GIOVANNI FRONZA CURRICULUM VITAE Nato a Nave San Rocco ...

GIOVANNI FRONZA
CURRICULUM VITAE
Nato a Nave San Rocco (TN) il 5 Settembre 1943.
Maturità conseguita nel 1963 presso il Liceo Classico Prati di Trento.
Laureato presso l’Università degli Studi di Pavia nel Luglio 1969 con una tesi sperimentale in
seguito pubblicata e votazione di 110/110.
Il 1 Novembre 1969 ottenne la nomina ad assistente incaricato presso la Cattedra di Chimica II della
Facoltà di Ingegneria del Politecnico di Milano.
Il 1 Novembre 1970 vinse il concorso per il posto di Aspirante Ricercatore del C.N.R. presso il
Centro per lo Studio della Chimica della Sostanze Organiche Naturali di Milano.
Il 1 Novembre 1975 è nominato Ricercatore qualificato.
Dal 1 Luglio 1989 è inquadrato nel livello II, profilo Primo Ricercatore presso il Centro per lo
Studio della Chimica delle Sostanze Organiche Naturali di Milano confluito dal 1 gennaio 2002
nell’Istituto di Chimica del Riconoscimento Molecolare.
Con decreto del Presidente del CNR n° 13612 del 18 Dicembre 1995 è nominato membro del
Consiglio Scientifico del Centro nel quale svolge anche la funzione di segretario, incarico che
ricopre fino al 31 Dicembre 2001.
Con provvedimento del Direttore dell’Istituto di Chimica del Riconoscimento Molecolare del 20
gennaio 2002 è nominato componente del Comitato di Istituto.
Ha coordinato l’attività di servizio svolta essenzialmente nel reparto Grandi Apparecchiature del
Centro per lo Studio della Chimica delle Sostanze Organiche Naturali in precedenza ed ora
dell’Istituto di Chimica del Riconoscimento Molecolare.
Attività Scientifica
L’attività scientifica del candidato si è svolta nell’ambito della Chimica Organica strutturale usando
quale mezzo di indagine prevalentemente la Spettroscopia di Risonanza Magnetica Nucleare. Essa
ha riguardato studi strutturali di sostanze naturali, studi conformazionali di molecole
biologicamente attive, studi meccanicistici di reazioni mediate da microrganismi, studi sulla
determinazione dell’origine di sostanze di uso alimentari e studi sul riconoscimento molecolare
mediante ciclodestrine di sostanze di interesse farmacologico e alimentare.
Autore o coautore di numerose pubblicazioni.
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Ha partecipato a numerosi Congressi con comunicazioni su invito, orali e poster.
Descrizione analitica dell’attività scientifica
Le ricerche sulle sostanze naturali hanno portato a determinare la struttura di nuovi
composti che sono responsabili del sapore acre e delle intossicazioni gastro-intestinali provocate da
alcuni funghi non commestibili appartenenti alla classe dei Basidiomiceti. Queste sostanze sono
principalmente composti sesquiterpenici e triterpenici poliossidrilati alcuni dei quali hanno
dimostrato attività antitumorale in vitro. Nell’ambito delle sostanze naturali particolare rilievo
hanno avuto gli studi strutturali e conformazionali di una serie di glicolipidi, detti gangliosidi,
componenti normali della membrana esterna delle cellule nervose dei vertebrati. Essi sono costituiti
da una catena oligosaccaridica idrofilica e da una porzione idrofobica, il ceramide, legate da un
legame glicosidico la cui funzione è di interagire con leganti esterni e trasmettere opportuni segnali
attraverso la membrana stessa. Sono stati isolati sia dal cervello umano che da cellule nervose di
roditori alcuni lattoni di gangliosidi di cui è stato determinato il sito di lattonizzazione e la struttura
secondaria della catena oligosaccaridica. Tra le sostanze naturali sono stati studiati alcuni
importanti antibiotici quali adriamicina, daunomicina e alcuni derivati dell’eritromicina di cui sono
state determinate approfonditamente le proprietà conformazionali in soluzione.
Gli studi strutturali su sostanze di origine sintetica hanno avuto importanza nelle ricerche
sull’addizione di varie specie nucleofile su alcuni composti carbonilici otticamente attivi ottenuti
dall’aldeide cinnamica e dall’aldeide acetica per fermentazione. L’interesse di queste reazioni era
duplice. Da un punto di vista sintetico esse hanno portato alla sintesi di un gran numero di
desossizuccheri della serie L, biologicamente importanti e difficilmente accessibili per altre vie. Da
un punto di vista meccanicistico si è dimostrato che la stereoselettività e l’orientamento della
reazione di addizione dipende dal nucleofilo usato. L’individuazione del decorso sterico delle
reazioni è stato possibile soltanto dall’analisi dei prodotti ciclici finali ed ha comportato la
determinazione della struttura e della conformazione di una serie di desossiamminosaccaridi.
In questo filone si collocano anche gli studi sul decorso sterico di alcune trasformazioni mediate da
microorganismi (lievito di panificazione ed altri) condotte mediante l’impiego di molecole marcate
con deuterio. Queste ricerche richiedono l’uso combinato della spettroscopia NMR dell’idrogeno e
del deuterio. E’ stata così determinata la stereochimica di varie reazioni: la riduzione dei doppi
legami nella biogenerazione di (S)--decanolide da idrossiacidi saturi, la trasformazione del 3-
cloropropiofenone in propiofenone, la riduzione del 2--decenolide in 2--decanolide, l’origine del
frammento C3 nella biogenerazione di (R) S-benziltioglicerato.
L’esperienza nella spettroscopia del deuterio sviluppata negli studi sopra accennati con l’uso
di molecole marcate ha costituito lo stimolo per estendere le ricerche a nuovi problemi andando a
misurare il nucleo del deuterio in abbondanza naturale. Il deuterio è un nucleo poco abbondante e
sono necessari strumentazione adeguata e tempi lunghi per ottenere buoni spettri. Esso apre però
orizzonti nuovi poiché la misura quantitativa del contenuto di deuterio nelle varie posizioni di una
molecola fornisce delle informazioni sulla storia sintetica che ha portato alla formazione della
molecola stessa: in altre parole costituisce un metodo sia per lo studio di cammini biosintetici di
sostanze naturali che per avere informazioni sull’origine di un prodotto. E’ del tutto superfluo
sottolineare qui l’importanza di conoscere l’origine di un prodotto specialmente nel campo degli
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alimenti dove è richiesta grande attenzione per garantire genuinità e sicurezza. Abbiamo preso in
considerazione un certo numero di aromi usati come additivi in alimenti
Parallelamente e ricerche hanno riguardato lo studio di complessi supramolecolari con
ciclodestrine. Lo studio del meccanismo di azione di una molecola biologicamente attiva passa
necessariamente attraverso la conoscenza dettagliata delle modalità di binding della molecola stessa
con un sito recettoriale. L’uso di ciclodestrine quali semplici modelli recettoriali può essere utile per
lo studio di possibili siti di binding, delle proprietà conformazionali della molecola legata ad un
recettore e delle interazioni non covalenti che stabilizzano il complesso molecola/recettore. La
natura e l’intensità delle relazioni che governano il binding possono essere ottenute dall’analisi
degli effetti NOE intermolecolari in soluzione tra molecola ospitante e substrato con essa
interagente. Questi studi sono di interesse per l’industria farmaceutica, cosmetica ed alimentare in
quanto generalmente i complessi con ciclodestrine portano ad un aumento della idrosolubilità,
stabilità e biodisponibilità delle molecole incluse e possono essere importanti per la veicolazione di
molecole attive. Proprio dalla collaborazione con una industria farmaceutica sul problema preciso
del complesso ciclodestrina/piroxicam (nome commerciale Brexin), un antiinfiammatorio non
steroideo è nato l’interesse del candidato nel campo della chimica supramolecolare, esteso poi allo
studio dei complessi con altre molecole di interesse farmacologico o alimentare.
Elenco delle pubblicazioni
1. P. Bravo, G. Fronza, G. Gaudiano, C. Ticozzi and M. G. Zubiani
Trisubstituted Cyclopropanes from the Reaction of Stable Sulphonium Ylides with -Halocarbonyl
Compounds.
Tetrahedron, 27, 3563 (1971)
2. T. Caronna, G. Fronza, F. Minisci and O. Porta
Nucleophilic Character of Acyl Radicals. Substituent Effects on the Homolitic Acylation of Protonated
Heteroaromatic Bases.
