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Número 1 - EII al día

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<strong>EII</strong>29. Inohara N, Chamaillard M, McDon<strong>al</strong>d C, Nunez G. NOD-LRR Proteins:Role in Host-Microbi<strong>al</strong> Interactions and Inflammatory Disease. AnnuRev Biochem 2004.30. Aldhous MC, Nimmo ER, Satsangi J. NOD2/CARD15 and the Panethcell: another piece in the genetic jigsaw of inflammatory bowel disease.Gut 2003;52:1533-5.31. Grimm MC, Pavli P. NOD2 mutations and Crohn's disease: are Panethcells and their antimicrobi<strong>al</strong> peptides the link? Gut 2004;53:1558-60.32.*L<strong>al</strong>a S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, et <strong>al</strong>. Crohn'sdisease and the NOD2 gene: a role for paneth cells. Gastroenterology2003;125:47-57.33.*Ogura Y, L<strong>al</strong>a S, Xin W, Smith E, Dowds TA, Chen FF, et <strong>al</strong>. Expressionof NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut2003;52:1591-7.Implicación de las células de Paneth en la expresión de NOD2.34. De Jager PL, Franchimont D, W<strong>al</strong>iszewska A, Bitton A, Cohen A, LangelierD, et <strong>al</strong>. The role of the Toll receptor pathway in susceptibilityto inflammatory bowel diseases. Genes Immun 2007;8:387-97.35.*Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, D<strong>al</strong>y MJ, et<strong>al</strong>. A genome-wide association study identifies IL23R as an inflammatorybowel disease gene. Science 2006;314:1461-3.Primera identificación del gen IL23R en la EICI.36. Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, et<strong>al</strong>. Interleukin-23 drives innate and T cell-mediated intestin<strong>al</strong> inflammation.J Exp Med 2006;203:2473-83.37. Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS,et <strong>al</strong>. IL-23 plays a key role in Helicobacter hepaticus-induced T celldependentcolitis. J Exp Med 2006;203:2485-94.38. Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, KeniryA, et <strong>al</strong>. IL23R variation determines susceptibility but not disease phenotypein inflammatory bowel disease. Gastroenterology 2007;132:1657-64.39. Tremelling M, Parkes M. Genome-wide association scans identify multipleconfirmed susceptibility loci for Crohn's disease: lessons forstudy design. Inflamm Bowel Dis 2007;13:1554-60.40.*Massey DC, Parkes M. Genome-wide association scanning highlightstwo autophagy genes, ATG16L1 and IRGM, as being significantly associatedwith Crohn's disease. Autophagy 2007;3:649-51.Estudio de confirmación de genes involucrados en autofagia en la enfermedadde Crohn.41. Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, et <strong>al</strong>.A nonsynonymous SNP in ATG16L1 predisposes to ile<strong>al</strong> Crohn's diseaseand is independent of CARD15 and IBD5. Gastroenterology2007;132:1665-71.42.*Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, FisherSA, et <strong>al</strong>. Sequence variants in the autophagy gene IRGM andmultiple other replicating loci contribute to Crohn's disease susceptibility.Nat Genet 2007;39:830-2.Primera identificación del gen IRGM en la enfermedad de Crohn. Segundogene implicado en autofagia.43. Van Limbergen J, Russell RK, Nimmo ER, Drummond HE, Smith L,Anderson NH, et <strong>al</strong>. Autophagy gene ATG16L1 influences susceptibilityand disease location but not childhood-onset in Crohn's disease inNorthern Europe. Inflamm Bowel Dis 2008;14:338-46.44. Wehkamp J, Harder J, Weichenth<strong>al</strong> M, Schwab M, Schaffeler E,Schlee M, et <strong>al</strong>. NOD2 (CARD15) mutations in Crohn's disease areassociated with diminished mucos<strong>al</strong> <strong>al</strong>pha-defensin expression. Gut2004;53:1658-64.45.*Wehkamp J, S<strong>al</strong>zman NH, Porter E, Nuding S, Weichenth<strong>al</strong> M, PetrasRE, et <strong>al</strong>. Reduced Paneth cell <strong>al</strong>pha-defensins in ile<strong>al</strong> Crohn's disease.Proc Natl Acad Sci U S A 2005;102:18129-34.Se describe el papel de la defensinas como determinación de loc<strong>al</strong>izaciónen la enfermedad de Crohn.46.*Wehkamp J, Wang G, Kubler I, Nuding S, Gregorieff A, Schnabel A,et <strong>al</strong>. The Paneth Cell {<strong>al</strong>pha}-Defensin Deficiency of Ile<strong>al</strong> Crohn's DiseaseIs Linked to Wnt/Tcf-4. J Immunol 2007;179:3109-18.Se determina un gen primario específico de predisposición paraCrohn ile<strong>al</strong> en la vía Wnt y Tcf-4 importante para la diferenciación decélulas de Paneth47.