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Adefovir… Entekavir… Tenofovir… - Klimik

Adefovir… Entekavir… Tenofovir… - Klimik

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Fosfor, proteinler ve glikoz proksimal tübülde yeniden<br />

absorbe edilir<br />

RENAL GLOMERÜL<br />

PROKSİMAL<br />

TÜBÜL<br />

DISTAL<br />

TÜBÜL<br />

Yeniden absorbe ettikleri:<br />

• Glikoz, küçük proteinler, fosfor<br />

TDF proksimal tübülde birikir 1–3<br />

• MRP4 TDF’i aktif olarak proksimal tübüle<br />

taşır 3<br />

• MRP4 doyuca TDF intrasellüler ortamda<br />

birikip tübüler zarara yol açabilir<br />

TOPLAYICI KANAL<br />

HENLE HALKASI<br />

MESANEYE<br />

Created from 1.Rodriguez-Novoa S, et al. Clin. Infect. Dis. 2009;48:108–16; 2. Ray AS, et al. Antimicrob Agents Chemother. 2006;50:3297–304;<br />

3. Viread ® (tenofovir) SmPC December 2012.

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