J. Chem. Soc., Perkin II, 1477 (1972)
3. T. Caronna, G. Fronza, F. Minisci and O. Porta
Homolytic Acylation of Protonated Pyridine and Pyrazine Derivatives.
J. Chem. Soc., Perkin II, 2035 (1972)
4. P. Bravo, G. Fronza, G. Gaudiano and C. Ticozzi Palladium(II) Complexes with
Sulphonium Ylides.
Gazz. Chim. Ital., 103, 623 1973)
5. M. Croci, G. Fronza and P. Vita-Finzi
Concerning the Structures of 4,4'-Azoisoxazol-5-ones and Some of Their Methyl Derivatives.
Gazz. Chim. Ital., 103, 1045 (1973)
6. C. Cistaro, G. Fronza, R. Mondelli, S. Bradamante and G. Pagani
The Sign of J in Thietane Sulphones and Correlation with Stereochemistry.
Tetrahedron Letters, 189 (1973)
7. A. d'Annibale, L. Lunazzi, G. Fronza, R. Mondelli and S. Bradamante
Conformational Investigation of Cyclobutane and Thietan in Liquid Crystalline Solvents.
J. Chem. Soc., Perkin II, 1908 (1973)
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8. P. Bravo, G. Fronza, G. Gaudiano and C. Ticozzi Palladium(II)
Complexes with Sulphonium Ylides.
J. Organometal. Chem., 74, 143 (1974)
9. G. Fronza, A. Gamba, R. Mondelli and G. Pagani
Sign Determination of Carbon-Proton and Proton-Proton Coupling Constants in Thiete-1,1-Dioxide.
J. Magn. Resonamce, 12, 231 (1973)
10. G. Fronza, R. Mondelli and E. W. Randall
Effects of Relaxation Reagents on the Relative Widths of Lines in Spin Multiplets.
J. Chem. Soc., Chem. Comm., 195 (1974)
11. C. Cistaro, G. Fronza, R. Mondelli, S. Bradamante and G. Pagani
NMR Study of Four-membered Rings. VI. 1 H Spectra and Conformation of Thietane-l-Oxide and
Thietane-1,1-Dioxide.
J. Magn. Resonance, 15, 367 (1974)
12. G. Vidari, L. Garlaschelli, M. De Bernardi, G. Fronza and P. Vita-Finzi
The Structure of a New sesquiterpene Epoxylactone from Lactarius scrobiculatus Scop. (Russulacae)
by spectroscopic methods.
Tetrahedron Letters, 1773 (1975)
13. C. Cistaro, G. Fronza, R. Mondelli, S. Bradamante and G. A. Pagani
NMR Study of Four-menbered Rings. VII. Preferential Axial Orientation of Groups in 3-Substituted
Thietane-1,1-Dioxides.
J. Magn. Resonance, 17, 219 (1975)
14. M. De Bernardi, G. Fronza, G. Vidari and P. Vita-Finzi
Fungal Metabolites II: New Sesquiterpenes from Lactarius scrobiculatus Scop. (Russulaceae).
La Chimica & L'Industria, 58, 177 (1976)
15. G. Fronza, R. Mondelli, G. Scapini, G. Ronsisvalle and F. Vittorio
C-13 NMR Studies of N-Heterocycles. Conformation of Phenothiazines and 2,3-Diazaphenothiazines.
J. Magn. Resonance, 23, 437 (1976)
16. G. Vidari, M. De Bernardi, P. Vita-Finzi and G. Fronza
Sesquiterpenes from Lactarius blennius.
Phytochemistry, 15, 1953 (1976)
17. A. Arnone, G. Fronza, R. Mondelli and A. Vigevani
C-13 NMR Analysis of the Antitumor Antibiotics Daunorubicin and Adriamycin.
Tetrahedron Leters, 3349 (1976)
18. P. Bravo, G. Fronza and C. Ticozzi
Palladium(II) Complexes with Sulfur Ylides: a New Complex Containing Methylsulfoxonium
Dimethylide as a Chelating Ligand.
J. Organometal. Chem., 118, C78 (1976)
19. P. Bravo, G. Fronza and C. Ticozzi
Palladium(II) Complexes with Keto-Stabilized Phosphonium, Arsonium and Pyridinium Ylides.
J. Organometal. Chem., 111, 361 (1976)
20. P. Bravo, G. Fronza, D. Maggi and C. Ticozzi
2-( -Hydroxy- - Methylsulfinylmethyl)Alkyl-2,3-Dihydro-l-Benzofurans by Addition of the Whole
Molecule of Dimethyloxosulfonium Methylide to o-Hydroxybenzalketones.
Tetrahedron Letters, 1077 (1977)
21. G. Fronza, R. Mondelli, E. W. Randall and G. Gardini
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C-13 Nuclear Magnetic Resonance of N-Heterocygles. Part 2. Natural Abundance Carbon-13 and
Nitrogen-15 NMR Studies of - and 4 -Pyrrolin-2-ones and Model Compounds.
J. Chem. Soc., Perkin II, 1746 (1977)
22. A. Arnone, G. Fronza, R. Mondelli and J. St. Pyrek
C-13 NMR Analysis of Anthraquinones as Models for Anthracycline Antibiotics.
J. Magn. Resonance, 28, 69 (1977)
23. G. Fronza, C. Fuganti and P. Grasselli
Non-Carbohydrate-Based Enantioselective Synthesys of D(-)-Allomuscarine.
Tetrahedron Letters, 3941 (1978)
24. G. Fronza, P. Bravo and C. Ticozzi
Carbon-13 Nuclear Magnetic Resonance Studies of Some Phosphonium, Arsonium, Sulfonium and
Pyridinium Keto-Stabilized Salts and Ylides and of Their Palladium(II) Complexes.
J. Organometal. Chem., 157, 299 (1978)
25. G. Fronza, C. Fuganti, P. Grasselli and G. Marinoni
Synthesis of N-benzoyl L- and D-2,3,6-Trideoxy-3-amino-xylo-hexose from NonCarbohydrate
Precursors.
Tetrahedron Letters, 3883 (1979)
26. A. Arnone, L. Camarda, R. Cardillo, G. Fronza, L. Merlini, R. Mondelli, G. Nasini and J. St. Pyrek
C-13 NMR Analysis of Dihydrogranaticin Methyl Ester. A Case of Mixed Biogenesis.
Helv. Chim. Acta, 62, 30 (1969)
27. G. Fronza, R. Mondelli and S. Bradamante
NMR Study of Four-Membered Rings. IX. Conformation of Thietan-1,1-Dioxide and Thietan-1-Oxide
from Their NMR Spectra in a Nematic Solvent.
J. Magn. Resonance, 36 343 (1979)
28. M. De Bernardi, G. Fronza, G. Mellerio, G. Vidari and P. Vita-Finzi
New Sesquiterpene Hydroxylactones from Lactarius Species.
Phytochemistry, 18, 293 (1979)
29. P. Bravo, C. Ticozzi, G. Fronza, R. Bernardi and D. Maggi
Oxygen Heterocycles by Sulfur Ylide Annulation. 2,3,4,5-Tetrahydro-3-Hydroxy-l-Benzooxepins from 2-
(o-Hydroxyphenyl) Allylketones and Dimethyloxosulfonium Methylide.
Gazz. Chim. Ital., 109, 137 (1979)
30. G. Fronza, C. Fuganti and P. Grasselli
Synthesis of N-Trifluoroacetyl-L-Acosamine and L-Daunosamine.
J. Chem. Soc., Chem. Commum., 442 (1980)
31. G. Fronza, C. Fuganti and P. Grasselli
Synthesis of N-Benzoyl-L-Ristosamine.
Tetrahedron Letters, 2999 (1980)
32. D. Andina, M. de Bernardi, A. Del Vecchio, G. Fronza, G. Mellerio, G. Vidari and P. Vita-Finzi.
Sesquiterpenes from Russula sardonia.
Phytochemistry, 19, 93 (1980)
33. M. De Bernardi, G. Fronza, G. Mellerio, G. Vidari and P. Vita-Finzi
Stereochemistry of Blennin A and Blennin D from Lactarius blennius.
Phytochemistry, 19, 99 (1980)
34. S. Bruckner, G. Fronza, L. Malpezzi-Giunchi, V. A. Kozinski and O. Zelenskaja
Synthesis and Structure of the New Mesoionic 1-Thiasydnonimine System.