*Fellermann K, Stange DE, Schaeffeler E, Schm<strong>al</strong>zl H, Wehkamp J, BevinsCL, et <strong>al</strong>. A chromosome 8 gene-cluster polymorphism with lowhuman beta-defensin 2 gene copy number predisposes to Crohn diseaseof the colon. Am J Hum Genet 2006;79:439-48.Primer ejemplo de <strong>al</strong>teraciones en el número de copias de un gencomo predisposición de enfermedad .48. Pena AS. [The significance of CARD15 mutations in Crohn's disease.The Spanish contribution] El Significado de las mutaciones deCARD15 en la enfermedad de Crohn. La contribución Española. RevEsp Enferm Dig 2007;99:563-9.49. King K, Bagn<strong>al</strong>l R, Fisher SA, Sheikh F, Cuthbert A, Tan S, et <strong>al</strong>. Identification,evolution, and association study of a novel promoter andfirst exon of the human NOD2 (CARD15) gene. Genomics 2007.50. Lesage S, Zou<strong>al</strong>i H, Cezard JP, Colombel JF, Belaiche J, Almer S, et <strong>al</strong>.CARD15/NOD2 mutation<strong>al</strong> an<strong>al</strong>ysis and genotype-phenotype correlationin 612 patients with inflammatory bowel disease. Am J HumGenet 2002;70:845-57.51.*Economou M, Trik<strong>al</strong>inos TA, Loizou KT, Tsianos EV, Ioannidis JP. Differenti<strong>al</strong>effects of NOD2 variants on Crohn's disease risk and phenotypein diverse populations: a metaan<strong>al</strong>ysis. Am J Gastroenterol2004;99:2393-404.Estudio que define la frecuencia geográfica de las mutaciones delNOD2.52. De Diego C, Alcantara M, V<strong>al</strong>le J, Perez-Grueso MJ, Munoz-Rosas C,Carrobles JM, et <strong>al</strong>. Frequency of CARD15 polymorphisms in patientswith Crohn's disease from Toledo, Spain: genotype-phenotype correlation.Genet Test 2006;10:178-85.53. Heresbach D, Gicquel-Douabin V, Birebent B, D'H<strong>al</strong>luin P N, Heresbach-LeBerre N, Dreano S, et <strong>al</strong>. NOD2/CARD15 gene polymorphismsin Crohn's disease: a genotype- phenotype an<strong>al</strong>ysis. Eur JGastroenterol Hepatol 2004;16:55-62.54. Crawford NP, Colliver DW, Eichenberger MR, Funke AA, Kolodko V,Cobbs GA, et <strong>al</strong>. CARD15 genotype-phenotype relationships in a sm<strong>al</strong>linflammatory bowel disease population with severe disease affectionstatus. Dig Dis Sci 2007;52:2716-24.55.*Ahmad T, Armuzzi A, Bunce M, Mulcahy-Hawes K, Marsh<strong>al</strong>l SE, OrchardTR, et <strong>al</strong>. The molecular classification of the clinic<strong>al</strong> manifestationsof Crohn's disease. Gastroenterology 2002;122:854-66.Estudio pionero de clasificación molecular de la enfermedad de Crohnbasado en marcadores genéticos.56. Wehkamp J, Schmid M, Fellermann K, Stange EF. Defensin deficiency,intestin<strong>al</strong> microbes, and the clinic<strong>al</strong> phenotypes of Crohn's disease.J Leukoc Biol 2005;77:460-5.57. Dassopoulos T, Frangakis C, Cruz-Correa M, T<strong>al</strong>or MV, Burek CL, DattaL, et <strong>al</strong>. Antibodies to saccharomyces cerevisiae in Crohn's disease:higher titers are associated with a greater frequency of mutantNOD2/CARD15 <strong>al</strong>leles and with a higher probability of complicateddisease. Inflamm Bowel Dis 2007;13:143-51.58. Brant SR, Wang MH, Rawsthorne P, Sargent M, Datta LW, Nouvet F,et <strong>al</strong>. A population-based case-control study of CARD15 and other riskfactors in Crohn's disease and ulcerative colitis. Am J Gastroenterol2007;102:313-23.59. de Diego C, Alcantara M, V<strong>al</strong>le J, Repiso A, Carrobles JM, Martinez-Castro P. Influence of smoking habits and CARD15 mutations on theonset of Crohn's disease. Scand J Gastroenterol 2006;41:1209-11.60. Laine ML, Farre MA, Garcia-Gonz<strong>al</strong>ez MA, van Dijk LJ, Ham AJ, WinkelEG, et <strong>al</strong>. [Risk factors in adult periodontitis: polymorphism inthe interleukin-1 gene family]. Ned Tijdschr Tandheelkd 2002;109:303-6.61. Laine ML, Murillo LS, Morre SA, Winkel EG, Pena AS, van WinkelhoffAJ. CARD15 gene mutations in periodontitis. J Clin Periodontol2004;31:890-3.62. Birrenbach T, Bocker U. Inflammatory bowel disease and smoking: areview of epidemiology, pathophysiology, and therapeutic implications.Inflamm Bowel Dis 2004;10:848-59.12 ENFERMEDAD INFLAMATORIA INTESTINAL AL DÍA

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