In vitro Analyse der Interaktion von IgA und - Stiftung Tierärztliche ...

=XVDPPHQIDVVXQJHQ
=XVDPPHQIDVVXQJ
��
'HQGULWLV�KH =HOOHQ '& JHK|UHQ PLW 0DNURSKDJHQ XQG % =HOOHQ ]X GHQ SURIHVVLR
QHOOHQ DQWLJHQSUlVHQWLHUHQGHQ =HOOHQ 6LH VLQG LQ GHU /DJH EHVRQGHUV HIIHNWLY UX
KHQGH /\PSKR]\WHQ ]X VWLPXOLHUHQ 'LH 9RUOlXIHU GHU '& VWDPPHQ DXV GHP .QR
�KHQPDUN XQG ZHUGHQ PLW GHP %OXWVWURP LQ QDKH]X DOOH QL�KW O\PSKRLGHQ *HZHEH
DXVJHV�KZHPPW ,P *HJHQVDW] ]XU %LQGXQJ YRQ ,J$ ZXUGH GLH %LQGXQJ YRQ ,J*
XQG $QWLJHQ ,J* .RPSOH[HQ EHL '& EHUHLWV EHV�KULHEHQ
%LV GDWR LVW HV P|JOL�K EHL GHU 0DXV '& DXV %OXW 0LO] 7K\PXV +DXW XQG .QR
�KHQPDUN ]X JHZLQQHQ 'LH ,VROLHUXQJ YRQ 9RUOlXIHU]HOOHQ DXV GHP .QR�KHQPDUN
PLW DQV�KOLH‰HQGHU .XOWLYLHUXQJ ELHWHW GDEHL LP *HJHQVDW] ]XU GLUHNWHQ ,VROLHUXQJ
YRQ '& DXV GHQ *HZHEHQ HLQ 6\VWHP GDV HV HUODXEW UHODWLY JUR‰H 0HQJHQ DQ KR
PRJHQHQ '& ]X JHZLQQHQ $P %HJLQQ PHLQHU $UEHLW VWDQG GLH (WDEOLHUXQJ GLHVHU
0HWKRGLN DQKDQG DNWXHOO SXEOL]LHUWHU 3URWRNROOH 'DEHL VWHOOWH VL�K KHUDXV GDVV PLW
+LOIH GHV YRQ /87= HW DO DEJHOHLWHWHQ 3URWRNROOV JHJHQ EHU GHU 0HWKRGH YRQ
,QDED HW DO EHVRQGHUV HIIHNWLY '& JHZRQQHQ ZHUGHQ N|QQHQ
$XI GLHVHQ YRQ PLU LQ YLWUR LQGX]LHUWHQ '& NRQQWH GLH VSH]LILV�KH %LQGXQJ YRQ ,J$
QD�KJHZLHVHQ ZHUGHQ 'DEHL EDQG VRZRKO SRO\NORQDOHV DOV DX�K PRQRNORQDOHV ,J$
DQ GLH '& 'LH %LQGXQJ YRQ ,J$ HLQHU YRQ PLU LVROLHUWHQ ,VRW\S 6ZLW�K 9DULDQWH PLW
6SH]LILWlW I U GDV EDNWHULHOOH JUR(/ 3URWHLQ NRQQWH HEHQIDOOV JH]HLJW ZHUGHQ %HL GHU
9HUZHQGXQJ YRQ SRO\PHUHP ,J$ HUJDE VL�K HLQH GHXWOL�KH 'RVLVDEKlQJLJNHLW 0LW
VWHLJHQGHU .RQ]HQWUDWLRQ DQ HLQJHVHW]WHP ,J$ EDQGHQ PHKU '& ,J$ DXI LKUHU 2EHU
IOl�KH
0LW +LOIH XQWHUV�KLHGOL�KHU 6WLPXODQ]LHQ ZDU L�K LQ GHU /DJH GDV $XVPD‰ GHU %LQ
GXQJ YRQ ,J$ ]X YDULLHUHQ 6R I KUWH 71) D LP *HJHQVDW] ]X SXEOL]LHUWHQ %HIXQGHQ
ZlKUHQG HLQHU NXU]HQ ,QNXEDWLRQV]HLW ]X HLQHU $EQDKPH GHU %LQGXQJ ,J$ 8QWHU GHU
:LUNXQJ YRQ 71) D EHU HLQHQ =HLWUDXP YRQ 6WXQGHQ NRQQWH LQ KRKHQ .RQ]HQ
WUDWLRQHQ YRQ 71) D HLQH $EQDKPH XQG LQ QLHGULJHQ .RQ]HQWUDWLRQHQ HLQ 6WHLJHUXQJ
GHU %LQGXQJ YRQ ,J$ EHRED�KWHW ZHUGHQ 'LH %LQGXQJ YRQ ,J* ZXUGH GXU�K 71) D
GDJHJHQ NDXP EHHLQIOXVVW