Tetrahedron Letters, 2101 (1980)
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35. R. Battaglia, M. De Bernardi, G. Fronza, G. Mellerio, G. Vidari and P. VitaFinzi
Fungal Metabolites. VIII. Structure of New Sesquiterpenes from Lactarius scrobiculatus.
J. Nat. Products, 43, 319 (1980)
36. M. De Bernardi, G. Mellerio, G. Vidari, P. Vita-Finzi and G. Fronza
Fungal Metabolites. Part 5. Uvidins, New Drimane Sesquiterpenes from Lactarius uvidus Fries.
J. Chem. Soc., Perkin I, 221 (1980)
37. E. Conca, M. De Bernardi, G. Fronza, M. A. Girometta, G. Mellerio, G. Vidari and P. Vita-Finzi
Fungal Metabolites 10. New Chromenes from Lactarius fuliginosus and Lactarius picinus Fries.
Tetrahedron Letters, 4327 (1981)
38. G. Bertolli, G. Fronza, C. Fuganti, P. Grasselli, L. Majori and F. Spreafico
On the -Ketols Obtained from -Unsaturated Aromatic Aldehydes and Bakers' Yeast.
Tetrahedron Letters, 965 (1981)
39. M. De Bernardi, G. Mellerio, G. Vidari, P. Vita-Finzi, G. Fronza, M. Kocor and J. St. Pyrek
Fungal Metabolites. IX. Triterpenes from Naematoloma sublateritium.
J. Nat. Products, 44, 351 (1981)
40. G. Fronza, C. Fuganti, P. Grasselli, G. Pedrocchi-Fantoni and C. Zirotti
On the Steric Course of the Addition of Diallylzinc onto alfa,beta-Dialkoxy Chiral Carbonyl
Compounds: Stereospecific Synthesis of 2,6-Dideoxysugars of the L-Series.
Tetrahedron Lett., 3143 (1982)
41. G. Fronza, E. Ragg and G. Ronsisvalle
Conformation of Thiantren and 2,7-Dichlorothiantren Partially Oriented in a Nematic Phase.
J. Chem. Soc. Perkin II, 1209 (1982)
42. G. Fronza, C. Fuganti, P. Grasselli, L. Majori, G. Pedrocchi-Fantoni and F. Spreafico
Synthesis of Enantiomerically Pure Forms of N-Acyl Derivatives of C-Methyl Analogues of the
Aminodeoxy Sugar L-Acosamine from Non- Carbohydrate Precursors.
J. Org. Chem., 47, 3289 (1982)
43. E. Ragg, G. Fronza and R. Mondelli
Dynamic Aspects of the Stereochemistry of Phenothiazines in Solution. Part 2. Segmental Motion and
Conformational Analysis of the Side-Chain in Promazines.
J. Chem. Soc., Perkin II, 1587 (1982)
44. G. Fronza, C. Fuganti and P. Grasselli
Structure and Conformation of N-Benzoyl Derivatives of the Biologically Important 3-Amino-2,3,6-
trideoxy-L-hexoses and Their Synthetic Precursor - and -Lactones; a H-1 and C-13 Nuclear
Magnetic Resonance Study.
J. Chem. Soc., Perkin I, 885 (1982)
45. G. Fronza and E. Ragg
Conformational Investigation of Dibenzo-p-Dioxin by Proton Magnetic resonance in a Liquid
Crystalline Solvent.
J. Chem. Soc., Perkin Trans. II, 291 (1982)
46. E. Beltrami, M. De Bernardi, G. Fronza, G. Mellerio, G. Vidari and P. Vita-Finzi
Coatline A and B, two C-Glucosyl--Hydroxydihydrochalcones from Eysenhardtia polystachya.
Phytochemistry, 21, 2931 (1982)
47. E. Ragg, G. Fronza, R. Mondelli and G. Scapini
C-13 Nuclear Magnetic Resonance Spectroscopy of Nitrogen Heterocycles. Part 4. intra-extra
Configuration of the N-Acetyl Group in Phenothiazine and Related Systems with a 'Butterfly' Shape.
J. Chem. Soc., Perkin II, 1289 (1983)
48. G. Fronza, C. Fuganti, P. Grasselli and G. Pedrocchi-Fantoni
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Synthesis of the Four Configurational Isomers of N-Benzoyl-2,3,6-trideoxy-3C-Methyl-3-Amino-L-Hexoses
from the (2S,3R)-Diol Obtained from - Methylcinnamaldehyde by Fermentation with Bakers' Yeast.
J. Carbohydrate Chem., 2, 225 (1983)
49. M. De Bernardi, G. Mellerio, G. Vidari, P. Vita-Finzi and G. Fronza
Fungal Metabolites. Part 15. Structure and Chemical Correlations of Uvidin C, D, and E, New Drimane
Sesquiterpenes from Lactarius uvidus Fries.
J. Chem. Soc., Perkin Trans. I, 2739 (1983)
50. G. Fronza, R. Mondelli, F. Lelj, E. W. Randall and C. A. Veracini
Structural Changes Induced in the NH 2 Group of Aniline by Substituents the Structure and Orientation of
para-Bromo- and para-Nitroaniline [1- 15 N] in Nematic Liquid Crystal Solvent by NMR.
J. Magn. Resonance, 37, 275 (1980)
51. G. Fronza, C. Fuganti, P. Grasselli and G. Pedrocchi-Fantoni
Synthesis of the N-Benzoyl Derivatives of L-arabino, L-xylo and L-lyxo (L-Vancosamine) Isomers of 2,3,6-
trideoxy-3C-methyl-3-amminohexose from a Non-carbohydrate Precursor.
Tetrahedron Letters, 5073 (1981)
52. M. De Bernardi, G. Fronza, G. Mellerio, V. Valla, G. Vidari and P. Vita-Finzi
Fungal Metabolites. XVII. Sesquiterpenes from Lactarius pallidus Peerson.
Gazz. Chim. Ital., 114, 163 (1984)
53. P. Bravo, G. Fronza and C. Ticozzi
Oxygen Heterocycles by Sulfur Ylide Annulation. The Reaction of Dimethylsulphoxonium Methylide on
ortho-Hydroxybenzal Ketones: a Case of Annulation Leading to a Mixture of Unexpected Oxygen
Heterocycles.
Gazz. Chim. Ital., 114, 93 (1984)
54. R. Mondelli, A. Arnone, G. Fronza, G. Cassinelli, B. Gioia and A. Vigevani N,0-Isopropylidene Derivatives
of the Antitumor Antibiotics Daunorubicin and Doxorubicin.
J. Chem. Res. (S), 180 (1984)
55. G. Fronza, C. Fuganti, P. Grasselli, G. Pedrocchi-Fantoni and C. Zirotti
On the Steric Course of the Addition of Crotyl Metals onto (2S,3S) 2,3-Isopropylidenedioxybutyraldehyde
and (3S,4S) 3,4-Isopropylidenedioxypentanone. Synthesis of 2,6-Dideoxy-2-C-Methyl Branched Sugars of
the L-Series.
Chemistry Letters, 335 (1984)
56. M. De Bernardi, G. Fronza, M. P. Giannotti, G. Mellerio, G. Vidari and P. Vita-Finzi
Fungal Metabolites. XIII: New Cytotoxic Triterpene from Hebeloma Species (Basidiomycetes).
Tetrahedron Letters, 1635 (1983)
57. W. M. Daniewsky, A. Wawrzun, M. De Bernardi, G. Vidari, P. Vita-Finzi, G. Fronza and G. Gatti
Structural Studies on Lactarius Sesquiterpenes: Structure Elucidation of Lactarorufins D and E and
Conformational Analysis of Lactaran-5-Olides.
Tetrahedron, 40, 2757 (1984)
58. G. Fronza, C. Fuganti, P. Grasselli and G. Pedrocchi-Fantoni
Carbohydrate-like Chiral Synthons: Synthesis of the N-trifluoroacetyl Derivatives of 4-Amino-2,4,6-
Trideoxy-L-lyxo, L-arabino and L-ribo-hexose from the (2S,3R)-2,3-Diol formed from Cinnamaldehyde
in Fermenting Bakers' Yeast.
Carbohydrate Research, 136, 115 (1985)
59. O. Sterner, R. Bergman, J. Kihlberg, J. Oluwadiya, B. Wickberg, G. Vidari, M.
De Bernardi, F. De Marchi, G. Fronza and P. Vita-Finzi
Basidiomycete Sesquiterpenes: the Silica Gel Induced Degradation of Velutinal Derivatives.
