RESEARCH ARTICLE DOI: 10.4274/tjh.2015.0280 Turk J Hematol 2016;<strong>33</strong>:265-272 Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study <strong>of</strong> the <strong>Turkish</strong> Pediatric Bone Marrow Transplantation Study Group Otolog Hematopoetik Kök Hücre Nakli Uygulanmış Hodgkin Lenfomalı Çocuk ve Adölesanlarda Prognostik Faktörler ve Yeni Bir Prognostik İndeks Modeli: Türk Pediatrik Kemik İliği Nakli Çalışma Grubundan Çok Merkezli Çalışma Vural Kesik 1 , Erman Ataş 1 , Musa Karakükcü 2 , Serap Aksoylar 3 , Fatih Erbey 4 , Nurdan Taçyıldız 5 , Alphan Küpesiz 6 , Haldun Öniz 7 , Ekrem Ünal 2 , Savaş Kansoy 3 , Gülyüz Öztürk 4 , Murat Elli 8 , Zühre Kaya 9 , Emel Ünal 5 , Volkan Hazar 6 , Şebnem Yılmaz Bengoa 10 , Gülsün Karasu 11 , Didem Atay 4 , Ayhan Dağdemir 8 , Hale Ören 10 , Ülker Koçak 9 , M. Akif Yeşilipek 11 1Gülhane Training and Research Hospital Clinic <strong>of</strong> Pediatric Oncology, Ankara, Turkey 2Erciyes University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric <strong>Hematology</strong>-Oncology and Bone Marrow Transplantation Unit, Kayseri, Turkey Öz 3Ege University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric Oncology and Bone Marrow Transplantation Unit, İzmir, Turkey 4Medical Park Bahçelievler Hospital, Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey 5Ankara University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric Oncology and Bone Marrow Transplantation Unit, Ankara, Turkey 6Akdeniz University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric <strong>Hematology</strong>-Oncology and Bone Marrow Transplantation Unit, Antalya, Turkey 7Tepecik Training and Research Hospital, Clinic <strong>of</strong> Pediatric Oncology and Bone Marrow Transplantation Unit, İzmir, Turkey 8Ondokuz Mayıs University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric Oncology and Bone Marrow Transplantation Unit, Samsun, Turkey 9Gazi University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric <strong>Hematology</strong> and Bone Marrow Transplantation Unit, Ankara, Turkey 10Dokuz Eylül University Faculty <strong>of</strong> Medicine, Department <strong>of</strong> Pediatric <strong>Hematology</strong> and Bone Marrow Transplantation Unit, İzmir, Turkey 11Medical Park Göztepe Hospital, Pediatric Bone Marrow Transplantation Unit, İstanbul, Turkey Abstract Objective: The prognostic factors and a new childhood prognostic index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin’s lymphoma (HL) were evaluated. Materials and Methods: The prognostic factors <strong>of</strong> 61 patients who underwent AHSCT between January 1990 and December 2014 were evaluated. In addition, the Age-Adjusted International Prognostic Index and the Childhood International Prognostic Index (CIPI) were evaluated for their impact on prognosis. Results: The median age <strong>of</strong> the 61 patients was 14.8 years (minimummaximum: 5-20 years) at the time <strong>of</strong> AHSCT. There were single relapses in 28 patients, ≥2 relapses in eight patients, and refractory disease in 25 patients. The chemosensitivity/chemorefractory ratio was 36/25. No pretransplant radiotherapy, no remission at the time <strong>of</strong> Öz Amaç: Relaps/refrakter Hodgkin lenfomanın (HL) otolog hematopoetik kök hücre nakli (OHKHN) sonrasındaki prognozunu gösterecek belirteçler ve çocukluk çağında yeni bir prognostik skorlama araştırıldı. Gereç ve Yöntemler: Bu çalışmada, Ocak 1990-Aralık 2014 tarihleri arasında OHKHN uygulanan 61 hastanın OHKHN sonrası prognozunu etkileyen faktörlerin sağkalım üzerine etkisi araştırıldı. Aynı zamanda Yaşa Göre Düzeltilmiş Uluslararası Prognostik İndeks ve Çocukluk Dönemi Uluslararası Prognostik İndeks’lerinin (ÇDUPİ) prognoz üzerindeki etkisi değerlendirildi. Bulgular: Altmış bir hastanın ortanca yaşı OHKHN sırasında 14,8 yıl (5-20 yıl) idi. Hastalardan, 28 olguda bir relaps, 8 olguda ≥2 relaps ve 25 olguda refrakter hastalık vardı. Kemosensitivite/kemoterapiye dirençlilik oranı 36/25 idi. Nakil öncesi radyoterapi almamak, nakil öncesi remisyonda olmamak, nakil sonrası beyaz kan hücresi sayısının Address for Correspondence/Yazışma Adresi: Vural KESİK, M.D., Gülhane Training and Research Hospital Clinic <strong>of</strong> Pediatric Oncology, Ankara, Turkey Phone : +90 312 304 43 94 E-mail : vural73@yahoo.com Received/Geliş tarihi: July 29, 2015 Accepted/Kabul tarihi: November 02, 2015 265
Kesik V, et al: Prognostic Markers <strong>of</strong> Hodgkin’s Lymphoma after Autologous Hematopoietic Stem Cell Transplantation Turk J Hematol 2016;<strong>33</strong>:265-272 transplantation, posttransplant white blood cell count over 10x10 3 / µL, posttransplant positron emission tomography positivity at day 100, and serum albumin <strong>of</strong>
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