Cardiomiopatia aritmogena: dall'autopsia al topo transgenico. - sicoa

RASSEGNE
Gaetano Thiene
Cardiomiopatia aritmogena: dall’autopsia al topo transgenico
RASSEGNE
geni e in casi estremi il trapianto cardiaco.
Il defibrillatore impiantabile, con un catetere in
ventricolo destro in grado di scaricare uno shock
elettrico all’insorgenza di una fibrillazione ventricolare,
ha del miracoloso convertendo la fibrillazione
ventricolare in ritmo sinusale,
come una vera e propria
“resurrezione” (vita
morte vita) come
dimostrato da Dome nico
Corrado 40, 41 (Fig. 22).
Si tratta di approcci terapeutici
sintomatici, che
non intervengono sul problema
biologico della ma -
lattia, ovvero nella morte
spontanea del cardiomiocita.
Collasso delle giunzioni
cellulari a seguito
dello stiramento meccanico
nelle fasi di dilatazione-contrazione
della sisto -
le-diastole Segnali intracellulari
aberranti, provenienti dalle proteine de -
smosomiali geneticamente difettose È questa la
Bibliografia
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Fig. 23 - A confronto il frontespizio del De Re Anatomica di Realdo
Colombo, dipinto da Paolo Veronese, con il logo dell’Association for
European Cardiovascular Pathology, che mette insieme cuore, teatro
anatomico di Fabrizio d’Acquapendente e doppia elica.
sfida per il prossimo futuro, per vincere la lotta
contro la cardiomiopatia aritmogena e assicurare
ai pazienti affetti una vita senza l’incubo dell’arresto
cardiaco e per una procreazione responsabile
senza il rischio di trasmettere una malattia incurabile
42 .
Conclusioni
La storia degli studi e scoperte
sulla cardiomiopatia
aritmogena, scritte al l’Uni -
versità di Padova, ripercorre
le tradizioni anatomiche
del nostro Ateneo e
l’apertura verso il nuovo,
ovvero la Me dicina Mo -
lecolare, da Ve salio e Re -
aldo Co lombo a Watson e
Crick. Non a caso il logo
del l’As so cia zione Eu ro -
pea di Pato logia Cardio -
va scolare vede il cuore e
il DNA all’interno del teatro di Fabrizio d’Acqua -
pendente (Fig. 23).
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CARDIOLOGY SCIENCE 243
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VOL 10 • GENNAIO-MARZO 2012