J. Org. Chem., 50, 950 (1985)
60. F. Menegus and G. Fronza
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Modulation of Glycerophosphorylcholine and Glycerophosphoryletanolamine in Rice Shoots by
Environment Oxygen Level. A P-31 NMR Study.
FEBS Letters, 187, 2731 (1985)
61. S. Sonnino, G. Kirschner, G. Fronza, H. Egge, R. Ghidoni, D. Acquotti and G. Tettamanti
Synthesis of GM1 Ganglioside Inner Ester.
Glycoconjugate J., 343 (1985)
62. G. Fronza, C. Fuganti, P. Grasselli and S. Servi
Bakers' Yeast Mediated Preparation of Carbohydrate-like Chiral Synthons.
Tetrahedron Letters, 4961 (1985)
63. D. Acquotti, S. Sonnino, M. Masserini, L. Casella, G. Fronza and G. Tettamanti
A New Chemical Procedure for the Preparation of Gangliosides Carrying Fluorescent or Paramagnetic
Probes on the Lipid Moiety.
Chem. Phys. Lipids, 40, 71 (1986)
64. M. De Bernardi, G. Fronza, A. Scilingo, G. Vidari and P. Vita-Finzi
Fungal Metabolites XX: Chemical Correlation of Lactarane and Secolactarane Sesquiterpenes. Absolute
Configuration of Furosardonin A, Lactaral and Blennin C.
Tetrahedron, 42, 4277 (1986)
65. G. Fronza, C. Fuganti, P. Grasselli and S. Servi
Bakers' Yeast Mediated Synthesis of Epimeric 2,3-Dideoxy-2-C-Methyl-D-Glucose Derivatives.
Tetrahedron Letters, 4363 (1986)
66. S. Sonnino, D. Acquotti, G. Kirschner, G. Fronza and G. Tettamanti Advances in
Ganglioside Chemistry.
in Gangliosides and Neuronal Plasticity, Fidia Research Series, Vol. 6, 1746 (1986), Springer-Verlag
67. R. Mondelli, E. Ragg and G. Fronza
Conformational Analysis of N-Aeetyldaunomycin in Solution. A Transient H-1 Nuclear Overhauser
Effect Study of the Glycosidic Linkage Geometry.
J. Chem. Soc. Perkin Trans.II, 27 (1987)
68. R. Mondelli, E. Ragg, G. Fronza and A. Arnone
Nuclear Magnetic Resonance Conformational Study of Daunomycin and Related Antitumor Antibiotics in
Solution. The Conformation of Ring A.
J. Chem. Soc. Perkin II, 15 (1987)
69. G. Fronza, C. Fuganti, G. Pedrocchi-Fantoni and S. Servi
Stereochemistry and Synthetic Applications of the Products of Yeast Reduction
of 3-Hydroxy-3-methyl-5-phenylpent-4-en-2-one.
J. Org. Chem., 52, 1141 (1987)
70. G. Fronza, C. Fuganti, P. Grasselli and S. Servi
Baker's Yeast Mediated Synthesis of 4-Deoxy-D-lyxo-hexopyranose (4-Deoxy-D-mannose).
J. Org. Chem., 52, 2086 (1987)
71. D. Acquotti, G. Fronza, L. Riboni, S. Sonnino and G. Tettamanti
Ganglioside Lactones: H-1 NMR Determination of the Inner Ester Position of GD1b Ganglioside Lactone
Naturally Occurring in Human Brain or Produced by Chemical Synthesis.
Glycoconjugate J., 4, 119 (1987)
72. W. M. Daniewski, W. Kroszczynski, P. Skibicki, M. De Bernardi, G. Fronza, G. Vidari and P. Vita-Finzi
Normarasmane Sesquiterpenes from Lactarius vellereus.
Phytochemistry, 27, 187 (1988)
73. G. Fronza, G. Kirschner, D. Acquotti, R. Bassi, L. Tagliavacca and S. Sonnino
Synthesis and Structural Characterization of the Dilactone Drivative of GD1a Ganglioside.
8

Carbohydrate Research, 182, 31 (1988)
74. S. Sonnino, L. Riboni, D. Acquotti, G. Fronza, G. Kirschner, R. Ghidoni and G. Tettamanti
Biochemistry of Ganglioside Lactones.
in 'New Trends in Ganglioside Research - Neurochemical and Neurogenerative Aspects', Fidia Research
Series, Vol. 14, 47-61 (1988)
75. G. Fronza, C. Fuganti, G. Pedrocchi-Fantoni and D. Pizzi
Synthesis of the Eight Configurational Isomers of N-trifluoroacetyl-2-Cmethyl-2,3,6-trideoxy-3-amino-Lhexose
from Non-carbohydrate Precursors.
J. Carbohydrate Chem., 7, 33 (1988)
76. W. M. Daniewski, M. Gumulka, K. Ptaszynka, G. Vidari, L. Garlaschelli, G. Fronza and M. Budesinsky
7-Epi-pipertriol, a Lactarane Sesquiterpene from Lactarius necator.
Phytochemistry, 27, 3315 (1988)
77. G. Fronza, C. Fuganti, H. Hogberg, G. Pedrocchi-Fantoni and S. Servi
Chiral -Methyl-homoallylic Alcohols from Yeast Genarated Precursors. Synthesis of (4R,5S) Sitophilure.
Chemistry Letters, 385 (1988)
78. F. Menegus, L. Cattaruzza, A. Chersi, A. Selva and G. Fronza
Production and Organ Distribution of Succinate in Rice Seedlings During Anoxia.
Physiol. Plantarum, 74, 444 (1988)
79. P. Bravo, E. Piovosi, G. Resnati and G. Fronza
Asymmetric Synthesis and Structural Analysis 5-O-Benzoyl-2,3-dideoxy-3-fluoro- ,-D-ribofuranose and
-xylofuranose from Homochiral 1-Fluoro-3-sulphynilacetone.
J. Org. Chem., 54, 5171 (1989)
80. F. Menegus, L. Cattaruzza, A. Chersi and G. Fronza
Differences in the Anaerobic Lactate-Succinate Production and in the Changes of Cell Sap pH for Plants
with High and Low Resistance to Anoxia.
Plant Physiol., 90, 29 (1989)
81. A. Bosetti, G. Fronza, G. Vidari and P. Vita-Finzi
Norlactarane and Lactarane Sesquiterpenes from Lactarius scrobiculatus.
Phytochemistry, 28, 1427 (1989)
82. D. Faiardi, G. Fronza, C. Fuganti, G. Pedrocchi-Fantoni and D. Pizzi
Synthesis of N-trifluoroacetyl Derivatives of Enantiomeric 2,5,6-Trideoxy-5amino hexoses from Noncarbohydrate
Precursors.
J. Carbohydrate Chem., 8, 469 (1989)
83. G. Fronza, C. Fuganti and G. Pedrocchi-Fantoni
Synthesis of the Four Configurational Isomers of a Protected Form of Ntrifluoroacetyl-4-C-methyl-2,4,6-
trideooxy-4-amino-L-hexose.
J. Carbohydrate Chem., 8, 85 (1989)
84. R. Cardillo, G. Fronza, C. Fuganti, P. Grasselli, V. Nepoti, M. Barbeni and P. Guarda
On the Mode of Conversion of Racemic C(14)--C(19) -Hydroxy Alkene Fatty
Acids into C(7)--C(11) Optically Active and -Lactones in Cladosporium suaveolens.
J. Org. Chem., 54, 4979 (1989)
85. G. Fronza, G. Kirschner, D. Acquotti and S. Sonnino
Synthesis, Structure and Conformation of the Dilactone Derivative of GD1b Ganglioside.
Carbohydrate Research, 194, (1989)
86. G. Fronza, C. Fuganti, P. Grasselli, G. Poli and S. Servi
On the Products Obtained from -Oxygen Substituted Crotonaldehyde in Fermenting Baker's Yeast.
Biocatalysis, 3, 51 (1990)
9

87. S. Sonnino, D. Acquotti, G. Fronza, D. Cantù, V. Chigorno, M. Pitto, G. Kirschner and G. Tettamanti
Semisynthetic Preparation of N-glycolylneuraminic Acid Containing GM1 Ganglioside: Chemical
Characterization, Physico-chemical Properties and Some Biochemical Features.
