Stroke During TAVI: An Unmet Clinical Need? - Paragon Conventions

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Background • TAVI-related stroke is an important complication (1- 10%). The risk of silent cerebral embolism is not elucidated yet. • Diffusion-weighted MRI allows detection and localization of acute - apparent and silent - ischemic cerebral lesions. • DW-MRI studies are of potential interest for preinterventional risk stratification, peri-interventional anticoagulation management... Grube et al., JACC (2007), Webb et al., Circulation (2008), Zajarias et al., JACC (2009)
Study design Evaluation Clinical and neurological assessment (NIHSS) Lab - Tests (incl. Lactate, NSE) MRI TAVI Clinical and neurological assessment (NIHSS) Lab - Tests (incl. Lactate, NSE) MRI Clinical and neurological assessment (NIHSS) Lab - Tests (incl. Lactate, NSE) MRI E1 E2 E3
Page 1 and 2: Stroke During TAVI: An Unmet Clinic
Page 3 and 4: Stroke prevention in TAVI: An unmet
Page 5: Stroke is still a major source of c
Page 9 and 10: The Source Registry
Page 11: New Perspectives on Stroke During T
Page 15 and 16: DW - MRI
Page 17 and 18: NIH-Stroke Score 20 18 16 4 2 0 NIH
Page 19 and 20: What about Transfemoral vs Transapi
Page 21 and 22: DW-MRI Results Post TAVI
Page 23 and 24: Neurological and Cognitive Test Res
Page 25 and 26: Significance of MRI lesions? • No
Page 27 and 28: Mechanisms of Stroke during TAVI -
Page 35 and 36: What can we do stop the shower?
Page 37 and 38: Brachiocephalic trunk Cerebral Filt
Page 39 and 40: Embolic Material
Page 41 and 42: Embrella Embolic Deflector • Poro
Page 43 and 44: Embrella Case Example
Page 45 and 46: Embrella Case Example
Page 47 and 48: Embrella Clinical Experience
Page 49 and 50: Average number of Lesions/Subject
Page 51 and 52: Aortic Embolic Protection Device (
Page 53 and 54: Post TAVI Antiplatelet Therapy •

Stroke During TAVI: An Unmet Clinical Need? - Paragon Conventions

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