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Safety of antibody drug conjugates

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Concentrations <strong>of</strong> measured analytes following a 30<br />

mg/kg dose <strong>of</strong> T-DM1 to cynomolgus monkeys<br />

Concentration (!g/mL)<br />

10000<br />

1000<br />

100<br />

10<br />

1<br />

0.1<br />

0.01<br />

0.001<br />

0.0001<br />

females<br />

0 21 42 63 84 105<br />

Time (day)<br />

Total Tmab<br />

T-DM1<br />

DM1<br />

Genentech, Inc.

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