Chem. Phys. Lipids, 46, 181 (1988)
88. G. Fronza, E. Ragg and R. Mondelli
Dynamic Aspects of the Stereochemistry of Phenothiazines in Solution.
Actualitè de Chimie Therapeitique - 8° Serie, 245 (1981)
89. G. Fronza, C. Fuganti, G. Pedrocchi-Fantoni and S. Servi
(R)-S-benzyl Thioglycerate: a New C-3 Bifunctional Chiral Material Obtained in Fermenting Baker's
Yeast from Benzyl Mercaptan.
Chemistry Letters, 2141 (1989)
90. G. Bettinetti, F. Giordano, G. Fronza, A. Italia, R. Pellegatta, M. Villa and P. Ventura
Sobrerol Enantiomers and Racemates: Solid State Spectroscopy, Thermal. Behaviour and Phase
Diagrams.
J. Pharmaceutical Sciences, 79, 470 (1990)
91. P. Bravo, M. Frigerio, G. Fronza, A. Ianni and G. Resnati
Synthesis of Four Homochiral 3,4-Dideoxy-3-fluoro-hexoses from a Noncarbohydrate Precursor.
Tetrahedron, 46, 997 (1990)
92. E. Ragg, C. Ulbricht, R. Mondelli, G. Fronza and S. Penco
Conformational Analysis of Doxorubicin and Analogues in Aqueous solution. Determination of the
Glycosidic Linkage Geometry by H-1 2D-Inversion Recovery Difference NOE Spectroscopy.
Gazz. Chim. Ital., 120, 501, (1990)
93. G. Fronza, C. Fuganti, D. Pizzi and S. Servi
Stereoselective Preparation of Allylic Alcohol Intermediates in the Synthesis of Deoxysugars.
J. Carbohydrate Chem., 9, 317 (1990)
94. G. Fronza, A. Mele, G. Pedrocchi-Fantoni, D. Pizzi and S. Servi
Addition of Activated Grignard Reagents to 2-Phenyloxazolines.
J. Org, Chem., 55, 6216 (1990)
95. G. Fronza, C. Fuganti, P. Grasselli, A. Mele, G. Allegrone, M. Barbeni and A. Pisciotta
Stereochemistry of the Methyne-Methylene Conversion in the Biogeneration of (S) -Decanolide and (S)-
-Dodecanolide from (13RS)-13-Hydroxyoctadeca-9Z,11E-dienoic and (10RS)-10-Hydroxyoctadec-8Eenoic
Acid.
J. Chem. Soc. Perkin Trans. I, 2977 (1991)
96. G. Fronza, C. Fuganti, P. Grasselli, R. Pulido-Fernandez, S. Servi, A. Tagliani and M. Terreni
On the Mode of Baker's Yeast Reduction of Enantiomeric 4-Acyl Butanolides.
Tetrahedron, 47, 9247 (1991)
97. G. Fronza, C. Fuganti, A. Mele and G. Pedrocchi-Fantoni
On the Use of (4S,5S)-2-Phenyl-4,5-dimethyl-4-formyl-4,5-dihydrooxazole in the Synthesis of N-
protected 2,3,4,6-Tetradeoxy-4-C-methyl-4-amino-L-hexose Derivatives.
J. Carbohydrate Chem., 10, 197 (1991)
98. S. Auricchio, G. Fronza, S. V. Meille and A. Mele
8-Bromoerythronolide 5,9:6,9-Spiroacetal B: Synthesis, Structure, Conformation, and Nucleophilic
Substitution Reactivity.
J. Org. Chem., 56, 2250 (1991)
99. R. Cardillo, G. Fronza, C. Fuganti, P. Grasselli, A. Mele, D. Pizzi. G. Allegrone, M. Barbeni and A.
Pisciotta
10

Stereochemistry of the Microbial Generation of -Decanolide, -Dodecanolide, and -Nonanolide from
C(18) 13-Hydroxy, and C(19) 14-Hydroxy Unsaturated Fatty Acids.
J. Org. Chem., 56, 5237 (1991)
100. G. Fronza, C. Fuganti, P. Grasselli and A. Mele
On the Mode of Bakers' Yeast Transformation of 3-Chloropropiophenone and related Ketones. Synthesis
of (2S)-[2- 2 H]Propiophenone, (R)-Fluoxetine, and (R)- and (S)-Fenfluramine.
J. Org. Chem., 56, 6019 (1991)
101. D. Acquotti, G. Fronza, E. Ragg and S. Sonnino
Three Dimensional Structure of GD1b and Gdlb-monolactone Gangliosides in Dimethylsulphoxide: a
Nuclear Overhauser Effect Investigation Supported by Molecular Dynamics Calculations.
Chem. Phys. Lipids, 59, 107 (1991)
102. M. Aquino, S. Cardani, G. Fronza, C. Fuganti, R. Pulido-Fernandez and A. Tagliani
Baker's Yeast Reduction of Arylalkyl and Arylalkenyl and -Ketoacids.
Tetrahedron, 47, 7887 (1991)
103. G. Fronza, C. Fuganti, P. Grasselli, G. Pedrocchi-Fantoni and S. Servi
Minor Synthetic Capacities of Baker's Yeast towards Unnatural Substrates.
Pure & Appl. Chem., 64, 1099 (1992)
104. G. Fronza, C. Fuganti, A. Mele, G. Pedrocchi-Fantoni and S. Servi
On the Origin of the C 3 Framework of Yeast-Generated (R)-S-Benzyl Thioglycerate.
J. Org. Chem., 57, 999 (1992)
105. P. Bravo, L. Bruche, D. Diliddo and G. Fronza
Synthesis of Trifluoromethyl-substituted 4,5-Dihydropyrazoles.
J. Chem. Research (S), 40 (1992)
106. G. Fronza, C. Fuganti and P. Grasselli
Stereochemistry of the Yeast-Mediated Conversion of Delta 2-Decenolide into Delta Decanolide.
Tetrahedron Letters, 33, 6375 (1992)
107. M. De Bernardi, G. Vidari, P. Vita-Finzi and G. Fronza
The Chemistry of Lactarius fuliginosus and Lactarius picinus.
Tetrahedron, 48, 7331 (1992)
108. G. Fronza, C. Fuganti, P. Grasselli and M. Terreni
On the Mode of Baker's Yeast Reduction of Methyl Substituted Arylalkyl Gamma and Delta Keto Acids.
Synthesis of Cis-(+)-Rose Oxide.
Tetrahedron, 48, 7363 (1992)
109. G. Fronza, C. Fuganti, P. Grasselli, G. Pedrocchi-Fantoni and S. Servi
Enzyme Assisted Synthesis of (S)-Sotolon.
Tetrahedron Letters, 33, 5625 (1992)
110. S. Auricchio, G. Fronza. A. Mele and D. Favara
Structure and Conformation of Erythronolide B and (8S)-(8-Fluoroerythronolide B Spiroacetals and of Their
Acetyl Derivatives. A H-1 NMR Study.
J. Org. Chem., 57, 452 (1992)
111. P. Bravo, L. Bruche, G. Fronza and G. Zecchi
A Cycloadditive Route to Trifluoromethyl-Substituted Aminoalcobols.
Tetrahedron, 48, 9775 (1992)
112. M. Schiavi, S. Serafini, A. Italia, M. Villa, G. Fronza and A. Selva
Identification of the Major Degradation Products of 4-Methoxy-2-(3-phenyl-2propynyl)phenol Formed by
Exposure to Air and Light.
J. Pharmaceutical Sciences, 81, 812 (1992)
11

113. G. Fronza, A. Mele, E. Redenti and P. Ventura
Proton Nuclear Magnetic Resonance Spectroscopy Studies of the Inclusion Complex of Piroxicam with
Beta-Cyclodextrin.
J. Pharmaceutical Sciences, 81, 1162 (1992)
114. E. Redenti, G. Fronza, G. Bovis and P. Ventura
Application of Gamma Cyclodextrin to, Enantiomeric Purity Determination of a New 2-Amino-Tetralin
Derivative by 1 H-NMR Spectroscopy.
Chirality, 404 (1992)
115. G. Fronza
Stereochimica della Riduzione dei Doppi Legami nella Biogenerazione di (S)Delta-Decanolide e di (S)-
Gamma-Dodecanolide da Beta-Idrossiacidi Insaturi.
