101108-a - IMEA

In-vitro cross-resistance between LPV
and other PIs in multi-PI exp. patients
Log RTV EC 50
3
2.5
2
1.5
1
0.5
RTV
R 2 = 0.82
Log IDV EC 50
2.5
2
1.5
1
0.5
IDV
R 2 = 0.67
Log NFV EC 50
2.5
2
1.5
1
0.5
NFV
R 2 = 0.49
0
0 0.5 1 1.5 2 2.5
Log LPV EC 50
0
0 0.5 1 1.5 2 2.5
Log LPV EC 50
0
–0.5
0 0.5 1 1.5 2 2.5
Log LPV EC 50
Log APV EC 50
2
1.5
1
0.5
0
APV
R 2 = 0.21
Log SQV EC 50
3
2.5
2
1.5
1
0.5
0
-0.5
SQV
R 2 = 0.27
-0.5
0 0.5 1 1.5 2 2.5
-1
0 0.5 1 1.5 2 2.5
78
Log LPV EC 50
Log LPV EC 50
Kempf D. 2001