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Giovanni ADDOLORATO

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• ACAMPROSATO e GHB:<br />

- Iperammoniemia<br />

Iperammoniemia Laborit et al, Int J Neuropharmacol 1964<br />

Ahboucha et al, Metab Brain Dis 2004<br />

• NALTREXONE:<br />

- controindicato nei pz epatopatici<br />

- causa epatotossicità<br />

Atkinson et al, Clin Pharm Ther 1985<br />

Weinrieb et al, Psychosomatics 2001<br />

• TOPIRAMATO<br />

- Iperammonemia<br />

- induce alterazioni della funzionalità epatica<br />

Latour et al, Hum Psychopharmacol 1992<br />

epatica Harden, Epilepsia 2000

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