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involvement (8) . This elevation of liver enzyme<br />

may possibly be related to the increased<br />

drug usage or to shock or other factors that<br />

would need to be studied further. This<br />

abnormal elevation of AST in most suspected<br />

cases of dengue infection may be used as an<br />

early indicator of dengue illness as suggested<br />

earlier (6) .<br />

References<br />

1. Nimmannitya S. Clinical manifestations and<br />

2.<br />

management of dengue/dengue haemorrhagic<br />

fever. In: Thongchareon P. ed. Monograph on<br />

dengue/dengue haemorrhagic fever. New Delhi:<br />

WHO Regional Office for South-East Asia, 1993:<br />

48-54, 55-61.<br />

Anonymous. Annual morbidity and mortality<br />

reports of the Division of Epidemiology, Office of<br />

the Permanent Secretary, Ministry of Public<br />

Health, 1958-2001.<br />

3. Nimmannitya S. <strong>Dengue</strong> haemorrhagic fever:<br />

Diagnosis. In DJ Gubler and G Kuno (eds). <strong>Dengue</strong><br />

and dengue haemorrhagic fever. CAB<br />

4.<br />

International, 1997: 133-145.<br />

WHO. <strong>Dengue</strong> haemorrhagic fever: Diagnosis,<br />

treatment, prevention and control. 2nd edition.<br />

Geneva, 1997.<br />

5. Halstead SB. Pathophysiology and pathogenesis of<br />

dengue haemorrhagic fever. In: Thongchareon P<br />

ed. Monograph on dengue/dengue haemorrhagic<br />

fever. New Delhi: WHO Regional Office for<br />

South-East Asia, 1993: 80-103.<br />

<strong>Dengue</strong> Patients at the Children’s Hospital, Bangkok: 1995-1999 Review<br />

Acknowledgements<br />

We are grateful to the AFRIMS for their<br />

continuing serological and virological<br />

laboratory support. This study was a part of<br />

the project “Clinical database management”<br />

at the Queen Sirikit National Institute of<br />

Child Health (Children’s Hospital) which was<br />

funded by UNCINPAC through the AFRIMS.<br />

6. Kalayanarooj S, Vaughn DW, Nimmannitya S,<br />

Green S, Suntayakorn S, Kunentrasai N,<br />

7.<br />

Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S,<br />

Innis BL, Rothman AL, Nisalak A and Ennis FA.<br />

Early clinical and laboratory indicators of acute<br />

dengue illness. JID, 1997, 176: 313-21.<br />

Kalayanarooj S, Nimmannitya S, Suntayakorn S,<br />

Vaughn DW, Nisalak A, Green S, Chansiriwongs<br />

V, Rothman A and Ennis FA. Can doctors make an<br />

accurate diagnosis of dengue? <strong>Dengue</strong> <strong>Bulletin</strong>,<br />

1999, 23: 1-9.<br />

8. Kalayanarooj S and Nimmannitya S. Clinical and<br />

laboratory presentations of dengue patients with<br />

different serotypes. <strong>Dengue</strong> <strong>Bulletin</strong>, 2000, 24:<br />

53-59.<br />

<strong>Dengue</strong> <strong>Bulletin</strong> – Vol 26, 2002 43

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