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NTOG 2011 02

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misoprostol-induced abortion after cesarean<br />

delivery: a systematic review. Obstet Gynecol<br />

2009;113:1117-23.<br />

5. Bagga R, Chaudhary N, Kalra J. Rupture in an<br />

unscarred uterus during second trimester<br />

pregnancy termination with mifepristone and<br />

misoprostol. Int J Gynaecol Obstet 2004;87:42-3.<br />

6. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC,<br />

Gilstrap LC, Wenstrom KD. Williams Obstetrics.<br />

22nd ed. USA: McGraw-Hill, 2005.<br />

7. Daskalakis GJ, Mesogitis SA, Papantoniou NE,<br />

Moulopoulos GG, Papapanagiotou AA, Antsaklis<br />

AJ. Misoprostol for second trimester pregnancy<br />

termination in women with prior caesarean<br />

section. BJOG 2005;112:97-9.<br />

8. Jeurissen SE, Harinck HI, Oepkes D. Low dose<br />

synthetic prostaglandin E2: always safe for<br />

pregnancy termination? Lancet 2004;364:1010.<br />

9. Berghella V, Airoldi J, O’Neill AM, Einhorn K,<br />

Hoffman M. Misoprostol for second trimester<br />

pregnancy termination in women with prior<br />

caesarean: a systematic review. BJOG 2009;116:1151-<br />

7.<br />

10. Dickinson JE, Brownell P, McGinnis K, Nathan EA.<br />

Mifepristone and second trimester pregnancy<br />

termination for fetal abnormality in Western<br />

Australia: Worth the effort. Aust N Z J Obstet<br />

Gynaecol 2010;50:60-64.<br />

Samenvatting<br />

Een ruptuur in een uterus zonder litteken in het tweede<br />

trimester is zeldzaam. We bespreken een dergelijke<br />

casus en geven een literatuuroverzicht. De ruptuur<br />

ontstond tijdens zwangerschapsafbreking met<br />

misoprostol in het tweede trimester en werd ontdekt<br />

bij curettage. Bekendheid met deze complicatie die<br />

zelden voorkomt in het tweede trimester kan doctor’s<br />

delay en potentieel gevaarlijke curettage voorkomen.<br />

Trefwoorden<br />

uterusruptuur, uterus zonder litteken, complicatie,<br />

tweede trimester, misoprostol<br />

Summary<br />

This case reports the unsuspected rupture of an unscarred<br />

second trimester uterus during self-induced<br />

termination of pregnancy. After five days of misoprostol-induced<br />

abortion at 21-weeks’ gestation, a<br />

woman was referred for intrauterine infection and<br />

failed induction. After undergoing a curettage, a uterine<br />

rupture was suspected. At laparotomy, the foetus<br />

and placenta were found expelled into the right<br />

broad ligament. Rupture of the unscarred second trimester<br />

uterus during misoprostol-induced abortion is<br />

a rare complication. Awareness of the complication<br />

may prevent delay and a potentially unsafe curettage.<br />

11. Brouns JF, Wely M van, Burger MP, Wijngaarden<br />

WJ van. Comparison of two dose regimens of<br />

misoprostol for second-trimester pregnancy<br />

termination. Contraception 2010;82:266-75.<br />

12. Lohr PA, Hayes JL, Gemzell-Danielsson K. Surgical<br />

versus medical methods for second trimester<br />

induced abortion. Cochrane.Database Syst Rev<br />

2008; CD006714.<br />

13. Carbonell JL, Gallego FG, Llorente MP, Bermudez<br />

SB, Sala ES, Gonzalez LV, et al. Vaginal vs.<br />

sublingual misoprostol with mifepristone for<br />

cervical priming in second-trimester abortion by<br />

dilation and evacuation: a randomized clinical trial.<br />

Contraception 2007;75:230-7.<br />

14. Hackett GA, Reginald P, Paintin DB. Comparison of<br />

the Foley catheter and dinoprostone pessary for<br />

cervical preparation before second trimester<br />

abortion. BJOG 1989;96:1432-4.<br />

15. Jansen NE, Pasker-de Jong PC, Zondervan HA.<br />

Mifepristone and misoprostol versus Dilapan and<br />

sulprostone for second trimester termination of<br />

pregnancy. J Matern Fetal Neonatal Med<br />

2008;21:847-51.<br />

16. Borras A, Gomez O, Sanz M, Martinez JM, Puerto<br />

B. Feticide followed by mifepristone-misoprostol<br />

regimen for midtrimester termination of pregnancy<br />

in two cases of complete placenta previa. Fetal<br />

Diagn Ther 2010;28:114-16.<br />

Keywords<br />

uterine rupture, unscarred uterus, complication,<br />

second trimester, misoprostol<br />

Gemelde (financiële) belangenverstrengeling<br />

geen<br />

Auteurs<br />

Mw. drs. W. Wiltenburg, gynaecoloog, UMC St<br />

Radboud, Nijmegen, thans chef de clinique, Rijnstate<br />

ziekenhuis, Arnhem<br />

Mw. drs. K.M.W.H. Smeets, gynaecoloog, Slingeland<br />

ziekenhuis, Doetinchem<br />

Prof. dr. F.K. Lotgering, gynaecoloog, UMC St Radboud,<br />

Nijmegen<br />

Correspondentieadres<br />

Mw. drs. W. Wiltenburg, gynaecoloog<br />

Afdeling Verloskunde & Gynaecologie<br />

UMC St Radboud<br />

Huispost 791<br />

Postbus 9101<br />

6500 HB Nijmegen<br />

Telefoon: 06 23185569<br />

E-mail: w_wiltenburg@hotmail.com<br />

74

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