Download - Berlin School of Mind and Brain
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Corinde Wiers<br />
The Neural Effects <strong>of</strong> Alcohol Bias Modification Training<br />
The pathology <strong>of</strong> alcoholism is associated with maladaptive attention- <strong>and</strong> approach<br />
biases towards substance-related stimuli, i.e. the tendency <strong>of</strong> alcoholic patients to<br />
approach rather than avoid these stimuli, even though they are not rationally inclined to.<br />
From animal studies it is known that limbic areas are structurally <strong>and</strong> functionally altered<br />
after long-term drinking, but the neural mechanisms <strong>of</strong> alcohol biases in humans remain<br />
largely unknown. In this talk I present my currently ongoing research, in which I use fMRI<br />
<strong>and</strong> EEG to study brain regions involved in these biases in alcoholic patients. My<br />
hypothesis is that limbic brain activity predicts performance on a computerised alcohol<br />
bias task. My next step is to underst<strong>and</strong> how bias modification training, a promising<br />
intervention in which patients selectively learn to avoid rather than approach stimuli,<br />
modulates the brain <strong>and</strong> may prevent relapse. Finally I talk about how neuroimaging can<br />
be <strong>of</strong> use for the treatment <strong>of</strong> alcohol addiction directly.<br />
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