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1 MEDICAL/SURGICAL LASER UPDATE - American Society for ...

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condition. Two classes of drugs commonly used to treat BPH are alpha-1 antagonists<br />

(alpha blockers) and 5- alpha-reductase inhibitors. Sales of drugs to treat BPH in the<br />

seven major markets were approximately $900 million in 1997 and will grow to more<br />

than $1.3 billion by 2007.<br />

"Benign Prostatic Hyperplasia" is a new study from Decision Resources, that provides<br />

a comprehensive evaluation of this condition. The report, which is based on in-depth<br />

interviews with opinion-leading physicians, contains detailed in<strong>for</strong>mation on<br />

epidemiology, medical practice, and current and emerging therapies -- including a<br />

description of current and emerging laser techniques. The study also includes an in-depth<br />

unmet needs analysis, an evaluation of economic issues, and sales <strong>for</strong>ecasts <strong>for</strong><br />

pharmaceutical therapies to treat BPH in the seven major markets through 2007. The<br />

report is part of Mosaic, a series of studies on timely topics, focusing on medical<br />

indications that are distinguished by major unmet need or significant changes in medical<br />

practice. The report is priced at $12,000. For more detailed report in<strong>for</strong>mation, contact<br />

Jean Carbone, director, Research Publications, at 781.487.3737.<br />

1/11 ESC Medical Systems announced that fourth quarter operating results will be affected<br />

by a slowdown in product sales in the U.S. aesthetic market, specifically in the area of<br />

hair removal. Additionally, the company commented that international sales accelerated<br />

on a sequential basis in the fourth quarter, primarily in Europe. As a result, the company<br />

expects revenues <strong>for</strong> the fourth quarter to be approximately $50 million, down from the<br />

$53.8 million reported <strong>for</strong> the third quarter (and <strong>for</strong> the $63.6 million <strong>for</strong> the previous<br />

quarter). The company expects to be profitable on an operating basis <strong>for</strong> the fourth<br />

quarter of 1998. The company attributes the revenue shortfall to a shift in purchasing<br />

patterns of its physician customers and is currently evaluating various aspects of its<br />

business to be able to better serve the marketplace. Despite the recent slowdown, ESC<br />

continues to maintain its leading position in the U.S. aesthetic market.<br />

Dr. Shimon Eckhouse, chairman, president and CEO, commented, "We plan to devote<br />

the first half of 1999 to strengthen and optimize our sales and marketing organization and<br />

to further adapt to the changes in the aesthetic markets. Additionally, we intend to<br />

implement steps to improve efficiencies in other areas of the company's operations.<br />

These ef<strong>for</strong>ts are expected to give ESC a stronger market position, tighter control over<br />

expenses and, as a result, a higher level of profitability. Looking ahead, we expect to<br />

realize the benefits of these initiatives in the second half of 1999." ESC Medical Systems<br />

expects to announce its financial results <strong>for</strong> the 1998 fourth quarter and year on or about<br />

January 26, 1999.<br />

1/12 EDAP TMS S.A. announced that it had received an IDE from the FDA to begin U.S.<br />

clinical trials of the company's proprietary, transrectal High Intensity Focused Ultrasound<br />

("HIFU") technology, used in the minimally-invasive treatment of prostate cancer. The<br />

technology is utilized through EDAP's Ablatherm, the medical device that will be<br />

7

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