Chun, K. J., Choi, C. w., Lim, S. M. and Hong, S. W.
“Apoptosis by Continuous Low Dose-Rate Beta Irradiation Therapy with 188 Re-Perrhenate in
Human Burkitt’s Lymphoma Cell Line,” J. Nucl. Med., 43, 354P (2002) (Abstract).
Luo, C., Chen, Z.-N., Bian, H.-J., Li, J. and Zhou, S.-B. “Pharmacokinetics of
Radioimmunotherapeutic Agent of Direct Labeling mAb 188 Re-HAb18,” World J. Gastroenterol., 8,
69-73 (2002).
Manka-Waluch, A., Albers, P., Gulke, S., Matthies, A., Joe, A., Ezziddin, S. and Palmedo, H.
“Rhenium-188-Hydroxyethylidenediphosphonate (HEDP) in the Treatment of Bone Metastases from
Prostatic Carcinoma,” Annual Meeting, German Society of Nuclear Medicine, Freiburg, Germany,
2002 (In German).
Meyer, J. M., Nowak, B., Schuermann, K., Buecker, A., Moltzahn, F., Kulisch, A., Heussen, N.,
Gorgen, T., Bull, U. And Gunther, R. W. „Inhibition of Neointimal Proliferation with 188 Re-Labeled
Self-Expandng Nitinol Stent in a Sheep Model,“ Radiology, 229, 847-854 (2003).
Miao, Y., Owen, N. K., Wittener, D., Gallazzi, F., Hoffman, T. J. and Quinn, T. P. “In Vivo Evaluation
of 188 Re-Labeled Alpha-Melanocyte Stimulating Hormone Peptide Analogs for Melanoma Therapy,”
Int. J. Cancer, 101, 480-487 (2002).
Miao, Y., Owen, N. K., Wittener, D., Gallazzi, F., Hoffman, T. J. and Quinn, T. P. “Optimizing the
Tumor to Kidney Uptake Ratios of 188 Re-Labeled Alpha-Melanocyte Stimulating Hormone Peptide
Analogs Through Chemical Modification,” In, Proceedings, 6 th International Symposium on
Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, Sept. 4-7, 2002.
Miao, Y., Owen, N., Whitener, D., Gallazzi, F., Hoffman, T. and Quinn, T. “In Vivo Evaluation of
188 Re-Labeled Alpha-Melanocycte Stimulating Hormone Peptide Analogs for Melanoma Therapy,”
Int. J. Cancer, 101, 48-487 (2002).
Miao, Y., Owen, N., Whitener, D., Hoffman, T. and Quinn, T. “Improving the Tumor to Kidney
Uptake Ratio of 188 Re-Labeled Alpha-Melanocyte Stimulating Hormone Peptide Analogues,” J.
Nucl. Med., 43, 42 P (2002) (Abstract).
Mukerjee, A., Pandey, U., Sarma, H., Gupta, S, Pillai, M. R. A. and Venkatesh, M. “ 90 Y and 188 Re
Skin Patches: Studies on Treatment of Superficial Tumors,” J. Nucl. Med., 43, 318P (2002)
(Abstract).
Oh, S. J., Won, K. S., Moon, D. H., Cheon, J. H., Ha, H.-J., Jeong, J. M. and Lee, H. K. “Preparation
and Biological Evaluation of 188 Re-Ethylenediammine-N,N,N’,N’-Tetrakis(methylenephosphonic
Acid) as a Potential Agent for Bone Pain Palliation,” Nucl. Med. Commun., 23, 75-81 (2002).
29

Paeng, J. C., Jeong, J. M., Lee, Y. S., Kim, Y. J., Yoon, C.-J., Park, J. C., Chung, J. W., Lee, D. S.
Chung, J. K. and Lee, M. C. “ 188 Re-Lipiodol as a New Therapeutic Agent for Liver Cancer: A
Preclinical Study in Liver Cancer-Xenografted Rabbits,” J. Nucl. Med., 43, 42 P (2002) (Abstract).
Palmedo, H., Albers, P., Guhlke, S., Manka-Waluch, A., Reinhardt, M. J., Klemm, E., Matthies, A.
Joe, A., Schmaljohann, J. and Biersack, H.-J. “ 188 Re-HEDP in the Treatment of Bone Metastases
Generating From Prostrate Cancer,” J. Nucl. Med., 43, 160P (2002) (Abstract).
Pasqualini, R., Bellande, E., Mevellec, F., Roucoux, A., Noiret, N. and Patin, H.
“Radiopharmaceutical Products Suitable for the Selective Labeling of Lymphocytes, and Their
Preparation,” U.S. Patent # US6,469,146 B1, issued October 22, 2002.
Pervez, S., Mushtaq, A. and Arif, M. “Preparation of 188 Re-labeled Hydroxyapatite for
Radiosynovectomy,” J. Radioanalyt. Nucl. Chem., 245, 383-385 (2002).
Ponsard, B., Hiltunen, J., Pentilla, P., Vera Ruiz, H., Beets, A. L., Mirzadeh, S. and Knapp, F. F., Jr.
“The Tungsten-188/Rhenium-188 Generator: Effective Coordination of Tungsten-188 Production
Between the HFIR and BR2 Reactors,” In, Proceedings of the Fourth International Isotope
Conference, Cape Town, South Africa, March 10-14, 2002.
Popov, Y. S., Zakharova, L. V., Privalova, P. A., Kupriyanov, V. N. and Timofeev, G. A. “Nuclear-
Physical Properties of 188 W, 188 Re and 188 Os,” Radiochmistry, 44, 533-537 (2002) (Translated
from Radiokhimiya, 44, 481-485, 2002).
Ren, X.-Q. and Huang, G. “Effect of 188 Re on Vascular Smooth Muscle Cells, Endothelial Cells
and Myocardial Cells: A Dose Response Study,” J. Nucl. Med., 43, 169P (2002) (Abstract).
Schaart, D. R., Bos, A. J., Winkelman, A. J. And Clarijs, M. C. „The Radial Depth-Dose Distribution
of a 188 W/ 188 Re Beta Line Source Measured with Novel, Ultra-Thin TLDs in a PMMA Phantom:
Comparison with Monte Carlo Simulations,” Phys. Med. Biol., 47, 3605-3627 (2002).
Schibli, R., Schwarzbach, R., Alberto, R., Ortner, K., Schmalle, H., Dumas, C., Egli, A. and
Schubiger, A. “Steps Toward High Specific Activity Labeling of Biomolecules for Therapeutic
Application: Preparation of Precursor [ 188 Re(H20)(CO3)]+ and Synthesis of Tailor-Made Bifunctional
Ligand Systems,” Bioconj. Chem., 13, 750-756 (2002).
Scheffler, J., Derejko, M., Bandurski, T. and Romanowicz, G. “Application of Rhenium-188 HEDP
in Bone Metasteses Therapy,“ Nucl. Med. Rev. Cent. East Eur., 6, 55-57 (2003).
Sudati, F., Crudo, J. L., fabro, A., Chinol, M., de castiglia, S. G. and Fazio, F. “High Radiochemical
Purity of 188 Re-MAG3 Biotin Conjugates Using S-Benzoyl-MAG3 as Chelating Agent,” 6 th
International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy,
Sept. 4-7, 2002.
Sundram, F. X., Yu, S., Somanesan, S., Jeong, J. M., Bernal, P., Osorio, M., Esguerra, R., Chau, T.
C. M., Long, H. D., Hoa, N. V., Huay, N. D. S., Onkhuudai, P., Lamjav, T., Zanzonica, P., Padhy, A.
K., Saw, M. M., Rooland, Y., and Knapp F. F., Jr. “Phase I Study of Transarterial Rhenium-188-
30

HDD Lipiodol in Treatment of Inoperable Primary Hepatocellular Cacinoma - A Multicentre
Evaluation,” World J. Nucl. Med., 1, 5-11 (2002).
Ures, M. C., Savio, E., Malanga, A., Fernandez, M., Paolino, A. and Guadiano, J. “Physico-
Chemical Characterization and Biological Evaluation of 188-Rhenium Colloids for
Radiosynovectomy,” BioMed Central, 2, 1-19 (2002).
Verdera, S., Balter, H., Rodriguez, G., Oliver, P., Souto, B., Lopez, A. and Goncalvez, Z. “Labeling
and Quality Control of 188 Re-Lanreotide,” Cell. Mol. Biol. (Noisy-le-grand), 48, 741-745 (2002).
Vucina, J. and Lukic, D. “Radionuclide Generators for the production of technetium-99m and
Rhenium-188,” Facta Universitatis, Series: Physics, Chemistry and Technology, 2, 235-243 (2002).
Vucina, J. and Han, R. “Production and Therapeutic Use of Rhenium-186/188 – The Future of
Radionuclides,” Med. Pregl., 56, 362-365 (2003) (In Croatian).
Whiting, J. S., Li, A. N. and Eigler, N. L. “System and Method for Automatically Eluting and
Concentratng a Radioisotope,” U.S. Patent # US6157036, Issued December 5, 2000.
Wuu, C. A., Schiff, P. B., Marylanski, M., Liu, T., Borzillary, S. and Weinberger, J. “3D Dosimetry
Study of 188 Re Liquid Balloon for Intravascular Brachytherapy Using Bang Polymer Gel
Dosimeters,” Radiat. Prot. Dosimetry, 99, 397-400 (2002).
Zanzonica, P., Divgi, C, Sundram, F. X., Somaesan, S., Bernal Trujillo, P., Osorio, M., Chau, T. T.
M., jeong, J. M. and Padhy, A. K. “Maximum-Tolerated Activity Treatment Planning Protocol for
Intrahepatic Artery 188 Re-Lipiodol Therapy of Liver Cancer,” J. Nucl. Med., 43, 355P (2002)
(Abstract).
Zhao. Z. G., Ran, Y. L., Zheng, R., Kong, J., Chen, S. Z., Yu, L. And Tang Z. H.
“Radioimmunodetection of 188Re-Labeled anti-Carcnoembryonic Antigen Chimeric Antibody in
Nude Mice Bearing Human Colon carcinoma,” Ai Zheng, 21, 460-463 (2002) (in Chinese).
Zimmerman, B. A., Cessna, J. T. and Unterweger, M. P. “The Standardization of 188 W/ 188 Re by 4π
Liquid Scintillation Spectrometry with the CIEMAT/NIST 3 H-Standard Efficiency tracing Method,”
Appl. Radit. Isot., 56, 315-320 (2002).
Published In 2001:
Andocs, G., Balogh, L., Bodo, K., Polyak, A., Methe, D. and Janoki, G. “Pharmacokinetic
Evaluation of 188 Re-HEDP in Healthy Beagle Dogs and Dogs Having Spontaneous Osteosarcoma,”
EANM Congress, Naples, Italy, August 24-29, 2001, Eur. J. Nucl. Med. (2001).
Azure, M. T., Guaraldi, M. T., Zinn, K. R., Coan, P. N., Pearson, D. A., Wilson, D. M., Cyr, J. E.,
Manchanda, R., Lister-James, J. and Dean, R. T. “Dosimetry Evaluation of 188 Re P2045 in
Primates as Determined by Necropsy and Scintigraphic Region of Interest Analysis Biodistribution
Methods,” J. Nucl. Med., 42, 69P (2001)(Abstract).
31

Bacher, K., Thierens, H., Van de Putte, S., Brans, B., Monsieurs, M., and Dierckx, R. A. “ 188 Re-
Lipiodol: Prediction of the Patient Dose Based on 131 I-Lipiodol Bi-Planar Scanning and Monte Carlo
Simulation,” Eur. J. Nucl. Med., 28, 1196 (2001) (Abstract).
Banerjee, S., Das, T., Samuel, G., Sarma, H. D., Venkatesh, M. and Pillai, M. R. A. “A Novel
[ 186,188 Re]-Labelled Porphyrin for Targeted Radiotherapy,” Nucl. Med. Commun., 22, 1101-1107
(2001).
Bender, H., Guhlke, S., Ezzidin, S., Bangard, M., Palmedo, H., Zamora, P. S. and Biersack, H. J.
“Biodistribution of 188 Re-Labeled Somatostatin Analogue RC160 After Intrapleural Injection in
Patients,” J. Nuc. Med., 42, 312P (2001) (Abstract).
Bender, H., Guhlke, S., Ezzidin, S., Bangard, M., Palmedo, H., Zamora, P. S. and Biersack, H. J.
“Local Ablation of Solitary Metastases of Melanoma by 188 Re-Labeled Somatostatin Analogue
RC160,” J. Nuc. Med., 42, 312P (2001) (Abstract).
Bolzati, C., Sanimaria, M., Bosch, A., Uccelli, L., Duatti, A., Riva, P. and Piffanelli, “An Improved
Procedure for the Efficient Labeling of Antibodies with Re-188,” J. Lab. Cmpds. Radiopharm., 44,
Suppl. 1, S564-S566 (2001).
Buchman, I., Bunjes, D., Rattat, D., Glatting, G., Kotzerke, J., Doehner, H., Martin, H. and Reske, S.
N. “Myeloablative Radioimmunotherapy with 188 Re-Labeled Anti-CD66-MAb Prior to Stem Cell
Transplantation of Leukemia Patients: Correlation of Bone Marrow Dose and Engraftment as Well
as Probability of Relapse,” J. Nuc. Med., 42, 123P (2001) (Abstract).
Bunjes, D., Buchmann, I., Duncker, C., Seitz, U., Kotzerke, J., Wiesenth, M., Dohr, D., Stafnic, M.,
Buck, A., Harsdorf, S. V., Glatting, G., Grimminger, W., Karakas, T., Munzert, G., Dohner, H.,
Bergmann, L. and Reske, S. N. “Rhenium-188-Labeled anti-CD-66 (a,b,c,e) Monoclonal Antibody to
Intensify the Conditioning Regimen Prior to Stem Cell Transplantation for Patients with High-Risk
Acute Myeloid Leukemia or Myelodyspalstic Syndrome: Results of Phase I-II Study,” Blood, 98,
564-572 (2001).
Chang, Y. S., Jeong, J. M., Baek, M. Y., Lee, S. J., Kim, J. K., Lee, D. S., Chung, J.-K. and Lee, M.
C. “Development of 188 Re-Tin Colloid-Coated Balloon for the Prevention of Coronary Restenosis,”
J. Nuc. Med., 42, 71P (2001) (Abstract).
Chen, F. D., Hsieh, B. T., Wang, H. E., Ou, Y. H., Yang, W. K., Whang-Peng, J., Liu, R. S., Knapp,
F. F., Ting, G. and Yen, S. H. “Efficacy of Re-188-Labelled Sulfur Colloid on Prolongation of
Survival Time in Melanoma-Bearing Animals,” Nucl. Med. Biol., 28, 835-844 (2001).
Chen S., Xu, K., Liu, W., Yao, Z., Chen, K., Yin, D. and Wang, X. „Treatment of Metastatic Bone
pain with Rhenium-188 Hydroxyethylidene Diphasohonate,“ Medical Principles and Practice, 10, 98-
101 (2001).
Cheng, Z., Chen, J. Q., Quinn, T. P. and Jurrison, S. S. “Radioidination of Rhenium Cyclized αMSH
Analogs Via D-Lysine,” J. Nuc. Med., 42, 112P (2001).
32

Chung, J.-K., Kim, Y. J., Jeong, J. M., Lee, Y.-S., Lee, D. S., Suh, Y.-G., and Lim, M. C.
“Preparation of Lipiodol Solution of 188 Re-4-Hexadecyl-2,2,9,9-Tetramethyl-4,7-Diaza-1,10-
Decanethiol (HTDD) for Treatment of Liver Cancer,” Eur. J. Nucl. Med., 28, 1228 (2001) (Abstract).
Crudo, J. L., Edreira, M. M., Obenaus, E. R., and de Castiglia, S. G. “Labeling of the Anti-Melanoma
14F7 Moncloncal Antibody with Rhenium-188 using a Pre-Labeled MAG3 Chelate: Optimization, In
Vitro and In Vivo Analysis,” Eur. J. Nucl. Med., 28, 1160 (2001) (Abstract).
Dean, R. T. and McBride, W. “Somatostatin Derivatives and Their Radiolabeled Products,” U.S.
patent # 6241965, issued June 5, 2001.
Du, J., Hiltunen, J., Marquez, M., Nilsson, S. and Holmberg, A. R. “Technetium-99m Labelling of
Glycolsylated Somatostatin-14,” Appl. Radiat. Isot., 55, 181-187 (2201).
Fassbender, M., Phillips, D. R., Ott, K. C. and Arterburn, J. B. “Non-Carrier-Added 186,188 Re-
Labeled 17α-Ethynylestradiol: A Potential Breast Cancer Imaging and Therapy Agent,” J. Lab.
Cmpds. Radiopharm., 44, Suppl. 1, S657 (2001).
Fox, R. A., Barker, P., Guy, D., Smart, G., Henson, P. W., Mews, G. C. and Gibbons, F. “The Use
of 188 Re to Treat In-Stent Re-Stenosis of Corornary Arteries,” Australas. Phys. Eng. Sci. Med., 24,
160-165 (2001).
Gali, H., Hoffman, T. J., Sieckman, G. L. Owen, N. K., Katti, K. V. and Volkert, W. A. “Synthesis,
Characterization, and Labeling with 99m Tc/ 188 Re of Peptide Conjugates Containing a Dithiabisphosphine
Chelating Agent,” Bioconj. Chem., 12, 354-363 (2001).
Garcia-Salinas, L., Ferro-Flores, G., Artega-Murphy, C., Pedraza-Lopez, M., Hernandez-Gutirrez, S.
and Azorin-Nieto, J. “Uptake of the 188 Re(V)-DMSA Complex by Cervical Carcinoma Cells in Nude
Mice: Pharmacokinetics and Dosimetry,” Appl. Radiat. Isot., 54, 413-418 (2001).
Gestin, J. F., Loussouram, A., Berdies, M., Gautherot, E., Gruaz-Guyon, A., Sai-Maurel, C., Barbet,
J., Curtet, C., Chatal, J. F. and Faivre-Chauvet, A. “Two-Step Targeting of Xenografted Colon
Carcinoma Using Bispecific Antibody and 188 Re-Labeled Bivalent Hapten: Biodistribution and
Dosimetry Studies,” J. Nucl. Med., 42, 146-153 (2001).
Hafeli, U. “Radiolabeled Magnetic Microcapsules for Magnetically Targeted Radionuclide Therapy,”
In, Microspheres, Microcapsules and Liposomes, Vol. 3, Radiolabeled and Magnetic Particles in
Medicine and Biology, pp.559-584 (2001); Citus Books, London.
Hafeli, U., Pauer, G., Failing, S. and Tapolsky, G. “Radiolabeling of Magnetic Particles with
Rhenium-188 for Cancer Therapy,” J. Magnetism and Magnetic Mat., 225, 73-78 (2001).
Hafeli, U., Roberts, W. K., Pauer, G. J., Kraeft, S.-K. and Macklis, R. M. “Stability of Biodegradable
Radioactive Rhenium (Re-186 and Re-188) Microspheres After Neutron-Activation,” Appl. Radiat.
Isot., 54, 869-879 (2001).
33

