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Measles IgG serology - UK NEQAS for MICROBIOLOGY

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<strong>UK</strong> National External Quality Assessment Service <strong>for</strong> Microbiology<br />

Distribution : 2836<br />

Dispatch Date : 09-May-2011<br />

<strong>for</strong> <strong>Measles</strong> <strong>IgG</strong> <strong>serology</strong><br />

Intended Result Your Report<br />

<strong>UK</strong> <strong>NEQAS</strong> <strong>for</strong> Microbiology<br />

PO Box 63003<br />

London NW9 1GH<br />

Phone +44 (0)20 8905 9890 Fax +44 (0)20 8205 1488<br />

Hosted by the Health Protection Agency - Colindale<br />

Laboratory :<br />

Page 1 of 3<br />

Specimen 0338 <strong>Measles</strong> <strong>IgG</strong> negative <strong>Measles</strong> <strong>IgG</strong> negative 2<br />

Specimen 0339 <strong>Measles</strong> <strong>IgG</strong> positive <strong>Measles</strong> <strong>IgG</strong> positive 2<br />

Specimen 0340 <strong>Measles</strong> <strong>IgG</strong> positive <strong>Measles</strong> <strong>IgG</strong> positive 2<br />

Specimen 0341 <strong>Measles</strong> <strong>IgG</strong> positive <strong>Measles</strong> <strong>IgG</strong> positive 2<br />

Cumulative score in<strong>for</strong>mation<br />

Total number of specimens sent to you <strong>for</strong> <strong>UK</strong> <strong>NEQAS</strong> <strong>for</strong> <strong>Measles</strong> <strong>IgG</strong> <strong>serology</strong> over the last 2 distributions is 8<br />

For these distributions specimen numbers 0019 0020 0021 0338 0339 0340 0341 have been analysed and scored.<br />

Number of reports analysed 7<br />

Number of specimens reported as not examined (not scored) 0<br />

Number of specimens received too late <strong>for</strong> analysis (not scored) 0<br />

Number of specimens <strong>for</strong> which no report was received (scored as 0) 0<br />

Your cumulative score <strong>for</strong> these specimens was 14 out of a possible total of 14<br />

Your Score<br />

The mean score calculated from the reports returned by <strong>UK</strong> laboratories was 13.75 (with a standard error of 1.21).<br />

Your per<strong>for</strong>mance rating <strong>for</strong> <strong>UK</strong> <strong>NEQAS</strong> <strong>for</strong> <strong>Measles</strong> <strong>IgG</strong> <strong>serology</strong> (i.e. the number of standard errors by which your cumulative score lies above or below the<br />

mean) <strong>for</strong> <strong>UK</strong> laboratories is 0.21.<br />

A per<strong>for</strong>mance rating of more than 1.96 standard errors below the mean indicates possible poor per<strong>for</strong>mance.<br />

Your per<strong>for</strong>mance rating may change if other participants' results are amended.<br />

Per<strong>for</strong>mance Rating<br />

4<br />

3<br />

2<br />

1<br />

0<br />

-1<br />

-2<br />

-3<br />

-4<br />

Your per<strong>for</strong>mance rating over the past 3 distributions<br />

Your current per<strong>for</strong>mance rating is 0.21<br />

2654 2714 2836<br />

Distribution<br />

Turn around time: The time taken to report your results was 0 days. This in<strong>for</strong>mation is provided <strong>for</strong> your own use and does not <strong>for</strong>m part of your per<strong>for</strong>mance<br />

assessment.<br />

Comments<br />

Per<strong>for</strong>mance was very good with 98.4% of participants reporting correct results.<br />

Specimen 0338 was a negative specimen. Of the 171 participants responding 166 (97.1%) reported a negative result, 2 (1.17%) reported an equivocal result and 3<br />

(1.75%) reported a positive result.<br />

Specimens 0339, 0340 and 0341 were strong positives. Where participants used quantitative assays the following ranges of results were reported:<br />

Specimen 0338: Siemens Enzygnost: 39-150 mIU/mL, median 85 IU/mL; Virion: 81-800 mIU/mL, median 110 IU/mL.<br />

Specimen 0339: Siemens Enzygnost: 7200-13000 mIU/mL, median 9008 IU/mL; Virion: 2280-5562 mIU/mL, median 3308 IU/mL.<br />

Specimen 0340: Siemens Enzygnost: 1822-2900 mIU/mL, median 2200 IU/mL; Virion: 540-1400 mIU/mL, median 591 IU/mL.<br />

Specimen 0341: Siemens Enzygnost: 2124-3900 mIU/mL, median 3161 IU/mL; Virion: 1070-1556 mIU/mL, median 1330 IU/mL.<br />

Acknowledgements<br />

We thank colleagues at Southampton Health Protection Agency <strong>for</strong> assistance with pre-distribution testing.<br />

