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Geneesmiddeleninteracties - Imelda

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Metabolisme<br />

• dextromethorfan = CYP2D6 substraat<br />

• amiodarone = CY2D6 inhibitor<br />

Amiodarone (Cordarone)<br />

+ dextromethorfan (Dexir, Tussipect,...)<br />

• risico op toxiciteit dextromethorfan (excitatie, verwardheid)<br />

• monitoring effect - eventueel dosis dextromethorfan reduceren of ander<br />

preparaat kiezen<br />

Hormonale contraceptiva<br />

+ Sint-Janskruid (Zibrine, Perika,...)<br />

• desogestrel, ethinylestradiol, norethisteron = CYP3A4<br />

substraat<br />

• Sint-Janskruid = CYP3A4 inducer<br />

• risico op doorbraakbloedingen en falen contraceptie<br />

• combinatie vermijden - bijkomende contraceptie toepassen<br />

8

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