Safety of antibody drug conjugates
Safety of antibody drug conjugates
Safety of antibody drug conjugates
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Non-reversible axonal degeneration observed<br />
in sciatic nerve, spinal cord (dorsal funiculus)<br />
Incidence<br />
– 6 <strong>of</strong> 14 animals<br />
(10 mg/kg)<br />
– 14 <strong>of</strong> 14 animals<br />
(30 mg/kg)<br />
Severity<br />
– Minimal (10 mg/kg)<br />
– Slight to severe<br />
(30 mg/kg)<br />
HNSTD<br />
10 mg/kg<br />
(2000 µg DM1 /m 2 )<br />
A axon B<br />
Control, Day 66 30 mg/kg x 4, Day 66<br />
C D<br />
10 mg/kg x 4, Day 66 10 mg/kg x 4 + 3 wk recovery<br />
Genentech, Inc.
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