Hausleiter, J., Li, A., Makkar, R., Berman, D., Robinson, A., Litvack, F., Eigler, N. and Whiting, J.
“Leakage of a Liquid 188 Re-Filled Balloon System During Intracorornary Brachytherapy. A Case
Report,” Cardiovasc. Radiat. Med., 2, 7-10 (2001).
Jeong, J. M., Kim, Y. J., lee, Y.-S., Lee, D. S., Chung, J. K., Cho, J.-H., Suh, Y. G. and Lee, M. C.
“Introduction of Long Alkyl Group Helps Uptake and Retention of Lipiodol Solution of 188 Re-N2S2
Derivatives in the Tissues,” J. Lab. Cmpds. Radiopharm., 44, Suppl. 1, S532-S533 (2001).
Jeong, J. M., Kim, Y. K., Lee, Y. S., Ko, J. I., Son. M., Lee, D. S., Chung, J.-K., Park, J. H. and Lee,
M. C. “Lipiodol Solution of a Lipophilic Agent, 188 Re-TDD, for the Treatment of Liver Cancer,”
Nucl. Med. Biol, 28, 197-204 (2001).
Jia, B., Chen, X.-H., Wang, Y.-Q., Bai, H.-S., and Fan, H.-Q. “Preparation of 188 W/ 188 Re Generator
with Clinical-Meaning,” Atomic Energy Science and Technology, 35, 127-132 (2001).
Kahlid, M., Mustaq, A. and Iqbal, M. Z. “Sorption of Tungsten(VI) and Rhenium-(VII) on Various Ion-
Exhcnage Materials,” Sep. Sci. and Tech., 36, 283-294 (2001).
Kassing, W. M. “A Monte Carlo Investigation of the Radiation Dose Distribution in Intravascular
Brachytherapy,” Ph.D. Thesis, Nuclear and Radiological Engineering, University of Cincinnati, 2001.
Kim, Y. J., Lee, Y. S., Joeng, J. M., Lee, D. S., Chung, J.-K. and Lee, M. C. “Increased Tissue
Uptake and Retention of Lipiodol Solution of 188 Re-N2S2 Derivatives After Introduction of Long
Chain Alkyl Groups,” J. Nuc. Med., 42, 116P (2001).
Knapp, F. F., Jr., Spencer, R. and Kropp, J. “Intravascular Radiation Therapy with Radioactive
Liquid-Filled Balloons for inhibition of Restenosis After Angioplasty - A New Opportunity for Nuclear
Medicine ?,” J. Nucl. Med., 42, 1384-1387 (2001).
Knapp, F. F., Jr. “Therapeutic Applications of Rhenium-188 - New Opportunities for Nuclear
Medicine, Oncology and Interventional Cardiology,” IAEA Training Course on Nuclear Oncology,
European Nuclear Medicine Congress, Naples, Italy, August 24-29, 2001 (Invited).
Lee, T. S., Ahn, S. H., Lim, S. J., Chung, W. S., Lee, S. J., Woo, K. S., Choi, C. W., and Lim, S. M.
“Comparison of the Preparation and In Vivo Stability Between 188 Re-MAG3-Lym-1 and 188 Re–
HYNIC-LYM-1 Immunoconuugates for Radioimmunotherapy,” Eur. J. Nucl. Med., in press (2001).
Li, S., Liu, J., Zhang, H., Tian, Wang, J. and Zheng, X. “Rhenium-188 HEDP to Treat Painful Bone
Metastases,” J. Clin. Nucl. Med., 26, 919-922 (2001).
Liepe, K., Hliscs, R., Kropp, J., Runge, R., Knapp, F. F. and Franke, W. G. “Radiation Adsorbed
Dose pf Rhenium-188-HEDP in Bone Metastases, Bone Marrow and Bone Surface,” EANM
Congress, Naples, Itlay, August 24-29, 2001, Eur. J. Nucl. Med. (2001).
Lim, S. J., Woo, K. S., Kim, E. H., Chung, W. S., Lee, S. J., Lee, T. S., Choi, C. W. and Lim, S. M.
“G2 Arrest and Apoptosis of Cultured RAJI Cells by Continuous Low Dose Rate Beta Particle
Irradiation Therapy with 188 Re-Perrhentae,” Eur. J. Nucl. Med., 28, 1246 (2001) (Abstract).
34

Lisic, E. C., Philips, M., Ensor, D., Nash, K. L., Beets, A. L. and Knapp, F. F., Jr. “Synthesis of a
New Bisphosphonic Acid Ligand (SEDP) and Preparation of a 188 Re-(Sn)SEDP Bone Seeking
Radiotracer,” Nucl. Med. Biol, 28, 419-424 (2001).
Makker, R., Whiting, J., Li, A., Hidehiko, H., Fishbein, M. C., Knapp, F. F., Jr., Litvack, F. and Eigler,
N. L. “Effects of β - -Emitting Liquid Isotope (Rhenium-188) Filled Balloon in Stented Porcine
Coronaries: An Angiographic, Intravascular Ultrasound and Histomorphometric Follow-up Study,”
Circulation, 102, 117-3123 (2001).
Melendez-Alafort, L. and Mather, S. J. “ 188 Rhenium-Labelling of HYNIC-[Tyr 3 ]Octreotide,” J. Lab.
Cmpds. Radiopharm., 44, Suppl. 1, S685-S687 (2001).
Murray, A., Simms, M. S., Schofield, D. P., Vincent, R. M., Denton, G., Bishop, M. C., Prince, M. R.
and Pekins, A. C. “Production and Characterization of 188 Re-C595 Antibody for
Radioimmunotherapy of Transitional Cell Bladder Cancer,” J. Nucl. Med., 42, 726-732 (2001).
Murray A., Scholfeld, D. P., Schibli, R., Novak, I., Waibel, R., Vincent, R. M. and Perkins, A. C. “A
Preliminary Comparison of Methods for Production of 188 Re-C595 Antibody for
Radioimmunotherapy of Bladder Cancer,” J. Lab. Cmpds. Radiopharm., 44, Suppl. 1, S573-S575
(2001).
Murphy, C. A., Ferro-Flores, G., Pedraza-Lopez, M., Melendez-Alafort, L., Croft, B. Y., Raimrez, F.
M. and Padilla, J. “Labelling of Re-ABP with 188 Re for Bone Pain Palliation,” Appl. Radiat. Isot., 54,
435-442 (2001).
Nowak, B., Meyer, J. M. A., Goergen, T., Fluehs, D., Block, S., Guenther, R. W., Hoecker, H. and
Buell, U. “Dosimetry of a 188 Rhenium-Labeled Self-Expanding Stent for Endovascular
Brachytherapy in peripheral Arteries,” Cardiovasc. Rad. Med., 2, 246-253 (2001).
Nowak, B., Goergen, T., Meyer, J., Block, S., Schaefer, W., Hoecker, H., Guenther, R. and Buell, U.
“Development and Dosimetry of a 188 Rhenium-Labelled Vascular Stent,” J. Nuc. Med., 42, 161P
(2001).
Oh, S. J., Moon, D. H., Ha, H.-J., Park, A. W., Hong, M. K., Park, S. J., Choi, T. H., Lim, S. M., Choi,
C. W., Knapp, F. F., Jr. and Lee, H. K. “Synthesis of Highly Concentrated 188 Re-MAG3 and
Automation for Intracoronary Radiation Therapy,” Appl. Rad. Isot., 54, 419-427 (2001).
Oh, S. J., Moon, D. H., Park, S. W. and Lee, H. K. “A New Automated System for Routine
Preparation of 188 Re-Labeled Radiopharmaceuticals,” J. Nuc. Med., 42, 265P (2001).
Paeng, J. C., Jeong, J. M., Cheon, C. J., Kim, Y. K., Chung, J.-K., Lee, M. C., Lee, K. H. and Park,
J. H. “Dosimetry of 188 Re-N2S2-Lipiodol in Liver Cancer-Bearing Rabbits After Transhepatic
Arterial Administration,” J. Nuc. Med., 42, 246P (2001).
Park, S. W., Hong, M. K., Moon, D. H., Oh, S. J., Lee, C. W., Kim, J. J. And Park, S. J. “Treatment
of Diffuse In-Stent Restenosis with Rotational Atherectomy Followed by Radiation Therapy with a
Rhenium-188-mercaptoacetyltriglycine-Filled Balloon,” J. Am. Coll. Cardiol., 38, 631-637 (2001).
35

Park, S.-J. “4R: Korean Clinical Trial Using Rhenium-188 Liquid-Filled Balloons,” In, Proceedings,
Cardiovascular Radiation Therapy V Syllabus, Washington, D.C., February 4-7, 2001.
Pedone, C., Morelli, G., De luca, S., Dolmella, A., Mazzi, U., Saviano, M. Tesauro, D. and Visentin,
R. “New Peptide Conjugates As Ligand for Cholecystokinin Receptor Labelled with Rhenium,” For,
EANM Congress, Naples, Italy, August 24-29, 2001, Eur. J. Nucl. Med., 28, 1160 (2001) (Abstract).
Pinkert, J., Matzky, C., Wunderlich, G., Bergmann, R., Andreef, M., Kropp, J and Franke, W. G.
“Factors Affecting the Tumor Retention of Intralesional Injected Beta Emitters,” J. Nucl. Med., 42,
318P (2002) (Abstract).
Pirmettis, I., Limouris, G. S., Bouziotis, P., Papadopolous, M., Knapp, F. F., Jr. and Chiotellis, E.
“Pentavalent Rhenium-188 Dimercaptosuccinic Acid: A New Kit Formulation and its Initial
Evaluation in Mice,” Radiochmica Acta, 89, 115-118 (2001).
Reynaert, N. and Hafeli, U. “Self-Adsorption Correction for 32 P, 198 Au and 188 Re Stents: Dose Point
Kernal Calculations versus Monte Carlo,” Med. Phys., 28, 1883-1897 (2001).
Reske, S. N., Bunjes, D., Buchmann, I., Seitz, U., Glatting, G., Neumaier, B., Kotzerke, J., Buck, A.,
Martin, H., Doehner, H. and Begrmann, L. “Targeted Bone Marrow Ablation in the Conditioning of
High-Risk Leukaemia Prior to Stem Cell Transplantation,” Eur. J. Nucl. Med., 28, 807-815 (2001).
Savio, E., Gaudiano, J., Robles, A., Martinez, G., Leon, A., Verdera, S., Muniz, S., Hermida, J. C.
and Knapp, F. F., Jr. “Rhenium-188 HEDP: Pharmacokinetic Characterization in Osseous
Metastatic Patients and Clinical Evaluation,” Eur. J. Nucl. Med., submitted.
Schibli, R., Alberto, R., Petrig, J., Ortner, K., Schmalle, H., Sigrisi, B., Stahel, J., Schwarzbach, R.
and Schubiger, P. A. “Making the Step from Diagnosis to Therapy: Improved 99m Tc/ 188 Re-
Tricarbonyl Preparation for High Specific Activity Labeling of Biomolecules,” J. Lab. Cmpds.
Radiopharm., 44, Suppl. 1, S723-S725 (2001).
Schoetzig, U., Schrader, H., Schoenfled, E., Guenther, E. and Klein, R. “Standardization of 177 Lu
and 188 Re,” Appl. Radit. Isot., 55, 89-96 (2001).
Schuelen, H., Eigler, N., Whiting, J. S., Haubner, R., Hausleiter, J., Dirhinger, J., Kastrati, A.,
Schwaiger, M. and Schoemig, A. “Usefulness of Intracoronary Brachytherapy for In-Stent
Restenosis with a 188 Re Liquid-Filled Balloon,” Amer. J. Cardiol., 87, 463-466 (2001).
Sundram, F. F., Yu, S. W., Jeong, J. M., Somnesan, S., premaraj, J., Saw, M. M. and Tang, B. S.
“188Rhenium-188-TDD-Lipiodol in Treatment of Inoperable Primary Hepatocelular Carcinoma - A
Case Report,” Ann. Acad. Med. Singapore, 30, 542-545 (2001).
Turner, J. H., Faivre-Chauvert, A., Loussouran, A., Rose, A. H., Gestin, J.-F., Barbert, J. and
Chatal, J.-F. “Preclinical 2-Step Radioimmunotherapy in a Large Animal Model: F6 679 Antibody:
188 Re AG 8-0 Hapten in Human Colony Cancer Xenografts in Sheep,” J. Nuc. Med., 42, 316P
(2001).
36

Waksman, R. “Rhenium and W-188 Cather-Based Systems,” In, Proceedings, Cardiovascular
Radiation Therapy V Syllabus, Washington, D.C., February 4-7, 2001.
Wang, S. J., Zhang, C. L., Yu, L. Z., Bai, Y. and Guo, Y. F. “Labeling Study and Bio-Activity
Evaluation of Re-188-Anti Bladder Cancer Monoclonal Antibody BDI-1,” For, EANM Congress,
Naples, Italy, August 24-29, 2001, Eur. J. Nucl. Med., (2001).
Wang, S. J., Lin, W. Y., Chen, M. N., Chen, J. T., Ho, W.-L., Hsieh, B.- T., Huang, H., Shen, L.- H.,
Ting, G. and Knapp, F. F., Jr. “Histologic Study of Effects of Radiation Synovectomy with
Rhenium-188 Microsphere,” Nucl. Med. Biol., 28, 727-732 (2001).
Wang, S. J., Lin, W. Y., Chen, M. N., Hsieh, B. T., Huang, H., Shen, L. H. and Ting, G. “Histologic
Study of the Effects of Radiation Synovectomy with Rhenium-188 Microsphere,” Eur. J. Nucl. Med.,
28, 1244 (2001) (Abstract).
Wang, S. J., Lin, W. Y., Chen, M. N., Hsieh, B. T., Huang, H., Shen, L. H. and Ting, G. “Histologic
Study of the Effects of Radiation Synovectomy with Rhenium-188 Microsphere,” Nucl. Med. Biol.,
28, 709-717 (2001).
R. Wang, Zhang, C., Yu, L., Guo, Y. and Bai, Y. “Radiochemical Synthesis and Preliminary
Evaluation of Anti-Bladder Cancer Monclonal Antibody BDI-1 labeled with Rhenium-188,” J. Label.
Cmpds. Radipharm., 44, 437-444 (2001).
Weinberger, J. and Knapp, F. F., Jr. “Use of Liquid-Filled Balloons for Coronary Irradiation,” In,
Vascular Brachytherapy, R. Waksman, Editor, Third Edition, Futura Publishing Co., Inc., Armonk,
NY, pp. 753-790 (2002).
Weinberger, J. “Human Experience with Rhenium-188 Liquid-Filled Balloon,” In, Proceedings,
Cardiovascular Radiation Therapy V Syllabus, Washington, D.C., February 4-7, 2001.
Whiting, J. “Dosimetry Calculations for Liquid-Filled Balloons,” In, Proceedings, Cardiovascular
Radiation Therapy V Syllabus, Washington, D.C., February 4-7, 2001.
Wong, E., Bennett, S., Lawrence, B., Fauconnier, T., Lu, L. F. L., Bell, R. A., Thornback, J. R. and
Eschima, D. “Tuftsin receptor-Binding Peptide Labeled with technetium: Chemistry and Preliminary
receptor-Binding Study,” Inorg. Chem., 40, 5695-5700. (I.e. Cold Re-complex also described).
Wohlfrom, M., Kotzerke, J., Kamena, J., Eble, M., Hess, B., Wohrle, J., Reske, S. N., Hombach, V.,
Hanke, H. and Hoher, M. “Endovascular Irradiation with the Liquid Beta-Emitter Rhenium-188 to
Reduce Restenosis After Experimental Wall Injury,” Cardiovasc. Res., 49, 169-176 (2001).
Zhang, G., Shi, Z., tang, G., Chen, J. and Liu, G. “Interference of the Low-Energy Neutrons on
Activations Cross-Section Measurements of the 186 W(n,γ) 188 W Reaction,” Nucl. Sci. and
Engineer., 137, 107-110 (2001).
Zinn, K. R., Coan, P. N., Pearson, D. A., Azure, M. T., Guaraldi, M. T., Manchanda, R., Lister-
James, J. and Dean, R. T. “Dosimetry Evaluation of 188 Re P2045 in Primates as Determined by
37

Necropsy and Scintigraphic Region of Interest Analysis Biodistribution Methods,” J. Nuc. Med., 42,
69P (2001).
Zucker, L. S., Dadachova, E., Li, Y., Donan, O., and Carrasco, N., “Comparative Biodistribution of
Perrehnate, Pertechnetate and Iodide in the NIS-Expressing and Non-Expressing Tissues of Mice,”
J. Nucl. Med., 42, 325P (2002) (Abstract).
Published in 2000:
Azure, M. Guaraldi, M. T., Zinn, K. R., Coan, P. N., Pearsons, A., Wilson, D. M., Cyr, J. E.,
Manachada, R., Lister-James, J. and Dean, R. T. ”Dosimetry Evaluation of Rhenium 188 Re-P2045
in Primates as Determined by Necropsy and Scintigraphic Region of Interest Analysis
Biodistribution Methods,” In, Proceedings, 2000 international Chemical Congress of Pacifichem
Basin Societies, Honolulu, Hawaii, December 14-19, 2000.
Banerjee, S., Samuel, G., Das, T., Sarma, H. D., Kothari, K. and Pillai, M. R. A., “A Novel N2S2
Bifunctional Chelating Agent and its Radiolabeling with 99m Tc and 188 Re,” J. Nucl. Med., 41
(Supplement), 248P (2000).
Bernhardt, P., Benjegard, S. A., Koelby, L., Johanson, V., Nilsson, O., Ahlman, H. and Forssell-
Aronssen, E. “Dosimetric Comparison of Radionuclides for Therapy of Somatostatin Receptor-
Expressing Tumors,” Nucl. Med. Commun., 21, 566 (2000).
Blower, P. J., Kettle, A. G., O’Doherty, M. J. O., Coakley, A. J. and Knapp, F. F., Jr.
“ 99m Tc(V)DMSA Quantitatively Predicts 188 Re(V)DMSA Distribution in Patients with Prostate
Cancer Metastatic to Bone,” Eur. J. Nucl. Med., 27, 1405-1409 (2000).
Blower, P. J. and Prakash, S. “The Chemistry of Rhenium in Nuclear Medicine,” In, Perspectives on
Bioinorganic Chemistry, JAI Press, Inc., 91-143 , 2000.
Blower, P. J., Kettle, A. G., O’Doherty, M. J., Coakley, A. J. and Knapp, F. F., Jr. “ 99m Tc(V)DMSA
Quantitatively Predicts 188 Re(V)DMSA Distribution,” 28 th Annual Meeting, British Nuclear Medicine
Society, Brighton, UK, April 10-12, 2000.
Blower, P. J., Kettle, A. G., O’Doherty, M. J. and Knapp, F. F., Jr. “Quantitative Prediction of
188 99m
Re(V)DMSA Distribution from Tc(V)DMSA Scans for Targeted Radiotherapy Planning,” J.
Nucl. Med., 41 (Supplement), 274P (2000) (Abstract).
Boch, M., Bruchertseifer, F., Haubner, R., Senekowitsch-Schmidtke, R., Kessler, H., Schwaiger, M.
and Wester, H. J. “ 99m Tc, 188 Re and 90 Y-Labelled α,β-Antagonists: Promising Tracers for Tumor
Induced Angiogenesis,” J. Nucl. Med., 41 (Supplement), 41P (2000) (Abstract).
Bolzati, C., Boschi, A., Uccelli, L., Duatti, A., Franceschini, R. and Piffanelli, A. “An Alternative
Approach to the Preparation of 188 Re Radiopharmaceuticals from Generator-Produced [ 188 ReO4]:
Efficient Synthesis of 188 Re(V)-meso-2,3-Dimercaptosuccinic Acid,” Nucl. Med. Biol., 29, 309-314
(2000).
38