La Chimica 6 L'Industria, 74, 408 (1992)
116. G. Fronza, C. Fuganti and P. Grasselli
Stereochemical Features of Baker's Yeast Mediated Transformation of Racemic and Enantiomerically Pure
2-Deutero-3-Chloropropiophenone.
Tetrahedron Asymmetry, 4, 1909 (1993)
117. G. Fronza, C. Fuganti, P. Grasselli. A. Mele, A. Sarra, G. Allegrone and M. Barbeni
On the Mode of Baker's Yeast Reduction of C-7---C-10 2-Alken-4-Olides.
Tetrahedron Letters, 34, 6467 (1993)
118. Bravo, L. Bruchè, A. Farina, G. Fronza, S. V. Meille and A. Merli
Synthesis of Optically Pure Fluorosubstituted Isoxazol.idines by 1,3-Dipolar Cycloaddition of Nitrones to
Chiral Methyl Enol Ethers of 3-Fl.uoro-lsulphinyl-2-propanones.
Tetrahedron Asymmetry, 4, 2131 (1993)
119. G. Fronza, C. Fuganti, P. Grasselli, G. Pedrocchi-Fantoni and S. Servi
On the Mechanism of the Formation of Tetrahydrofurans from 1,4-Dials Mediated by Triphenylphosphine
and N-Bromosuccinimide.
Tetrahedron Letters, 34, 2981. (1993)
120. G. Ronsisvalle, L. Pasquinucci, M. S. Pappalardo, F. Vittorio, G. Fronza, C. Romagnoli, E. Pistacchio, S.
Spampinato and S. Ferri
Non-Peptide Ligands for Opioid Receptors. Design of K-Specific Agonists.
J. Medicinal Chem., 36, 1860 (1993)
121. G. Fronza, C. Fuganti, P. Grasselli and S. Servi
Biogeneration of Aromas.
Chimia, 47, 107 (1993)
122. G. Fronza, C. Fuganti, P. Grasselli, M. Barbeni and M. Cisero
Natural Abundance 2 H Nuclear Magnetic Resonance Study of the Origin of (R)-Delta-Decanolide.
J. Agric. Food Chem., 41, 235 (1993)
123. G. Fronza, C. Fuganti, P. Grasselli, G. Zucchi, G. Allegrone, M. Barbeni, P. Cabella and M. Cisero
Stereochemistry of the Conversion of (R) Coriolic Acid into Delta Decanolide in Cladosporium suaveolens.
Biotechnology Letters, 15, 1233 (1993)
124. G. Fronza, C. Fuganti, A. Mele, G. Pedrocchi-Fantoni, S. Servi
On the Mechanism of Baker's Yeast Mediated Synthesis of (R) S-Benzyl Thioglycerate. Experiments in
Deuterated Water.
Tetrahedron, 50, 857 (1994)
125. G. Fronza, C. Fuganti, P. Grasselli and A. Mele
On the Asymmetric Dihydroxylation of (2S,3R) 5-Phenyl-4-en-2,3-diol Derivatives.
Tetrahedron, 50, 5021 (1994)
12

126. G. Fronza, C. Fuganti, P. Grasselli, L. Malpezzi and A. Mele
Bakers' Yeast Mediated Preparation of Esters of (R)- and (S)-Ethyl 2-Formyl-3-hydroxy-2-
methylpropionate.
J. Org. Chem., 59, 3487 (1994)
127. P. Bravo, L. Bruchè, A. Merli, G. Fronza
High Asymmetric Induction of Intermolecular 1,3-Dipolar Cycloadditions of Nitrile Oxides to Chiral Vinyl
Sulphoxides.
Gazz. Chim. Ital. 124, 275 (1994).
128. G. Fronza, C. Fuganti, P. Grasselli, S. Lanati, R. Rallo, S. Tchilibon
Stereochemistry of the Baker's yeast Mediated Reduction of the C=C Bond of (Z)- and (E)5-Benzoyloxyex-3-en-
2-one.
J. Chem. Soc. Perkin Trans. I, 2927 (1994).
129. C. Boschetti, G. Fronza, C. Fuganti, P. Grasselli, A. G. Magnone, A. Mele, C. Pellegatta A Nuclear Magnetic
Resonance method for the Determination of the Purity of Commercial Dequalinium Chloride.
Arzneim. Forsch./Drug Res., 45(II), 1217 (1995).
130. A. Bravo, F. Fontana, G. Fronza, F. Minisci, A. Serri
Oxidation of Alkyl and Aryl Iodides, Phenylacetaldehyde and Alkenes by Dimethyldioxirane. Reaction
Products and mechanism.
Tetrahedron Letters, 36, 6945 (1995).
131. G. Fronza, C. Fuganti, A. Mele, G. Pedrocchi-Fantoni, A. Sarra, S. Servi
On the Mechanism of Baker's Yeast-Mediated Synthesis of S-Benzyl (R)- Thioglycerate. Experiments
with C 3 Precursors.
Gazz. Chim. Ital., 125, 305 (1995).
132. G. Fogliato, G. Fronza, C. Fuganti, S. Lanati, R. Rallo, R. Rigoni, S. Servi
Baker's Yeast Reduction of Arylidenecycloalkanones.
Tetrahedron, 51, 10231 (1995).
133. A. Bravo, F. Fontana, G. Fronza, A. Mele, F. Minisci
Induced Homolysis of Dimethyldioxirane by Alkanes and Alkyl Radicals in Oxidation Processes.
The Dramatic Role of Molecular Oxygen and Radical inhibitors.
J. Chem. Soc., Chem. Commun.,1573 (1995).
134. Fronza, G.; Fuganti, C.; Grasselli, P.; Servi, S.; Zucchi, G.; Barbeni, M.; Cisero, M.
On the Microbial Biogeneration of and lactones: Species-Dependence of the Mode of degradation of
Hydroxylated Forms of C-18 Unsaturated Fatty Acids”
Bioflavour 95, INRA, Les Colloques n 75, 1995, 283-96.
135. Fronza, G.; Fogliato, G.; Fuganti, C.; Lanati, S.; Rallo, R.; Servi, S.
On the Mode of Baker's Yeast Reduction of Benzylidenecyclohexanone
Tetrahedron Lett., 1995, 36, 123-4
136. Fogliato, G.; Fronza, G.; Fuganti, C.; Grasselli, P.; Servi
S. “ Bakers' yeast-mediated synthesis of (R)-aminoglutethimide.”
J. Org. Chem. 1995 , 60, 5693-5.
137. Fuganti, C.; Rigoni, R.; Zucchi, G.; Barbeni, M; Cisero, M.; Villa, M.
On the soybean type-I lipoxygenase-mediated conversion of linoleic acid into (S)-2-nonen-4-olide.
Biotechnol. Lett. 1995 , 17, 301-4.
138. Fogliato, G.; Fronza, G.; Fuganti, C.; Grasselli, P.; Servi, S.; Zucchi, G.
Stereochemistry of the bakers' yeast-mediated reductive conversion of furfurol into 2-furylmethanethiol.
Biotechnol. Lett. 1995, 17, 1175-6.
13

139. Fronza, G.; Fuganti, C.; Grasselli, P.; Servi, S.; Zucchi, G.
Natural Abundance 2H Nuclear Magnetic Resonance Study of the Origin of 2-Phenylethanol and 2-
Phenylethyl Acetate.
J. Agric. Food Chem. 1995 , 43, 439-43.
140. Fronza, G.; Fuganti, C.; Grasselli, P.; Servi, S.; Zucchi, G.; Barbeni, M.; Villa, M.
Reduction of carboxylates to alkanols catalyzed by Colletotrichum gloeosporioides.”
J. Chem. Soc. Chem. Commun. 1995, 439-40.
141. Bravo, P.; Crucianelli, M.; Fronza, G.; Zanda, M.
Enantioselective Pummerer-Type Rearrangementof -Fluoro--Enaminosulfoxides: Efficient Approach to
Chiral Non-Racemic ,-N,S-Disubstituted Ketals of -Fluoro-Pyruvaldehydes”.
Synlett. 1996, 249-251.
142. Arnone, A.; Bravo, P.; Capelli, S.; Fronza, G.; Meille, S. V.; Zanda, M.; Crucianelli, M.; Cavicchio, G.
New Versatile Fluorinated Chiral Building Blocks: Synthesis and Reactivity of Optically Pure -fluoroalkyl-sulfinylenamines”.
