Tetracycline-inducible protein expression in pancreatic cancer cells

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nor recurrence of hiatal hernia was found for 4 years after surgery. It has been reported that primary laparoscopic hiatal hernia for paraesophageal hernia is associated with up to a 42% recurrence rate [11,12] . The most important reason is the absence of strong fascia at the hiatal aperture leading to suture pullout [13] . We decided to use synthetic mesh reinforcement for the crural repair, because direct suturing of the aperture of paraesophageal defect was difficult due to the size and the absence of strong fascia. Although mesh repair improved the recurrence rate [14] , the use of mesh for the repair of hiatal hernia has still been controversial because mesh-related complications have frequently reported. Several clinical studies with significant patient numbers have demonstrated the safety and effectiveness of synthetic mesh reinforcement for the repair of hiatal hernia [14,15,16] . An improved recurrence rate has been reported in cases with the use of mesh for the tension free crural repair [17] . However, some surgeons have pointed out the risk of erosion into the esophageal or gastric lumen caused by placing the mesh [15,11,18] . Because several types of nonabsorbable mesh have recently been used for the repair of hiatal hernia [9,19] , further evaluation of clinical outcome may be required. Stadlhuber et al [17] analyzed 28 cases of meshrelated complications in patients undergoing laparoscopic or open hiatal closure. They demonstrated that 23 cases required reoperation, and surprisingly 7 patients required esophagectomy. Among the patients who required reoperation, PTFE was used in 12 cases for the hiatal repair. A total of 10 patients had mesh intraluminal erosion, 2 patients had dense hiatal fibrosis. Although there is no apparent relationship between mesh type and configuration with the complications, they suggested that it may be due both to the technical aspects of mesh placement and to the type of mesh material used [17] . Nonetheless, they concluded that complications related to synthetic mesh placement at the esophageal hiatus are more common than previously reported and that further studies are needed to determine the best method and type of mesh for implantation. In summary, we experienced a case with mesenterioaxial volvulus of the stomach and duodenum associated with hiatal hernia, which was successfully treated with complete laparoscopic repair of the large-sized hiatal defect using a PTPE mesh associated with Toupet fundoplication. These laparoscopic procedures are safe and useful to obtain shortterm as well as long-term clinical outcomes of patients with a large-sized hiatal hernia. Further accumulation of cases is required to precisely determine the best method and type of mesh for reinforcement and long-term clinical outcome. REFERENCES 1 McIntyre RC Jr, Bensard DD, Karrer FM, Hall RJ, Lilly JR. The pediatric diaphragm in acute gastric volvulus. J Am Coll Surg 1994; 178: 234-238 WJG|www.wjgnet.com Inaba K et al . Laparoscopic repair of hiatal hernia with mesenterioaxial hiatal hernia 2 Naim HJ, Smith R, Gorecki PJ. Emergent laparoscopic reduction of acute gastric volvulus with anterior gastropexy. Surg Laparosc Endosc Percutan Tech 2003; 13: 389-391 3 Wastell C, Ellis H. Volvulus of the stomach. A review with a report of 8 cases. Br J Surg 1971; 58: 557-562 4 Katkhouda N, Mavor E, Achanta K, Friedlander MH, Grant SW, Essani R, Mason RJ, Foster M, Mouiel J. Laparoscopic repair of chronic intrathoracic gastric volvulus. Surgery 2000; 128: 784-790 5 Maruyama T, Fukue M, Imamura F, Nozue M. Incarcerated paraesophageal hernia associated with perforation of the fundus of the stomach: report of a case. Surg Today 2001; 31: 454-457 6 Iannelli A, Fabiani P, Karimdjee BS, Habre J, Lopez S, Gugenheim J. Laparoscopic repair of intrathoracic mesenterioaxial volvulus of the stomach in an adult: report of a case. Surg Today 2003; 33: 761-763 7 Krähenbühl L, Schäfer M, Farhadi J, Renzulli P, Seiler CA, Büchler MW. Laparoscopic treatment of large paraesophageal hernia with totally intrathoracic stomach. J Am Coll Surg 1998; 187: 231-237 8 Perdikis G, Hinder RA, Filipi CJ, Walenz T, McBride PJ, Smith SL, Katada N, Klingler PJ. Laparoscopic paraesophageal hernia repair. Arch Surg 1997; 132: 586-589; discussion 590-591 9 Pitcher DE, Curet MJ, Martin DT, Vogt DM, Mason J, Zucker KA. Successful laparoscopic repair of paraesophageal hernia. Arch Surg 1995; 130: 590-596 10 Zaninotto G, Costantini M, Anselmino M, Boccù C, Molena D, Rigotti P, Merigliano S, Ancona E. Oesophageal and cardia function in patients with paraoesophageal hiatus hernia. Br J Surg 1997; 84: 1163-1167 11 Hashemi M, Peters JH, DeMeester TR, Huprich JE, Quek M, Hagen JA, Crookes PF, Theisen J, DeMeester SR, Sillin LF, Bremner CG. Laparoscopic repair of large type