Buchman, I., Bunjes, D., Kotzerke, J., Seitz, U., Glatting, G., Rattat, D., Martin, H. J., Doehner, H.
and Reske, S. N. “Radioimmunotherapy with 188 Re Labelled Anti-CD36 Antibody for Myeloablation
Prior to Stem Cell transplantation in High Risk Leukemia Patients,” J. Nucl. Med., 41
(Supplement), 31P (2000) (Abstract).
Buchman, I., Bunjes, D., Seitz, U., Neumaier, B., Kotzerke, J., Bergmann, L. and Reske, S. N.
“Radioimmunotherapy for Myeloablation Prior to Stem Cell Transplantation with Re-188 CD 66
a,b,c,d,e Antibody in High Risk Leukemia Pateints,” Eur. J. Nucl. Med.,27,S81 (2000).
Buck, A. K., Schirrmeister, H., Guhlmann, I., Glatting, G., Kotzerke, J. and Reske, S. N. “Acute Side
Effects of Radioimmunotherapy with 188 Re-Labeled Anti-CD-66 A,B,C,E Antibody for Conditioning
to Bone Marrow Transplantation in Acute Leukemia,” J. Nucl. Med., 41 (Supplement), 79P (2000)
(Abstract).
Cha, I.-H., Lee, M. M., Sung, J. D., Kim, H. S., Sohn, D. W., Oh, B. H., Park, Y. B., Choi, Y. S., Lee,
Y. W., Lee, M. C., Chung, J.-K. and Lee, D. S. “Intracoronary Irradiation with 188 Re-Filled Balloon
System to Reduce Restenosis after Coronary Interventions,” J. Nucl. Med., 41 (Supplement), 128P
(2000) (Abstract).
Chattopadhyay, P., Chiu, Y.-H., Lo, J.-M., Chung, C.-S. And Lu, T.-H. “Synthesis and Structural
Characterization of a Re(V) Complex with a 2N1S Donor and the Radiochemical Behaviour of its Tc
Analog,” Appl. Radit. Isot., 52, 217-223 (2000).
Chen, S. L. “Treatment of Metastatic Bone Pain with 188 Re-HEDP,” J. Nucl. Med., 41
(Supplement), 265P (2000) (Abstract).
Cheon, G. J., Jeong, J. M., Song, Y. W., Lee, E. B., Lee, Y. T., Son, M., Yeo, J. S., Lee, D. S.,
Chung, J.-K. and Lee, Y. T. “Safety and Effectiveness of 188 Re Tin Colloid for Radiation
Synovectomy in the Steroid Non-Responsive Rheumatoid Arthritis Patients,” J. Nucl. Med., 41
(Supplement), 94P (2000) (Abstract).
Coursey, B. M., Colle’, R., Zimmerman, B. E. and Cessna, J. T. “National Radioactivity Standards
for Beta-Emitting Radionuclides Used in Intravascular Brachytherapy,” Int. J. Radiat. Oncol Biol.
Physics, in press
Das, T., Banerjee, S., Samuel, G., Kothari, K., Unni, P. R., Sarma, H. D., Ramamoorthy, N. and
Pillai, M. R. A. “[ 186,188 Re]-Rhenium Ethylene Dicystiene (Re-Ec): Preparation and Evaluation for
Possible Use in Endovascular Brachytherapy,” Nuc. Med. Biol., 27, 189-197 (2001).
Dean, R. T. “Progress in Targeted Radiotherapy: Improving the Therapeutic Index,” In,
Proceedings, 2000 international Chemical Congress of Pacifichem Basin Societies, Honolulu,
Hawaii, December 14-19, 2000.
Ding, H.-J., Tzeng, C.-C., Ting, G., Hsieh, B.-T., Huang, Y. F., Lee, C.-H. And Liu, Y.-C.
“Biodistribution Study and Characteristic Analysis of Rhenium-188-Sn-1,1-Hydroxyehylidene
39

Diphosphonate in Radionuclide Therapy for Nuclear Medicine,” Annals Nucl. Med. (Taiwan), 13,
157-164 (2000) (In Chinese).
Dinkelborg, L. M., Tepe, G., Noll, B., Muschik, P. and Duda, S. H. “ 186 Re-Labeled Stents for
Prophylaxis of Restenosis: First Animal Results,” J. Nucl. Med., 41 (Supplement), 7P (2000).
Du, J., Marques, M., Hiltunen, J., Nilsson, S. and Holmberg, A. R. “Radiolabeling of Dextran with
Rhenium-188,” Appl. Radiat. Isot., 53, 443-448 (2000).
Eidherr, H., Miiterhauser, M., Krcal, A., Bartosch, E., Zettining, G., Knapp, F. F., Jr. and Dudczak,
R. “Evaluation of the 188 W/ 188 Re Generator and Online Concentration System,” In, Proceedings,
24 th International Symposium on Radioactive Isotopes in Clinical Medicine and Research, Bad
Gastein, Austria, January 11-14, 2000; Eur. J. Nucl. Med.,27,S92 (2000).
Eigler, N., Whiting, J., Makkar, R., Honda, H., Knapp, F. F., Jr. Livack, F. and Li, A. “Radiant�
Liquid Isotope Intravascular Radiation Therapy System,” In, Proceedings, Cardiovascular
Radiation Therapy IV Syllabus, Washington, D.C. February 18-20, 2000, p. 514-517.
Faintuch, B. L., Pereia, N. S. and Silva, C. P. “Optimization of Labeling of Lanreotide and Octreotide
with 188 Re for Radioimmunotherapy,” J. Nucl. Med., 41 (Supplement), 253P (2000).
Fox, R. A. and Henson, P. W. “The Dosimetry for a Corornary Artery Stent Coated with Radioactive
188 Re and 32 P,” Phys. Med. Biol., 45, 3643-3655 (2000).
Glatting, G., Kotzerke, J., Wller, R., Seitz, U., Neumaier, B., Buchmann, I., Bunjes, D. and Reske, S.
N. “Radioimmunotherapy Before Stem Cell Transplantation: Dependence of Dosimetry on the
Length of the Measured Time Interval,” J. Nucl. Med., 41 (Supplement), 239P (2000) (Abstract).
Granadas, O. H., Stevens, S. L., Donnell, R. L., Costanza, M. J., Spencer R. H., Knapp, F. F., Jr.,
Shoieb, A. M., Brown, K. J., Reddick, T. T., Freeman, M. B. and Goldman, M. H. “Effect of
Intravascular Radiation on the Distribution of Macrophages, Platelet-Derived Growth Factor and
Transforming Growth Factor in the Swine Iliac Artery,” Annals Vasc. Surg., in press.
Guhlke, S., Beets, A. L., Mirzadeh, S., Biersack, H.-J. and Knapp, F. F. (Russ), Jr. “Tandem
Cation/Anion Column Treatment of Ammonium Acetate Eluants of the Alumina-Based Tungsten-
188/Rhenium-188 Generator: A New Simple Method for Effective Concentration of Rhenium-188
Perrhenate Solutions,” J. Nucl. Med., 41, 1271-1278 (2000).
Hafeli, U., Pauer, G. J. and Erzurium, V. Z. “Local Application of β-Emitting Rhenium-188 to
Reduce Venous Intimal Hyperplasia in PTFE AV Grafts,” In, Proceedings, Cardiovascular
Radiation Therapy III, Washington, D.C., February 16-18, 2000; Abstract 23 (2000).
Hafeli, U. O., Roberts, W. K., Meier, D. S., Ciezki, J. P., Pauer, G. J., Lee, E. J. and Weinhous, M.
S. “Dosimetry of a W-188/Re-188 Beta Line Source for Endovascular Brachytherapy,” Med. Phys.,
27, 668-675 (2000).
Haubner, R., Wester, H. J., Bock, M. Bruchersifer, F., Senekowitsch-Schmidtke, R., Kessler, H. and
Schwaiger, M. “Targeting of αvβs Integrins Using Cyclic RGD-Peptides labeled with [ 123/131 ]Iodine,
40

[ 18 F]-fluorine, [ 99m Tc]Technetium, [ 188 Re]Rhenium and [ 88/90 Y]Yttrium,” Nucl. Med. Commun., 21,
571 (2000).
Havlik, E., Mitterhauser, M., Eidherr, H., Kiristis, C., Krcal, A., Peitfellner, J., Zettinig, G. and
Dudczak, R. “Handling of a Tungsten-188/Rhenium-188 Generator System for Vessel Treatment
Using a Balloon Dilitation catheter: Radiation Protection and Dosimetry,” In, IRPA 10, Proceedings
of the 10 th int. Congress of the Int. Radiation Protection Association, pp 309-310, P-7-51 (2000).
Hoeher, M., Woerle, J., Wohlfrom, M. Hanke, H., Voisard, R., Osterhues, H., Kochs, M., Reske, S.
N., Hombach, V. and Kotzerke, J. “Intracoronary β-Irradiation with a Liquid 188 Re-Filled Balloon,”
Circulation, 101, 2355-2360 (2000).
Hoeher, M. Wohrie, J., Schutte, C., Reske, S. N. and Kotzerke, J. “Intracoronary Radiotherapy with
Liquid Rhenium-188 to Prevent Restenosis Following Balloon Angioplasty - First Results from a
Randomized Trial,” In, Proceedings, Cardiovascular Radiation Therapy III, Washington, D.C.,
February 16-18, 2000, Abstract 34 (2000).
Hosono, M. N., Hosono, M., Mishra, A. K., Faivre-Chauvet, A., Gautherot, E., barbet, J., Knapp, F.
F., jr. and Chatla J.-F. “Rhenium-188-labeled Anti-Neural Cell Adhesion Molecule Antibodies with 2-
Iminothiolane Modification for targeting Small-Cell Lung Cancer, Ann. Nucl. Med., 14, 173-179
(2000).
Hsieh, B.-T., Leung, S. W., lin, W.-Y., Huang, H.-T., Ting, G., Wang and S.-J. “Rhenium-188-
Labeled DTPA for Intravascular Radiation Therapy,” In, Proceedings, Cardiovascular Radiation
Therapy III, Washing ton, D.C., February 16-18, 2000, Abstract 33 (2000).
Huang, G. and Ren, Q. “The Relation Between Irradiation Dose of 188 Re and Smooth Muscle Cells
Proliferation and Apoptosis,” J. Nucl. Med., 41 (Supplement), 1P (2000).
Jeong, J. M., Lee, Y. J., Kim, Y. J., Chang, Y. S., Lee, D. S., Chung, J.-K., Song, Y. W. and Lee, M.
C. “Preparation of Rhenium-188-Tin Colloid as a Radiation Synovectomy Agent and Comparison
with Rhenium-188-Sulfur Colloid,” Appl. Radiat. Isot., 52, 851-855 (2000).
Karacay, H., McBride, Griffiths, G. L., Sharkey, R. M., Barbet, J., Hansen, H. and Goldenberg, D. M.
“Experimental Pretargeting Studies of Cancer with a Humanized anti-CEA x Murine Anti-[In-DTPA]
Bispecific Antibody Construct and a (99m)Tc/(188)Re-Labeled Peptide,” Bioconj. Chem., 11, 842-
854 (2000).
Karacay, H., McBride, W. J., Sharkey, R. M., Griffiths, G. L., Spiegelman, H., Hansen, H. and
Goldenberg, D. M. “Humanized Anti-CEA X Chimeric Anti[Indium-DTPA]Bispecific Antibody
(bisMAb) Conjugates for Radioimmunotherapy of CEA-Positive Tumors with 188 Re,” J. Nucl.
Med., 41 (Supplement), 120P (2000).
Karacay, H., McBride, W. J., Griffiths, G. L., Sharkey, R. M., Barbet, J., Hansen, H. J. and
Goldenberg, D. M. “Experimental pretargwting Studies of Cancer with a Humanized anti-CEA x
Murine anti-[In-DTPA]Bispecific Antibody Construct and a (99m)Tc/(188)Re-LAbeled Peptide,”
Bioconjugate Chem., 11, 842-854 (2000).
41

Knapp, F. F., Jr., Mirzadeh, S. and Beets, A . L. “Tungsten-188/Rhenium-188 Generators Using
Tungsten-188 Reactor-Produced from Irradiation of Natural Tungsten Targets,” J. Nucl. Med., 41
(Supplement), 149P (2000).
Knapp, F. F., Jr. “Rhenium-188 Labeled Radioactive Particles and Other Radiopharmaceuticals for
the Treatment of Liver Cancer,” In, Proceedings, IAEA Workshop on Radionuclide Treatment of
Liver Cancer, Singapore, February 14-18, 2000.
Kobayashi, K., Motoishi, S., Terunuma, K., Rauf, A. A. and Hasimoto, K. “Production of 186,188 Re
and recovery of Tungsten from Spent 188 W/ 188 Re Generator,” Radiochemistry, 42, 551-554 (2000)
(Translation from, Radiokhymia, 42(6), 495-498).
Kotzerke, J., Hanke, H. and Hoeher, M. “Endovascular Brachytherapy for the Prevention of
Restenosis after Angioplasty,” Eur. J. Nucl. Med., 27, 223-236 (2000).
Kotzerke, J., Glatting, G., Seitz, U., Rentschler, M., Neumaier, B., Bunjes, D., Duncker, C., Dohr, D.,
Bergmann, L. and Reske, S. N. “Radioimmunotherapy for the Intensification of Conditioning Before
Stem Cell Transplantation: Differences in Dosimetry and Biokinetics of 188 Re- and 99m Tc-Labeled
Anti-NCA-95 Mabs,” J. Nucl. Med., 41, 531-537 (2000).
Kotzerke, J., Woehrle, J., Hanke, H., Hombach, V., Reske, S. N. and Hoher, M. “Successful
Prevention of Restenosis after PTCA by 188 Re-Filled Balloon Catheter - Preliminary Results from
the ECRIS-2 Trial,” J. Nucl. Med., 41 (Supplement), 128P (2000).
Lee, J. L., Lee, D. S., Kim, K. M., Yeo, J. S., Cheon, G. J., Kim, S. K., Ahn, J. Y., Jeong, J. M.,
Chung, J. K. and Lee., M. C. “Dosimetry of Rhenium-188 Diethylenetriamminepentaaceric Acid for
Endovascular Intra-Balloon Brachytherapy After Corornayr Angioplasty,” Eur. J. Nucl. Med., 27, 76-
82 (2000).
Lee, J., Lee, D. S., Kim, K. M., Yeo, J. S., Cheon, S. Y., Kim, S. K., Ahn, J. Y., Jeong, J. M., Chung,
J.-K. and Lee, M. C. “Dosmietry of Rhenium-188 Diethylenetriamminepentaacetic Acid for
Endovascular Intra-Balloon Brachytherapy After Coronary Angioplasty,” Eur. J. Nucl. Med., 27, 76-
82 (2000).
Lee, J. S., Choi, C. W., Kim, B. I., Yang, W. I., Lim, S. M. and Hong, S. W. “Evaluation of Adsorbed
Dose of 188 Re-HEDP in Patients with Bone Metastases Using Gamma Camera,” J. Nucl. Med., 41
(Supplement), 239P (2000).
Liepe, K., Hliscs, R., Kropp, J., Ningl, T. G., Rungel, R., Koch, R., Knapp, F. F., Jr. and Franke, W.-
G. “Rhenium-188-HEDP in the Palliative Treatment of Bone Metastases,” Eur. J. Nucl. Med.,
submitted.
Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W.-G. “Radiation
Dosimetry of Rhenium-188-HEDP in the Therapy of Painful Bone Metastases,” Eur. J. Nucl. Med.,
submitted.
42

Liepe, K., Franke, W. G., Kropp, J., Koch, R., Runge, R. and Hliscs, R. “Comparison of Rhenium-
188 and Strontium-89 in Palliation of Painful Bone Metastases,” Nuklearmedizin, 39, 146-151
(2000) (In German).
Liepe, J. K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W. G. “Radiation Dose of
188 Re in Bone Metastases,” J. Nucl. Med., 41 (Supplement), 266P (2000).
Limouris, G. S., Pirmetiis, I., Frantzis, A. P., Shukla, S. K., Voliotopolous, V., Lyra, M., Dardoufas,
K., Kouvaris, I., Knapp, F. F., Jr., Stavraka, A. and Vlahos, I. “Rhenium-188 (Sn)-Labeled HEDP
and -(V)-DMSA in the Treatment of Painful Osseous and Disseminated Soft Tissue Metastases,”
In, Proceedings, 24 th International Symposium on Radioactive Isotopes in Clinical Medicine and
Research, Bad Gastein, Austria, January 11-14, 2000; Eur. J. Nucl. Med.,27,S85 (2000).
Lin, W.-Y., Tsai, S.-C., Hsieh, B.-T., Lee, T.-W., Ting, G. and Wang, S.-J. “Evaluation of Three
Rhenium-188 candidates for Intravascular Radiation Therapy with Liquid-Filled Balloons to prevent
Restenosis,” J. Nucl. Cardiol., 37-42 (2000).
Lin, W. Y. and Wang, S. J. “Evaluation of the Biodistribution and Excretion Kinetics of Three 188 Re-
Candidates for Intravascular Radiation Therapy with Liquid-Filled Balloons to Prevent Restenosis,”
J. Nucl. Med., 41 (Supplement), 175P (2000).
Lin, W.-Y., Hsieh, J.-F., Tsai, S.-C., Yen, T.-C., Wang, S.-J. and Knapp, F. F., Jr. “A Comprehensive
Study of Thyroid and Gastric Uptake of 188 Re-Perrhenate in Endovascular Irradiation Using Liquid-
Filled Balloons to Prevent Restenosis,” Nucl. Med. Biol., 27, 83-87 (2000).
Machulla, H. J.and Wiebe, L. I. „Proceedings from the International Radiopharmaceutical Education
Consortium Workshop,“ J. Pharm. Pharmaceut. Sci., 4, 52-75 (2001).
Makkar, R., Whiting, J., Honda, H., Li, A., and Cordero, H. “Inhibition of In-Stent Restenosis by β-
Emitting Rhenium-188 Balloon is Dose-Dependent and Injury Dependent,” In, Proceedings,
Cardiovascular Radiation Therapy III, Washing ton, D.C., February 17-19, 2000, Abstract 40 (2000).
Mihailescu, G., Lungu, V. V., Niculae, D., Manolescu, N. and Comisel, V. “Labelling Lanreotide with
Rhenium-188,” Nucl. Med. Commun., 21, 574 (2000).
Mirzadeh, S., Du., M., Beets, A. L. and Knapp, F. F., Jr. “Thermoseparation of Neutron-Irradiated
Tungsten from Re and Os,” Indust. Engineering Chem. Res., 39, 3169-3172 (2000).
Mushtaq, A., Pervez, S. and Haider, I. “Preparation of 188 Re-Lantreotide Peptide and its Quality
Control,” Radiochim. Acta, 88, 495-498 (2000).
Nogorodova, A. F., Bruchertseifer, F., Brockmann, J., Lebedev, N. A. and Roesch, F.
“Thermochromatographic Separation of No-Carrier-Added 186 Re and 188 Re from Tungsten Targets
Relevant to Nuclear Medical Applications,” Radiochim. Acta, 88, 163-167 (2000).
Oh, S. J., Moon, D. H., Park, S.-W., Hong, M.-K., Park, S.-J. Knapp, F. F., Jr. and Lee, H. K.
“Automated Synthesis of Highly Concentrated Re-188-MAG3 for Intracorornary Radiation Therapy,”
43

In, Proceedings, Cardiovascular Radiation Therapy III, Washington, D.C., February 16-18, 2000,
Abstract 35 (2000).
Oh, J. S., Moon, D. H., Ryu, J. S., Park, S. W., Hong, M. K., Park, S. J. and Lee, H. K. “Semi-
Automated Synthesis of Highly Concentrated 188 Re-Labeled Radiopharmaceuticals for Intracornary
Radiation Therapy,” J. Nucl. Med., 41 (Supplement), 255P (2000).
Oh, J. S., Moon, D. H., Park, S.-W., Hong, M.-K., Park, S.-J., Knapp, F. F., Jr., and Lee, K.
“Automated Synthesis of Highly Concentrated Re-188-MAG3 for Intracoronary Radiation Therapy,”
In, Proceedings, Cardiovascular Radiation Therapy IV Syllabus, Washington, D.C. February 18-20,
2000, p. 54.
Palmedo, H., Guhlke, S., Bender, H., Schoemich, G., Gruenwald, F., Knapp, F. F., Jr. and Biersack,
H.-J. “Dose Escalation Study with Rhenium-188-HEDP in Prostate Cancer Patients with Osseous
Metastases,” Eur. J. Nucl. Med., 27, 123-130 (2000).
Park, A.-W., Hong, M.-K., Monn, D. H., Oh, S. J. and Park, S.-J. “Rotational Atherectomy and
Radiation Therapy with 188 Re-MAG3-Filled Balloon for In-Stent Resetenosis (R4 Trial),” In,
Proceedings, Cardiovascular Radiation Therapy III, Washington, D.C., February 17-19, 2000,
Abstract 25 (2000).
Pietzsch, H.-J., Gupta, A., Reisgys, M., Drews, A., Siefert, S., Syhre, R., Spies, H., Alberto, R.,
Abram, U., Schubiger, P. A. and Johannsen, B. “Chemical and Biological Characterization of
Technetium(I) and Rhenium(I) Tricarbonyl Complexes with Dithioether Ligands Serving as Linkers
for Coupling the Tc(CO3) and Re(CO3) Moieties to Biologically Active Molecules,” Bioconuugate
Chem., 11, 414-424 (2000).
Polyakov, V., Sharma, V., Dahlheimer, J. L., Pica, C. M., Luker, G. D. and Piwnica-Worms, D.
“Novel Tat-Peptide Chelates for Direct Transduction of Technetium-99m and Rhenium into Human
cells for Imaging and Radiotherapy,” Bioconj. Chem.., 11, 762-771 (2000).
Roka, R., Sera, T., Pajor, L., Thurzo, L., Lang, J., Csernay, L. and Pavics, L. “Clinical Experience
with Rhenium=188 HEDP Therapy for Metastatic Bone Pain,” Orv. Hetil., 141, 1019-1023 (2000) (In
Hungarian).
Schmaljohan, J., Guhlke, S., Dudczak, R. and Biersack, H. J. “Kit Preparation of 188 Re-HEDP:
Comparison of Three Different Formulations,” J. Nucl. Med., 41 (Supplement), 255P (2000).
Spear, S. K., Griffin, S. T., Huddleston, J. G. and Rogers, R. D. “Radiopharmaceutical and
Hydrometallurgical Separations of Perrhenate Using Aqueous Biphasic Systems and the Analagous
Aqueous Biphasic Chromatographic Resins,” Indust. Engineering Chem. Res., 39, 3173-3180
(2000).
Toth, G. Y. , Koemyei, J. and Baranyai, L. “Medium Flux Reactor Production of W-188 and Mo-99
Providing Carrier-Free Re-188 and Tc-99m,” Eur. J. Nucl. Med., 27,S96 (2000).
44