J. Org. Chem. 1996, 61, 3375-3387.
143. Fronza, G.; Mele, A.; Redenti, E.; Ventura, P.
1 H-NMR and Molecular Modeling Study on the -Cyclodextrin-Indomethacin Inclusion Complex.",
J. Org. Chem. 1996, 61, 909.
144. Fattori, R.; Pellacini, F.; Romagnano, S.; Fronza, G.; Rallo, R.
Unusual Isoxazoline Formation by Intramolecular Cyclization of (9E)-Erythromycin A Oxime.”
J. of Antibiotics 1996, 49, 938.
145. Fronza, G.;. Fuganti, G.; Pedrocchi-Fantoni, G.; Perozzo, V.; Servi, S.; Zucchi, G.; Joulain, D.
Stereochemistry of the Baeyer-Villliger type conversion of 4-(4-hydroxyphenyl) butan-2-one (Raspberry Ketone)
into tyrosol mediated by Beauveria bassiana.”
J. Org. Chem. 1996, 61, 9362-9367.
146. Favino, T. F., Fronza, G.; Fuganti, C.; Fuganti, D.; Grasselli, P.; Mele, A.
Penicillin acylase mediated synthesis of 2-acetyl-1-pyrroline and 2-propionyl-1-pyrroline, key roast-smelling
odorants in food. Inclusion complexes with-cyclodextrin and their NMR and MS characterization.
J. Org. Chem.., 1996, 61, 8975-8979.
147. Fronza, G.; Fuganti, C.; Mendozza, M.; Rallo, R. S.; Ottolina, G.; Joulain, D. Stereochemistry of the Double
Bond saturation in the Formation in Baler’s Yeast of 4-(4-hydroxyphenyl)-2-butanone (Raspberry Ketone).
Tetrahedron 1996, 52, 4041.
148. Fronza, G.; Fuganti, C.; Zucchi, G.; Barbeni, M.; Cisero, M.
Natural abundance 2 H Nuclear Magnetic Resonance Study of the Origin of n-Hexanol.
J. Agric. Food. Chem. 1996, 44, 887-891.
149. Fronza, G.;.Fuganti, C.; Mendozza, M.; Rigoni, R.; Servi, S.; Zucchi, G.
Stereochemical Aspects of Flavor biogeneration through Baker’s Yeast Mediated Reduction of cCarbonylactivated
double bonds.
Pure & Appl. Chem. 1996, 68, 2065-2071.
150. Fronza, G.; Fogliato, G.; Fuganti, C.; Grasselli, P.; Rigoni, R.
Synthesis of (S) 2 -Ethyl-2-methyl-pentanoic Acid from the Formate Ester of (S) Ethyl 2-formyl-3-hydroxy-2-
methylpropionate.
Tetrahedron 1996, 52, 14281-14286.
151. Brenna, E.; Caraccia, N.; Fogliato, G.; Fronza, G.; Fuganti, C.
On a Baker’s Yeast Mediated Approach to Verapamil’s Optically Active Intermediates
Tetrahedron, 1997, 53, 10555-10564.
14

152. Volonterio, A.; Zanda, M.; Bravo, P.; Fronza, G.; Cavicchio, G.; Crucianelli, M.
Preparation of (R)-Fluoropyruvaldehyde-N,S-Ketals by Highly Stereospecific Tandem Pummerer
Rearrangement/1,2-p-Tolylthio Group Migration of (R)--(Fluoroalkyl)--sulfinylenamines.
J. Org. Chem., 1997, 62, 8031-8040.
153. Redenti E., Zanol M., Amari G., Ventura P., Fronza G., Bacchi A., Pelizzi G.
Structural Characterization and Solution Rotational Isomerism of Delapril Hydrochloride, a Dipeptide
Angiotensin-converting Enzyme Inhibitor.
Farmaco, 1998, 53, 214-223.
154. Fronza G., Fuganti C., Guillou C., Reniero F., Joulain D.
Natural Abundance 2 H Nuclear Magnetic Resonance Study of the Origin of Raspberry Ketone
J. Agric. Food Chem., 1998, 46, 248-254.
155. Fronza G., Fuganti C., Grasselli P., Reniero F., Guillou C., Breas O., Sada E., Rossmann A., Hermann A.
Determination of the 13 C Content of Glycerol Samples of Different Origin.
J. Agric. Food Chem. 1998, 46, 477-480.
156. Caccia F., Dispenza R., Fronza G., Fuganti C., Malpezzi L., Mele A.
Structure of Neohesperidin Dihydrochalcone/beta-Cyclodextrin Inclusion Complex : NMR, MS, and X-ray
Spectroscopic Investigation
J. Agric. Food Chem., 1998, 46, 1500-1505.
157. Bravo A., Fontana F., Fronza G., Minisci F., Zhao L.
Molecule-Induced Homolysis versus "Concerted Oxenoid Oxygen Insertion" in the Oxidation of Organic
Compounds by Dimethyldioxirane
J. Org. Chem., 1998, 63, 254-263.
158. Aleu J., Fronza G., Fuganti C., Perozzo V., Serra S.
On the Baker’s Yeast Mediated Transformation of alfa-Bromoenones. Synthesis of (1S,2R)-2-bromoindan-1-ol
and (2S,3S)-3-bromo-4-phenylbutan-2-ol.
Tetrahedron-asymmetry, 1998, 9, 1589-1596.
159. Ronzoni S., Cerri A., Dondio G., Fronza G., Petrillo P., Raveglia L. F., Gatti P. A.
Synthesis and NMR characterization of a novel class of thienomorphinans
Org. Letters, 1999, 1, 513-515.
160. Redenti E., Zanol M., Ventura P., Fronza G., Comotti G., Taddei P., Bertoluzza A.
Raman and solid state C-13 NMR investigation of the structure of the 1:1 amorphous Piroxicam: beta-
Cyclodextrin inclusion compound.
Biospectroscopy, 1999, 5, 243-251.
161. Redenti E., Ventura P., Fronza G., Selva A., Rivara S., Plazzi P.V., Mor M.
Experimental and theoretical analysis of the interaction of (+/-)-cis-ketoconazole with beta-cyclodextrin
in the presence of (+)-L-tartaric acid.
J. Pharm. Sci., 1999, 88, 599-607.
162. Fronza G., Fuganti C., Pedrocchi Fantoni G., Serra S.,Zucchi G., Fauhl C., Guillou C., Reniero F.
Stable isotope characterization of raspberry ketone extracted from taxus baccata and obtained by
oxidation of the accompanying alcohol (betuligenol).
J. Agric. Food Chem., 1999, 47, 1150-1155.
163. Brenna E., Fuganti C., Fronza G., Malpezzi L., Righetti A., Serra S.
Enzyme-mediated preparation of (+) and (-)-cis and trans-alfa-irone.
Helv. Chim. Acta, 1999, 82, 2246-2259.
164. Brenna E., Fronza G., Fuganti C., Righetti A., Serra S.
Enzyme-mediated preparation of the single enantiomers of the olfactory active components of the woody
odorant Timberol®.
Helv. Chim. Acta, 1999, 82, 1762-1773.
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165. Cisero M., Fronza G., Fuganti C., Guillou C., Reniero F.
Biogeneration of aromas: mechanistic aspects of the microbial generation of several aroma components
and authentication of their origin using the H-2 NMR spectroscopy.
Flavour and Fragrance Chemistry - Kluwer Academic Publishers - Dordrecht - The Nederlands, 2000,
pp. 121-130, (Chapter 13).
166. Volonterio A., Bravo P., Corradi E., Fronza G., Meille S.V., Vergani B., Zanda M.
Unusual nonchelation controlled allylation of a N-monoprotected -amino aldehyde: stereoselective entry to
nonracemic trifluoromethyl dipeptide isosteres
Journal of Fluorine Chemistry, 2001,108, 245-252.
167. Fronza G., Fuganti C., Grasselli P., Serra S., Reniero F., Guillou C.
13 C- and 18 O-values of glycerol of food fats.
Rapid Communications in Mass Spectrometry, 2001,18, 763-768.
168. Fronza G., Fuganti, C., Serra S., Burke A. Guillou C., Reniero F.
The positional of - 18 O values of extracted and synthetic vanillin
Helvetica Chimica Acta, 2001, 84, 351-362.
169. Fustero S., Navarro A., Belen P., Garcia Soler J., Bartolomé A., Asensio A., Simon A., Bravo P., Fronza G.,
Volonterio A., Zanda M.