III hiatal hernia: objective followup reveals high recurrence rate. J Am Coll Surg 2000; 190: 553-560; discussion 560-561 12 Luostarinen M, Rantalainen M, Helve O, Reinikainen P, Isolauri J. Late results of paraoesophageal hiatus hernia repair with fundoplication. Br J Surg 1998; 85: 272-275 13 Tierney BJ, Iqbal A, Awad Z, Penka W, Filipi CJ, Mittal SK. Sub-diaphragmatic fascia: role in the recurrence of hiatal hernias. Dis Esophagus 2006; 19: 111-113 14 Frantzides CT, Madan AK, Carlson MA, Stavropoulos GP. A prospective, randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair vs simple cruroplasty for large hiatal hernia. Arch Surg 2002; 137: 649-652 15 Edelman DS. Laparoscopic paraesophageal hernia repair with mesh. Surg Laparosc Endosc 1995; 5: 32-37 16 Leeder PC, Smith G, Dehn TC. Laparoscopic management of large paraesophageal hiatal hernia. Surg Endosc 2003; 17: 1372-1375 17 Stadlhuber RJ, Sherif AE, Mittal SK, Fitzgibbons RJ Jr, Michael Brunt L, Hunter JG, Demeester TR, Swanstrom LL, Daniel Smith C, Filipi CJ. Mesh complications after prosthetic reinforcement of hiatal closure: a 28-case series. Surg Endosc 2009; 23: 1219-1226 18 Awad ZT, Magee DJ, Wanis N, Firozvi A. Type IV hiatal hernia post laparoscopic Nissen fundoplication: report of a case. Surg Today 2001; 31: 156-158 19 Paul MG, DeRosa RP, Petrucci PE, Palmer ML, Danovitch SH. Laparoscopic tension-free repair of large paraesophageal hernias. Surg Endosc 1997; 11: 303-307 S- Editor Sun H L- Editor O’Neill M E- Editor Ma WH 2057 April 21, 2011|Volume 17|Issue 15|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i15.2058 Treatment of advanced rectal cancer after renal transplantation Hai-Yi Liu, Xiao-Bo Liang, Yao-Ping Li, Yi Feng, Dong-Bo Liu, Wen-Da Wang Hai-Yi Liu, Xiao-Bo Liang, Yao-Ping Li, Yi Feng, Dong-Bo Liu, Wen-Da Wang, Department of Anal and Colorectal Surgery, Shanxi Cancer Hospital, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030013, Shanxi Province, China Author contributions: Liu HY, Liang XB and Li YP designed the research; Liu HY, Feng Y, Liu DB and Wang WD performed the research; Liu HY wrote the paper. Correspondence to: Dr. Hai-Yi Liu, Department of Anal and Colorectal Surgery, Shanxi Cancer Hospital, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030013, Shanxi Province, China. shanxiliuhaiyi@126.com Telephone: +86-351-4651225 Fax: +86-351-4651667 Received: January 6, 2011 Revised: February 15, 2011 Accepted: February 22, 2011 Published online: April 21, 2011 Abstract Renal transplantation is a standard procedure for endstage renal disease today. Due to immunosuppressive drugs and increasing survival time after renal transplantation, patients with transplanted kidneys carry an increased risk of developing malignant tumors. In this case report, 3 patients with advanced rectal cancer after renal transplantation for renal failure were treated with anterior resection or abdominoperineal resection plus total mesorectal excision, followed by adjuvant chemotherapy. One patient eventually died of metastasized cancer 31 mo after therapy, although his organ grafts functioned well until his death. The other 2 patients were well during the 8 and 21 mo followup periods after rectal resection. We therefore strongly argue that patients with advanced rectal cancer should receive standard oncology treatment, including operation and adjuvant treatment after renal transplantation. Colorectal cancer screening in such patients appears justified. © 2011 Baishideng. All rights reserved. Key words: Rectal cancer; Renal transplantation; Endstage renal disease; Treatment; Screening WJG|www.wjgnet.com 2058 World J Gastroenterol 2011 April 21; 17(15): 2058-2060 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. CASE REPORT Peer reviewer: Dr. Marek Bebenek, MD, PhD, Department of Surgical Oncology, Regional Comprehensive Cancer Center, pl. Hirszfelda 12, 53-413 Wroclaw, Poland Liu HY, Liang XB, Li YP, Feng Y, Liu DB, Wang WD. Treatment of advanced rectal cancer after renal transplantation. World J Gastroenterol 2011; 17(15): 2058-2060 Available from: URL: http://www.wjgnet.com/1007-9327/full/v17/i15/2058.htm DOI: http://dx.doi.org/10.3748/wjg.v17.i15.2058 INTRODUCTION Renal transplantation, commonly performed for end-stage renal disease (ESRD), is an alternative to dialysis. An increased incidence of malignancy in transplant recipients is well recognized, which may be related to impaired immunosurveillance, direct neoplastic action of immunosuppressive agents, oncogenic viruses such as Epstein-Bar virus or cytomegalovirus, and chronic antigenic stimulation, uremia, or genetic predisposition [1] . There is evidence that renal transplant recipients are approximately three times more likely to develop cancer than the general population [2,3] . Their risks vary in different tumors. The risk of Kaposi’s sarcoma is the highest (200 times increased risk) followed by that of non-melanocytic