Waibel, R., Stichelberger, R., Alberto, R., Schubiger, P. A., Chester, K. A. and Begent, R. H. J.
“Site-Directed Labelling of Single Chain Antibodies with Tc-99m and Re-188,” Eur. J. Nucl.
Med.,27,S89 (2000).
Wirskirchen,, J., Dittmann, H., Schoeber, W., Dinkelborg, L., Tepe, G., Claussen, C. D. and Duda,
H. “Dose Dependent Effects of 188-Rhenium to Inhibit Cell Growth of Human Aortic Smooth
Muscle Cells in Order to Prevent Restenosis After Transluminal Angioplasty - An In Vitro Study,”
In, Proceedings, Cardiovascular Radiation Therapy IV, Washing ton, D.C., February 16-18, 2000,
Abstract 20 (2000).
Wunderlich, G., Pinkert, J., Franke, W.-G., Knapp, F. F., Jr. and Kropp, J. “Preparation and
Biodistribution of Rhenium-188-Labeled Albumin Microspheres: A Promising New Agent for
Endoradiotherapy of Tumors,” Appl. Radiat. Isot., 52, 63-68 (2000).
Wuu, C. S., Weinberger, J., Maryanski, M., Ranade, M., Borzillary, S. and Schiff, P. B. “Dosimetry
Study of Re-188 Liquid Balloon for Intravascular Brachytherapy Using Optical Laser CT Scanning of
Polymer Gel Dosimeters,” In, Proceedings, Cardiovascular Radiation Therapy IV, Washing ton,
D.C., February 16-18, 1999, Abstract 18 (2000).
Yu, J., Zhang, R., Dai, X., Min., X., Xu, J., Yin, S., X., H., Wang, Y. and Knapp, F. F., Jr.
“Intratumoral Injection with [ 188 Re]-Rhenium Sulfide Suspension for Treatment of Transplanted
Human Liver Carcinoma in Nude Mice,” J. Amer. Can. Soc., submitted.
Zamora, P. O., Osaki, S., Som, P., Ferretti, J. A., Choi, J. S., Hu, C., Tsang, R., Kuan, H. M.,
Singletary, S., Stern, R. A. and Oster, Z. H. “Radiolabeling Brachytherapy Sources with Re-188
Through Chelating Microfilms:Stents,” J. Biomed. Mater. Res., 53, 244-251 (2000).
Zamora, P. O., Kim, H. S., Ferreti, J. A., Choi, J. S., Tio, F. O., Bhargava, B., Osaki, S., Som, P.,
Waksman, R., Kuan, H. M. and Oster, Z. H. “ 188 Re-Stents for Prevention of Restenosis,” J. Nucl.
Med., 41 (Supplement), 8P (2000).
Zettining, G., Kirisits, C., Preitfellner, J., Mitterhauser, M., Eidherr, H., Kreal, A., Cejna, M.,
Wexberg, P. Havlik, E., Aiginger, H., Poetter, R. and Dudczak, R. “Gafchromic Film Dosimetry of
Balloons Filled with Rhenium-188: Preliminary Results,” Eur. J. Nucl. Med.,27,S87 (2000).
Published in 1999:
Azure, M. T., Jones, W. B., Cyr, J. E., De Rosch, M. A., Zinn, K. R. and Bush, L. R. “High Specific
Activity Rhenium-188 Labeled Somatostatin Analogues for Tumor Eradication,” In, Proceedings,
ACS Symposium on Bioconjugate Chemistry in Nuclear Medicine, Anaheim, CA, March 21-15,
1999.
Bartis, J., Liu, S. and Edwards, D. S. “Hynic Technology for Therapeutic Rhenium
Radiopharmaceuticals,” In, Proceedings of the Fifth International Symposium on Technetium in
Chemsitry and Nuclear Medicine, Bressanone, Italy, Sept. 6-8, 1998; Technetium, Rhenium and
other Metals in Chemistry and Nuclear Medicine, SGEditorali, Padova, 1999; M. Nicolini and U.
Mazzi, editors, pp. 409-417.
45

Beets, A. L., Guhlke, S., Biersack, H.-J. and Knapp, F. F., Jr. “Availability of Very High Radiopurity
Rhenium-188 from a Clinical-Scale Generator Using a “Tandem” Concentration System,” European
Association of Nuclear Medicine Congress, Barcelona, Spain, Oct. 9-13, 1999; Eur. J. Nucl. Med.,
26, 1010 (1999).
Blower, P. J. and Prakash, S. “The Chemistry of Rhenium in Nuclear Medicine,” In, Perspectives on
Bioinorganic Chemistry, Vol. 4, pp. 91-143; JAI Press, Inc. (1999).
Bruchertseifer, F., Brockman, J., Novgorodov, A. F., Lebedev, N. A. and Roesch, F.
“Thermochromatographic Separation of 186 / 188 Re from Tungsten Targets Used to Design a
188 188 186 186
W/ Re Generator or to Separate Re as Produced via the W(p,n) Reaction,” J. Label.
Cmpds. Radiopharm., 42 (Suppl. 1) S930-933 (1999).
Eigler, N., Whiting, J., Makkar, R., Honda, H., Knapp, F. F., Jr., Litvack, F., and Li, A. “The 188 Re
Generator Approach,” In, Syllabus, Cardiovascular Radiation III Conference, Washington, D. C.,
February 17-19, 1999, pp 391-397.
Ferro-Flores, G., Pimentel-Gonzales, G., Gonzales-Zavala, M. A., de Murphy, C. A., Melendez-
Alafort, L., Tendilla, J. I. and Croft, B. Y. “Preparation, Biodistribution and Dosimetry of 188 Re-
Labeled MoAb ior ceal and Its F(ab’)2 Fragments by Avidin-Biotin Strategy,” Nucl. Med. Biol., 26,
57-62 (1999).
Fox, R. A. Barker, P. and Smart, G. “The Use of GAFchromic Film to Determine the Absolute
Activity of Beta Emitters,” Phys. Med. Biol., 44, 833-842 (1999).
Fox, R. A. and Henson, P. W. “The Effect of Contrast Medium and Balloon Shape on Dosimetry for
Arterial Irradiation with 188 Re,” Med. Phys., 26, 771-776 (1999).
Gaudiano, J., Savio, E., Robles, A., Muniz, S., Leon, A., Verdera, S., Martinez, G., Hermida, J. C.
and Knapp, F. F., Jr. “Rhenium-188-HEDP in the Treatment of Pain in Bone Metastases,” In,
Proceedings (TECDOC), International Seminar on Therapeutic Applications of
Radiopharmaceuticals (IAEA-SR-209), Hyderabad, India, January 18-22, 1999, in press.
Guhlke, S., Scheithauer, S., Bender, H., Knapp, F. F., Jr. and Biersack, H.-J. “Rhenium-188 DMSA:
In vitro and in vivo Evaluation of the Individual Isomers,” Annual Meeting, Society of Nuclear
Medicine, Los Angeles, CA, June 6-10, 1999; J. Nucl. Med., 40, 315P (1999).
Guhlke, S., Scheithauer, S., Bender, H., Knapp, F. F., Jr. and Biersack, H.-J. “Rhenium-188-
DMSA: Animal Experiments with the Three Stereoisomers,” 37 th Annual Meeting of the German
Society of Nuclear Medicine, Ulm, Germany, April 14-17, 1999 (in German).
Hafeli, U. O., Casillas, S., Dietz, D. W., Pauer, G. J., Rybicki, L. A., Conzone, S. D. and Day, D. E.
“Hepatic Tumor Radioembolization in a Rat Model Using Radioactive Rhenium ( 186 Re/ 188 Re) Glass
Microspheres,” Int. J. Radiat. Oncol. Biol. Phys., 44, 189-199 (1999).
Hashimoto, K. “labelling of Aminoethylenephosponate Derivatives with Generator-Produced 188 Re,
and a Study of Their Stability,” Appl. Radiat, Isot., 51, 307-313.
46

Hausleiter, J., Li, A., Knapp, R., Eigler, N. and Whiting, J. “Low Body Exposure in Cases of
Radioactive Balloon Leakage - A Biodistribution and Elimination Study of Rhenium-188 in Pigs,” J.
Amer. Coll. Cardiol., 33, Suppl. A, 44A (1999).
Hausleiter, J., Li, A., Knapp, R., Eigler, N. and Whiting, J. “Low Body Exposure in Case of
Radioactive Balloon Leakage - A Biodistribution and Elimination Study of Rhenium-188 in Pigs,”
Proceedings, Cardiovascular Radiation Therapy III Conference, Washington, D. C., February 17-19,
1999; p 32.
Hseih, B. T., Lin, W. Y., Wang, S. J., Hunag, H. T., Kuan, P. L., Leung, S. W., Ting, G. and Knapp,
F. F., Jr. “A New Potential Radiopharmaceutical for Intravascular Radiation Therapy - Rhenium-
188-DTPA,” Third Annual Symposium on Radiotherapy to Reduce Restenosis, La Jolla, CA,
January 15-16, 1999.
Hsieh, B. T., Hsieh, J. F., Tsai, S. C., Lin, W. Y., Huang, H. T., Ting, G. and Wang, S. J. “Rhenium-
188-Labeled DTPA: A New Radiopharmaceutical for Intravascular Radiation Therapy,” Nucl. Med.
Biol. , 26, 967-972 (1999).
Hsieh, B. T., Hsieh, J. F., Tsai, S. C., Lin, W. Y., Wang, S. J. and Ting, G. “Comparison of Various
Rhenium-188-Labeled Diphosphonates for the Treatment of Bone Metastases,” Nucl. Med. Biol.,
26, 973-976 (1999).
Jeong, J. M., Lee, Y. J., Kim, Y. J., Lee, D. S., Chung, J.-K. and Lee, M.C. “Comparison of
Rhenium-188-Tin Colloid and Rhenium-188 Sulfur Colloid as a Radionuclide Therapeutic Agent,”
J. Nucl. Med., 40, 317P (1999)
Kim, B. K., Jeong, J. M., Hong, M. K., Lee, D. S., Chung, J.-K. and Lee, M. C. “A Study of Stability
of High Specific Activity Rhenium-188-Labeled Antibody,” J. Nucl. Med., 40, 316P (1999)
Klein, J., Du, M., Mirzadeh, S., Beets, A. L. and Knapp, F. F., Jr. “Tungsten-188/Rhenium-188
Production at Oak Ridge National Laboratory,” In, Proceedings, 3 rd International Conference on
Isotopes, Vancouver, Canada, September 6-10, 1999.
Knapp, F. F., Jr., Guhlke, S., Beets, A. L., Lin, W.-Y., Stabin, M., Amols, H. and Weinberger, J.
“Endovascular Beta Irradiation for Prevention of Restenosis Using Solution Radioisotopes:
Pharmacologic and Dosimetric Properties of Rhenium-188 Compounds,” Cardiovasc. Rad. Med., 1,
86-97 (1999).
Knapp, F. F., Jr., Spencer, R. H. and Stabin, M. “Use of Rhenium-188 Liquid-Filled Balloons for
Inhibition of Corornary Restenosis After PTCA - A New Opportunity for Nuclear Medicine, “ In,
Radionuclides for Myocardium - Current Status and Future Aspects, Mediterra-Publishers, Athens,
Greece, 1999, pp 61-72 (ISBN 960-85227-9-X).
Knapp, F. F., Jr., Beets, A. L., Pinkert, J., Kropp, J., Lin, W.-Y. and Wang, S.-Y. “Rhenium
Radioisotopes for Radiopharmaceutical Development,” In, Proceedings (TECDOC), International
Seminar on Therapeutic Applications of Radiopharmaceuticals (IAEA-SR-209), Hyderabad, India,
January 18-22, 1999.
47

Knapp, F. F., Jr., “Use of Rhenium-188 Liquid-Filled Balloons for Inhibition of Coronary Restenosis
After PTCA,” Invited Lecture, Proceedings, 9 th Mediterranean Meeting on Nuclear Medicine and
Radiopharmaceuticals - Radionuclides for the Heart, Cyprus, May 13-17, 1998, Mediterrea, Athens,
pp 61-72 (1999).
Knapp, F. F., Jr. “The Tungsten-188/Rhenium-188 Generator - An Attractive System for Therapy -
Current Status and Expected Applications,” European Community Working Group, Brussels,
Belgium, May 21, 1999 (Invited).
Knapp, F. F., Jr., Guhlke, S., Beets, A. L., Lin, W.-Y., Stabin, M., Amols, H. and Weinberger, J.
“Endovascular Beta Irradiation for Prevention of Restenosis Using Solution Radioisotopes:
Pharmacologic and Dosimetric Properties of Rhenium-188 Compounds,” Cardiovasc. Rad. Med., 1,
86-97 (1999).
Knapp, F. F., Jr. “Production and Availability of Beta-Emitting Radioisotopes for Vascular Radiation
Therapy,” Proceedings, Cardiovascular Radiation Therapy III Conference, Washington, D. C.,
February 17-19, 1999, pp 140-143 (Invited).
Knapp, F. F., Jr. “Rhenium-188 - An Important Generator-Derived Radioisotope for Therapy,”
Invited, For, Seminar on Therapeutic Radiopharmaceuticals, IAEA , Hyderabad, India, January 18-
22, 1999.
Knapp, F. F., Jr. “Beta-Emitting Radionuclides for Coronary Restenosis Therapy,” High Country
Nuclear Medicine Conference Vail, Colorado, February 26-March 3, 1999 (Invited).
Knapp, F. F., Jr. “Use of Beta-Emitting Radioisotope Sources for Inhibition of Coronary Restenosis
after High Pressure Balloon Angioplasty,” Invited Lecture, For, Categorical Seminar on Recent
Developments in Therapeutic Nuclear Medicine, Annual Meeting, Society of Nuclear Medicine, Los
Angeles, CA, June 6, 1999 (Invited).
Kothari, K. K., Banerjee, S., Samuel, G., Unni, P. R., Sarma, H. D., Ventakesh, M and Pillai, M. R.
A. “Rhenium-186 and Rhenium-188 Phosphonate Ligands,” J. Nucl. Med., 40, 228P (1999).
Kotzerke, J., Wohrle, J., Hombach, V., Reske S. N. and Hoher, M. “Can Restenosis Following
PTCA Be Prevented by Irradiation From Rhenium-188-Filled Balloon Catheter ? ” J. Nucl. Med.,
40, 85P (1999).
Kotzerke, J., Seitz, U., Neumaier, B., Glatting, G., Bunjes, D., Duncker, C., Bergmann, L., Dohr, D.
and Reske, S. N. “Use of Rhenium-188-Labeled Anti NCA-95 Antibodies in Treatment of Leukemia:
First Results,” J. Nucl. Med., 40, 65P (1999).
Kotzerke, J., Woehrie, J., Hombach, Y., Reske, S. N. and Hoeher, M. “Endovascular Brachytherapy
with a Rhenium-188-Filled Balloon Catheter for the Prevention of Restenosis After PTCA - First
Results,” German Nuclear Medicine Meeting, Ulm, Germany, April 1999 (in German).
48

Kotzerke, J., Seitz, L., Bunjes, D., Neumajer, R., Glatting, G., Duncker, C., Bergmann, L., Dohr, D.
and Reske, S. N. “Radioimmunotherapy of Bone Metastases with Leukemia,” German Nuclear
Medicine Meeting, Ulm, Germany, April 1999 (in German).
Lee, S., Shin, A., Chung, J.-K., Lee, M. M., and Lee, M. C. “Rhenium-188-DTPA Liquid-Filled
Balloon to Inhibit Restenosis After Angioplasty: Development of Software of Dose Calculation and
Application,” J. Nucl. Med., 40, 181P (1999).
Li, A. N., Hausleiter, J., Knapp, F. F., Jr., Eigler, N. and Whiting, J. S. “A Biodistribution and
Elimination Study of Rhenium-188 in Pigs,” J. Nucl. Med., 40, 88P (1999).
Liepe, K., Hiliscs, R., Runge, R., Kropp, J., Knapp, F. F., Jr. and Franke, W. G. “Dose Calculation
and Clinical Efficacy of Rhenium-188-HEDP in Bone Metastases,” European Association of Nuclear
Medicine Congress, Barcelona, Spain, Oct. 9-13, 1999; Eur. J. Nucl. Med., 26, 1052 (1999).
Liepe, K., Kropp, J., Knapp, F. F., Jr., Hilscs, R., Kuehne, A. and Franke, W. G. “Kinetics and
Therapeutic Effect of Rhenium-188 in Palliative Treatment of Metastatic Bone Pain,” Annual
Meeting, Society of Nuclear Medicine, Los Angeles, CA, June 6-10, 1999; J. Nucl. Med., 40, 219P
(1999).
Limouris, G. S., Pirmettis, I., Frantziz, A. P., Shukla, S. K., Gouliamos, A., Voliotopoulos, V., Lyra,
M., Chiotellis, E., Knapp, F. F., Jr. and Stavraka, A. “Rhenium-188-Labelled HEDP and (V)-DMSA
in the Treatment of Painful Osseous and Disseminated Soft Tissue Metastases,” European
Association of Nuclear Medicine Congress, Barcelona, Spain, Oct. 9-13, 1999; Eur. J. Nucl. Med.,
26, 1208 (1999).
Lin, C.-P., Lin, W.-Y., Hsieh, B.-T., Ting, G., Wang, S.-J., Yen, T.-C., Knapp, F. F., Jr. and Yeh, S.-
J. “Effect of Reaction Conditions on Preparation of Rhenium-188 Hydroxyethylidene Diphosphonate
Complexes,” Nucl. Med. Biol., 26, 455-459 (1999).
Macey, D. J. and Meredith, R. F. “A Strategy to Reduce Red Marrow Dose for Intraperitoneal
Radioimmunotherapy,” Clin Can. Res., 5 (10 Suppl.), 3044-3047s (1999),
Melendez-Alafort, L., Ferro-Flores, G., Arteaga-Murphy, C., Pedraza-Lopez, M., Gonzales-Zavala,
M. A., Tendilla, J. L. and Garcia-Salinas, L. “Labeling Peptides with Rhenium-188,” Int. J. Pharm.,
25, 165-172 (1999).
Oh, S. J., Moon, D. H., Park, S. W., Lee, B. Y., Hong, M. K.., Park, S. J., Kim, E. H., Lim, S. M.,
Choi, T. H., Choi, H., and Lee, H. K. “Radiation Dosimetry of a Balloon Filled with Rhenium-188
and ionic Contrast for Endovascular Radiation Therapy,” J. Nucl. Med., 40, 309P (1999)
Oh, S. J., Moon, D. H., Park, S. W., Hong, M. K.., Shin, J. W., Shin, S. K., Kim, E. H., Lim, S. M.,
Choi, C. A., Choi, T. H., and Lee, H. K.“Comparison of Radiation Adsorbed Dose of Rhenium-188
Radiopharmaceuticals for Intracoronary Radiation Therapy in Case of Balloon Rupture,” J. Nucl.
Med., 40, 41P (1999).
Oh, S. J., Moon, D. H., Ha, H. J., Park, S. W., Choi, T. H., Lim, S. M., Choi, C. W. and Lee, H. K.
“Synthesis and Automation of 188 Re-Labeled Radiopharmaceuticals for Intracoronary Radiation
Therapy,” J. Label. Cmpds. Radiopharm., 42 (Suppl. 1) S850-852 (1999).
49

