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Giovanni ADDOLORATO

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Naltrexone<br />

Antagonista dei recettori degli oppioidi, agisce con un<br />

meccanismo di estinzione. Efficace nel ridurre il craving e<br />

l’intake di alcol. Approvato dall’FDA nel 1994<br />

Naltrexone<br />

Placebo<br />

Rates of continuous abstinence according to<br />

treatment groups (n = 97)<br />

100 p < 0.01<br />

80<br />

- NTX/Coping skills<br />

- NTX/Supportive therapy<br />

- Placebo/Coping skills<br />

- Placebo/Supportive therapy<br />

60<br />

61%<br />

40<br />

20<br />

21%<br />

19%<br />

28%<br />

0<br />

20 40 60 80<br />

O'Malley et al, Arch Gen Psychitry, 1992<br />

Volpicelli et al, Arch Gen Psychiat 1992<br />

O’Malley et al, Arch Gen Psychiat 1992

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