and melanocytic skin cancer (9-20 times increased risk) [2,3] . The risk other solid-organ cancers, such as colorectal cancer, is increased by approximately 2-3 times higher in renal transplant recipients than in general population [3,4] . Cancers occurring in transplanted patients are generally de novo and mainly diagnosed after the third year with an increase after 10 years [5] . The mean onset time of colorectal malignancies is 10.4 years [1] . The prognosis of renal transplant recipients with advanced-stage cancer is extremely poor. Currently, posttransplant malignancies are an important cause of mortality and the leading reason of death within the next 20 years [6] . Immunosuppression and late diagnosis have been implicated [7] . We report 3 cases of advanced rectal cancer after renal transplantation for renal failure. April 21, 2011|Volume 17|Issue 15|
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World Journal of Gastroenterology W
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Robert JL Fraser, Daw Park Jacob Ge
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Italy Donato F Altomare, Bari Piero
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Fernando Azpiroz, Barcelona Ramon B
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S Contents EDITORIAL ORIGINAL ARTIC
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Contents APPENDIX FLYLEAF EDITORS F
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Said ZNA. An overview of OBI Allain
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Said ZNA. An overview of OBI (seron
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Said ZNA. An overview of OBI No tra
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Said ZNA. An overview of OBI ntatio
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Said ZNA. An overview of OBI titis
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Said ZNA. An overview of OBI 114 Ch
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Besides physical examination (findi
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Ruffolo et al . Perianal Crohn’s
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Ruffolo et al . Perianal Crohn’s
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plates, and positive clones identif
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A Luciferase activity (RLU × 10 2
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A CapG (fold increase) B D Clone #
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CAPG HNRPH1 protein T-complex prote
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A A450 nm B C35-dox C35-dox TET29-d
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microtubule-based organelles involv
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Online Submissions: http://www.wjgn
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Akbulut S et al . Atypic histopatho
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Savino F et al . Ghrelin in breast
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Giovannini M, Beyer J, Demmelmair H
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Fiderkiewicz B, Rydzewska-Rosołows
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Figure 1 A sketch of the probe capa
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Axial force amplitude (g) Gravesen
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Gravesen F et al . Influence of bol
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Xinopoulos D et al . Pancreatic duc
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Mohamed N et al . Microscopic colit
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A B Mohamed N et al . Microscopic c
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Mohamed N et al . Microscopic colit
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Page 103 and 104: Du CZ et al . Effect of MDT treatme
Page 105: Yuan XL et al . Gastric cancer cell
Page 108 and 109: A Foxp3 B CD4 + Foxp3 + Tregs (%) C
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Page 112: expression in naive human CD4+FOXP3
Page 121 and 122: Yu SJ et al . Prognostic markers of
Page 124: A B C D (Bethyl Laboratories Inc, M
Page 127 and 128: Shi XH et al . DEC1 nuclear express
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Page 131 and 132: A Relative cell number Dang SS et a
Page 133 and 134: Dang SS et al . Apoptotic bone marr
Page 136 and 137: Table 2 Odds ratio and 95% CIs for
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Page 140 and 141: CASE REPORT A 70-year-old Japanese
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Page 147 and 148: Ustundag Y et al . Pancreatic hyper
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Page 151 and 152: Instructions to authors ISSN and EI
Page 153 and 154: Instructions to authors used rather
Page 155: Instructions to authors Chaoyang Di
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