Palmedo, H., Guhlke, S., Schoencich, G., Bender, H., Risse, J., Gruenwald, F., Knapp, F. F., Jr.
and Biersack, H.-J. “Pain Therapy with Rhenium-188-HEDP of the Bone Metastases from Prostate
Carcinoma,” German Nuclear Medicine Meeting, Ulm, Germany, April 1999 (in German).
Palmedo, H., Guhlke, S., Bender, H., Sartor, J., Schoeneich, G., Risse, J., Gruenwald, F., Knapp, F.
F., Jr. and Biersack, H.-J. “Dose Escalation Study with Re-188-HEDP in Prostate Cancer Patients
with Osseous Metastases,” Annual Meeting, Society of Nuclear Medicine, Los Angeles, CA, June 6-
10, 1999; J. Nucl. Med., 40, 218P (1999).
Pinkert, J., Wunderlich, G., Franke, W.-G., Andreef, M., Kropp, J. and Knapp, F. F., Jr. “Rhenium-
188 Labeled Micropheres for Intraarterial Radioembolization,” Australian & New Zealand Society of
Nuclear Medicine, 1999.
Pinkert, J., Wunderlich, G., Franke, W.-G., Bergman, R., Hiliscs, R. Kropp, J. and Knapp, F. F., Jr.
“Re-188-Labeled HSA Microspheres for Radioembolization,” European Association of Nuclear
Medicine Congress, Barcelona, Spain, Oct. 9-13, 1999; Eur. J. Nucl. Med., Eur. J. Nucl. Med., 26,
1010 (1999).
Pinkert, J., Wunderlich, G., Franke, W.-G., Andreef, M., Kropp, J. and Knapp, F. F., Jr. “Re-188-
Labeled Microspheres for Intraarterial Radioembolization,” Australian & New Zealand Society of
Nuclear Medicine, 1999.
Roberts, W. K. and Hafeli, U. O. “Modeling Rhenium-186 and Rhenium-188 Distribution in a
Neutron-Activated Rhenium Wire and Effect of the Distribution on Beta Dosimetry in a Water
Phantom,” Appl. Radiat. Isot., 51, 543-549 (1999).
Runge, R., Andreef, M., Kropp, J., Wunderlich, G., Knapp, F. F., Jr., and Franke, W. G. “Two Years
Experience with Quality Control of the Tungsten-188/Rhenium-188 Generator with High Levels of
Activity,” Annual Meeting, Society of Nuclear Medicine, Los Angeles, CA, June 6-10, 1999; J. Nucl.
Med., 40, 316P (1999).
Safavy, A., Khazaeli, M. B., Safavy, K., Mao, M. A. and Buchsbaum, D. J. “Biodistribution Study of
188 Re-Labeled Trisuccin-HuCC49 and Trisuccin-HuCC49deltaCh2 Conjugates in Athymic Nude
Mice bearing Intraperitoneal Colon Cancer Zenografts,” Clin. Can. Res., 5 (Suppl. 10), 2994s-3000s
(1999).
Skaddan, M. B. and Katzenellenbogen, J. A. “Integrated “3+1" Oxorhenium(V) Complexes as
Estrogen Mimics,” Bioconj. Chem., 10, 199-129 (1999).
Sietz, U., Neumaier, B., Galtting, G., Kotzerke, J., Bunjes, SD. And Reske, S. N. “Preparation and
Evaluation of the Rhenium-188-Labelled Anti-0NCA Antigen Monocloncal Antibody BW 250/183 for
Radioimmuniotherapy of Leukemia,” Eur. J. Nucl. Med., 26,1265-1273 (1999).
Spencer, R. H., Granadas, O. S., Stevens, S. L., Donnell, R. L., Stabin, M., Knapp, F. F., Jr.,
Costanza, M., Shoieb, A. H., Reddick, T. T., Freeman, M. B., Brown, K. and Goldman, M. H.
“Dosimetry Considerations of Rhenium-188 Perrhenate Liquid-Filled Balloons in the Prevention of
Restenosis of Injured Swine Iliac Arteries,” American Heart Association Meeting, Atlanta, Georgia,
Nov. 7-10, 1999.
50

Waibel, R., Alberto, R., Willuda, J., Finnern, R., Scibli, R., Stichelberger, A., Egli, A., Abram, U.,
Mach, J.-P., Plueckthun and Schbiger, A. “Stable One-Step Technetium-99m Labeling of His-
Tagged Recombinant Proteins with a Novel Tc(I)-Carbonyl Complex,” Nature Biotech., 17, 897-901
(1999).
Weinberger, J. and Knapp, F. F., Jr. “Use of Liquid-Filled Balloons for Coronary Irradiation,”
Chapter 45, In, Vascular Brachytherapy, R. Waksman, Editor, Second Edition, Futura Publishing
Co., Inc., Armonk, NY, 1999, pp. 521-535 (ISBN 0-87993-4131).
Weinberger, J., Amols, H. I., Schiff, P. B., Trichter, F., Wang, T. S-T., Berke, A., Brogno, S., Flier,
J., Knapp, F. F., Jr. and Wasserman, H. S. “Initial Results of the CURE Safety Trial Coronary
Brachytherapy With Radioactive Liquid-Filled Balloons,” Amer. Coll. Card. Meet., New Orleans, LA,
March 6-11, 1999; J. Amer. Coll. Cardiol., 33, No. 2, Suppl. A, 94A (1999).
Weinberger, J., P. B. Schiff, Trichter, F., Wu, C.-S., Knapp, F. F. and Schwartz, A. “Results of the
Columbia Safety and Feasibility (CURE) Trial of Liquid Radioisotopes for Coronary Vascular
Brachyhtherapy,” American Heart Association Meeting, Atlanta, Georgia, Nov. 7-10, 1999.
Weinberger, J., Giedd, K. N., Simon, A. D., Marboe, C., Knapp, F. F., Jr., Trichter, F. and Amols H.
“Radioactive Beta-Emitting Solution-Filled Balloon Treatment Prevents Porcine Coronary
Restenosis,” Cardiovasc. Rad. Med., 1, 252-256 (1999).
Weinberger, J. and Knapp, F. F., Jr. “Use of Liquid-Filled Balloons for Coronary Irradiation,” In,
Vascular Brachytherapy, R. Waksman, Editor; Future Pub. Co., Armonk, NY, 1999; Chapter 45, pp.
521-535 (1999).
Wiskirchen, J., Dittman, H., Schoeber, W., Dimkelborg, L., Tepe, G., Claussen, C. D. and Duda, S.
H. “Dose Dependent Effects of 188-Rhenium to Inhibit Cell Growth of Human Aortic Smooth Muscle
Cells in order to Prevent Restenosis After Transluminal Angioplasty - An In Vitro Study,” In,
Proceedings, Cardiovascular Radiation Therapy III, Washing ton, D.C., February 17-19, 1999,
Abstract 20 (1999).
Wohlfrom, M., Kamenz, J., Kotzerke, J., Eble, M., Hess, B., Schultz, C., Lunz, C., Hembach, V.,
Reske, S. N., and Hanke, H. “Proliferation from Endovascular Brachytherapy with Rhenium-188:
Animal Experiment Dose Estimates,” German Nuclear Medicine Meeting, Ulm, Germany, April
1999 (in German).
Wunderlich, G., Pinkert, J. and Franke, W.-G. “Studies on the Processing and in vivo stability of
Re-188 Labelled Microsperes,” In, Proceedings of the Fifth International Symposium on
Technetium in Chemsitry and Nuclear Medicine, Bressanone, Italy, Sept. 6-8, 1998; Technetium,
Rhenium and other Metals in Chemistry and Nuclear Medicine, SGEditorali, Padova, 1999; M.
Nicolini and U. Mazzi, Editors, pp. 709-712.
Yu, J., Yin, D., Min, X., Guo, Z., Zhang, J., Wang, Y. and Knapp, F. F., Jr. “Preparation of [ 188 Re]-
Rhenium Sulfide Suspension and its Biodistribution Following Intra-Tumoral Injection in Mice,” J.
Lab. Cmpds. Radiopharm., 42, 233-243 (1999).
51

Yu, J., Duanzhi, Y., Xiaofeng, M. Zili, G., Jiong, Z., Yongxian, W. and Knapp, F. F., Jr.
“[ 188 Re]Rhenium Sulfide Suspension: A Potential Radiopharmaceutical for Tumor Treatment
Following Intra-Tumor Injection,” Nucl. Med. Biol., 26, 573-579 (1999).
Zimmerman, B. E., Cessna, J. T., Unterweger, M. P., Li, A. N., Whiting, J. S. and Knapp, F. F., Jr.
“A New Experimental Determination of the Dose Calibrator Setting for Rhenium-188,” J. Nucl. Med.,
40, 1508-1516 (1999).
Zinn, K. R., Bush, L. R., Mountz, J. M., Chaudhuri, T. R., Hwang, S. B., Dean, R. T. and Azure, M.
T. “Dose-Dependent Tumor Suppression in Nude Mice by Radiotherapy with Rhenium-188-Labeled
P829, A Somatotstatin Receptor (SSTR) Avid Peptide,” J. Nucl. Med., 40, 223P (1999).
Published in 1998:
Al-Amir, M. A. E.-E., “Evaluation of Tungstocerate Gel for Manufacturing of Rhenium-188
Radioisotope Generator,” Ph.D. Thesis, Faculty of Engineering, Cairo University (1998).
Amols, H. I., Trichter, F. and Weinberger, J. “Intracoronary Radiation for Prevention of Restenosis
- Dose Perturbations Caused by Stents,” Circulation, 98, 2024-2029 (1998).
Basmonov, V., Kolesnik, O. and Lisichkina, N. “The Development of Chromatographic W-188/Re-
188 Generators for Therapy,” In, Proceedings, Radioactive Isotopes in Clinical Medicine and
Research, 23 rd International Symposium, Badgastein, Austria, January 13-16, 1998; Eur. J. Nucl.
Med., 25, S6 (1998) (Abstract).
Basmonov, V., Kolesnik, O. and Ignatova, A. “Rhenium-188 Chromatographic Generator and
Therapeutic Radiopharmaceutical,” Eur. J. Nucl. Med., 25, 1043 (1998) (Abstract ).
Blower, P. J., Lam, A. S. K., O’Doherty, M. J., Kettle, A. G., Coakley, A. J. and Knapp, Jr., F. F.
“Biodistribution and Dosimetry of Pentavlaent Rhenium-188-Dimercaptosuccinic Acid In Patients
with Disseminated Bone Metastasis,” Eur. J. Nucl. Med., 25, 613-621 (1998).
Chang, Y. S., Jeong, J. M., Lee, D. S., Chung, J.-K and Lee, M. C. “Quality Control of the Tungsten-
188/Rhenium-188 Generator,” Korean Journal of Nuclear Medicine, 32, 425-432 (1998) (in Korean;
Abstract in English).
Chen, J. and Quinn, T. P. “Alpha-Melanocyte Stimulating Hormone Analogues - Tc-99m/Re-188
Labeling and Their Pharmacokinetics in Malignant Melanoma-Bearing Mice,” J. Nucl. Med., 39,
222P (1998) (Abstarct ).
Chen, J.-Q., Strand, S.-E., Tennvall, J., Lidgren, L., Hindorf, C. and Sjoegren, H.O. “Extracorporeal
Immunoadsorption Compared to Avidin Chase: Enhancement of Tumor-to-Normal Tissue Ratio for
Biotinylated Rhenium-188-Chimeric BR96,” J. Nucl. Med., 38, 1934-1939 (1998).
Chung, Y. S., Jeong, J. M., Lee, D. S., Chung, K.-K., Lee, M. C., Koh, C.-S., Yu, H.-J., Cho, J. H.
and Knapp, F. F., Jr. “Effect of Carrier on Labeling and Biosdistribution of Re-188-
Hydroxyethylidene Diphosphonate (HEDP) in Mice and Rats,” J. Nucl. Med., 39, 235P (1998)
(Abstract).
52

Conzone, S. D., Hafeli, U. O., day, D. E. and Ehrhardt, G. J. Preparation and Properties of
Radioactive Rhenium Glass Microspheres Intended for In Vivo Radioembolization Therapy,” J.
Biomed. Mater. Res., 42, 617-625 (1998).
Eigler, N., Whiting, J., Chernomorsky, A., Jackson, J., Knapp, F. F., Jr. and Litvack, F. “RADIANT TM
Liquid Isotope Intravascular Radiation Therapy System,“ In, Proceedings, Second Annual
Symposium on Radiotherapy to Reduce Restenosis,” Sponsored by Scripps Clinic and Research
Foundation, La Jolla, CA, January 16-17, 1998.
Escobar, N.-I. “ 188 Re-Direct Labeling of Monoclonal Antibodies for Radioimmunotherapy of Solid
Tumors: Biodistribution, Normal Organ Dosimetry, and Toxicology,” Nucl. Med. Biol., 25, 441-447
(1998).
Fox, R., Barker, P. and Smart, G. “The Measurement of the Activity of 188 Re Using GAF Film and
Liquid Scintillation Counting,” In, Proceedings, Advances in Cardiovascular Radiation Therapy II;
March 8-10, 1998, Washington, D.C. , 35 (1998).
Fox, R., Guy, D., Barker, P., Hedland-Thomas, B., Dufty, A., Mew, G. and Gibbons, F. “Protection
Problems Associated with the Use of 188 Re,” In, Proceedings, Advances in Cardiovascular
Radiation Therapy II; March 8-10, 1998, Washington, D.C. , 44 (1998).
Fox, R. and Henson, P. “Effect of Contrast Media and Elliptical Arteries on the Radiation Dose
Delivered by 188 Re,” In, Proceedings, Advances in Cardiovascular Radiation Therapy II; March 8-
10, 1998, Washington, D.C. , 20 (1998).
Giblin, M., Wang, N., Hoffman, T. J., jurisson, S. S. and Quinn, T. P. “Design and Characterization
of α-Melanotrophic Peptide Analogs Cyclized throuhg Rhenium and Technetium metal
Coordination,” Proceed. Nat. Acad. Sci. USA, 95, 12814-12818 (1998).
Guhlke, S., Schaffland, A., Zamora, P. O., Sartor, J., Diekmann, D., Bender, H., Knapp, Jr., F. F.
and Biersack, H.-J. "Rhenium-188 and Technetium-99m Labeling of Peptides via
Mercaptoacetyltriglycyl (MAG3) Conjugates and Applications for Labeling the RC-160 Somatostatin
Analogue," Nucl. Med. Biol., 25, 621-632 (1998).
Hafeli, U. O., Warburton, M. C. and Landau, U. “Electrodeposition of Radioactive Rhenium onto
Stents to Prevent Restenosis,” Biomaterials, 19, 925-933 (1998).
Hong, M. K., Jeong, J. M., Yeo, J. S., Kim, K. M., Chang, Y. S., Lee, Y. L., Lee, D. S., Chung, J.-K.,
Lee, M. C. and Lee, S. J. “In Vitro Properties and Biodistribution of Tc-99m and Re-188-Labeled
Monoclonal Antibody CEA79.4,” Korean Journal of Nuclear Medicine, 32, 516-524 (1998) (in
Korean; Abstract in English).
Hosono, M. N., Hosono, M., Zamora, P. O., Guhlke, S., Harberberger, T., Bender, H., Knapp, F. F.,
Jr. and Biersack, H.-J. “Localization of Colorectal Carcinoma by Rhenium-188-Labeled B72.3
Antibody in Xenografted Mice,” Ann. Nucl. Med., 12, 83-88 (1998).
53

Hoher, M., Wohrie, J., Schults, C., Reske, S. N. and Kotzerke, J. “Intracoronary Radiotherapy with
Liquid Rhenium-188 to Prevent Restenosis Following Balloon Angioplasty - First Results from a
Randomized Trial,” Circulation, Supplement I, I-65 (1998) (Abstract ).
Iznaga-Escobar, N., Luis, I., Amador, J. F., Lopez, A., Izquierdo, J. C., and Perez, R.
”Radioimmunotherapy of 188 Re-Labeled Anti-Human EGF-R Antibody ior egf/r3 in H-125 Human
Lung Adenocarcinoma Xenografted Nude Mice,” Eur. J. Nucl. Med., 25, 890 (1998) (Abstract ).
Iznaga-Escobar, N. “ 188 Re Direct Labeling of Monoclonal Antibodies for Radioimmunotherapy of
Solid Tumors: Biodistribution, Normal Organ Dosimetry and Toxicology,” Nucl. Med. Biol., 25, 441-
447 (1998).
Jeong, J. M., Kim, Y.-J., Lee, Y.-L., Lee, D. S., Chung, J.-K., Lee, M. C. and Koh, C. S. “Colloidal
Rhenium-188 Entrapped Chitosan for Radionuclide Therapy,” J. Nucl. Med., 39, 235P (1998)
(Abstract ).
Juweid, M., Sharkey, R. M., Swayne, L. C., Griffiths, G. L., Dunn, R., Siegel, J. and Goldenberg, D.
M. "Pharmacokinetics, Dosimetry and Toxicity of anti-CEA Monoclonal Antibody, MN-14, Labeled
with Rhenium-188 in Patients with Gastrointestinal Cancer," J. Nucl. Med., 39, 34-42 (1998).
Kariemo, K. J., Stromberg, S., Nikula, T. K. and Karonen, S. L. “Expression Profile of Vascular Cell
Adhesion Molecule-1 (CD1-6) in Inflammatory Foci Uisng Rhenium-188 Labelled Monoclonal
Antibody in Mice,” Cell. Adhes. Commun., 5, 325-333 (1998).
Kim, Y. K., Jeong, J. M., Chang, Y. S., Lee, D. S., Chung, J.-K., Lee, M. C. and Koh, C.-S. “Study of
188Re(V)-DMSA for Treatment of Cancer: Radiolabeling and Biodistribution,” Korean Journal of
Nuclear Medicine, 32, 81-88 (1998) (in Korean; Abstract in English).
Kim, Y. J. Jeong, J. M., Chang, Y. S., Lee, Y. J. Lee, D. S., Chung, J.-K., Lee, M. C. and Song, Y.
W. “Preparation and Biodistribution of Rhenium-188 Sulfur Colloid,” Korean Journal of Nuclear
Medicine, 32, 298-304 (1998) (in Korean; Abstract in English).
Kim, Y.-J., Jeong, J. M., Kim, S. K., Lee, D. S., Chung, J.-K., Lee, M. S. and Koh, C.-S. “Rhenium-
188 Sulfur Colloid Suspended in Lipiodol: A Capillary-Blocking Radiopharmaceutical for Targeting
Liver Cancer,” J. Nucl. Med., 39, 235P (1998) (Abstract).
Knapp, F. F., Jr., Beets, A. L., Pinkert, J., Kropp, J., Lin, W.-L. and Wang, S.-Y. “Therapeutic
Applications of Rhenium-188 - A Readily Available Generator-Derived Radioisotope,” Invited Paper,
International Seminar on Therapeutic Applications of Radiopharmaceuticals (IAEA-SR-209),
Hyderabad, India, January 18-22, 1998, in press.
Knapp, F. F., Jr., Beets, A. L., Guhlke, S., Weinbereger, J., Kotzerke, J. and Stabin, M. “Rhenium-
188 Liquid-Filled Balloons for Vascular Therapy - Tungsten-188/Rhenium-188 Generator
Performance and Concentration of Re-188 to High Specific Volumes,” In, Proceedings of Advances
in Cardiovascular Raidation Therapy II; March 8-10, 1998, Washington, D.C. , 48 (1998).
Knapp, F. F., Beets, A. L., Guhlke, S., Biersack, H.-J., Stabin, M. and Spencer, R. “Liquid-Filled
Balloons for Coronary Restenosis Therapy - Strategy and Dosimetry for Use of Rhenium-188,” Eur.
J. Nucl. Med., 25, 883 (1998) (Abstract ).
54