Enquiries<br />

For any queries about this distribution please contact Dr Brigitte Senechal at the address below.<br />

Repeat specimens can be obtained by fax +44 (0)20 8205 1488 or email organiser@ukneqasmicro.org.uk<br />

Please state your laboratory identification number, the distribution name and number and specimen number(s).<br />

All<br />

<strong>UK</strong><br />

Total score<br />

18<br />

15<br />

12<br />

9<br />

6<br />

3<br />

0<br />

Total score you achieved <strong>for</strong> each of the last 3 distributions<br />

Your current total score is 8<br />

2654 2714 2836<br />

Distribution<br />

© Copyright. The data in <strong>UK</strong> <strong>NEQAS</strong> reports are confidential.<br />

Participants must consult the scheme organiser be<strong>for</strong>e quoting data from the<br />

scheme.<br />

Published at 12:05:02 on Wednesday 13 July 2011


<strong>UK</strong> National External Quality Assessment Service <strong>for</strong> Microbiology<br />

Distribution : 2836<br />

Dispatch Date : 09-May-2011<br />

<strong>for</strong> <strong>Measles</strong> <strong>IgG</strong> <strong>serology</strong><br />

Laboratory :<br />

Page 2 of 3<br />

Four specimens were dispatched with a request to report on the presence of <strong>Measles</strong> <strong>IgG</strong> antibodies. All specimens were single donations of thrombinised human<br />

plasma.<br />

Specimen : 0338 <strong>Measles</strong> <strong>IgG</strong> negative<br />

Trinity: Captia<br />

Siemens:EIA<br />

Nova Tec<br />

Radim : EIA<br />

Bouty Technogenetics<br />

BioRad : Platelia<br />

Virotech<br />

Other<br />

Euroimmun<br />

Diesse : Chorus<br />

Virion Serion<br />

bioMerieux: Vidas<br />

0 20 40 60 80 100<br />

Number of Reports<br />

Positive Equivocal Negative<br />

Specimen : 0339 <strong>Measles</strong> <strong>IgG</strong> positive (9859 mIU/mL- Siemens Enzygnost)<br />

Trinity: Captia<br />

Siemens:EIA<br />

Nova Tec<br />

Radim : EIA<br />

Bouty Technogenetics<br />

BioRad : Platelia<br />

Virotech<br />

Other<br />

Euroimmun<br />

Diesse : Chorus<br />

Virion Serion<br />

bioMerieux: Vidas<br />

0 20 40 60 80 100<br />

Number of Reports<br />

Positive Equivocal Negative<br />

Specimen : 0340 <strong>Measles</strong> <strong>IgG</strong> positive (2928 mIU/mL- Siemens Enzygnost)<br />

Trinity: Captia<br />

Siemens:EIA<br />

Nova Tec<br />

Radim : EIA<br />

Bouty Technogenetics<br />

BioRad : Platelia<br />

Virotech<br />

Other<br />

Euroimmun<br />

Diesse : Chorus<br />

Virion Serion<br />

bioMerieux: Vidas<br />

0 20 40 60 80 100<br />

Number of Reports<br />

<strong>UK</strong> <strong>NEQAS</strong> <strong>for</strong> Microbiology<br />

