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IMAGE 2010-11 ISSN: 2229-5658 Vol No: 11 ISSUE No: 4 49
* The importance of prostaglandins in
maintaining renal blood flow should be
taken into account in patients with
impaired cardiac or renal function, those
being treated with diuretics or
recovering from major surgery. Effects on
renal function are usually reversible on
withdrawal of aceclofenac.
Renal impairment: Patients with mild renal
impairment should be kept under surveillance
since the use of NSAIDs may result in
deterioration of renal function. the lowest
effective dose should be used and renal function
monitored regularly.
Hepatic Impairment: dose should be
appropriately reduced.
Pediatric use: In Children, It is not
recommended.
Geriatric use: Generally no dose reduction is
necessary, however, consider the
precautions.
Pregnancy & Lactation: The combinations are
not recommended in pregnant & breast-feeding
women.
Effect on ability to drive and use machines:
There are not data available of the effect on
driving vehicles and using machines. Although
only rare cases of drowsiness have been
reported, this has to be taken into account when
driving vehicles and operating machines.
******************
DRUG INTERACTIONS:
Drug interactions with other drugs are not
known/reported with thiocolchicoside.
Similar to other NSAIDs aceclofenac may
increase plasma concentrations of lithium,
digoxin and methotrexate, increase the activity
of anticoagulants, inhibit the activity of
diuretics, enhance cyclosporin nephrotoxicity
and precipitate convulsions when
co-administered with quinolone antibiotics.
When concomitant administration with
potassium sparing diuretics is employed,
serum potassium should be monitored.
Further more, hypo or hyperglycaemia may
result from the concomitant administration of
aceclofenac and antidiabetic drugs althoug this
is rare. the co-administration of aceclofenac with
other NSAIDs or carticosteroids may result in
increased frequency of side effects.
Caution should be exercised in NSAIDs and
methotrexate are administered within 2-4 hours
of each other, since NSAIDs may increase
methotrexate plasma levels, resulting in
increased toxicity.
ADVERSE EFFECTS:
Commonly reported adverse events:
Gastrointestinal disorders such as diarrhoea.
gastralgia, nausea, vomiting, drowsiness &
Cutaneous allergic reactions including
angioedema, elevated liver enzymes.
OVERDOSAGE:
There are no published reports of overdose. In
cases of overdose. The stomach should be
emptied promptly by lavage or by induction of
Standard supportive measures.
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The International Journal of Indian Dental Association, Kunnamkulam Branch. Indexed in Journals Master List of IC TM