Knapp, F. F., Jr. Beets, A. L., Guhlke, S., Gledd, K. N., Marboe, C., Amols, H. and Weinberger, J.
“Rhenium-188 Liquid-Filled Balloons Effectively Inhibit Restenosis in a Swine Coronary Overstretch
Model - A Simple New Method Bridging Nuclear Medicine and Interventional Cardiology,” J. Nucl.
Med., 39, 48P (1998).
Knapp, F. F., Jr., Beets, A. L., Mirzadeh, S. and Guhlke, S. “Use of a New Tandem Cation/Anion
Exchange System with Clinical Scale Generators Provides High Specific Volume Solutions of
Technetium-99m and Rhenium-188,” In, Proceedings, Symposium on International Trends in
Radiopharmaceuticals for Diagnosis and Therapy, Organized by the International Atomic Energy
Agency (IAEA); Lisbon, Portugal, March 30-April 2, 1998; IAEA, pp. 419-425.
Knapp, F. F., Jr. “Rhenium-188 - An Attractive Therapeutic Radioisotope Available from a Long
Shelf-Life Generator for Use in Liquid-Filled Balloons for Inhibtion of Restenosis After Coronary
Angioplasty and for Palliation of Bone Pain from Skeletal Metastases,” Invited Lecture, In,
Proceedings, Symposium on International Trends in Radiopharmaceuticals for Diagnosis and
Therapy, Organized by the International Atomic Energy Agency (IAEA); Lisbon, Portugal, March
30-April 2, 1998; IAEA, pp. 485-495.
Knapp, Jr., F. F., Beets, A. L., Mirzadeh, S. and Guhlke, S. “Concentration of Perrhenate and
Pertechnetate,” U.S. Patent No. 5,729,821, Issued March 17, 1998.
Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., O’Doherty, M., Blower, P. J., Verdera, E. S., Gaudiano,
J. S., Kropp, J., Guhlke, J., Palmedo, H. and Biersack, H.-J. "Reactor-Produced Radionuclides from
the ORNL-HFIR for Treatment of Bone Pain," Symposium for Radionuclides Used in Bone Pain
Palliation Therapy ; Held under the Auspices of the Council on Ionizing Radiation Measurements
and Standards (CIRMS), National Institute for Standards and Technology (NIST), Gaithersburg,
Maryland; September 27, 1996; Appl Radiat Isot., 49, 379-382 (1998).
Knapp, F. F., Jr. “Rhenium-188 - A Generator-Derived Radioisotope for Cancer Therapy,” Cancer
Biotherapy and Radiopharm., 13, 337-349 (1998).
Kolesnik. O. and Basmanov, V. “Investigation of a Rhenium Complex Formation for Development of
Bone-Seeking Kit for W-188/Re-188 Generator,” Proceedings of Radioactive Isotopes in Clinical
Medicine and Research, 23 rd International Symposium, Bagastein, Austria, January 13-16, 1998;
Eur. J. Nucl. Med., 25, S21 (1998) (Abstract ).
Kotzerke, J., Gertler, R. Bauer, R., Ickrath, O. Both, A., Hombach, V., Reske, S. N. and Voisard, R.
“Inhibition of Proliferative Activity of Human Coronary Vascular Cells After Radiation From a Balloon
Catheter Filled with Liquid Rhenium-188,” Eur. J. Nucl. Med., 25, 883 (1998) (Abstract ).
Kotzerke, J., Rentschler, M., Glatting, G., Schneider, E., Knapp, F. F., Jr. and Reske, S. N.
“Radiation Dose Measurements of a Balloon Catheter-Filled with Liquid Rhenium-188 by Means of
a TLD System,” J. Nucl. Med., 39, 84P (1998) (Abstract ).
Kotzerke, J., Fenchel, S., Guhlmann, A., Stabin, M., Renstchler, M., Knapp, F. F., Jr. and Reske, S.
N. “Pharmacokinetics of Tc-99m-Pertechnetate and Re-188-Perrhenate After Oral Application of
Perchlorate - Option of Subsequent Care Using Liquid Re-188 in a Balloon Catheter,” Nucl. Med.
Commun., 19, 795-801 (1998).
55

Kotzerke, J., Rentschler, M., Schneider, E., Stabin, M., Knapp, F. F., Jr. and Reske, S. N.
“Dosimetric Fundamentals of Endovascular Brachytherapy Using Re-188 to Prevent Restenosis
after Angioplasty,” Nuklearmedizin , 37, 68-72 (1998) (In German).
Kotzerke, J., Fenchel, S., Stabin, M., Knapp, F. F., Jr. and Reske, S. N. “Oral Application of
Perchlorate Can Reduce Radiation Dose After Artificial Release of Re-188-Perrhenate into the
Circulation,” In, Proceedings, Advances in Cardiovascular Radiation Therapy II; March 8-10, 1998,
Washington, D.C. ,41 (1998).
Kotzerke, J., Rentschler, M., GlattIng, G., Schneider, E., Knapp, F. F., Jr. and Reske, S. N.
“Confirmation of Radiation Dose Calculations of a Balloon Catheter Filled With Liquid Re-188 by
Means of a TLD System,” In , Proceedings , Advances in Cardiovascular Riadation Therapy II;
March 8-10, 1998, Washingotn, D.C. , 10 (1998).
Kramer, A., Alberto, R., Egli, A., Novak-Hofer, I., Hegetschweiler, K., Abram, U., Bernhardt, P. V.
and Schubiger, A. “Derivatives of 1,3,5-Triamino-1,3,5-Tridexoy-cis-Inositol as Versatile
Pentadentae Ligands for Protein Labeling with Re-186/188. Prelabeling, Biodistribution and X–ray
Structural Studies,” Bioconj. Chem., 9, 691-7092 (1998).
Kushita, K. N. and Du, J. “Radioactivity Measurement of 188 Re by Cherenkov Counting,” Appl.
Radit. Isot., 49, 1069-1072 (1998).
Lee, J., Lee, D. S., Jeong, J. M., Lee, M. Y., Kim, Y. J., Chang, S. A., Shin, S. A., Lee, M. M. ,
Chang, J.-K. and Lee, J.-K. ”Dosimetry and MIRD of Re-188-DTPA for Endovascular Balloon
Brachytherapy Against Restenosis after Coronary Angioplasty: Comparison with Re-188-
Perrhenate,” Eur. J. Nucl. Med., 25, 1137 (1998) (Abstract ).
Lee, J., Lee, D. S., Kim, Y. J., Chang, Y. S., Jeong, J. M., Shin, S.-A., Chung, J.-K., Lee, M. C. and
Koh, C.-S. “Rhenium-188-DTPA,” Korean Journal of Nuclear Medicine, 32, 427-432 (1998) (in
Korean; Abstract in English).
Li, A. N., Zimmerman, B. E., Knapp, F. F., Jr., Amols, H. I. and Whiting J. S. “Reconciliation of
Directly Measured Re-188 Balloon Dosimetry with Calculations Based on a New NIST Activity
Calibration,” Proceedings, Second Annual Symposium on Radiotherapy to Reduce Restenosis,
Sponsored by Scripps Clinic and Research Foundation, La Jolla, CA, January 16-17, 1998.
Liepe, K., Hilsex, R., Kropp, J., Kuehnig, A. and Franke, W.-G. “Rhenium-188-HEDP for the
Palliative Therapy of Osseous Metastases,” German Nuclear Medicine Meeting, Ulm, Germany,
April 1999 (in German).
Liepe, K. Kropp, J., Knapp, F. F., Jr., Hiscs, R., Kuehne, A. and Franke, W. G. “Rhenium-188 In
Comparison to Rhenium-186 and Strontium-89 in the Treatment of Bone Metastases,” Eur. J. Nucl.
Med., 25, 861 (1998) (Abstract ).
Makkar, R., Whiting, J., Honda, H., Li, A., Cordero, H., Chernomorsky, A., Litvack, F. and Eigler, N.
“Inhibition of Stent Restenosis by β-Emitting Rhenium-188 Balloon is Dose Dependent and Injury-
Independent,” Circulation, Supplement I, I-65 (1998) (Abstract).
56

Makkar, R., Honda, H., Li, A., Cordero, H., Sebastien. M., Chernomorsky, A., Whiting, J., Litvack, F.
and Eigler, N. “Brachytherapy with β-Emitting Rhenium-188 Balloon Following Stent Implantation
Inhibits Restenosis,” Circulation, Supplement I, I-65 (1998) (Abstract).
Maxon, H. R., Schroder, L. E., Washburn, L. C., Thomas, S. R., Samarantuga, R. C., Biniakiewicz,
D., Moulton, J. S., Cummings, D., Ehrhardt, G. J. and Morris, V. “Rhenium-188 (Sn)HEDP for
Treatment of Osseous Metastases,” J. Nucl. Med., 39, 659 (1998).
Milner, R. J., Dormehl, I. C., Louw, W. K. A., Chaparro, F. and Kilian, E. “The Bisodistribution,
Pharmacokinetics, Bone Localization and Therapeutic Effect of Rhenium-188-HEDP in Normal
Dogs and Dogs with Osteosarcoma of the Appendicular Skeleton,” Eur. J. Nucl. Med., 25, 1109
(1998) (Abstract )
Palmedo, H., Guhlke, S., Bender, H., Sartor, J., Knapp, F. F., Jr., Bangard, M., Otte, R. and
Biersack, H.-J. “Rhenium-188 HEDP for Multiple Metastases - A Dose Escalation Study,”
Nuklearmedizin, 37, A30 (1998)(Abstract ) (In German ).
Palmedo, H., Guhlke, S., Bender, H., Sartor, J., Knapp, F. F., Jr., Risse, J. and Biersack, H.-J.
“Rhenium-188 HEDP for Palliation of Multiple Bone Metastases - A Dose Escalation Study,” Eur. J.
Nucl. Med., 25, 1047 (1998) (Abstract ).
Peiyong, L., Junfeng, Y. and Zhu, C. ”Rhenium-188 Sulfide Suspension: Potential
Radiopharmaceutical for Radiation Synovectomy,” Eur. J. Nucl. Med., 25, 960 (1998) (Abstract ).
Pinkert, J., Wunderlich, G., Franke, W.-G., Andreef, M., Kropp, J. and Knapp, F. F., Jr. “Labeling of
Microspheres with Re-188 for Intraarterial Tumor Treatment,” Eur. J. Nucl. Med., 25, 894 (1998)
(Abstract ).
Roka, R., Sera, T., Knapp, F. F., Lang, J., Pajor, L., Turzo, L., Dux, L., Palmedo, H. and Biersack,
H.-J. “First Clinical Results on Two-Step Re-188-HEDP Treatment of Metastatic Bone Pain,” Eur.
J. Nucl. Med., 25, 1133 (1998) (Abstract ) .
Schmidt, P., Smith, S. V. and Bundesen, P. G. “ 188 Re DD-3B6/22 Fab’ for Use in Therapy of
Ovarian Cancer: Labelling and Animal Studies,” Nucl. Med. Biol., 25, 639-650 (1998).
Wang, S.-J., Lin, W.-Y., Chen, M.-N., Chi, C.-S., Chen, J.-T., Ho, W.-L., Hsieh, B.-T., Shen, L.-H.,
Tsai, Z.-T., Ting, G., Mirzadeh, S. and Knapp, F. F., Jr. “The Efficacy of Intratumoral Injection of
Rhenium-188 Microsphere in An Animal Model with Hepatoma,” J. Nucl. Med., 39, 1752-1756
(1998).
Wang, S. J., Lin, W. Y., Chen, M. N., Hsieh, B. T., Shen, L. H., Tsai, Z. T., Ting, G., Chen, J. T., Ho,
W. L., Mirzadeh, S. and Knapp, F. F., Jr. “Rhenium-188 Microspheres: A New Radiation
Synovectomy Agent,” Nucl. Med. Commun., 19, 427-433 (1998).
57

Wang, T. S. T., Fawwaz, R. A. and Van Heertum, R. L. “A Study of the Preparation, Quality Control,
and In Vitro Stability of Re-188-MAG3: A Potential Agent for Inhibition of Restenosis after PTCA,”
Eur. J. Nucl. Med., 25, 978 (1998) (Abstract )
Woods, M. J., Keightley, J. D., Ciocanel, M. and Walsh, C. P. “NPL Secondary Standard
Radionuclide Calibrator: New Calibration Figures for 106 Ru, 153 Sm and 188 Re,” Appl. Radiat. Isot.,
49, 1191-1193 (1998).
Zierbus, M., Bangard, M., Guhlke, S., Pizzrulli, L., Hagendorff, A., Knapp, F. F., Jr., Biersack, H.-J.
and Luederitz, B. “A New Method fo Applying Intravsacular Brachytherapy Using Re-188-
Perrhenate and Commercially Available Balloon Catheter Systems,” Circulation, Supplement I, I-65
(1998) (Abstract ).
Published in 1997:
Alberto, R., Schibli, R., Abram, U., Egli, A., Knapp, F. F., Jr. and Schubiger, P. A. “Potential of the
Organometallic “[M(CO)3] + ” (M = Re, Tc) Fragment for the Labelling of Proteins and Small
Molecules,” Radiochmica Acta, 79(2), 99-104 (1997).
Bogatzky, J., Guhlke, S., Bender, H., Sartor, J., Knapp, Jr., F. F. and Biersack, H.-J. “Receptor
Binding Studies with Rhenium-RC-160, A Directly-Labeled Somatostatin Analog, with Membranes
of the Colon Cancer Cell Line HT29 and CHO Cells,” Second International Conference on Isotopes,
Sydney, Australia, October 12-16, 1997.
Dadachova, M. S. and Lambrecht, R. M. “Synthesis and Crystal Structure of Zirconium Tungstate
ZrW2O7(OH,Cl)22·H2O,” J. Mater. Chem., 7(9), 1867-1870 (1997).
Dadadchova, E. and Mirzadeh, S. “The Role of Tin in the Direct Labelling of Proteins with
Rhenium-188,” Nucl. Med. Biol., 605-607 (1997).
Demaimay, F., Dazord, L., Roucoux, A., Noiret, N., Patin, H. and Moisan, A. “Rhenium-188 and
Technetium-99m Nitridobis(N-ethoxy-N-ethyldithiocarbamate) Leucocyte Labeling
Radiopharmaceuticals: [ 188 ReN(NOET)2] and [ 99m Tc(NOET)2] NOET = Et(EtO)NCS2: Their In Vitro
Localization and Chemical Behaviour,” Nucl. Med. Biol., 24(8), 701-706 (1997).
Elder, R. C., Yuan, J., Helmer, B., Pipes, D., Deutsch, K. and Deutsch, E. “Studies of the Structure
and Composition of Rhenium-1,1-Hydroxyethylidenediphosphonate (HEDP) Analogues of the
Radiotherapeutic Agent 186 Re-HEDP,” Inorg. Chem., 36, 3055-3063 (1997).
Fox, R. A. “Dosimetry of Beta Emitting Radionuclides for Use in Balloon Angioplasty,” Australasian
Physical and Engineering Science in Medicine, 20, 139-146 (1997).
Gaudiano, J., Martinez, G., Hermida, J. C., Robles, A., Verdera, S., Leon, A., Savio, E. and Knapp,
F. F., Jr. “188-Re-HEDP: Tratemiento Del Dolor En Metasrasis Oseas - Experiencia Clinica Inicial,”
ALASBAMIN 97, 44 (1997)(Abstract )(in Spanish).
Giedd, K. N., Amols, H., Marboe, C., Knapp, Jr., F. F. and Weinberger, J. “Effectiveness of Beta-
Emitting Liquid-Filled Perfusion Balloon to Prevent Restenosis,” American Heart Association 70 th
Scientific Meeting, Orlando, Florida, November 9-12, 1997; Circulation, 96, I-200 (1997)
58

Grillenberger, K. G., Glatz, S. and Reske, S. N. “Rhenium-188 Labeled Hydroxyapatite and
Rhenium-188 Sulfur Colloid,” Nuklearmedizin, 36, 71-75 (1997) (in German).
Guhlke, S., Beets, A. L., Biersack, H.-J. and Knapp, F. F., Jr. “Elution of Re-188 from W-188/Re-
188 Generators With Salts of Weak Acids Permits Efficient Concentration to Low Volumes Using A
New Tandem Cation/Anion Exchange System,” Annual Meeting of the Society of Nuclear Medicine,
San Antonio, Texas, June 1-6, 1997; J. Nucl. Med., 38,125P (1997).
Guhlke, S., Oetjen, K., Beets, A. L., Knapp, Jr., F. F. and Biersack, H.-J. “188-Rhenium (V)
Dimercaptosuccinc Acid: Separation and Stability Studies of Stereoisomers and Preliminary In Vivo
Studies with the Individual Isomers in Rats,” Second International Conference on Isotopes, Sydney,
Australia, October 12-16, 1997.
Guhlke, S., Zamora, P. O., Sartor, J., Knapp, F. F., Jr. and Biersack, H.-J. “Ascorbic Acid
Stabilization of Re-188- and I-131-Labeled Peptides for Radiotherapy,” Radiochmica Acta, 79(2),
93-98 (1997).
Guhlke, S., Palmedo, H., Sartor, J., Beets, A. L., McPherson, D. W., Knapp, F. F., Jr. and Biersack,
H.-J. “Re-188-HEDP for the Palliative Therapy of Bone Pain: Preparation, Radiochemistry and In
Vivo Quality Control in Mice and Rats,” Nuklearmedizin, 36, A76 (1997) (Abstract; In German).
Guhlke, S., Oetjen, K., Beets, A. L., Bender, H., Knapp, F. F., Jr. and Biersack, H.-J.
“Rhenium(V)Dimercaptosuccinic Acid: Isolation and Stability Evaluation of the Sterioisomers and
Initial Studies of the Various Isomers in Rats,” Nuklearmedizin, 36, A76 (1997) (Abstract; In
German).
Guhlke, S., Knapp, F. F., Jr., Zamoa, P. O., Sharon, S., Beets, A. L., Oetjin, K., Palmedo, H.,
Bender, H. and Biersack, H.-J. “Clinical-Scale Tungsten-188/Rhenium-188 Generators Routinely
Provide > 18 GBq (500 mCi/ml) Specific Volume Solutions of Carrier-Free Rhenium-188: Recent
Generator Improvements and First Clinical Applications,” In, Proceedings, Boettstein Colloquim
1997: 11 th Meeting of the International Research Group in Immunoscintigraphy and Immuotherapy
(IRIST), Villigen, Switzerland, March 21-22, 1997.
Guhlke, A., Beets, A. L., Oetjin, K., Sartor, J., Mirzadeh, S., Knapp, Jr., F. F. and Biersack, H.-J.
“Convenient Concentration of Rhenium-188 and Technetium-99m Eluates from Tungsten-
188/Rhenium-188 or (n,γ)-Produced Molybdenum-99/Technetium-99m Generators to High Specific
Volumes,” In, Proceedings, XII International Symposium on Radiopharmaceutical Chemistry,
Uppsala, Sweden, June 15-19, 1997, pp 294-297.
Guhlke, S., Zamora, P. O., Sartor, J., Knapp, Jr., F. F., Rhodes, B. A. and Biersack, H.-J.
“Stabilization of Rhenium-188 and Iodine-131-Labeled Peptides for Radiotherapy,” European
Nuclear Medicine Congress, Glasgow, Scotland, August 23-27, 1997; Eur. J. Nucl. Med., 24, 1059
(1997).
Hamby, C. V., Chinol, M., Manzo, C. and Ferrone, S. “Purification by Affinity Chromatography with
Anti-Idiotypic Monoclonal Antibodies of Immunoreactive Monoclonal Antibodies Following Labeling
with 188 Re,” Hybridoma, 16, 27-31 (1997).
59

