PROBIOTICS WATCH - Probiotics In Practice

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PROBIOTICS WATCH ISSUE N°4 Contents : EDITORIAL THE MAIN POINTS OF THE QUARTER 1. CHARACTERISATION OF PROBIOTICS AND PROBIOTIC FOODS 2. PHYSIOLOGICAL INTERACTION WITH THE HOST 3. IN VIVO OUTCOMES OF PROBIOTIC INTAKE REFERENCES KEY DATES 3. IN VIVO OUTCOMES OF PROBIOTIC INTAKE L. reuteri consumption improves colic symptoms in breastfed newborns OBJECTIVES/BACKGROUND Infantile colic, defined as paroxysmal, excessive, and inconsolable crying without an identifiable cause in an otherwise healthy newborn infant, is common in the first 3 months of life. The role of an aberrant intestinal microflora has recently been reproposed to affect gut motor function and gas production that lead to colicky behaviour. This work aimed to test the efficacy of Lactobacillus reuteri on infantile colic and to evaluate its relationship with gut microbiota. DESIGN Randomized, double-blind, placebo-controlled trial. SETTINGS & PARTICIPANTS Fifty exclusively breastfed colicky infants (aged 2-16 weeks, 29 boys and 21 girls), diagnosed according to modified Wessel’s criteria, were randomly assigned to receive either L. reuteri DSM 17 938 (108 CFU) or a placebo daily for 21 days. Parental questionnaires monitored daily crying time and adverse effects. Stool samples were collected for microbiologic analysis. MAIN OUTCOME Primary outcome was defined as a reduction of average crying time to
PROBIOTICS WATCH ISSUE N°4 3. IN VIVO OUTCOMES OF PROBIOTIC INTAKE Contents : EDITORIAL THE MAIN POINTS OF THE QUARTER 1. CHARACTERISATION OF PROBIOTICS AND PROBIOTIC FOODS 2. PHYSIOLOGICAL INTERACTION WITH THE HOST 3. IN VIVO OUTCOMES OF PROBIOTIC INTAKE REFERENCES KEY DATES 3.5. NUTRITION: OBESITY, CHOLESTEROL, ETC. Probiotics against central adiposity in pregnant women OBJECTIVES/BACKGOUND The objective of this trial was to establish whether probiotic supplemented dietary counselling influences maternal anthropometric measurements during and after pregnancy. DESIGN Randomized, double-blind, placebo-controlled trial. SETTINGS & PARTICIPANTS At the first trimester of pregnancy, 256 women were randomly assigned to receive nutrition counselling to modify dietary intake according to current recommendations or as controls. Dietary intervention groups were further randomized to receive Lactobacillus rhamnosus GG (ATCC 53103) and Bifidobacterium lactis (diet/probiotics) or placebo (diet/placebo) capsules, whilst the controls received placebo (control/ placebo). The intervention lasted until the end of exclusive breastfeeding for up to six months. MAIN OUTCOME The primary outcome measures were mothers’ anthropometric measurements, most importantly BMI and adiposity defined as a waist circumference of 80 cm or more, and the proportion of body fat over the 12-month postpartum period. Secondary outcomes were dietary intakes of foods and nutrients and a healthy eating index during the postpartum period. RESULTS The risk of central adiposity was lowered in women in the diet/probiotics group compared with the control/placebo group (OR 0.30, 95%CI 0.11-0.85, P=0.023 adjusted for baseline BMI), whilst the diet/placebo group did not differ from the controls (OR 1.00, 95% CI 0.38-2.68, P=0.994) at 6 months postpartum. The number needed to treat with diet/ probiotics to prevent one woman from developing a waist circumference ≥80 cm was 4. Healthy eating pattern at 12 months postpartum (P=0.001) and BMI prior to pregnancy (P
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PROBIOTICS WATCH - Probiotics In Practice

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