Enantioselective synthesis of fluorinated -amino acids and derivatives in combination with ring-closing
metathesis: intramolecular -stacking interactions as a source of stereocontrol
Organic Letters, 2001, 3, 2621-2624.
170. Aleu J.,Fronza G., Fuganti C., Serra S., Fauhl C., Guillou C., Reniero F.
Differentiation of natural and synthetic phenylacetic acids by 2 H NMR of the derived benzoic acids.
European Food Research and Technology, 2002, 214, 63-66.
171. Fronza G., Fuganti C., Schmidt H. L., Werner R. A.
The - 18 O-value of the p-OH group to L-tyrosine permits the assignment of its origin to plant or animal sources
European Food Research And Technology, 2002, 215, 55 -,58.
172. Fronza G., Fuganti C., Serra S., Cisero M., Koziet J.
Stable isotope labeling pattern of resveratrol and related natural stilbenes
J. Agric. Food Chem., 2002, 50, 2748-2754.
173. G. Fronza, C. Fuganti, E. Genesio, A. Mele
Structural Features of the -CD Complexes with Naringin and its Dihydrochalcone and Aglycon Derivatives
by 1 H NMR.
J. Incl. Phenomena and Macrocyclic Chem., 2002, 44, 225-228.
174. A. Abate, E. Brenna, G. Fronza, C. Fuganti, S. Ronzani, S. Serra
Enzyme-Mediated Preparation of Chiral 1,3-Dioxane Odorants.
Helv. Chim. Acta, 2003, 86, 592-606.
175. E. Brenna, G. Fronza, C. Fuganti, M. Pinciroli,
Differentiation of natural and synthetic phenylalanine and tyrosine through Natural Abundance 2 H Nuclear
Magnetic Resonance"
J. Agric. Food Chem., 2003 , 51, 4866 – 4872.
176. S. Armellin, E. Brenna, G. Fronza, C. Fuganti, G. A. Magnone, C. Pellegatta
Structural characterisation of an impurity of a commercial sample of Tamoxifen.
Pharm. Ind., 2004, 66, 224-227.
177. S. Armellin, E. Brenna, G. Fronza, C. Fuganti, M. Pinciroli, S. Serra
Establishing the synthetic origin of amphetamines by 2 H NMR spectroscopy.
Analyst, 2004, 129, 130-133.
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178. L. Malpezzi, G. Fronza, C. Fuganti, A. Mele, S. Bruckner
Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochloridecyclomaltoheptaose
(-cyclodextrin), by X-ray diffraction.
Carbohydrate Research, 2004, in press.
179. G. Fronza, C. Fuganti, M. Pinciroli, S. Serra
Stereochemical Aspects of the Bioreduction of the conjugated double bond of perillaldehyde.
Tetrahedron: Asymmetry, 2004, 15, 3073-3077.
180. E. Brenna, G. Fronza, C. Fuganti, F. G. gatti, M. Pinciroli, S. Serra
Differentiation of Extractive and Synthetic salicin. The 2 H Aromatic Pattern of Natural 2-Hydroxybenzyl
Alcohol.
J. Agric. Food Chem., 2004, 52, 7747– 7751.
181. A. Abate, E. Brenna, G. Fronza, C. Fuganti, F. G. Gatti, S. Serra, E. Zardoni
Preparation of the enantiomerically enriched isomers of the odorous cyclic ethers Clarycet, Florol and
Rhubafuran by enzymatic catalysis.
Helv. Chim. Acta, 2004, 87, 765-780.
182. T. Haack, R. Fattori, M. Napoletano, F. Pellacini, G. Fronza, G. Raffaini, F. Ganazzoli
Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstitutedderivatives.
Bioorg. Med. Chem., 2005, 13, 4425-4433.
183. Arnone, A. Bava, G. Fronza, G. Nasini, E. Ragg
Concavine, an unusual diterpenic alkaloid produced by the fungus Clitocybe concava.
Tetrahedron Lett., 2005, 46, 8037-8039.
184. E. Brenna, G. Fronza, C. Fuganti, F. G. Gatti, V. Grande, S. Serra, C. Guillou, F. Remiero, F. Serra
Stable isotope characterization of the ortho-oxygenated phenylpropanoids: Coumarin and Melilotol.
J. Agric. Food Chem., 2005, 53, 9383-9388.
185. Mele, G. Romanò, M. Giannone, E. Ragg, G. Fronza, G. Raos, V. Marcon
The local structure of ionic liquids: cation-cation NOE interactions and internuclear distances in neat [BMIN][BF 4 ] and
[BDMIM}[BF 4 ].
Angew. Chem. Int. Ed., 2006, 45, 1123-1126.
186. H-L. Schmidt, R. A. Werner, W. Eisenreich, C. Fuganti, G. Fronza, G. Remaud, R. J. Robins
The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: Basis of
the isotopic characteristics of natural aromatic compounds.
Phytochemistry, 2006, 67, 1094-1103
187. S. Armelli, E. Brenna, S. Frigoli, G. fronza, C. Fuganti, D. Mussida
Determination of the synthetic Origin of Methamphetamine samples by 2 H NMR Spectroscopy.
Anal. Chem., 2006, 78, 3113-3117
188. A. Bava, S. Dallavalle, G. Fronza, G. Nasini, O. Vajna de Pava
Absolute Configuration of Sporotricale and structure of 6-Hydroxysporotricale
J. Nat. Prod., 2006, 69, 1793-1795.
189. E. Brenna, G. Fronza, C. Fuganti
Traceability of synthetic drugs by position-specific deuterium isotope ratio analysis. The case of prozac and fluoxetine
generics.
Analytica Chimica Acta, 2007, 601, 234-239.
190. E. Brenna, S. Frigoli, G. Fronza, C. Fuganti, L. Malpezzi
Isolation and characterisation of a phenolic impurity in a commercial sample of duloxetine.
J. Pharm. Biomed. Analysis, 2007, 43, 1573-1575.
191. E. Brenna, C. Fuganti, G. Fronza, F. G. Gatti, F. sala, S. Serra
New synthetic approachto atipica retinoics: application of a versatile annulation procedure.
Tetrahedron, 2007, 63, 2351-2356.
192. G. Nasini, A. Bava, G. Fronza, G. Giannini
17

Microbial transformation of spirolaxine, a bioactive undecaketide fungal metabolita from Basidioycete Sporotrichum
laxum.
Chemistry & Biodiversity, 2007, 4, 2772-2779.
193. E. Brenna, S. Frigoli, G. Fronza, C. Fuganti, S. serra
Impurities of tazarotene: isolation and structural characterisation.
J. Pharm. Biomed. Anal., 2008, 46, 574-576.
194. D. Accett, E. Brenna, G. fronza, C. Fuganti
Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: the case of ibuprofen and naproxen.
Talanta, 2008, 76, 651.655.
195. A. arnone, A. bava, G. Fronza, G. Nasini
Anomalous microbial transformation on the taxane ring of 10-DAB by a strain of the fungus Curvularia lunata:
transbezoylation, transacetylation, and opening of the oxetane ring.
J. Nat. Prod., 2009, 72, 2000-2004.
196. G. Fronza, C. Fuganti, S. Serra
Stereochemical course of the Baker’s yeast mediated reduction of the tri- and tetrasubstituted double bonds of substituted
cinnamaldehydes.
Eur. J. Org. Chem., 2009, 6160-6171.
197. E. Beneventi, G. Ottolina, G. carrea, W. Panzeri, G. Fronza, P. C. K. Lau
Enzimatic Baeyer-Villiger oxidation of steroidswith cyclopentadecanone monooxygenase.
J. Mol. Catalysis B: Enzymatic, 2009, 58, 164-168.
198. E. Brenna, G. Fronza, C. Fuganti, F. G. Gatti
Stereochemical analysis of the enzimi reduction of the double bond of a- and b-substituted nitrostyrenes and a-
ethoxycinnamaldehyde through deuterium labelling experiments.
Eur. J. Org. Chem., 2010, 5077-5084.
199. A. Arnone, A. Bava, G. fronza, L. Malpezzi, G. Nasini
Microbial transformation of taxan ring of 10-DAB by some strains of the fungus Curvularia lunata: formation of the bisabeotaxanes
wallifoliol an 4-deacylwallifoliol.
J. Nat. Prod., 2010, 73, 1049-1052.
18