PO Box 63003<br />

London NW9 1GH<br />

Phone +44 (0)20 8905 9890 Fax +44 (0)20 8205 1488<br />

Hosted by the Health Protection Agency - Colindale<br />

Positive Equivocal Negative<br />

<strong>UK</strong> (%) All (%)<br />

11 (8.8) 13 (7.3)<br />

4 (3.2) 14 (7.9)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

2 (1.6) 2 (1.1)<br />

3 (2.4) 4 (2.3)<br />

1 (0.8) 4 (2.3)<br />

0 (0.0) 6 (3.4)<br />

6 (4.8) 7 (4.0)<br />

9 (7.2) 16 (9.0)<br />

87 (69.6) 98 (55.4)<br />

<strong>UK</strong> (%) All (%)<br />

11 (8.9) 13 (7.4)<br />

4 (3.2) 14 (8.0)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

2 (1.6) 2 (1.1)<br />

3 (2.4) 4 (2.3)<br />

1 (0.8) 4 (2.3)<br />

0 (0.0) 6 (3.4)<br />

6 (4.8) 7 (4.0)<br />

9 (7.3) 16 (9.1)<br />

86 (69.4) 97 (55.1)<br />

<strong>UK</strong> (%) All (%)<br />

11 (8.9) 13 (7.4)<br />

4 (3.2) 14 (8.0)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

2 (1.6) 2 (1.1)<br />

3 (2.4) 4 (2.3)<br />

1 (0.8) 4 (2.3)<br />

0 (0.0) 6 (3.4)<br />

6 (4.8) 7 (4.0)<br />

9 (7.3) 16 (9.1)<br />

86 (69.4) 97 (55.1)<br />

Your Report : <strong>Measles</strong> <strong>IgG</strong> negative<br />

Your Score : 2<br />

Overall Results<br />

<strong>UK</strong> All Score<br />

------------------------------------------------------------<br />

<strong>Measles</strong> <strong>IgG</strong> positive 1 3 -1<br />

<strong>Measles</strong> <strong>IgG</strong> equivocal 0 2 1<br />

<strong>Measles</strong> <strong>IgG</strong> negative 121 166 2<br />

------------------------------------------------------------<br />

Total<br />

122 171<br />

% Correct<br />

99.2 97.1<br />

Your Report : <strong>Measles</strong> <strong>IgG</strong> positive<br />

Your Score : 2<br />

Overall Results<br />

<strong>UK</strong> All Score<br />

------------------------------------------------------------<br />

<strong>Measles</strong> <strong>IgG</strong> positive 122 171 2<br />

<strong>Measles</strong> <strong>IgG</strong> equivocal 0 0 1<br />

<strong>Measles</strong> <strong>IgG</strong> negative 0 0 -1<br />

------------------------------------------------------------<br />

Total<br />

122 171<br />

% Correct<br />

100 100<br />

Your Report : <strong>Measles</strong> <strong>IgG</strong> positive<br />

Your Score : 2<br />

Overall Results<br />

<strong>UK</strong> All Score<br />

------------------------------------------------------------<br />

<strong>Measles</strong> <strong>IgG</strong> positive 118 165 2<br />

<strong>Measles</strong> <strong>IgG</strong> equivocal 4 5 1<br />

<strong>Measles</strong> <strong>IgG</strong> negative 0 1 -1<br />

------------------------------------------------------------<br />

Total<br />

122 171<br />

% Correct<br />

96.7 96.5<br />

© Copyright. The data in <strong>UK</strong> <strong>NEQAS</strong> reports are confidential.<br />

Participants must consult the scheme organiser be<strong>for</strong>e quoting data from the<br />

scheme.<br />

Published at 12:05:04 on Wednesday 13 July 2011


<strong>UK</strong> National External Quality Assessment Service <strong>for</strong> Microbiology<br />

Distribution : 2836<br />

Dispatch Date : 09-May-2011<br />

<strong>for</strong> <strong>Measles</strong> <strong>IgG</strong> <strong>serology</strong><br />

Laboratory :<br />

Page 3 of 3<br />

Four specimens were dispatched with a request to report on the presence of <strong>Measles</strong> <strong>IgG</strong> antibodies. All specimens were single donations of thrombinised human<br />

plasma.<br />

Specimen : 0341 <strong>Measles</strong> <strong>IgG</strong> positive (3181 mIU/mL- Siemens Enzygnost)<br />

Trinity: Captia<br />

Siemens:EIA<br />

Nova Tec<br />

Radim : EIA<br />

Bouty Technogenetics<br />

BioRad : Platelia<br />

Virotech<br />

Other<br />

Euroimmun<br />

Diesse : Chorus<br />

Virion Serion<br />

bioMerieux: Vidas<br />

0 20 40 60 80 100<br />

Number of Reports<br />

<strong>UK</strong> <strong>NEQAS</strong> <strong>for</strong> Microbiology<br />

PO Box 63003<br />

London NW9 1GH<br />

Phone +44 (0)20 8905 9890 Fax +44 (0)20 8205 1488<br />

Hosted by the Health Protection Agency - Colindale<br />

Positive Equivocal Negative<br />

<strong>UK</strong> (%) All (%)<br />

11 (8.9) 13 (7.4)<br />

4 (3.2) 14 (8.0)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

0 (0.0) 2 (1.1)<br />

2 (1.6) 2 (1.1)<br />

3 (2.4) 4 (2.3)<br />

1 (0.8) 4 (2.3)<br />

0 (0.0) 6 (3.4)<br />

6 (4.8) 7 (4.0)<br />

9 (7.3) 16 (9.1)<br />

86 (69.4) 97 (55.1)<br />

Your Report : <strong>Measles</strong> <strong>IgG</strong> positive<br />

Your Score : 2<br />

Overall Results<br />

<strong>UK</strong> All Score<br />

------------------------------------------------------------<br />

<strong>Measles</strong> <strong>IgG</strong> positive 122 171 2<br />

<strong>Measles</strong> <strong>IgG</strong> equivocal 0 0 1<br />

<strong>Measles</strong> <strong>IgG</strong> negative 0 0 -1<br />

------------------------------------------------------------<br />

Total<br />

122 171<br />

% Correct<br />

100 100<br />

© Copyright. The data in <strong>UK</strong> <strong>NEQAS</strong> reports are confidential.<br />

Participants must consult the scheme organiser be<strong>for</strong>e quoting data from the<br />

scheme.<br />

Published at 12:05:04 on Wednesday 13 July 2011

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