Hashimoto, K. “Labelling of Aminomethylenephosphonate Derivatives with Generator-Produced
188 Re, and a Study of Their Stability,” Appl. Radiat. Isot., 51, 307-313 (1997).
Knapp, F. F., Jr., Guhlke, S., Weinberger, J., Beets, A. L. Amols, H., Palmedo, H. and Biersack, H.-
J. “High Specific Volume Rhenium-188 - Clinical Potential of a Readily Available Therapeutic
Radioisotope,” Invited Lecture, 35 th International Meeting of the German Society of Nuclear
Medicine, Kassel, Germany, April 16-19, 1997; Nuklearmedizin, 36, A38 (1997).
Knapp, F. F., Jr. “Clinical Therapeutic Applications of Reactor-Produced Radioisotopes,” Invited
Paper, Symposium on Isotope Production and Applications, American Nuclear Society, 1997
Winter Meeting, Albuquerque, New Mexico, November 16-20, 1997; ANS Trans., 77, 539-540
(1997).
Knapp, F. F., Jr., Beets, A. L., Guhlke, S., Zamora, P. O., Bender, H., Palmedo, H. and Biersack,
H.-J. “Rhenium-188-Labeled Agents for Breast Cancer Treatment,” Seventh Mediterranean
Symposium of Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 7-12, 1997,
Mediterrean Pub., Athens, Greece.
Knapp, Jr., F. F., Guhlke, S., Beets, A. L., Amols, H. and Weinberger, J. "Rhenium-188 - Attractive
Properties for Introvascular Brachytherapy for Inhibition of Coronary Restenosis After PTCA," 3rd
International Conference of Nuclear Cardiology, Florence, Italy, April 6-9, 1997; J. Nucl. Cardiol., 4,
S-118 (1997).
Knapp, F. F., Jr., Guhlke, S., Beets, A. L., Amols, H. and Weinberger, J. “ Intraarterial Irradiation
with Rhenium-188 for Inhibition of Restenosis After PTCA - Strategy and Evaluation of Species for
Rapid Urinary Excretion,” Annual Meeting of the Society of Nuclear Medicine, San Antonio, Texas,
June 1-6, 1997; J. Nucl. Med., 38, 124P (1997) (Abstract).
Knapp, F. F., Jr. , Beets, A. L., Guhlke, S., Zamora, P. O., Bender, H., Palmedo, H. and Biersack,
H.-J. “Development of the Alumina-Based Tungsten-188/Rhenium-188 Generator and Use of
Rhenium-188-Labeled Radiopharmaceuticals for Cancer Treatment,” Anticancer Research, 17,
1783-1796 (1997).
Liang, Q., Ehrhardt, G. J., Ketring, A. R. and Miller, R. ”Effect of Stoichiometric and Preparation
Parameters on W-188/Re-188 Gel Generator Perfomance,“ Radhiochim. Acta, 79, 137-140 (1997).
Lin, W.-Y., Lin, C.-P., Hsieh, B.-T., Tsai, Z.-T., Yen, T.-C., Wang, S.-J., Ting, G., Yeh, S.-J. and
Knapp, Jr., F. F. “Rhenium-188 HEDP: A New Potential, Generator-Produced Radiotherapeutic
Drug for Bone Metastases,” Eur. J. Nucl. Med., 24, 590-595 (1997).
Martinez, G., Savio, E., Robles, A., Leon, A., Verdera, S., Muniz, S., Knapp, F. F., Jr. and
Gaudiano, J. “Caracterizacion Farmcocinetica De 188-Re-HEDP en Pacientes Metastasis Oseas,”
ALASBAMIN 97, 51 (1997)(Abstract )(in Spanish).
Mirzadeh, S., Beets, A. L. and Knapp, Jr., F. F. "Production of Rhenium-186 and Rhenium-188 in
the ORNL-HFIR," Symposium on Rhenium, Orlando, FL, February 9-13, 1997 (Abstract ).
60

Mirzadeh, S., Beets, A. L. and Knapp, F. F., Jr. “HFIR-Produced Radioisotopes of Current Medical
Interest,” In, Proceedings, Sixth Workshop on Targetry and Chemistry, Vancouver, B. C., Canada,
August 17-19, 1995; J. M. Link and T. J. Ruth, Editors, pp. 129-131 (1996).
Mirzadeh, S., Knapp, F. F., Jr. and Lambrecht, R. M. “Burn-up Cross Section of 188 W,”
Radiochimica Acta, 77, 99-102 (1997).
Palmedo, H., Guhlke, S., Beets, A. L., Sartor, J., Knapp, Jr., F. F. Bogatsky, J. and Biersack, H.-J.
“Rhenium-188-HEDP for Pain Palliation of Bone Metastases: First Clinical Results,” European
Nuclear Medicine Congress, Glasgow, Scotland, August 23-27, 1997; Eur. J. Nucl. Ed., 24, 962
(1997).
Safavy, A., Khazaeli, M. B., Mayo, M. S. and Buchsbaum, D. J. “Synthesis, Rhenium-188 labeling
and Biodistribution Studies of a Phenolic Ester Derivative of Trisuccin,” Can. Biother. Radiopharm.,
12, 375-384 (1997).
Safavy, A., Khazaeli, M. B., Qin, H. and Buchsbaum, D. J. “Synthesis of Bombesin Analogues for
Radiolabeling with Rhenium-188,” Cancer, 80 (Suppl. 12), 2354-2359 (1997).
Sykes, T. R., Somayaji, V., Bier, S., Woo, T. K., Kwok, C. S., Sniecklus, V. and Noujaim, A.,
“Radiolabeling of Monoclonal Antibody B43.13 with Rhenium-188 for Immunoreactivity,” Appl.
Radiat. Isot., 48, 899-906 (1997).
Verdera, E. S., Gaudiano, J., Leon, A., Martinez, G., Robles, A., Savio, E., Leon, E., McPherson, D.
W. and Knapp, Jr., F. F. “Rhenium-188-HEDP: Kit Formulation and Quality Control,” Radiochmica
Acta, 77(2), 113-118 (1997).
Weinberger, J., Mirzadeh, S., Knapp, Jr., F. F. and Amols, H. “Beta Irradiation for Restenosis After
Stent Implantation: Dose Variations Among Differing Stents,” 46 th Annual Scientific Sessions,
American College of Cardiology, Anaheim, CA, March 16-19, 1996; J. Amer. Coll. Cardiol., 29, No.
2 (Suppl. A), 238A, 1997 (Abstract # 973-59).
Zamora, P. O., Marek, M. J. and Knapp, Jr., F. F. "Preparation of Re-188-RC-160 Somatostatin
Analog: A Peptide for Regional Radiotherapy," Appl. Radiat. Isot., 48, 305-310 (1997).
Zamora, P. O., Marek, M. J., and Knapp, Jr., F. F. "Preparation of Re-188-RC-160 Somatostatin
Analog: A Peptide for Regional Radiotherapy," Appl. Radiat. Isot., 48, 305-310 (1997).
Zamora, P. O., Bender, H., Guhlke, S., Marek, M. J., Knapp, Jr., F. F., Rhodes, B. A. and Biersack,
H.-J. "Pre-Clinical Experience with Re-188-RC-160, A Radiolabeled Somoatostatin Analog for Use
in Peptide-Targeted Radiotherapy," Anticancer Research, 17, 1803-1808 (1997).
Published in 1996:
61

Alberto, R., Schibli, R., Egli, A., Schubiger, A., and Knapp, Jr., F. F. "Potential of the Organometallic
"[M(CO)3] + " (M=Re,Tc) Fragment for the Labeling of Proteins and Small Molecules," Symposium on
Radiochemistry and Radioimmunotherapy, American Chemical Society Annual Meeting, Orlando,
FL, August 25-29, 1996 (Abstract ).
Akhtar, M., Mushtaq, A. and Karim, H. M. A. “Separation of No-Carrier Added 188 Re from Neutron-
Irradiated Natural Tungsten,” Sep. Sci. Tech., 31, 1997-2000 (1996).
Amols, H. I., Weinberger, J., Mirzadeh, S., and Knapp, Jr., F. F. "Beta Irradiation for Restenosis:
Considerations for Stent Implantation," Annual Meeting of the American Heart Association, New
Orleans, Louisiana, November 10-13, 1996; Circulation, 94, Suppl. I, I-210 (1996) (Abstract ).
Arteburn, J. B., Fogarty, I. M., Hall, K. A., Ott, K. C. and Byron, J. C. “Functionalized
Organoimidorhenium(V) Complexes as Potential Radiopharmaceuticals: Synthesis of Glycine
Derivatives and the Structure Determination of a Rhenium Analogue of Chlorambucil,” Angew.
Chem. Int. Ed. Eng., 35, 2877-2879 (1996).
Blower, P. J., Lam, A., Knapp, Jr., F. F., O'Doherty, M. J., and Coakley, A. J. "Preparation,
Biodistribution and Dosimetry of Re-188-DMSA In Patients with Disseminated Bone Metastases,"
British Nuclear Medicine Society Meeting 1996, Brighton, England; April 1-3, 1996; Nucl. Med.
Comm., 17, 258 (1996) (Abstract ).
Dadachova, E., Smith, S. V. and Mirzadeh, S. "Electrolytic Reduction of Carrier-Free Rhenium-
188," Appl. Radiat. Isot., 47, (3), 361-364 (1996).
Fransceschini, R., Chinol, M., Pecorale, A., Deleide, G., Knapp, F. F., Jr. and Paganelli, G.
“Industrial Production of a W-188/Re-188 Generator and its Validation by Preparation of Re-188-
MDP Using Carrier-Free Re-188,” In, Proceedings of the 2 nd National Joint Congress of the
Radiochemistry Interdivisional Group (SIRR) and the Italian Chemical Society (GIR), Palermo, Italy,
September 11-14, 1996; pp 317-322 (1996).
Hashimoto, K, and Yoshihara, K. “Rhenium Complexes Labeled With 188,186 Re For Nuclear
Medicine,” In, Topics in Current Chemistry, 176; K. Yoshihara and T. Omori, Editors; Springer
Verlag, Berlin/Heidleberg/New York, 1996, pp. 275-292.
Hosono, M. N., Hosono, M., Mishra, A. K., Faivre-Chauvet, A., Barbet, J., Gautherot, E.,
Knapp, Jr., F. F., Yamada, R., Machida, K. and Chatal, J. F. “Localization of Small-Cell Lung
Cancer Xenografts by Re-188-Labeled Monoclonal Antibodies,” 1996 Congress of the European
Association of Nuclear Medicine, Copenhagen, Denmark, September 14-18, 1996; Eur. J. Nucl.
Med., 23, 1109, (1996) (Abstract).
Hosono, M. N., Hosono, M., Mishra, A. K., Faivre-Chauvet, A., Barbet, J., Gautherot, E.,
Knapp, Jr., F. F., Yamada, R. and Chatal, J. F. “Targeting of Small-Cell Lung Cancer Xenografts by
Re-188-Labeled Monoclonal Antibodies,” The 6 th Asia and Oceania Congress of Nuclear Medicine
and Biology, Kyoto, Japan, September 30-October 4, 1996, Ann. Nucl. Med., 10, 573 (1996)
(Abstract).
62

Hosono, M., Hosono, M. N., Haberberger, T., Zamora, P. O., Guhlke, S., Bender, H., Knapp, Jr., F.
F. and Biersack, H.-J. “Localization of Small-Cell Lung Cancer Xenographs with Iodine-125,
Indium-111 and Rhenium-188-Somatostatin Analogs,” Jpn. J. Cancer Res., 87, 995-1000 (1996).
Rhodes, B. A., Lambert, C. R., Marek, M. J., Knapp, Jr., F. F. and Harvey, E. B. "Rhenium-188-
Labeled Antibodies," Appl., Radiat. Isot., 47, 7-14 (1996).
Hsieh, B.-T., Hsieh, H. T., Shen, L. H., Tsai, Z. T., Ting, G. and Knapp, Jr., F. F. "The Study of
Preparation of Tungsten-188/Rhenium-188 Generators," In, Proceedings of the International
Conference on Isotopes, Beijing, China, May 7-12, 1995; J. Radioanalyt. Nucl. Chem., 205, 93-100
(1996).
Hsieh, B.-T., Callahan, A. P., Beets, A. L., Ting, G. and Knapp, Jr., F. F. "Ascorbic Acid/Saline
Eluant Increases Re-188 Yields After "Wet" Storage of W-188/Re-188 Generators," Appl. Radiat.
Isot., 47, 23-26 (1996).
Knapp, Jr., F. F., Mirzadeh, S. and Beets, A. L. “Reactor Production and Processing of Therapeutic
Radioisotopes for Applications in Nuclear Medicine,” J. Radioanalyt. Nucl. Chem. Lett., 205, 93-100
(1996).
Kremer, C., Dominguez, S., Perez-Sanchez, M., Mederos, A. and kremer, E. “Comparative
Electrochemistry of Technetium(V) and Rhenium(V) Dioxo Complexes,” J. Radioanalyt. Nucl.
Chem., 213, 263-274 (1996).
Mirzadeh, S. and Knapp, Jr., F. F. "Biomedical Radionuclide Generators Systems," Invited Review,
Centennial Issue - Discovery of Radioactivity, In, J. Radioanalyt. Nucl. Chem., 203, 469-486
(1996).
Mushtaq, A. “Recovery of Enriched 186 W from Spent 188 W/ 188 Re Generators,” Appl. Radiat. Isot.,
47, 727-729 (1996).
Sartor, J., Schaffland, A., Bogatsky, J., Guhlke, S., Knapp, Jr., F. F. and Biersack, H-J. "Tc-99m
and Re-188-Labeling of a D-Lys 6 -LHRH Analogue Using MAG3-p-Nitrophenylesters," European
Association of Nuclear Medicine Congress, Copenhagen, Denmark, September 14-18, 1996, Eur. J.
Nucl. Med., 23, 1142 (1996) (Abstract ).
Zamora, P. O., Bender, H., Knapp, Jr., F. F., Marek, M. J. and Biersack, H.-J. "Regional, Tumor
Radiotherapy with Re-188-RC-160 Somatostatin Analog," 43rd Annual Meeting, Society of Nuclear
Medicine, Denver, CO, June 3-6, 1996, J. Nucl. Med., 37, P236 (1996) (Abstract ).
Zamora, P. O., Guhlke, S., Rhodes, B. A., Marek, M. J., Bender, H., Biersack, H.-J., Mirzadeh, S.
and Knapp, Jr., F. F. "Radiotherapy Using the Re-188-Labeled RC-160 Peptide," Symposium on
Radiochemistry and Radioimmunotherapy, American Chemical Society Annual Meeting, Orlando,
FL, August 25-29, 1996 (Abstract ).
Zamora, P. O., Bender, H., Rhodes, B. A., Knapp, Jr., F. F. and Biersack, H. J. "Peptides for Tumor
Radiotherapy; Applications Based on Re-188-RC-160, A Somatostatin Analogue," Immunological
Approaches to Tumor Therapy. III. International Meeting on Idiotypic Network and Tumor Therapy,
Drug Targeting and Photodynamic Therapy, Bonn, Germany, February 29-March 2, 1996
(Abstract).
63

Wang, S. J., Lin, W. Y., Chen, M. N., Hsieh, B.-T., Shen, L. H., Tsai, Z. T., Ting, G. and
Knapp, Jr., F. F. "Biodistribution of Rhenium-188 Lipiodol Infused via the Hepatic Artery of Rats with
Hepatic Tumors," Eur. J. Nucl. Med., 23, 13-17 (1996).
Zamora, P. O., Guhlke, S., Bender, H., Diekmann, B. A., Rhodes, H. J., Biersack, H.-J. and
Knapp, Jr., F. F. “Radiotherapy of Intrathoracic Carcinoma Xenographs with 188 Re-RC-160, A
Somatostatin Analogue," Tumor Targeting, 2, 49-59 (1996).
Zamora, P. O., Guhlke, S., Bender, H., Diekmann, D., Rhodes, B. A., Biersack, H.-J. and
Knapp, Jr., F. F. "Experimental Radiotherapy of Receptor-Positive Human Adenocarcinoma with
188
Re-RC-160, A Directly-Radiolabeled Somatostatin Analog," International Journal of Cancer, 65,
214-220 (1996).
Verdera, E. S., Gaudiano, J., Leon, A., Martinez, G., Robles, A., Savio, E., McPherson, D. W. and
Knapp, Jr., F. F. “Rhenium-188-HEDP-Kit Formulation/Quality Control,” American Chemical Society
Annual Meeting, Orlando, FL, August 25-29, 1996 (Abstract ).
Wang, S. J., Lin, W. Y., Chen, M. N., Hsieh, B.-T., Shen,. L. H., Tsai, Z. T., Ting, G. and
Knapp, Jr., F. F. " Radiolabeling of Lipiodol with Generator-Produced Rhenium-188 for Hepatic
Tumor Therapy," Appl. Radiat. Isot., 47, (3) 355-359 (1996).
Winnard, P. Jr., Virzi, E., Fogarasi, M., Rusckowski, M. And Hnatowich, D. J. “Invetsigations of
Directly Labeling Antibodies with Rhenium-188,” Quar. J. Nucl. Med., 40, 151-160 (1996).
Published Prior to 1995:
Balchot, J., Herment, J. and Moussa, A. "Generator for W-188/Re-188," Int. J. Appl. Radiat., Isot.,
20, 467-470 (1969) (In French).
Barfeld, P. A. “Radionuclide Irradiation of the Choroid Plexus and Central Nervous System,” In,
Therapy in Nuclear Medicine, R. P. Spencer, ed., Grune and Stratton, New York, 1977; Chapter 14,
pp. 167-174.
Bardfeld, A. P. and Shulman, K. "Transport and Distribution of 188 Re in the Central Nervous
System", Experimental Neurology, 50, 1 (1976).
Binney, S. E., Walker, R. J. and Jordheim, D. P. “Production of 188 W/ 188 Re in a Research Reactor,”
Oregon State University, Department of Nuclear Engineering, Report # OSU-NE-MED-9003,
December 1990.
Bisunadan, M. M., Blower, P. J., Clarke, S. E. M., Singh, J., and Wend, M. J. "Synthesis and
Characterization of [ 186 ]Rhenium(V)dimercaptosuccinic Acid: A Possible Tumour Radiotherapy
Agent", Appl. Radiat. Isot., 42, 167-171 (1991).
Blower, P. J., Singh, J. Clarke, S. E. M., Lazarus, C. R., Reghibe, K., Callahan, A. P. and
Knapp, Jr., F. F. "Optimization of Simple Methods for Preparation of 186/188 Re(V)DMSA for
Assessment as Tumor Radionuclide Therapy Agents," European Symposium on Radiopharmacy
and Radiopharmacology, Cambridge University, Cambridge, England, March 1993 (Abstract ).
64

Botros, N., El-Garny, M., Abdulla, S. and Aly, H. F. "Comparative Studies on the Development of a
W-188/Re-188 Generator", Isotopenpraxis, 22, 368 (1986).
Brodskaya, G. A. and Gapurova, O. U. “Development of a High Activity 188 W- 188 Re Generator,”
From, Radiokhimiya, 35, No. 3, 92-97 (1993) (Translation UC 541.15:546-7, pp. 325-329, 1992).
Callahan, A. P., Rice, D. E. and Knapp, F. F., Jr. "Re-188 for Therapeutic Applications from an
Alumina Based W-188/Re-188 Radionuclide Generator System," NucCompact, 20, 3-6 (1989).
Callahan, A. P., Mirzadeh, S. and Knapp, F. F., Jr. "Large-Scale Production of Tungsten-188,"
Radioact. & Radiochem., 3, 46-48 (1992).
Carter, T. E., Barfeld, P. A. and Shulman, K. “The Uptake of Rhenium-188 in the Choroid Plexus
and Its Effect on CSF Production,” In, Cisternography and Hydrocephalus, Harbert, et al., Editors;
Charles Thomas, 1977; Chapter 10, pp. 131-140.
Chen, M. N., Lin, W. Y., Wang, S. J., Hseih, B. T., Tsai, Z. T., Ting, G. and Knapp, Jr., F. F.
"Rhenium-188 Labeling of Lipiodol for Hepatoma Therapy," European Association of Nuclear
Medicine Congress, Brussels, Belgium, August 23-28, 1995, Eur. J. Nucl. Med., 22, 886 (1995)
(Abstract # 647).
Coursey, B. M., Calhoun, J. M., Cessna, J., Hoppes, D. D., Schima, F. J., Unterweger, M. P., Golas,
D. B., Callahan, A. P., Mirzadeh, S. and Knapp, F. F., Jr. "Assay of the Eluent from the Alumina-
Based W-188/Re-188 Generator", Radioact. & Radiochem., 2, 39 (1990).
Dadachova, E., Mirzadeh, S., Lambrecht, R. M. and Kamioki, H. “Alumina-Based 188 W- 188 Re
Biomedical Generator: Physical and Chemical Study of Tungstate Ion Adsorption on Al 2O3,”
Synthesis and Applications of Isoptopically labeled Compounds, John Wiley and Sons, 1994, pp.
232-235.
Dadachova, E., Lambrecht, R. M. and Hetherington, E. “An improved Tungsten-188/Rhenium-188
Generator Based on Zirconium Tungstate,” J. Radioanalyt. Nucl. Chem., 188, 267-278 (1994).
Dadachova, E., Smith, S. V., Schmidt, P. F. and Mirzadeh, S. "Electrochemical Reduction of 188 Re
for Protein Labeling," XIth International Symposium on Radiopharm. Chem., Vancouver, Canada,
Aug 13-17, 1995; J. Lab. Cmpds. Radiopharm., 37, 524-525 (1995)(Abstract ).
Dadachova, E., Kamioki, H., Lambrecht, R. M. and Mirzadeh, S. "Alumina-Based 188 W- 188 Re
Biomedical Generator-Physical and Chemical Study of Tungstate Ion Adsorption on Al2O3,"
International Symposium on Synthesis and Preparation of Radioisotopes, Strasbourg, France,
June, 1994 (Abstract ).
Dadachova, E., Mirzadeh, S. and Lambrecht, R. M. "Tungstate-Ion-Alumina Interaction in a 188 W/
188 Re Biomedical Generator," J. Phys. Chem., 99, 10976-10981 (1995).
Deutsch, E., Libson, K., Vanderheyden, J. -L., Ketering, A. and Maxon, H. R. "The Chemistry of
Rhenium and Technetium as Related to the Use of Isotopes of the Elements in Therapeutic and
Diagnostic Nuclear Medicine," Nucl. Med. Biol., 13, 465-477 (1986).
65

