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Definition GOLD 2001:
COPD is a disease state characterised by airflow limitation
that is not fully reversible. The airflow limitation is usually
both progressive and associated with an abnormal inflammatory
response of the lungs to noxious particles or gases.
Definition ATS / ERS 2004:
Chronic obstructive pulmonary disease (COPD) is a
preventable and treatable disease state characterised by
airflow limitation that is not fully reversible. The airflow
limitation is usually progressive and is associated with an
abnormal inflammatory response of the lungs to noxious
particles or gases, primarily caused by cigarette smoking.
Although COPD affects the lungs, it also produces significant
systemic consequences.
Pathogenese der
Chronisch Obstruktiven
Bronchitis COPD
CD8+ Lymphozyt Makrophage Epithelzellen
IL-8
TNF-α
IL-8
LTB4
O2 - O2 -
Proteasen
Granulozyt
Fibroblast
Bindegewebsproliferation und Fibrose
Hypersekretion Fibrose Proteolyse
Chronische Bronchitis / Obstruktive Bronchiolitis / Emphysem
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