Early, J. F., Durack. L., Williams, D. and Vanderheyden, J.-L. “Considerations for Imaging Re-188
and Re-186 Isotopes,” Clin. Nucl. Med., 15, 911-916 (1990).
Ehrhardt, G. J., Vanderheyden, J.-L. and E. Su, F.-M. “Rhenium Generator System and Method for
its Preparation and Use,” U.S. Patent # CA 929644; Canadian Patent # CA 1323748 (1987).
Ehrhardt, G. J., Ketering, A. R. and Liang, Q. "Improved W-188/Re-188 Zirconium Tungstate Gel
Radioisotope Generator Chemistry," Radioact. & Radiochem., 3, 38-41 (1992).
Ehrhardt, G. J., Turpin, T. A., Razavi, M. S., Vanderheyden, J. -L., Su, F. M. and Fritzberg, A. R.,
"A Convenient W-188/Re-188 Generator for Therapeutic Applications Using Low Specific Activity
W-188," In, Technetium and Rhenium in Chemistry and Nuclear Medicine 3, (M. Nicolini and G.
Bandoli, eds.) Cortina International, Verona, Italy - Raven Press, New York, pages 631-634 (1990).
Ehrhardt, G. J., Ketring, A. R., Turpin, T. A., Razavi, M. S., Vanderheyden, J. -L. and Fritzberg, A.
R. "An Improved W-188/Re-188 Generator for Radiotherapeutic Applications," J. Nucl. Med., 28,
656 (1987) (Abstract).
Griffiths, G. .L., Goldenberg, D. M., Jones, A. L. and Hansen, H. J. "Radiolabeling of Monoclonal
Antibodies and Fragments with Technetium and Rhenium," Bioconjugate Chemistry, 3, 91-99
(1992).
Griffiths, G. L., Goldenberg, D. M., Sharkey, R. M., Knapp, F. F., Jr., Callahan, A. P., Tejada, G. and
Hansen, H. -J. "Evaluation of a 188 W/Re Generator System as a Ready Source of 188 Re for Use in
Radioimmunotherapy (RAIT)," Radioact. & Radiochem., 3, pp. 33-37 (1992).
Griffiths, G. L., Knapp, F. F., Jr., Callahan, A. P., Chang, C. -H., Hansen, H. J. and Goldenberg, D.
M. "Direct Radiolabeling of Monoclonal Antibodies with Generator-Produced Rhenium-188 for
Radioimmunotherapy," Cancer Research, 51, 4594 (1991).
Guhlke, S., Diekmann, D., Zamora, P. O., Knapp, Jr., F. F. and Biersack, H.-J. "Development of
MAG3 p-Nitrophenyl Ester for Technetium-99m and Rhenium-188 Labeling of Amines and
Peptides," Fourth International Symposium on Technetium in Chemistry and Nuclear Medicine,
Bressanone, Italy, September 12-14, 1994; SG Editorial, Padova, pp. 363-366 (1995).
Haberberger, T., Zamora, P. O., Hosono, M., Hosono, M. N., Bender, H., Guhlke, S., Knapp, Jr., F.
F. and Biersack, H.-J. "Direct Radiolabeling of the Somatostatin Analogs RC-160 and Octreotide
with 99m Tc and 188 Re: Initial Results with Stannous Reductions," Fourth International Symposium on
Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, September 12-14, 1994;
SG Editorial, Padova, pp. 367-372 (1995).
Hafeli, U., Tiefenauer, L. X., Schubiger, P. A. and Weber, H. G. “A Lipophilic Complex with 186 Re/
188 Re Incorporated in Liposomes Suitable for Radiotherapy,” Int. J. Appl. Instrument. B., 18, 449-
454 (1991).
Hafeli, V., Tiefenauer, L. X., Schubiger, P. A. and Weder, H. G. "A Lipophilic Complex with
186 188
Re/ Re Incorporated in Liposomes Suitable for Radiotherapy," Nucl. Med. Biol., 18, 449-454
(1991).
66

Hayes, R. L. and Rafter, J. J. “Rhenium-188 as a Possible Diagnostic Agent,” J. Nucl. Med., 7, 797
(1966) (Abstract ).
Hayes, R. L. and Rafter, J. J. “Rhenium-188 as a Possible Diagnostic Agent,” In, Research
Report, Medical Division, Oak Ridge Associated Universities, pp. 74-77, 1966.
Hosono, M., Hosono, M. N., Bender, H., Zamora, P. O., Guhlke, S., Knapp, Jr., F. F. and
Biersack, H.-J. "Scintigraphic Detection of Colorectal Carcinoma Xenografts With Re-188 Labeled
Monoclonal Antibody," 6th World Congress of Nuclear Medicine and Biology, Sydney, Australia,
October 23-28, (1994); Eur. J. of Nucl. Med., 21, S26 (1994) (Abstract ).
Hosono, M., Hosono, M. N., Haberberger, T., Zamora, P. O., Guhlke, S., Bender, H.,
Knapp, Jr., F. F. and Biersack, H.-J. "Targeting of Small-Cell Lung Cancer By Octreotide Labeled
with I-125, In-111 and Re-188 in a Mouse Model," Eur. J. Nucl. Med., 22, 845 (1995) (Abstract ).
Hosono, M., Hosono, M. N., Haberberger, T., Zamora, P. O., Guhlke, S., Bender, H.,
Knapp, Jr., F. F. and Biersack, H.-J. "Imaging of Small-Cell Lung Cancer Zenographs with I-125,
In-111, and Re-188 Octreotides," 42nd Annual Meeting of The Society of Nuclear Medicine,
Minneapolis, MN, June 12-15, 1995; J. Nucl. Med., 36., P72, (1995) (Abstract ).
Hsieh, B. T., Tsai, Z. T., Ting, G. and Knapp, Jr., F. F. "The Preparation of W-188/Re-188
Generators for Medical Applications," Symp. on Isot. and Radiation Applications, Chung-Hwa
Nuclear Science Society, Taiwan, July 6-8, 1994 (Abstract ).
Kamioki, H., Mirzadeh, S., Lambrecht, R. M., Knapp, Jr., F. F. and Dadachova, E. "Tungsten-
188/Rhenium-188 Generator for Biomedical Applications," Radiochim. Acta, 65, 39-46 (1994).
Kamioki, H., Mirzadeh, S., Lambrecht, R. M. and Dadachova, E. “Pre-Clinical Evaluation of the
188 188
W/ Re Biomedical Generator,” Synthesis and Applications of Isotopically Labeled Compounds,
John Wiley and Sons, 1994, pp. 237-240.
Kamioki, H., Mirzadeh, S. and Lambrecht, R. M. "Pre-Clinical Evaluation of 188 W/ 188 Re Biomedical
Generator," 10th International Symposium on Radiopharmaceutical Chemistry, Kyoto, Japan,
October 25-28, 1993; J. Lab. Cmpds. Radiopharm., XXXV, 279-281 (1994) (Abstract ).
Knapp, Jr., F. F. and Mirzadeh, S. "The Continuing Important Role of Radionuclide Generator
Systems for Nuclear Medicine," Invited Review Article, Eur. J. Nucl. Med., 21, 1151-1166 (1994).
Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S. and Callahan, A. P. "Tungsten-188/Carrier-Free
Rhenium-188 Perrhenic Acid Generator System," U.S. Patent No. 5,275,802, Issued January 4,
1994.
Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S. and Callahan, A. P. "Tungsten-188/Carrier-Free
Rhenium-188 Perrhenic Acid Generator System," U.S. Patent No. 5,186,913, Issued February 17,
1993.
Knapp, F. F., Jr., Lisic, E. C., Mirzadeh, S., Callahan, A. P. and Rice, D. E. "A New Clinical
Prototype Tungsten-188/Rhenium-188 Generator to Provide High Levels of Carrier-Free Rhenium-
67

188 for Radioimmunotherapy (RAIT)," In, Proceedings, European Association of Nuclear Medicine
Meeting, Wien, Austria, September 1-5, 1992; Schattauer Verlag, pp. 290-294 (1993).
Knapp, Jr., F. F. "Radionuclide Generator Systems," Nuclear Medicine - Diagnosis and Therapy,
J. C. Harbert, W. C. Eckelman, R. D. Neuman, Editors; Chapter 10, pp. 203-213, Editors, Thieme
Medical Publishers, Inc., New York, 1995.
Knapp, Jr., F. F., Callahan, A. P., Beets, A. L., Mirzadeh, S. and Hsieh. B.-T. "Processing of
Reactor-Produced Tungsten-188 for Fabrication of Clinical Scale Alumina-Based Tungsten-
188/Rhenium-188 Generators," Appl. Rad. and Isot., 45, 1123-1128 (1994).
Knapp, Jr., F. F., Beets, A. L., Callahan, A. P., Mirzadeh, M. and Hsieh, B. T. "Optimized
Processing of Reactor-Produced Tungsten-188 for Clinical-Scale W-188/Re-188 Generators,"
World Federation of Nuclear Medicine and Biology Congress, Sydney, Australia, October 23-28,
1994; Eur. J. of Nucl. Med., 21, S201 (1994) (Abstract).
Knapp, Jr., F. F., Mirzadeh, Beets, A. L., Sharkey, R., Griffiths, G., and Goldenberg, D. M. "Curie
Scale Tungsten-188/Rhenium-188 Generators Can Cost-Effectively Provide Carrier-Free Rhenium
188 for Routine Clinical Applications," Fourth International Symposium on Technetium and
Rhenium in Chemistry and Nuclear Medicine, Bressanone, Italy, September 12-14, 1994; SG
Editorali, Padova, pp. 319-324 (1995).
Knapp, Jr., F. F. and Mirzadeh, S. "Reactor Production of Radionuclides for Nuclear Medicine,"
Principles of Nuclear Medicine, 2nd Edition, H. N. Wagner and Z. Szabo, Editors, W. B. Saunders,
Co., pp 135-144 (1995).
Knapp, Jr., F. F., Brihaye, C. and Callahan, A. P. "Radionuclide Generator Systems for Nuclear
Medicine Applications," Principles of Nuclear Medicine, 2nd Edition, H. N. Wagner and Z. Szabo,
Editors, W. B. Saunders, Co., pp 150-165 (1995).
Knapp, Jr., F. F., Mirzadeh, S., Zamora, P., Guhlke, S., Biersack, H.-J., O'Doherty, M. J. and
Blower, P. J. "Rhenium-188 - Cost Effective Therapeutic Applications of A Readily Available
Generator-Derived Radioisotope," British Nuclear Medicine Society Meeting 1996, Brighton,
England, April 1-3, 1996, Nucl. Med. Comm. 17, 268 (1996) (Abstract ).
Knapp, Jr., F. F., Mirzadeh, S. and Beets, A. L. "Reactor Production and Processing of
Radioisotopes for Therapeutic Applications in Nuclear Medicine," International Conference on
Isotopes, Beijing, China, May 7-12, 1995 (Abstract ).
Kodina, G., Tulskaya, T., Gureev, E. Brodskaya, G., Gapurova, O. and Drosdovsky, B., "Production
and Investigation of Rhenium-188," In, Technetium and Rhenium in Chemistry and Nuclear
Medicine 3, (M. Nicolini and G. Bandoli, Editors) Cortina International, Verona, Italy - Raven Press,
New York; pages 635-641 (1990).
Lewis, R. E. and Eldridge, J. S. "Production of 70-Day W-188 and Development of a 17-hour Re-
188 Radioisotope Generator," J. Nucl. Med., 7, 804-805 (1966) (Abstract ).
68

Lin, W. Y., Chen, M. N., Wang, B. T., Hseih, B. T., Tsai, Z. T., Ting, G. and Knapp, Jr., F. F.
"Biodistribution of Rhenium-188 Lipiodol in Rats Following Hepatic Arterial Injection," Eur. J. Nucl.
Med., 22, 891 (1995) (Abstract ).
Lisic, E. C., Callahan, A. P., Mirzadeh, S. and Knapp, F. F., Jr. "The Tandem Tungsten-188/
Rhenium-188 Perrhenate/Perrhenic Acid Generator System," Radioact. & Radiochem., 3, 42-45
(1992).
Lisic, E. C., Mirzadeh, S. and Knapp, F. F., Jr. "Synthesis of Carrier-Free Rhenium-188(V)DMSA
Using Triphenyl Phosphine as a Facile Reducing Agent," J. Labl. Cmpd., 33, pp. 65-75 (1992).
Maxon, H. R., III., Schroder, L. E., Hertzberg, V. S., Thomas, S. R., Englaro, E., E., Samaratuga, R.,
Smith, H., Moulton, J. S., Williams, C. C., Ehrhardt, G. J. and Schneider, H. J., "Rhenium-
186(Sn)HEDP for Treatment of Painful Osseous Metastases: Results of a Double-Blind Crossover
Comparison with Placebo," J. Nucl. Med., 32, 1877 (1991) (Abstract).
Mikheev, N. B., Popvich, V. B., Rumer, I. A., Savelev, G. I. and Volkova, N. C., "Re-188
Generator," Isotopenpraxis, 8, 248-251 (1972) (In Russian ).
Mirzadeh, S., Knapp, Jr., F. F. and Alexander, C. W. "Evaluation of Neutron Inelastic Scattering for
Radioisotope Production," American Chemical Society Biannual Meeting, Denver, CO, March 28-
April 2, 1993 (Abstract ).
Mirzadeh, S. "Advances in the 188 W- 188 Re Generator," In, Proceedings of the International
Symposium on Advances in Radiopharmaceuticals, Sydney, Australia, February 5, 1993 (Abstract).
Mirzadeh, S., Knapp, F. F., Jr. and Callahan, A. P. "Production of Tungsten-188 and Osmium-194
in a Nuclear Reactor for New Clinical Generators," In, Proceedings, International Conference on
Nuclear Data for Science and Technology (S. M. Qaim, ed.), Julich, Germany, May 1991, p. 595
(Abstract ).
Mirzadeh, S, Dadachova, E., Hetherington, E., Knapp, Jr., F. F. and Lambrecht, R. M. "Evaluation
of 188 W/ 188 Re Biomedical Generator," International Symposium on Synthesis and Preparation of
Radioisotopes, Strasbourg, France, June 1994 (Abstract ).
Reilly, R. M. “Radioimmunotherapy of Malignancies,” Clin. Pharm., 10, 359-375 (1991).
Schaffland, A., Guhlke, S, Knapp, Jr., F. F., Zamora, P. O. and Biersack, H.-J. "Pre-and Post-
Conjugate Labeling of Amines and Peptides with 188 Re Using the MAG3 Chelate," XIth International
Symp. on Radiopharmaceutical Chem., Vancouver, Canada, Aug 13-17, 1995; J. Lab. Cmpds.
Radiopharm., 37, 493-495 (1995) (Abstract ).
Sharkey, R. M., Goldenberg, D. W., Levine, G., Vagg, R., Ahmad, M., Pawlyk, D., Siegel, J. A.,
Griffiths, G. L., Hansen, H. J., Callahan, A. P. and Knapp, Jr., F. F. "Phase I Radioimmunotherapy
(RAIT) Using A Rhenium-188-Labeled Murine Monoclonal Antibody (MAb)," Society of Nuclear
Medicine 40th Annual Meeting, Toronto, Canada, June 7-11, 1993, J. Nucl. Med., 34, 54 (1993)
(Abstract ).
69

Singh, J., Powel, A. K., Clarke, S. E. M. and Blower, P. J. "Crystal Structure and Isomerism of a
Tumour Targeting Radiopharmaceutical: [ReO(dmsa)2]," Chem. Soc. Chem. Commun., 1115
(1991).
Singh, J., Reghebi, K., Lazarus, C. R., Clarke, S. E. M., Callahan, A. P., Knapp, Jr., F. F. and
Blower, P. J. "Studies on the Preparation and Isomeric Composition of [ 186 Re]- and [ 188 Re]-
Pentavalent Rhenium Dimercaptosuccinic Acid Complex," Nucl. Med. Commun., 14, 197-203
(1993).
Tsang, B. W., Rebenspies, J. and Martell, A. E. "Rhenium(V)-Oxo Complexes of Neutral and
Monoanionic Tetraazamacrocycles," Inorg. Chem., 32, 988 (1993).
Vanderheyden, J. -L., Fritzberg, A. R., Rao, J. N., Kasina, S., Srinivasan, A., Reno, J. M. and
Morgan, A. C., Jr. "Rhenium Labeling of Antibodies for Radioimmunotherapy," J. Nucl. Med. 28,
465 (1987).
Vanderheyden, J. -L., Rao, T. N., Kasina, S., Wester, D., Su, F.-M. and Fritzberg, A. R. “Structural
and Biological Equivalence of Technetium and Rhenium Diamide Dithiolate Complexes: Application
to Antibody Labeling,” Fourth International Symposium on Technetium in Chemistry and Nuclear
Medicine, Bressanone, Italy, September 12-14, 1994; SG Editorial, Padova, pp. 623-629 (1995).
Venkatesan, P. P., Shortkroff, S., Zalustsky, M. R. and Sledge, C. B. "Rhenium Heptasulfide: a
Potential Carrier System for Radiation Synovectomy," Nucl. Med., Biol. 17, 357 (1990).
Wang, S.-J., Lin, W.-Y., Hsieh, B.-T., Ting, G. and Knapp, Jr., F. F. "Rhenium-188 Sulfur Colloid as
a Radiation Synovectomy Agent," Eur. J. Nucl. Med., 22, 505-507 (1995) (Abstract ).
Wang, S. J., Lin, W. Y., Hseih, B. T., Tsai, Z. T., Ting, G., and Knapp, Jr., F. F. "Studies On Re-188
Sulfur Colloid for Use as a Radiation Synovectomy Agent," Eur. J. Nucl. Med., 22, 898 (1995).
Zamora, P. O., Guhlke, S., Bender, H., Diekman, D., Rhodes, Biersack, H. J. and Knapp, Jr., F. F.
“Experimental Radiotherapy of Receptor-Positive human Prostate Adenocarcinoma with 188 Re-RC-
160, A Directly-Labeled Somatostatin Analogue,” Int. J. Cancer, 65, 214-220 (1996).
Zamora, P. O., Guhlke, S., Bender, H., Diekman, D., Rhodes, Biersack, H. J. and Knapp, Jr., F. F.
"Radiotherapy With Re-188-RC-160, A Directly-Labeled Somatostatin Analog in Athymic Mice With
PC-3 Tumors (Human Prostate Carcinoma)," 42nd Annual Meeting of The Society of Nuclear
Medicine, Minneapolis, MN, June 12-15, 1995; J. Nucl. Med., 36, p. 42, (1995) (Abstract ).
Zamora, P. O., Bender, H., Knapp, Jr., F. F. and Biersack, H.-J. "Interim Report on Intrathoracic
Radiotherapy of Human Small-Cell Carcinoma in Nude Mice with Re-188-RC-160," Fifth
Mediterranean Symposium of Nuclear Medicine and Radiopharmaceuticals, Athens, Greece,
May 2328, 1995, Mediterrean Pub., Athens, pp. 199-208, ISBN-960-85227-4-9 (1995).
FFK: 10/26/09
70